All New Products Listed Chronologically

Cat.No. Product Name Information Added
S2428 Isopropyl myristate Isopropyl myristate is used as a substitute for natural oils in cosmetics and a co-solvent with skin penetration enhancement properties of active ingredients in many topical and transdermal preparations. Isopropyl myristate is a novel pediculicide rinse (50%) and a safe and effective therapy for the treatment of head lice in children and adults. Apr 02 2020
S2429 2-Ethylaniline 2-Ethylaniline is an intermediate for pharmaceuticals, dyestuffs, pesticides, and other products. Apr 02 2020
S8944 G150 G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with IC50 of 10.2 nM. Apr 02 2020
S2434 IDRA-21 IDRA-21 is a partial allosteric modulator of AMPA receptor desensitization. IDRA-21 is a potent cognition-enhancing drug virtually devoid of neurotoxic liability. Apr 02 2020
S2465 CPI-1189 CPI-1189 is the proapoptotic cytokine tumor necrosis factor (TNF) alpha inhibitor. CPI-1189 intracellularly inhibits the p38 mitogen-activated protein kinase phosphoactivation and shows neuroprotective effects. Apr 02 2020
S2474 Fabomotizole hydrochloride Fabomotizole hydrochloride exhibits anxiolytic and neuroprotective properties. Fabomotizole hydrochloride is a potent sigma1-receptor agonist with IC50 of 7.1 µM and Ki of 5.9 µM. Apr 02 2020
S2488 VTP-27999 TFA VTP-27999 is an orally efficacious, selecitive alkyl amine renin inhibitor with IC50 of 0.47 nM for 0.3 nM of purified recombinant human renin. Apr 02 2020
S2272 Indoprofen Indoprofen is a nonsteroidal anti-inflammatory drug (NSAID) and cyclooxygenase (COX) inhibitor. Indoprofen prevents muscle wasting in aged mice through activation of PDK1/AKT pathway.Indoprofen selectively increases SMN2-luciferase reporter protein and endogenous SMN protein. Apr 02 2020
S2432 Tetramethylthiuram monosulfide Tetramethylthiuram monosulfide is used on a large scale as a catalyst in rubber-processing techniques. Tetramethylthiuram monosulfide possesses a medium-degree toxicity and causes point mutations in strains TA 100 and TA 1535 (Salmonella typhimurium LT 2). Apr 02 2020
S8913 TH5487 TH5487 is a selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM. Apr 02 2020
S2275 Gandotinib (LY2784544) Gandotinib is a potent, selective and ATP-competitive inhibitor of janus kinase 2 (JAK2) tyrosine kinase with IC50 of 3 nM. Gandotinib may have the potential to effectively reduce the JAK2V167F-induced MPN pathogenesis. Apr 02 2020
S2418 Frentizole Frentizole is a novel inhibitor of amyloid beta peptide (Abeta) binding alcohol dehydrogenase (ABAD) interaction with IC50 of 200 μM. Frentizole is a nontoxic antiviral and immunosuppressive agent used clinically in rheumatoid arthritis and systemic lupus erythematosus. Apr 02 2020
S2426 Tirapazamine Tirapazamine is a new anticancer drug in solid tumours. Tirapazamine exhibits preferential tumour cell killing and high specific toxicity to cells at low oxygen tensions. Apr 02 2020
S2436 Pranidipine Pranidipine is a new 1,4-dihydropyridine calcium channel blocker. Pranidipine can enhance cyclic GMP-independent nitric oxide-induced relaxation of the rat aorta. Apr 02 2020
S6684 IOX4 IOX4 is a potent and selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with IC50 of 1.6 nM. IOX4 induces HIFα in various mouse tissues and human cell lines. Apr 02 2020
S2213 AMG-47a AMG-47a is a potent, nonselective inhibitor of Lck kinase with IC50 of 3.4 uM and it also inhibits T cell proliferation. AMG-47a exhibit anti-inflammatory activity (ED50) of 11 mg/kg in the anti-CD3-induced production of interleukin-2 (IL-2) in mice. Apr 02 2020
