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Archives
CFTR
Lumacaftor-ivacaftor effects on cystic fibrosis-related liver involvement in adolescents with homozygous F508 del-CFTR
30 views | Sep 14 2021
David Drummond et al. suggested a potential beneficial effect of CFTR modulators on CF liver disease and warrant further investigation in larger, prospective studies. [Read the Full Post]
A Precision Medicine Approach to Optimize Modulator Therapy for Rare CFTR Folding Mutants
47 views | Aug 13 2021
Guido Veit et al. thought that HNE, as a precision medicine model, enabled the optimization of mutation-specific modulator combinations to maximize their efficacy and minimize life-long drug exposure of CF patients. [Read the Full Post]
Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control
47 views | Jun 22 2021
Kyoko Nakamura et al. found that blocking the NHEJ DNA repair pathway with AZD7648 in combination with RT leaded to durable immune-mediated tumor control. [Read the Full Post]
Partial Rescue of F508del-CFTR Stability and Trafficking Defects by Double Corrector Treatment
55 views | Jun 21 2021
Valeria Capurro et al. thought that it was still possible to further improve mutant CFTR rescue with the development of corrector combinations having maximal effects on mutant CFTR structural and functional properties. [Read the Full Post]
GDI2 is a target of paclitaxel that affects tumorigenesis of prostate cancer via the p75NTR signaling pathway
57 views | May 31 2021
Chi Liu et al. found that knocking down of GDI2 inhibited cell proliferation and promoted cell apoptosis via the p75NTR signaling pathway in prostate cancer. [Read the Full Post]
Transcriptomic analysis of CFTR-impaired endothelial cells reveals a pro-inflammatory phenotype
71 views | Feb 01 2021
Mathias Declercq et al. thought that normalisation of vascular inflammation might be a novel therapeutic strategy to ameliorate the disease severity of CF. [Read the Full Post]
Real-World Safety of CFTR Modulators in the Treatment of Cystic Fibrosis: A Systematic Review
79 views | Jan 05 2021
Renée V E Dagenais et al. thought that pharmacists played a key role in the safe initiation and monitoring of people with CF on CFTR modulator therapies. [Read the Full Post]
An integrated drug repurposing strategy for the rapid identification of potential SARS-CoV-2 viral inhibitors
97 views | Sep 01 2020
Alfonso Trezza et al. showed that Simeprevir and Lumacaftor bound the receptor-binding domain of the Spike protein with high affinity and prevented ACE2 interaction. [Read the Full Post]
The impact of ivacaftor on sinonasal pathology in S1251N-mediated cystic fibrosis patients
149 views | Jul 21 2020
Romee Gostelie et al. found that Ivacaftor appeared to improve sinonasal outcome parameters and thereby sinonasal health in patients with cystic fibrosis with an S1251N mutation. [Read the Full Post]
Corrector VX-809 promotes interactions between cytoplasmic loop one and the first nucleotide-binding domain of CFTR
223 views | Nov 12 2019
Loo TW et al. suggested that the mechanism by which VX-809 promotes maturation and stability of CFTR is by promoting CL1/NBD1 interactions. [Read the Full Post]
