Category
- PI3K/Akt/mTOR
- Epigenetics
- Methylation
- Immunology & Inflammation
- Protein Tyrosine Kinase
- Angiogenesis
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- ER stress & UPR
- JAK/STAT
- MAPK
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- Hippo
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- Endocrinology & Hormones
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Archives
Ras
The KRAS G12C Inhibitor MRTX849 Reconditions the Tumor Immune Microenvironment and Sensitizes Tumors to Checkpoint Inhibitor Therapy
130 views | Jun 22 2021
David M Briere et al. demonstrated KRAS inhibition reversed an immunosuppressive tumor microenvironment and sensitized tumors to CIT through multiple mechanisms. [Read the Full Post]
Flurbiprofen as a biphenyl scaffold for the design of small molecules binding to PD-L1 protein dimer
143 views | Jun 20 2021
Christian Bailly et al. found that the longer FLB derivative HCT1026 appeard as a suitable binder of the PD-L1 dimer, sliding well along the BMS binding cavity. [Read the Full Post]
Thyroglobulin as a negative marker for malignancy in canine and human breast tumors
136 views | May 19 2021
Sung-Hyun Hwang et al. found that Tg could be a negative indicator of malignancy in canine and human breast neoplasia. [Read the Full Post]
An essential role for Argonaute 2 in EGFR-KRAS signaling in pancreatic cancer development
164 views | Nov 22 2020
Sunita Shankar et al. supported a biphasic model of pancreatic cancer development: an AGO2-independent early phase of PanIN formation reliant on EGFR-RAS signaling, and an AGO2-dependent phase wherein the mutant KRAS-AGO2 interaction was critical for PDAC progression. [Read the Full Post]
