TAK1

A new hazard assessment workflow to assess soil contamination from large and artisanal scale gold mining

80 views | Sep 04 2023

The study developed a new workflow model combining spatial mapping, compositional analysis, and geostatistical modeling to identify and assess the contamination levels and potential risks associated with artisanal and small-scale gold mining activities in the Kedougou region, emphasizing the need for comprehensive risk assessments and improved regulation. [Read the Full Post]

Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis

81 views | Aug 19 2023

HS-276, a potent and selective orally bioavailable TAK1 inhibitor, shows promise in inhibiting TNF-mediated cytokine profiles and attenuating arthritic-like symptoms in a mouse model of inflammatory rheumatoid arthritis, suggesting it as a potential alternative to current biologic-based therapies. [Read the Full Post]

Transforming growth factor-β-activated kinase 1 (TAK1) mediates chronic pain and cytokine production in mouse models of inflammatory, neuropathic, and primary pain

48 views | Aug 19 2023

The study demonstrated that inhibiting TAK1 with the small molecule inhibitor takinib alleviated pain and inflammation in various models of chronic pain, indicating its potential as a novel drug target for the treatment of different types of chronic pain syndromes. [Read the Full Post]