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PI3K/Akt/mTOR
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Epigenetics
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Methylation
- DNA Methyltransferase
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Immunology & Inflammation
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Protein Tyrosine Kinase
- VEGFR
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Angiogenesis
- VEGFR
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- HIF
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Apoptosis
- PD-1/PD-L1
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- Caspase
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- TNF-alpha
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- Survivin
- Ras
- c-RET
- RIP kinase
- PERK
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- Ferroptosis
- Myc
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- PFKFB
- Apoptosis related
- OXPHOS
- Heme Oxygenase
- TRADD
- cytohesin
- Bcl-6
- Thymidylate Synthase
- Pyroptosis
- PKD
- FKBP
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Autophagy
- Autophagy
- Nrf2
- CXCR
- LRRK2
- cGAS
- FKBP
- LC3
- ULK
- Mitophagy
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- OGA
ER stress & UPR
- JNK
- HSP (HSP90)
- PERK
- ASK
- IRE1
- ATF-6
- eIF
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JAK/STAT
- JAK
- STAT
- EGFR
- Pim
MAPK
- S6 Kinase
- MEK
- Raf
- p38 MAPK
- JNK
- Ras
- TOPK
- ERK
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- Mixed Lineage Kinase
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Cytoskeletal Signaling
- Akt
- Bcr-Abl
- Wnt/beta-catenin
- PKC
- FAK
- HSP (HSP90)
- Kinesin
- ROCK
- Microtubule Associated
- Integrin
- MPS1
- Dynamin
- PAK
- Actin
- Gap-Junction
- PORCN
- TACC3
- MLCK
- Cardiac Myosin
Cell Cycle
- CDK
- DNA/RNA Synthesis
- PD-1/PD-L1
- Ras
- Aurora Kinase
- HSP (HSP90)
- Kinesin
- Chk
- ROCK
- Microtubule Associated
- DHFR
- PLK
- APC
- Wee1
- Rho
- Serine/threonin kinase
- PERK
- MPS1
- PAK
- Casein Kinase
- DYRK
- Myc
- TOPK
- FOXM1
- Nur77
- TACC3
- PP2A
- RUNX
- PFKFB
- Haspin Kinase
- LIM kinase
- BMI-1
- eIF
- DOCK
- Mad2
- Choline kinase
TGF-beta/Smad
- TGF-beta/Smad
- Bcr-Abl
- PKC
- ROCK
DNA Damage/DNA Repair
- HDAC
- ATM/ATR
- PARP
- DNA/RNA Synthesis
- PPAR
- Sirtuin
- Topoisomerase
- DNA-PK
- DHFR
- Telomerase
- High-mobility Group
- DNA alkylator
- MTH1
- Casein Kinase
- RNR
- SMN
- Nucleoside Analog/Antimetabolite
- LIM kinase
- RAD51
- CRISPR/Cas9
- FENs
- BMI-1
- Pax
- OGG1
- Thymidylate Synthase
- eIF
- G-quadruplex
Stem Cells & Wnt
- GSK-3
- JAK
- STAT
- TGF-beta/Smad
- Wnt/beta-catenin
- ROCK
- Gamma-secretase
- Hedgehog/Smoothened
- PKA
- ERK
- OCT
- KLF
- Stemness kinase
- Casein Kinase
- SFRP
- Fascin
- PORCN
- Notch
Hippo
- YAP
- TEAD
- MAP4K
- MST
Ubiquitin
- Proteasome
- DUB
- p97
- SUMO
- E2 conjugating
- E1 Activating
- E3 Ligase
Neuronal Signaling
- Calcium Channel
- Beta Amyloid
- 5-HT Receptor
- COX
- Gamma-secretase
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GABA Receptor
- P-gp
- P2 Receptor
- Cannabinoid Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- MAO
- FAAH
- Trk receptor
- CaMK
- NMDAR
- BACE
- GlyT
- Neurokinin Receptor
- Serotonin Transporter
- Notch
- Neurotensin Receptor
- CCK receptor
- Melanocortin Receptor
- NPY receptor
- Imidazoline Receptor
- COMT
- Adenosine Deaminase
- Adenosine Kinase
- BChE
- EAAT
- TRP Channel
- Sigma Receptor
NF-κB
- HDAC
- NF-κB
- IκB/IKK
- ROS
- MALT
- Nrf2
- NOD
GPCR & G Protein
- Ras
- 5-HT Receptor
- CCR
- GluR
- Adrenergic Receptor
- AChR
- Histamine Receptor
- Dopamine Receptor
- Opioid Receptor
- GPR
- P2 Receptor
- Cannabinoid Receptor
- Endothelin Receptor
- S1P Receptor
- Hedgehog/Smoothened
- SGLT
- LPA Receptor
- OX Receptor
- CGRP Receptor
- MT Receptor
- PAFR
- PKA
- CaSR
- LTR
- Glucagon Receptor
- CXCR
- Adenosine Receptor
- cAMP
- Vasopressin Receptor
- TAAR
- GHSR
- GNRH Receptor
- FPR
- CRFR
- Bradykinin Receptor
- Neurokinin Receptor
- Bombesin Receptor
- PKG
- AdipoR
- Angiotensin Receptor
- Sigma Receptor
- Parathyroid Hormone Receptor
- RGS
- Neurotensin Receptor
- DOCK
- PAR
- Melanocortin Receptor
- GRK
- NPY receptor
- GPCR19
- Imidazoline Receptor
- Guanylate Cyclase
- TSH Receptor
- CCK receptor
- Leukotriene
- PKD
- Prostaglandin Receptor
- Taste Receptor
Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
- Opioid Receptor
- Aromatase
- GPR
- Glucocorticoid Receptor
- PGES
- TSH Receptor
- GNRH Receptor
- GHSR
- Mineralocorticoid Receptor
- ACE
- THR
- CCK receptor
- PGDS
Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
- Chloride Channel
- Potassium Channel
- GluR
- AChR
- GABA Receptor
- P-gp
- Proton Pump
- CFTR
- P2 Receptor
- SGLT
- OCT
- NMDAR
- GlyT
- GLUT
- CRM1
- VDAC
- NKCC
- MTP
- NCX
- VMAT
- GlyR
- BCRP
- MCT
- Amino acid transporter
- TRP Channel
- OAT
- OATP
- Aquaporin
- VRAC
- EAAT
- Mechanosensitive Channel
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- Carbonic Anhydrase
- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- Vitamin
- Thioredoxin
- phosphatase
- Lipoxygenase
- Lipase
- NAMPT
- FXR
- Retinoid Receptor
- Serine/threonin kinase
- Transferase
- IDO/TDO
- PKM
- HMG-CoA Reductase
- FOX
- Casein Kinase
- Fatty Acid Synthase
- GLUT
- CETP
- LDL
- Decarboxylase
- RUNX
- Adenosine Deaminase
- PGC-1α
- Serine hydrolase
- SCD
- Adenosine Kinase
- 3-MST
- LDH
- Mitochondrial Metabolism
- PDHK
- Catalase
- PAI-1
- Neprilysin
- Glucosylceramide Synthase
- FAO
- FTO
- γGCS
- SREBP
- Leukotriene
- PARG
- GTPCH
- CPT
- PCSK9
- Epoxide Hydrolase
- FTase
- Acetyl-CoA carboxylase
- PGDS
- SGK
- ATP-citrate lyase
- ACE
- Thioredoxin Reductase
- Carbohydrate Metabolism
- Mannosidase
- THR
- CPSase
- Xanthine Oxidase
- Glutathione
- Aldose Reductase
- PREP
- OXPHOS
- Mitochondrial pyruvate carrier
- Peroxidases
- AdipoR
- FABP
- glucocerebrosidase
- PP2A
- ROR
- CAR
Proteases
- HDAC
- Proteasome
- Caspase
- Aminopeptidase
- Gamma-secretase
- HCV Protease
- DPP-4
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- Glutaminase
- Tyrosinase
- Serine Protease
- Cysteine Protease
- MALT
- SGK
- PREP
- 3C-Like Protease
- PCSK9
- DPP-2
- PGDS
- Cathepsin B
- Neprilysin
Microbiology
- HCV Protease
- Integrase
- Reverse Transcriptase
- HIV Protease
- Anti-infection
- HCV
- HBV
- HIV
- Fungal
- CMV
- Neuraminidase
- Parasite
- Thioredoxin Reductase
- Antibiotics
- β-lactamase
- Antiviral
- 3C-Like Protease
- Bacterial
- COVID-19
- Enterovirus
- Ribosomal Peptidyl Transferase
- Influenza Virus
- SARS-CoV
- RSV
- HPV
- HSV
Others
- ADC Cytotoxin
- ADC Linker
- Drug-Linker Conjugates for ADC
- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
- Antibiotics for Mammalian Cell Culture
- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

