phosphatase

Identification of GDC-1971 (RLY-1971), a SHP2 Inhibitor Designed for the Treatment of Solid Tumors

30 views | Jan 27 2024

The clinical trials combining GDC-1971, a SHP2 inhibitor, with divarasib (GDC-6036), a KRAS G12C inhibitor, represent a promising strategy for targeting RAS-driven MAPK signaling in solid tumors harboring KRAS G12C mutations. [Read the Full Post]

The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity

15 views | Jan 22 2024

The discovery of ABBV-CLS-484 (AC484), a first-in-class active-site inhibitor of PTPN2 and PTPN1, showcases a promising new direction in cancer immunotherapy by enhancing immune response and generating potent anti-tumour effects in preclinical models, offering hope for overcoming resistance to existing treatments. [Read the Full Post]

Rapid Formation of Intramolecular Disulfide Bridges using Light: An Efficient Method to Control the Conformation and Function of Bioactive Peptides

28 views | Jan 02 2024

The light-mediated strategy utilizing 2-nitroveratryl (oNv) for controlled disulfide bond formation in peptides offers precise spatiotemporal regulation, enabling the restoration of native structures and functions, showcasing potential for targeted therapies and smart biomaterial design. [Read the Full Post]

Identification of upregulated genes in glioblastoma and glioblastoma cancer stem cells using bioinformatics analysis

76 views | Dec 29 2023

This comprehensive study uncovered potential therapeutic targets for glioblastoma by identifying highly coexpressed genes in cancer stem cells, highlighting DUSP6 and SOX2 as prognostically relevant hub genes and proposing (E/Z)-BCI and BCI compounds as promising anti-cancer agents via strong binding interactions with DUSP6's ERK2 binding domain. [Read the Full Post]

miR-6071 inhibits hepatocellular carcinoma progression via targeting PTPN11

33 views | Dec 17 2023

The study reveals that miR-6071 functions as a crucial regulator by targeting PTPN11, inhibiting liver cancer stem cells' self-renewal and tumorigenesis, and sensitizing hepatocellular carcinoma cells to lenvatinib treatment, making it a potential therapeutic target and predictive biomarker for postoperative lenvatinib therapy. [Read the Full Post]

Pediatric glioblastoma cells are sensitive to drugs that inhibit eIF2α dephosphorylation and its phosphomimetic S51D variant

19 views | Dec 11 2023

The study demonstrates that combinations of histone deacetylase inhibitors and PARP-1 inhibitors, along with drugs increasing P-eIF2α or modulating its downstream effects, could be a promising and novel approach for treating pediatric glioblastoma (PED-GBM), particularly in cases with specific mutations. [Read the Full Post]

Low WIP1 Expression Accelerates Ovarian Aging by Promoting Follicular Atresia and Primordial Follicle Activation

27 views | Nov 30 2023

Decreased wild-type P53-induced phosphatase 1 (WIP1) expression accelerates ovarian aging by promoting excessive follicular atresia, primordial follicle activation, and granulosa cell death, leading to irregular estrous cycles, fertility decline, and reduced ovarian reserve in mice. [Read the Full Post]

Diverse Mechanisms of Resistance against Osimertinib, a Third-Generation EGFR-TKI, in Lung Adenocarcinoma Cells with an EGFR-Activating Mutation

47 views | Sep 14 2023

The study identified multiple mechanisms of osimertinib resistance in EGFR-mutant NSCLC cells, including wild-type EGFR amplification, KRAS amplification and mutation, dependence on EGFR and IGF1R signaling, Bid cleavage for apoptosis induction, and a SHP2/T507K mutation activating the ERK1/2 pathway, suggesting potential therapeutic strategies for overcoming resistance. [Read the Full Post]

Norepinephrine as the Intrinsic Contributor to Contact Lens-Induced Pseudomonas aeruginosa Keratitis

75 views | Sep 11 2023

This study reveals that norepinephrine, acting through the β2-adrenergic receptor, promotes Pseudomonas aeruginosa keratitis during contact lens wear, suggesting potential therapeutic targets for treating the condition. [Read the Full Post]

SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor

16 views | Aug 22 2023

The study reveals that the protein SHP2 plays a critical role in decidualization, influencing the nuclear localization of the progesterone receptor and highlighting its potential involvement in recurrent miscarriage. [Read the Full Post]