Category
- PI3K/Akt/mTOR
- Epigenetics
- Methylation
- Immunology & Inflammation
- Protein Tyrosine Kinase
- Angiogenesis
- Apoptosis
- Autophagy
- ER stress & UPR
- JAK/STAT
- MAPK
- Cytoskeletal Signaling
- Cell Cycle
- TGF-beta/Smad
- DNA Damage/DNA Repair
- Stem Cells & Wnt
- Hippo
- Ubiquitin
- Neuronal Signaling
- NF-κB
- GPCR & G Protein
- Endocrinology & Hormones
- Transmembrane Transporters
- Metabolism
- Proteases
- Microbiology
- Others
Archives
Wee1
Clinical benefit of systemic therapies for recurrent ovarian cancer-ESMO-MCBS scores
46 views | Aug 20 2021
K E Broekman et al. found that only a few licensed systemic therapies for recurrent ovarian cancer showed substantial clinical benefit based on ESMO-MCBS scores. [Read the Full Post]
Pharmacological Inhibition of WEE1 Potentiates the Antitumoral Effect of the dl922-947 Oncolytic Virus in Malignant Mesothelioma Cell Lines
77 views | Nov 27 2020
Carmelina Antonella Iannuzzi et al. suggested that the dl922-947-AZD1775 combination could be a feasible strategy against MM. [Read the Full Post]
The Apparent Requirement for Protein Synthesis during G2 Phase Is due to Checkpoint Activation
134 views | Jul 29 2020
Sarah Lockhead et al. showed that protein synthesis during G2 phase was not required for mitotic entry, at least when the p38 checkpoint pathway was abrogated. [Read the Full Post]
Orthotopic patient-derived xenografts of paediatric solid tumours
168 views | Apr 06 2020
Stewart E et al. identified several drug vulnerabilities and showed that the combination of a WEE1 inhibitor (AZD1775), irinotecan, and vincristine can lead to complete response in multiple rhabdomyosarcoma orthotopic patient-derived xenografts tumours in vivo. [Read the Full Post]
WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistance
172 views | Mar 14 2020
Zheng H et al. demonstrated that combined cisplatin treatment and WEE1 inhibition synergistically inhibits xenograft cancer growth accompanied by markedly reduced expression of TNBC signature genes. [Read the Full Post]
Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis
0 views | Oct 10 2019
Chen G et al. provided a novel therapeutic strategy to optimize MK-1775 treatment efficiency in lung cancers. [Read the Full Post]
Characterization of Three Novel H3F3A-mutated Giant Cell Tumor Cell Lines and Targeting of Their Wee1 Pathway
296 views | Jul 09 2019
Lübbehüsen C et al, offered valuable new tools for GCTB studies and presents a description of novel biomarkers and molecular targeting strategies. [Read the Full Post]
Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis
323 views | May 24 2019
Chen G et al. provided a novel therapeutic strategy to optimize MK-1775 treatment efficiency in lung cancers. [Read the Full Post]
WEE1 inhibition targets cell cycle checkpoints for triple negative breast cancers to overcome cisplatin resistance
0 views | Oct 03 2018
Zheng H et al. demonstrated that combined cisplatin treatment and WEE1 inhibition synergistically inhibits xenograft cancer growth accompanied by markedly reduced expression of TNBC signature genes. [Read the Full Post]
Expression and clinical significance of Wee1 in colorectal cancer
0 views | Oct 12 2017
Egeland EV et al. indicated that other tumor types might be better suited for further development of Wee1 inhibitors. [Read the Full Post]