IL Receptor

Rapamycin and trametinib: a rational combination for treatment of NSCLC

96 views | Jan 29 2022

Chao-Yue Sun et al. found that co-administration of rapamycin and trametinib caused a substantial suppression in tumor growth without obvious drug toxicity. Overall, our study identifies a reasonable combined strategy for treatment of NSCLC. [Read the Full Post]

Trichlorocarban induces developmental and immune toxicity to zebrafish (Danio rerio) by targeting TLR4/MyD88/NF-κB signaling pathway

461 views | Feb 04 2021

Jiaqi Xu et al. found the underlying molecular mechanisms on TCC-induced developmental and immune toxicity to zebrafish. [Read the Full Post]

Impacts of ABCB1 (G1199A) polymorphism on resistance, uptake, and efflux to steroid drugs.

1202 views | Aug 29 2018

Peng R, et al. found that the ABCB1 (G1199A) polymorphism may affect effective steroids concentration in target cells by regulating the drug transport and distribution. [Read the Full Post]

Chemokine CXCL13 mediates orofacial neuropathic pain via CXCR5/ERK pathway in the trigeminal ganglion of mice

1228 views | Mar 29 2017

Zhang Q et al. found that targeting CXCL13/CXCR5/ERK/TNF-α and IL-1β pathway in the trigeminal ganglion may offer effective treatment for orofacial neuropathic pain. [Read the Full Post]

GP130/JAK/STAT3 signaling pathway induces multiple myeloma

10885 views | Nov 24 2014

Dechow et al. determined GP130/JAK/STAT3 signaling pathway is sufficient to induce MM generation in mice retroviral murine BM transduction-transplantation model. [Read the Full Post]