Design, Synthesis, and Antitumor Activity of Erlotinib Derivatives

155 views | May 08 2022

Long-Fei Mao et al. suggested that compound 3d suppressed cancer cell proliferation through the EGFR-TK pathway. [Read the Full Post]

Treatment outcomes of erlotinib plus gemcitabine as late-line chemotherapy in unresectable pancreatic cancer

597 views | Jun 16 2021

Takafumi Mie et al. found that benefits of erlotinib plus gemcitabine as late-line chemotherapy were limited, particularly with respect to PFS. [Read the Full Post]

Selective reactivation of STING signaling to target Merkel cell carcinoma

707 views | Feb 13 2021

Wei Liu et al. found that targeted delivery and activation of STINGS162A/G230I/Q266I in tumor cells held great therapeutic promise for the treatment of MCC and many other STING-deficient cancers. [Read the Full Post]

The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

717 views | Feb 13 2021

Muyue Yang et al. found that the changes of TME at various stages during tumor development are required to be further elucidated so that more individualized nanoplatforms could be designed. [Read the Full Post]

Non-Photoinduced Biological Properties of Verteporfin

0 views | Jan 23 2020

Gibault F et al. indicated that VP is a multi-target drug interacting with several proteins implicated in major cellular processes. Although this does not impact its clinical use, VP does not seem to be the ideal drug for pharmacological inhibitions of YAP/TEAD. [Read the Full Post]

Lippert, J. W., 3rd (2007). "Vascular disrupting agents." Bioorg Med Chem 15(2): 605-615.

3508 views | May 10 2011

This review summary the six small molecule vascular disrupting agents and let us tell the difference between vascular disrupting agents and vascular targeting agents. [Read the Full Post]

Tozer, G. M., C. Kanthou, et al. (2005). "Disrupting tumour blood vessels." Nat Rev Cancer 5(6): 423-435.

3417 views | Apr 3 2011

This article which is published in Nature Review Cancer not only reviews the basic information of VDAs, but provides many results about tumor cells which are treated with VDAs as well. [Read the Full Post]