S2600 Fexinidazole Fexinidazole is a 5-nitroimidazole derivative. Fexinidazole is a DNA synthesis inhibitor and the only, all-oral agent for Human African Trypanosomiasis(HAT or sleeping sickness). Apr 02 2020
S2464 Sevoflurane Sevoflurane is a noncompetitive inhibitor of 5-HT3 receptor. Sevoflurane acts as a low-soluble inhalation anesthetics. Apr 02 2020
S2643 4-IPP 4-IPP is an irreversible inhibitor of macrophage migration inhibitory factor (MIF) and a specific suicide substrate for MIF. 4-IPP can inhibit receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis and potentiate osteoblast-mediated mineralization and bone nodule formation in vitro. Apr 02 2020
S2274 TMS TMS is a potent, selective and competitive cytochrome P450 1B1 (CYP1B1) inhibitor with IC50 of 6 nM. TMS exhibits 50-fold selectivity for P450 1B1 over P450 1A1 with IC50 of 300 nM and 500-fold over P450 1A2 with IC50 of 3 μM. Apr 02 2020
Cat.No. Product Name Information Added
S2441 Estramustine phosphate sodium Estramustine phosphate sodium is an antitumour drug with a unique dual mode of action. Estrone and estradiol, products of the metabolism of estramustine phosphate sodium, have shown antigonadotrophic activity resulting in reduced testosterone levels. Estramustine(the cytotoxic metabolite produced by dephosphorylation of estramustine phosphate sodium) is an antiprostatic tumor drug with antimicrotubule effects. Apr 02 2020
S2307 Roquinimex Roquinimex is a novel immunomodulator augmenting natural killer (NK) cell activity and T-lymphocyte related effector functions. Roquinimex is a potent oral active tumor antiangiogenic agent. Roquinimex inhibits the secretion of TNF-α. Apr 02 2020
S2419 Eprobemide Eprobemide is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia. Apr 02 2020
S2421 PF-04457845 PF-04457845 is a potent, favorable selective inhibitor of Fatty acid amide hydrolase (FAAH) with IC50 of 7.2 nM and 7.4 nM for hFAAH and rFAAH, respectively. PF-04457845 covalently modifies the active-site serine nucleophile of FAAH with exquisite selectivity relative to other members of the serine hydrolase superfamily. Apr 02 2020
S2430 Azodicarbonamide Azodicarbonamide is the first known nucleocapsid inhibitor that inhibits HIV-1 and a broad range of retroviruses by targeting the nucleocapsid CCHC domains. Azodicarbonamide inhibits the HIV-1RF-induced cytopathicity of CEM-SS cells with an EC50 of 38 µM in a standard cell-based antiviral assay . Apr 02 2020
S2444 Parbendazole Parbendazole is an extremely potent inhibitor of microtubule assembly with IC50 of 3 µM for the assembly of brain microtubules. Apr 02 2020
S2644 Lerisetron Lerisetron is a 5-HT3 receptor antagonist with IC50 of 0.81μM. Apr 02 2020
S2645 SIB 1757 SIB 1757 is a highly selective, noncompetitive antagonist of metabotropic glutamate receptor type 5 (mGluR5) with IC50 of 0.4 μM at hmGluR5 compared with >30 µM at hmGluR1b, hmGluR2, hmGluR4, hmGluR6, hmGluR7 and hmGluR8. Apr 02 2020
S8938 KGA-2727 KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models. Apr 02 2020
S8939 Mizagliflozin Mizagliflozin is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation. Apr 02 2020
S4354 Thiostrepton Thiostrepton is a natural cyclic oligopeptide antibiotic, derived from several strains of strepromycetes. Mar 29 2020
S7013 Guadecitabine (SGI-110) Guadecitabine (SGI-110) is a next-generation hypomethylating agent whose active metabolite decitabine has a longer in-vivo exposure time than intravenous decitabine. Mar 25 2020
P1087 Carperitide Acetate (alpha-human atrial natriuretic peptide) Carperitide is a potent natriuretic peptide receptor (NPR)-A agonist with EC50 of 10.8 nM. Carperitide is used to treat congestive heart failure. Mar 25 2020
