Blog of Signaling Pathways

Active natural compounds perturb the melanoma risk-gene network

61 views | Jan 07 2024

The study ingeniously employs network modeling of melanoma-associated genes, revealing crucial pathways and potential therapeutic targets while showcasing the predictive potential of this model in evaluating the efficacy of anti-melanoma phytochemicals. [Read the Full Post]

Optimized M24B Aminopeptidase Inhibitors for CARD8 Inflammasome Activation

34 views | Jan 07 2024

The development of CQ80 as a selective dual inhibitor of PEPD and XPNPEP1 presents a promising avenue to selectively activate the CARD8 inflammasome, offering a potent tool for studying its biology and therapeutic potential in inflammation-related conditions. [Read the Full Post]

Targeting stearoyl-coa desaturase enhances radiation induced ferroptosis and immunogenic cell death in esophageal squamous cell carcinoma

22 views | Jan 07 2024

Targeting Stearoyl-coa desaturase 1 (SCD1) using MF-438 induced ferroptosis, enhanced immunogenicity, and improved radiation sensitivity in esophageal squamous cell carcinoma (ESCC), offering potential therapeutic avenues and identifying SCD1 as a prognostic marker for ESCC survival. [Read the Full Post]

A pilot study of orelabrutinib treatment in three cases of refractory/relapsed autoimmune haemolytic anaemia/Evans syndrome

42 views | Jan 07 2024

The promising response of nine out of twelve patients in our orelabrutinib trial for refractory/relapsed AIHA/Evans Syndrome indicates its potential as a new second-line treatment, offering hope for improved management and quality of life in these conditions. [Read the Full Post]

Synthesis, Screening and Characterization of Novel Potent Arp2/3 Inhibitory Compounds Analogous to CK-666

33 views | Jan 07 2024

A comprehensive screening of 74 compounds related to CK-666 revealed two potent Arp2/3 inhibitors, compounds 59 and 69, which displayed improved in vivo efficiency despite being slightly less effective in vitro, validating original assays for Arp2/3 activity while offering promising candidates for further study. [Read the Full Post]

Pycard deficiency inhibits microRNA maturation and prevents neointima formation by promoting chaperone-mediated autophagic degradation of AGO2/argonaute 2 in adipose tissue

25 views | Jan 06 2024

The study reveals that PYCARD regulates neointima formation by inhibiting chaperone-mediated autophagy-induced degradation of AGO2, impacting microRNA biogenesis independently of inflammasome activity, offering potential therapeutic strategies for vascular conditions. [Read the Full Post]

Sertad1 Induces Neurological Injury after Ischemic Stroke via the CDK4/p-Rb Pathway

103 views | Jan 06 2024

Sertad1, upregulated in ischemic conditions, exacerbates neurological injury by activating the CDK4/p-Rb pathway, promoting cell cycle dysregulation and apoptotic cell death. [Read the Full Post]

Tuftelin 1 Facilitates Hepatocellular Carcinoma Progression through Regulation of Lipogenesis and Focal Adhesion Maturation

32 views | Jan 06 2024

The study delineates TUFT1's pivotal role in hepatocellular carcinoma (HCC) progression by elucidating its influence on lipid metabolism, cell proliferation through CREB1 interaction, and invasion via modulation of zyxin expression and recruitment to focal complexes in HCC cells. [Read the Full Post]

Mechanism of RIP2 enhancing stemness of glioma cells induces temozolomide resistance

53 views | Jan 06 2024

The study elucidates that the receptor-interacting protein 2 (RIP2) mediates temozolomide (TMZ) resistance in gliomas by regulating stemness through the NF-κB pathway, potentially offering a novel therapeutic target for overcoming drug resistance in these tumors. [Read the Full Post]

Inhibition of USP2 Enhances TRAIL-Mediated Cancer Cell Death through Downregulation of Survivin

20 views | Jan 06 2024

The study reveals that targeting Ubiquitin-specific protease 2 (USP2) using the inhibitor ML364 enhances TNF-related apoptosis-inducing ligand (TRAIL)-induced cancer cell death selectively by promoting ubiquitination and degradation of survivin, offering a potential avenue for targeted cancer therapies. [Read the Full Post]

