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Reversible translocation of acyl-CoA:cholesterol acyltransferase (ACAT) between the endoplasmic reticulum and vesicular structures

26 views | Jan 16 2024

The dynamic translocation of ACAT from the endoplasmic reticulum to vesicular structures, triggered by diverse stimuli and inhibitors while maintaining its enzymatic activity, underscores the intricate regulatory mechanisms governing lipid metabolism in response to cellular cues. [Read the Full Post]

Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology-College of American Pathologists Guideline Update

27 views | Sep 23 2023

The American Society of Clinical Oncology-College of American Pathologists (ASCO-CAP) affirms the 2018 recommendations for HER2 testing in breast cancer but highlights the importance of distinguishing between immunohistochemistry (IHC) 0 and 1+ results and provides best practice recommendations for this distinction. [Read the Full Post]