Comprehensive analysis of ubiquitin-specific protease 1 reveals its importance in hepatocellular carcinoma

61 views | Mar 28 2021

Yalei Zhao et al. found that USP1 was a promising target for HCC treatment with good prognostic value. [Read the Full Post]

Valve endothelial-interstitial interactions drive emergent complex calcific lesion formation in vitro

127 views | Jan 24 2021

Terence W Gee et al. established that VEC actively induced VIC pathological remodeling and calcification via EndMT and paracrine signaling. [Read the Full Post]

Expression of ubiquitin-specific protease 7 in lung tissue of preterm rats after hyperoxia exposure

78 views | Jan 11 2021

Xiao-Yue Huang et al. thought that USP7 specific inhibitor P5091 might accelerate the degradation of β-catenin by enhancing its ubiquitination, reduce lung epithelial-mesenchymal transition, and thus exert a certain protective effect against hyperoxic lung injury. [Read the Full Post]

Inhibiting PLK1 induces autophagy of acute myeloid leukemia cells via mammalian target of rapamycin pathway dephosphorylation

0 views | Sep 03 2018

Tao YF et al. may provided new insights into the molecular mechanism of PLK1 in regulating autophagy. [Read the Full Post]

Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma

555 views | Jul 06 2018

Chen X et al. found that ubiquitin-specific protease 14 could be a potential therapeutic target for oral squamous cell carcinoma patients. [Read the Full Post]

The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase

1555 views | Jun 18 2018

McGarry E et al. revealed a novel role for USP9X in the maintenance of genomic stability during DNA replication and provide potential mechanistic insights into its tumor suppressor role in certain malignancies. [Read the Full Post]

Inhibition of deubiquitinases primes glioblastoma cells to apoptosis in vitro and in vivo

1392 views | Jun 18 2018

Karpel-Massler G et al. suggested that targeting deubiquitinases for glioma therapy is feasible and effective. [Read the Full Post]

A novel hypoxia-selective epigenetic agent RRx-001 triggers apoptosis and overcomes drug resistance in multiple myeloma cells

701 views | Jun 03 2018

Das DS et al. provided the rationale for translation of RRx-001, either alone or in combination, to clinical evaluation in MM. [Read the Full Post]

USP7 inhibitor P5091 inhibits Wnt signaling and colorectal tumor growth

648 views | Jun 03 2018

An T et al. indicated that USP7 could be a potential drug target and its inhibitor P5091 deserves further development as anticancer agent for Wnt hyper-activated CRC therapy. [Read the Full Post]