Androgen Receptor

Baseline Plasma Tumor DNA (ctDNA) Correlates with PSA Kinetics in Metastatic Castration-Resistant Prostate Cancer (mCRPC) Treated with Abiraterone or Enzalutamide

31 views | May 16 2022

Vincenza Conteduca et al. thought that elevated ctDNA levels and AR gain were negatively and independently correlated with PSA kinetics in mCRPC men treated with abiraterone or enzalutamide. [Read the Full Post]

Long-term Outcomes for Ibrutinib-Rituximab and Chemoimmunotherapy in CLL: Updated Results of the E1912 Trial

53 views | Apr 17 2022

Tait D Shanafelt et al. found that Ibrutinib-rituximab therapy offered superior PFS relative to FCR in both IGHV mutated and unmutated CLL patients as well as superior OS. [Read the Full Post]

Impact of New Systemic Therapies in Overall Survival in Non-Metastatic Castration Resistant Prostate Cancer: Systematic Review and Meta-Analysis

97 views | Dec 20 2021

Alejo Rodriguez-Vida et al. found that first-line treatment of nmCRPC patients with anti-androgens increased OS with an acceptable safety profile. [Read the Full Post]

Prostate Cancer Detected by Choroidal Tumor and Complete Response to Hormonal Therapy: Case Report and Literature Review of 24 Patients With Choroidal Metastasis From Prostate Cancer

224 views | Jun 25 2021

Toshihiko Matsuo et al. found that metastatic choroidal tumors of prostate cancer would show good response to hormonal therapy when the therapy had not been initiated. [Read the Full Post]

Prognostic value of [ 18 F]FDG PET/CT in patients with CNS lymphoma receiving ibrutinib-based therapies

252 views | May 14 2021

Simone Krebs et al. found that higher lesional metabolic parameters were inversely related to outcome in patients undergoing ibrutinib-based therapies, and sumSUVmax emerged as a strong independent prognostic factor. [Read the Full Post]

Physcion, a novel inhibitor of 5α-reductase that promotes hair growth in vitro and in vivo

223 views | Mar 02 2021

Zizhao Lao et al. suggested that Physcion was a potent 5α-reductase inhibitor, as well as a new natural medicine for treating AGA. [Read the Full Post]

Prostate Cancer Foundation Hormone-Sensitive Prostate Cancer Biomarker Working Group Meeting Summary

226 views | Dec 30 2020

Martin R Hofmann wt al. proposed that there was no high level clinical evidence for treatment selection among these choices based on biological drivers of clinical disease. [Read the Full Post]

Low-Dose Enzalutamide in Late-Elderly Patients (≥ 75 Years Old) Presenting With Metastatic Castration-Resistant Prostate Cancer.

313 views | May 19 2020

Vinh-Hung V et al. found that Low-dose enzalutamide in very old, symptomatic, poor-performance patients with metastatic disease was associated with high response rate and survival comparable to standard dose. [Read the Full Post]

Inhibition of the erythropoietin-producing receptor EPHB4 antagonizes androgen receptor overexpression and reduces enzalutamide resistance

0 views | May 13 2020

Li C et al. provided critical insight into the mechanism of enzalutamide resistance in PCa, potentially offering a therapeutic avenue for enhancing the efficacy of enzalutamide to better manage this common malignancy. [Read the Full Post]

Investigation of lncRNA H19 in prostate cancer cells and secreted exosomes upon androgen stimulation or androgen receptor blockage

296 views | May 06 2020

Ozgur E et al. provided evidence that H19 might be involved in androgen receptor pathway. [Read the Full Post]