SGK

Vascular smooth muscle cell mechanotransduction through serum and glucocorticoid inducible kinase-1 promotes interleukin-6 production and macrophage accumulation in murine hypertension

35 views | Dec 27 2023

The investigation demonstrated that mechanical activation of serum and glucocorticoid-inducible kinase-1 (SGK-1) in aortic vascular smooth muscle cells (VSMCs), both in vivo in hypertensive mice and in vitro through cyclic stretch, promotes inflammatory signaling and macrophage accumulation, suggesting SGK-1 as a potential pharmacotherapeutic target for hypertensive vascular pathology. [Read the Full Post]

Protective effects of gallic acid and SGK1 inhibitor on oxidative stress and cardiac damage in an isolated heart model of ischemia/reperfusion injury in rats

31 views | May 29 2023

The study suggests that concomitant administration of gallic acid and the SGK1 gene inhibitor GSK650394 may have a more beneficial effect on cardiac ischemia/reperfusion injury than each drug alone. [Read the Full Post]