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ESKM, a novel therapeutic agent for sensitive and resistant PH+ leukemias

The mechanism of resistance to JAK2 inhibitor in myeloproliferative neoplasms patients

Effects of PARP inhibitors in BRCA gene-mutated ovarian cancer

DASATINIB; An inhibitor of Receptor Tyrosine Kinase

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

TGF-beta/Smad

Bone morphogenetic protein receptor inhibitors suppress the growth of glioblastoma cells

103 views | Mar 28 2022

Joel Kaye et al. suggested the need for development of BMP inhibitors and evaluation as potential therapeutic for GBMs. [Read the Full Post]

Penetration Cascade of Size Switchable Nanosystem in Desmoplastic Stroma for Improved Pancreatic Cancer Therapy

140 views | Dec 31 2021

Xiaozheng Zhao et al. found that the inhibition of ECM hyperplasia by VAC allowed TAX more ready access to the cancer cells in addition to its small size. [Read the Full Post]

Peptide-coating 2D and small chemical molecules prolong the passage of porcine spermatogonia stem cells

165 views | Dec 09 2021

Ying Zhang et al. found that feeder-free culture system optimized cell culture and might facilitate advanced research on SSC biology and genetic manipulation of germ cells. [Read the Full Post]

TGFβ1 Secreted by Cancer-Associated Fibroblasts as an Inductor of Resistance to Photodynamic Therapy in Squamous Cell Carcinoma Cells

167 views | Nov 28 2021

María Gallego-Rentero et al. found that the comparatively higher intrinsic resistance to PDT of SCC13 cells was mediated by the elevated levels of TGFβ1 secreted by this cell line. [Read the Full Post]

Reducing tumor invasiveness by ramucirumab and TGF-β receptor kinase inhibitor in a diffuse-type gastric cancer patient-derived cell model

196 views | Nov 03 2021

Song-Yi Lee et al. confirmed that combination of TEW-7197 and ramucirumab reduced tumor spheroid and GC PDC-induced blood vessel formation concomitantly in the spheroid-on-a-chip model. [Read the Full Post]

Graphene oxide-functionalized nanocomposites promote osteogenesis of human mesenchymal stem cells via enhancement of BMP-SMAD1/5 signaling pathway

273 views | Sep 19 2021

Zhong Li et al. demonstrated the biological activity and mechanism of action of GO-based nanosheets in augmenting the osteogenic capability of hMSCs. [Read the Full Post]

High WHSC1L1 Expression Reduces Survival Rates in Operated Breast Cancer Patients with Decreased CD8+ T Cells: Machine Learning Approach

381 views | Sep 15 2021

Hyung-Suk Kim et al. found that VX-11e, CZC24832, LY2109761, oxaliplatin and erlotinib were effective in inhibiting breast cancer cell lines with high WHSC1L1 expression. [Read the Full Post]

PM 2.5 and water-soluble components induce airway fibrosis through TGF-β1/Smad3 signaling pathway in asthmatic rats

308 views | Sep 03 2021

Hongyan Wu et al. thought that TGF-β1/Smad3 signaling pathway might be responsible for the pathological process of airway fibrosis in asthmatic rats following PM2.5 and water-soluble components exposure. [Read the Full Post]

Limb Remote Ischemic Conditioning Ameliorates Cognitive Impairment in Rats with Chronic Cerebral Hypoperfusion by Regulating Glucose Transport

528 views | Aug 27 2021

Changhong Ren et al. suggested that supplemental activation of glucose transport after CCH might provide a clinically applicable intervention for improving cognitive impairment. [Read the Full Post]

TGF-β Alters the Proportion of Infiltrating Immune Cells in a Pancreatic Ductal Adenocarcinoma

330 views | Jul 18 2021

Kasia Trebska-McGowan et al. found that TGF-β had an overall immunosuppressive effect mediated by TAM PD-L1 expression and decreased presence of DCs. [Read the Full Post]