Blog of Signaling Pathways

Digeda-4 decoction and its disassembled prescriptions improve dyslipidemia and apoptosis by regulating AMPK/SIRT1 pathway on tyloxapol-induced nonalcoholic fatty liver disease in mice

17 views | Oct 28 2023

This study demonstrated that DGD-4, a Mongolian herbal formulation, showed protective effects against NAFLD by improving dyslipidemia, inhibiting apoptosis, and regulating the AMPK/SIRT1 pathway. [Read the Full Post]

Dbf4-Cdc7 (DDK) Inhibitor PHA-767491 Displays Potent Anti-Proliferative Effects via Crosstalk with the CDK2-RB-E2F Pathway

39 views | Oct 28 2023

The study reveals that PHA-767491, through its potent inhibition of DDK and the CDK2-Rb-E2F transcriptional network, exhibits increased anti-proliferative effects in RB+ cancer cell lines by targeting the initiation phase of DNA replication and reducing the transcription of G1/S regulators. [Read the Full Post]

Treatment of eculizumab refractory paroxysmal nocturnal hemoglobinuria: A systematic review about current treatment options and future direction

15 views | Oct 28 2023

The systematic review highlights the need for individualized treatment plans and further research to evaluate the efficacy of different medications in managing eculizumab refractory Paroxysmal Nocturnal Hemoglobinuria (PNH). [Read the Full Post]

A novel denoising method for low-dose CT images based on transformer and CNN

77 views | Oct 28 2023

The paper proposes a novel LDCT image denoising method based on a transformer combined with a convolutional neural network (CNN), which effectively removes noise and improves image quality, outperforming state-of-the-art models in evaluation metrics such as PSNR, SSIM, and RMSE. [Read the Full Post]

Bioengineered stem cell membrane functionalized nanoparticles combine anti-inflammatory and antimicrobial properties for sepsis treatment

45 views | Oct 27 2023

The novel nanometer drug loading system, FZ/MER-AgMOF@Bm, effectively combats sepsis by delivering anti-inflammatory and antibacterial agents to infectious microenvironments, reducing inflammation, eliminating bacteria, and improving survival outcomes in a mouse model of sepsis. [Read the Full Post]

Synthesis and biological evaluation of novel N-benzyltriazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors

54 views | Oct 27 2023

The study designed and evaluated a novel N-benzyltriazolyl-hydroxamate scaffold, resulting in the identification of compound 4u as a highly potent and selective HDAC6 inhibitor, providing insights for the development of targeted therapies for neurodegenerative diseases, inflammation, and cancer. [Read the Full Post]

Novel vesicular and particulate drug delivery systems for topical treatment of acne

11 views | Oct 27 2023

The utilization of vesicular and particulate drug delivery systems in topical antiacne treatment shows promise in minimizing side effects while maintaining efficacy, offering a novel approach to improve patient outcomes. [Read the Full Post]

Traf2 and NCK Interacting Kinase Is a Critical Regulator of Procollagen I Trafficking and Hepatic Fibrogenesis in Mice

115 views | Oct 27 2023

The study identified TNIK as a key kinase involved in procollagen I trafficking and demonstrated its potential as a therapeutic target for hepatic fibrosis. [Read the Full Post]

The effectiveness of tivantinib for MET-high hepatocellular carcinoma: A protocol for meta analysis

31 views | Oct 27 2023

The meta-analysis findings suggest that tivantinib does not appear to confer a significant benefit for the treatment of MET-high hepatocellular carcinoma, and it is associated with an increased risk of grade ≥3 neutropenia and leukopenia. [Read the Full Post]

Inhibition of mitochondrial VDAC1 oligomerization alleviates apoptosis and necroptosis of retinal neurons following OGD/R injury

10 views | Oct 26 2023

The study found that inhibiting the oligomerization of Voltage-dependent anion channel 1 (VDAC1) rescues mitochondrial dysfunction and reduces apoptosis/necroptosis in retinal cells, offering a potential therapeutic strategy for ocular diseases caused by ischemia-reperfusion injury. [Read the Full Post]

Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production

86 views | Oct 26 2023

In this study, the increased expression of ribonucleotide reductase regulatory subunit M2 (RRM2) and its regulation of dGTP and dCTP production during temozolomide (TMZ) therapy were identified as key factors in driving chemoresistance in glioblastoma (GBM), and treatment with the RRM2 inhibitor 3-AP (Triapine) improved the efficacy of TMZ therapy in patient-derived xenograft (PDX) models. [Read the Full Post]

Tenuifolin in the prevention of Alzheimer's disease-like phenotypes: Investigation of the mechanisms from the perspectives of calpain system, ferroptosis, and apoptosis

37 views | Oct 26 2023

Tenuifolin (Ten), an active component of Polygala tenuifolia, prevents Alzheimer's disease (AD)-like phenotypes through multiple mechanisms, including regulation of synaptic plasticity, apoptosis, calcium signaling, oxidative stress, and ferroptosis. [Read the Full Post]

YAP and β-catenin cooperate to drive H. pylori-induced gastric tumorigenesis

77 views | Oct 26 2023

This study provides evidence that the interaction between Yes-associated protein 1 (YAP) and β-catenin synergistically promotes H. pylori-induced gastric carcinogenesis and identifies shared downstream genes, CDX2, LGR5, and RUVBL1, potentially contributing to the pathogenesis of H. pylori-associated gastric cancer. [Read the Full Post]

Genome-wide CRISPR screening reveals key genes and pathways associated with 20-hydroxyecdysone signal transduction in the silkworm (Bombyx mori)

93 views | Oct 26 2023

This study utilized a genome-wide CRISPR/Cas9-based library to identify key genes involved in the 20E signaling pathway in the silkworm, shedding light on the mechanisms underlying metamorphosis and hormone regulation. [Read the Full Post]

Agomelatine inhibits platelet aggregation through melatonin receptor-dependent and independent mechanisms

48 views | Oct 25 2023

In this study, agomelatine was found to inhibit platelet aggregation induced by arachidonic acid and collagen, suggesting its potential to prevent atherothrombotic ischemic events by reducing thrombus formation and vessel occlusion. [Read the Full Post]

In silico molecular study of hepatitis B virus X protein as a therapeutic target

37 views | Oct 25 2023

The study identified SC75741, Punicalagin, and Ledipasvir as promising antiviral compounds with strong binding affinity for the HBx protein, suggesting their potential for targeted inhibition of HBx and further research in Hepatitis B treatment. [Read the Full Post]

Early hyperlipidemia triggers metabolomic reprogramming with increased SAH, increased acetyl-CoA-cholesterol synthesis, and decreased glycolysis

24 views | Oct 25 2023

This study revealed metabolomic reprogramming in early hyperlipidemia, characterized by upregulated metabolites promoting trained immunity, uremic toxins, and proatherogenic metabolites, while highlighting the suppressive role of the antioxidant transcription factor NRF2 in this process. [Read the Full Post]

Tryptophan metabolism induced by TDO2 promotes prostatic cancer chemotherapy resistance in a AhR/c-Myc dependent manner

111 views | Oct 25 2023

Elevated expression of tryptophan 2,3-dioxygenase 2 (TDO2) promotes tryptophan metabolism and kynurenine production, activating the AhR/c-Myc/ABC-SLC transporters signaling pathway and contributing to chemoresistance in prostatic cancer. [Read the Full Post]

The effect of iodine-131 beta-particles in combination with A-966492 and Topotecan on radio-sensitization of glioblastoma: An in-vitro study

34 views | Oct 25 2023

The combination of iodine-131 with topoisomerase I and PARP inhibitors demonstrated marked effects in sensitizing glioblastoma cells to radiotherapy, indicating its potential as a targeted radionuclide therapy to enhance treatment efficacy. [Read the Full Post]

EGR1-mediated metabolic reprogramming to oxidative phosphorylation contributes to ibrutinib resistance in B cell lymphoma

33 views | Oct 24 2023

The study identifies EGR1-mediated metabolic reprogramming to oxidative phosphorylation as a key mechanism driving ibrutinib resistance in B cell malignancies, suggesting that targeting this pathway with agents like metformin or IM156 could provide a potential therapeutic strategy to overcome acquired drug resistance in relapsed/refractory DLBCL or MCL. [Read the Full Post]