Liquid chromatography-tandem mass spectrometry based simultaneous quantification of tryptophan, serotonin and kynurenine pathway metabolites in tissues and cell culture systems

30 views | Jan 05 2024

This groundbreaking UPLC-MS/MS method for quantifying kynurenine-related metabolites holds immense promise in unraveling intricate disease pathways and could pave the way for targeted therapeutic interventions. [Read the Full Post]

Combination of AS101 and Mefloquine Inhibits Carbapenem-Resistant Pseudomonas aeruginosa in vitro and in vivo

39 views | Jan 05 2024

The synergistic combination of AS101 and mefloquine exhibits potent antibacterial effects against carbapenem-resistant Pseudomonas aeruginosa, demonstrating promising potential for future clinical applications in treating CRPA infections. [Read the Full Post]

LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability

22 views | Jan 05 2024

The upregulation of LIPH in pancreatic ductal adenocarcinoma drives tumor progression by activating the LPA/LPAR axis, promoting aberrant glycolysis, and maintaining ALDOA stability, offering a potential avenue for a targeted gemcitabine-based combination therapy with limited side effects. [Read the Full Post]

Sulfatinib, a novel multi-targeted tyrosine kinase inhibitor of FGFR1, CSF1R, and VEGFR1-3, suppresses osteosarcoma proliferation and invasion via dual role in tumor cells and tumor microenvironment

48 views | Jan 05 2024

Sulfatinib demonstrates promise in inhibiting osteosarcoma growth while altering the tumor microenvironment towards an immune-activated state, offering potential for clinical translation. [Read the Full Post]

Current evidence for second-line treatment in metastatic renal cell carcinoma after progression to immune-based combinations

25 views | Jan 05 2024

The evolving landscape of metastatic renal cell carcinoma treatments, driven by immune checkpoint inhibitor-based combinations in the first line and uncertainties in subsequent therapies, highlights the need for predictive models and ongoing research to guide personalized, effective treatment strategies. [Read the Full Post]

Wnt signaling pathway inhibitor promotes mesenchymal stem cells differentiation into cardiac progenitor cells in vitro and improves cardiomyopathy in vivo

35 views | Jan 04 2024

"IWP-4 treatment of mesenchymal stem cells from human umbilical cord tissue enhances cardiac differentiation, leading to improved myocardial regeneration and functional recovery in a myocardial infarction rat model." [Read the Full Post]

The therapeutic effect of glycyrrhizic acid compound ointment on imiquimod-induced psoriasis-like disease in mice

36 views | Jan 04 2024

The compound ointment containing glycyrrhetinic acid and herbal monomers exhibited superior efficacy in ameliorating Imiquimod-induced psoriasis-like symptoms in mice, significantly reducing inflammatory factors and demonstrating a stronger therapeutic effect compared to calcipotriol ointment. [Read the Full Post]

iTRAQ-based quantitative proteomic analysis of the antibacterial mechanism of silver nanoparticles against multidrug-resistant Streptococcus suis

49 views | Jan 04 2024

The study elucidates that silver nanoparticles disrupt the morphology, inhibit key cellular processes, induce oxidative stress, and potentially interfere with biofilm formation in multidrug-resistant Streptococcus suis, proposing a multifaceted antibacterial mechanism. [Read the Full Post]

Utilization of AlphaFold models for drug discovery: Feasibility and challenges. Histone deacetylase 11 as a case study

59 views | Jan 04 2024

Your study on optimizing the HDAC11 AlphaFold model, validating it through molecular dynamics simulations and successful docking of known inhibitors, provides a promising foundation for structure-based drug design targeting HDAC11. [Read the Full Post]

Herbal compound cepharanthine attenuates inflammatory arthritis by blocking macrophage M1 polarization

36 views | Jan 04 2024

Cepharanthine (CEP) exhibits promising potential as a rheumatoid arthritis treatment by effectively reducing joint inflammation, inhibiting M1 macrophage polarization, and modulating key signaling pathways and metabolic processes associated with the disease. [Read the Full Post]