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Androgen Receptor

A novel antiandrogen, Compound 30, suppresses castration-resistant and MDV3100-resistant prostate cancer growth in vitro and in vivo

8 views | Jul 15 2019

Kuruma H et al. provided a preclinical proof-of-principle that Compound 30 could be a promising next generation anti-AR agent, especially in the context of antiandrogen-resistant tumors. [Read the Full Post]

Functional and Mechanistic Interrogation of BET Bromodomain Degraders for the Treatment of Metastatic Castration Resistant Prostate Cancer

59 views | Mar 30 2019

Kregel S et al. identified increases in polyunsaturated fatty acids (PUFAs) and Thioredoxin-interacting protein (TXNIP) as potential pharmacodynamics biomarkers for targeting BET proteins. [Read the Full Post]

Role of connexin 43 in cadmium-induced proliferation of human prostate epithelial cells

96 views | Jan 26 2019

Liu Q et al. found that Cx43 might be a target for prostatic diseases associated with Cd exposure. [Read the Full Post]

Robust and stimuli-responsive POSS hybrid PDMAEMA hydrogels for controlled drug release

225 views | Aug 30 2018

Chen Y, et al. showed that the increased Oa-POSS could improve the drug loading ability, and OP-PD gels showed well controlled-release effect in simulated human stomachic condition. [Read the Full Post]

The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer

0 views | Feb 26 2018

Luo J et al. suggested that the combination of bicalutamide and PARP inhibitor may be a potential strategy for TNBC patients and merits further evaluation. [Read the Full Post]

The Correlation Between PARP1 and BRCA1 in AR Positive Triple-negative Breast Cancer

328 views | Feb 26 2018

Luo J et al. suggested that the combination of bicalutamide and PARP inhibitor may be a potential strategy for TNBC patients and merits further evaluation. [Read the Full Post]

Role of protein S in castration-resistant prostate cancer-like cells

365 views | Feb 25 2018

Ning P et al. suggested that PROS may facilitate cell proliferation and promote castration resistance in human castration-resistant PCa-like cells via its apoptosis-regulating property. Future study emphasizing on delineating how PROS regulate cellular processes controlling transformation during the development of castration resistance should open new doors for the development of novel therapeutic targets for CRPC. [Read the Full Post]

CX4945 suppresses the growth of castration-resistant prostate cancer cells by reducing AR-V7 expression

418 views | Feb 25 2018

Deng C et al. presented a potential option for the treatment of prostate cancer, especially CRPC. [Read the Full Post]

Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells

0 views | Jan 31 2018

Chen C et al. proposed that the net effect of these AR-mediated expression changes shifts the balance of BCL2-family proteins, such that androgen signaling sensitizes mitochondria to apoptotic signaling, thus rendering HPr-1AR more vulnerable to cell death signals. [Read the Full Post]

Regulated expression of the prostacyclin receptor (IP) gene by androgens within the vasculature: Combined role for androgens and serum cholesterol.

872 views | May 26 2017

Eivers SB et al. found that the human IP gene is under the transcriptional regulation of DHT, where this regulation is further influenced by serum-cholesterol levels. [Read the Full Post]