S8812 CM272 CM-272 is a novel first-in-class dual reversible inhibitor of G9a (GLP) and DNMTs with IC50 of 8 nM, 382 nM, 85 nM, 1200 nM, 2 nM for G9a, DNMT1, DNMT3A, DNMT3B, GLP, respectively. CM-272 prolongs survival in in vivo models of haematological malignancies by at least in part inducing immunogenic cell death. Mar 25 2020
S6671 SN50 SN50, a cell-permeable NF-κB inhibitory peptide, is composed of the signal peptide of Kaposi fibroblast growth factor.SN50 inhibits the activation of NF-κB and attenuates ventilator-induced lung injury. Mar 25 2020
S8223 INT-777 (S-EMCA) INT-777 (S-EMCA) is a novel potent and selective TGR5 agonist with EC50 values of 0.18 μM, 3.9 μM and 1.45 μM for WT TGR5, TGR5(N76A) and TGR5(Y89F) respectively. Mar 25 2020
S6679 C25-140 C25-140 is a small-molecule inhibitor of TRAF6-Ubc13 interaction. C25-140 directly binds to TRAF6, thereby blocking the interaction of TRAF6 with Ubc13, and as a consequence lowers TRAF6 activity. C25-140 impedes NF-κB activation in various immune and inflammatory signaling pathways also in primary human and murine cells. Mar 25 2020
S8500 BAY1125976 BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP). Mar 25 2020
S6689 Merimepodib Merimepodib is a potent, specific, and reversible inosine monophosphate dehydrogenase(IMPDH) inhibitor with antiviral activity against hepatitis C virus (HCV) and a variety of DNA and RNA viruses in vitro.Merimepodib is an immunosuppressive agent. Mar 25 2020
S2255 BMOV BMOV is a potent oral vanadium complex with anti-diabetic properties and insulin-mimicking effects.BMOV is shown to improve cardiac dysfunctions in diabetic models. Mar 25 2020
Cat.No. Product Name Information Added
S6514 SU5408 SU5408 is a potent and selective inhibitor of VEGFR2 Kinase with IC50 of 70 nM. Mar 25 2020
S8927 GSK2983559 (compound 3) GSK2983559 is a potent inhibitor of receptor interacting protein 2 (RIP2) kinase with good kinase specificity. Mar 25 2020
S8949 Olutasidenib (FT-2102) Olutasidenib is a potent, orally bioavailable, brain penetrant and selective mutant IDH1 (mIDH1) inhibitor with IC50 of 21.1 nM, 114 nM for IDH1-R132H, IDH1-R132C, respectively. Mar 25 2020
S8926 Valemetostat (DS-3201) Valemetostat is a selective EZH1/2 dual inhibitor. Mar 25 2020
S6687 SIS17 SIS17 is a mammalian histone deacetylase 11 (HDAC 11)-specific inhibitor with IC50 of 0.83 μM. SIS17 inhibits the demyristoylation of HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. Mar 25 2020
S6773 Mertansine Mertansine,a thiol-containing derivative of maytansine,is a selective microtubule inhibitor and induces mitotic arrest and kills tumor cells at subnanomolar concentrations. Mar 25 2020
S8935 BAY-985 BAY-985 is a potent and highly selective TBK1/IKKε inhibitor. BAY-985 shows high potency toward TBK1 (IC50 = 2 nM, low ATP assay; 30 nM, high ATP assay) and IKKε(IC50 = 2 nM), as well as high potency in the mechanistic pIRF3 assay (IC50 = 74 nM), and an antiproliferative effect on SK-MEL-2 cells (IC50 = 900 nM). Mar 25 2020
S8941 NIK SMI1 NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM for NIK-catalyzed hydrolysis of ATP to ADP. Mar 25 2020
S8955 AMG-510 racemate AMG-510 racemate is a racemic of AMG-510 which is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity. Mar 18 2020
S6548 NKL 22 NKL 22 is a selective inhibitor of HDAC with IC50 of 78 µM. Mar 17 2020
S1099 SKLB4771 (FLT3-IN-1) SKLB4771 is a potent and selective inhibitor of human receptor-type tyrosine-protein kinase FLT3 with IC50 of 10 nM. Mar 17 2020
S2115 RG 13022 RG-13022 inhibits the autophosphorylation reaction of the EGF receptor in immunoprecipitates with IC50 of 4 µM. Mar 17 2020
S6688 Fmoc-Val-Cit-PAB Fmoc-Val-Cit-PAB is a cleavable linker for antibody-drug conjugates (ADC). Mar 17 2020
