DNA alkylator

Epigenetic Activation of TUSC3 Sensitizes Glioblastoma to Temozolomide Independent of MGMT Promoter Methylation Status

90 views | Jan 10 2024

This study presents compelling evidence that epigenetic reactivation of Tumor Suppressor Candidate 3 (TUSC3) can significantly enhance Temozolomide (TMZ) sensitivity in both MGMT-promoter-hypermethylated (MGMT-M) and MGMT-promoter-hypomethylated (MGMT-UM) glioblastoma stem cells, offering a potential breakthrough in addressing TMZ resistance and improving outcomes in glioblastoma patients. [Read the Full Post]

The Crystal Structure of Engineered Nitroreductase NTR 2.0 and Impact of F70A and F108Y Substitutions on Substrate Specificity

81 views | Dec 07 2023

A newly engineered nitroreductase enzyme, NTR 2.0, with enhanced reduction capabilities for the prodrug metronidazole, has been characterized through X-ray crystallography and substrate analysis, enabling faster cell ablation kinetics, cleaner interrogations of cell function, ablation of previously recalcitrant cell types, and extended ablation paradigms valuable for modeling chronic diseases and exploring applications such as alternative ablation prodrugs and environmental remediation. [Read the Full Post]

Intensity of endogenous thrombocytopenia after autologous stem cell transplantation in patients prophylactically transfused with platelets

71 views | Jun 26 2023

The study demonstrated that monitoring endogenous platelet counts using digital droplet PCR can accurately assess the impact of myelosuppressive chemotherapies on platelet regeneration, aiding in the development of tailored platelet transfusion regimens for patients undergoing high-dose chemotherapy with autologous stem cell transplantation. [Read the Full Post]

Management of antineutrophil cytoplasmic antibody-associated vasculitis: a changing tide

66 views | Mar 14 2023

Recent advances in the treatment of AAV have focused on reducing the toxicity of existing treatments and exploring newer treatments with better safety profiles, including targeted PLEX use, lower GC dosing, and increased rituximab use. [Read the Full Post]

Immunostimulatory effects of dairy probiotic strains Bifidobacterium animalis ssp. lactis HY8002 and Lactobacillus plantarum HY7717

186 views | Mar 14 2023

The study found that the combination of LAB strains HY8002 and HY7717 improved immune function in mice and has potential as an immunostimulant probiotic supplement for use in dairy foods. [Read the Full Post]

Effect of maca (Lepidium meyenii) extract on non-obstructive azoospermia in male mice

179 views | Mar 04 2023

The study found that maca can improve azoospermia by promoting testicular recovery and increasing testosterone levels, with the polysaccharide fraction identified as the active component. [Read the Full Post]

Association between the choice of the conditioning regimen and outcomes of allogeneic hematopoietic cell transplantation for myelofibrosis

114 views | Mar 04 2023

The study found that Fludarabine/busulfan is the optimal conditioning regimen for allogeneic hematopoietic cell transplantation in myelofibrosis based on lower mortality and graft versus host disease rates. [Read the Full Post]

Synthesis and mechanical properties of highly structure-controlled Zr-based metallic glasses by thermal rejuvenation technique

272 views | Feb 15 2023

A new thermal rejuvenation process was developed for Zr-based bulk metallic glass to improve ductility by re-introducing free volume through rapid heating and indirect liquid nitrogen quenching, which was confirmed to reduce STZ volume and enhance homogeneous deformation by molecular dynamics simulations. [Read the Full Post]

Alpha-kinase1 promotes tubular injury and interstitial inflammation in diabetic nephropathy by canonical pyroptosis pathway

187 views | Feb 15 2023

The study shows that ALPK1 activation in diabetic nephropathy causes renal injury and fibrosis through the activation of the canonical caspase-1-GSDMD pyroptosis pathway, which is regulated by the ALPK1/NF-κB pathway. [Read the Full Post]

Effect of Severe Renal Dysfunction on the Plasma Levels of DNA-Reactive Platinum after Oxaliplatin Administration

140 views | Feb 09 2023

Severe renal dysfunction has a limited effect on the elimination rate of reactive DNA-binding platinum (fPt) in plasma after oxaliplatin administration, as shown by the results from studies in rats with bilateral nephrectomy and in a hemodialysis patient with advanced metastatic gastric cancer. [Read the Full Post]