S1073 BML-210 (CAY10433) BML-210 is a small molecule inhibitor of HDAC.BML-210 inhibits the HDAC4-VP16-driven reporter signal in a dose-dependent manner with an apparent IC50 of ∼5 µM. Mar 17 2020
S6738 TC-H 106 TC-H 106 is a slow, tight-binding inhibitor of class I histone deacetylases(HDAC) with Ki value of 148 nM, about 102 nM, 14 nM for HDAC1, HDAC2, HDAC3, respectively. Mar 17 2020
S6680 L-779450 L-779450 is a highly potent low nanomolar inhibitor of B-raf with IC50 of 10 nM and Kd of 2.4 nM. Mar 17 2020
S2132 SR-4370 SR-4370 is a potent and selective inhibitor of class I HDACs with IC50 of 0.13 µM, 0.58 µM, 0.006 µM, 2.3 µM, 3.7 µM for HDAC 1, HDAC 2, HDAC 3, HDAC 8, HDAC 6, respectively.SR-4370 suppresses AR signaling and in vivo prostate tumor growth. Mar 17 2020
S6770 TT-OAD2 TT-OAD2 is a biased non-peptide agonist with slow kinetics. TT-OAD2 can activate the glucagon-like peptide-1 (GLP-1) receptor. Mar 17 2020
S6771 MAC-545496 MAC-545496 is a nanomolar glycopeptide-resistance-associated protein R(GraR) inhibitor with strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 can reverse β-lactam resistance in methicillin-resistant strains and synergize with CAMPs. MAC-545496 shows remarkable activity in macrophages and attenuates S. aureus virulence in a G. mellonella larvae infection model. Mar 17 2020
S6772 VERU-111 VERU-111 is a potent, orally bioavailable α and β tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. VERU-111 has an average IC50 value of 5.2 nM against a large panel of cancer cell lines. Mar 17 2020
Cat.No. Product Name Information Added
S8952 iRucaparib-AP6 iRucaparib-AP6 is a potent and selective small-molecule degrader of PARP1. iRucaparib-AP6 blocks the enzymatic activity of PARP1 in vitro, and PARP1-mediated poly-ADP-ribosylation signaling in intact cells. Mar 17 2020
S6769 Curcumin analog C1 Curcumin analog C1 is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer's disease. Mar 17 2020
S8392 NCB-0846 NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase) with an IC50 value of 21 nM. Mar 12 2020
S8932 Remdesivir (GS-5734) Remdesivir,a monophosphoramidate prodrug of an adenosine analog, is an investigational broad-spectrum antiviral agent with in vitro activity against multiple RNA viruses, including Ebola and CoV. Mar 12 2020
S1058 BI-1347 BI-1347 is small molecule inhibitor of Cyclin-dependent kinase 8(CDK8) with IC50 of 1.1 nM. Mar 11 2020
S2039 IRAK inhibitor 6 IRAK inhibitor 6 is a selective Interleukin-1 receptor-associated kinase 4(IRAK4) inhibitor with IC50 of 0.16 μM. Mar 11 2020
S2002 CZC-25146 CZC-25146 is a potent and selective LRRK2 inhibitor with IC50 of 4.76 nM and 6.87 nM for human wild type LRRK2 and G2019S LRRK2, respectively. Mar 11 2020
S2070 ISCK03 ISCK03 is a cell-permeable inhibitor of stem-cell factor (SCF)/c-kit signaling.ISCK03 inhibits SCF-induced c-c-kit phosphorylation and downstream ERK phosphorylation. Mar 11 2020
S2184 WDR5-0103 WDR5-0103 is a small-molecule antagonist of WDR5 (WD40 repeat protein 5) with Kd of 450 nM. Mar 11 2020
S1054 AG99 AG99 is a potent and selective inhibitor of EGFR. Mar 11 2020
S6681 Paricalcitol Paricalcitol is a selective vitamin D receptor agonist. Paricalcitol suppresses parathyroid hormone mRNA expression and inhibits parathyroid cell proliferation. Pariccitol is used to treat secondary hyperparathyroidism in chronic kidney disease. Mar 11 2020
S6690 TOFA (5-(Tetradecyloxy)-2-furoic acid) TOFA is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA). Inside the cell, TOFA is converted to TOFyl-CoA (5-tetradecyloxy-2-furoyl-CoA), exerting an allosteric inhibition on ACCA. TOFA blocks fatty acid synthesis and induces cell death in a dose-dependent manner. Mar 11 2020
S6682 Bobcat339 Bobcat339 is a selective cytosine-based TET enzyme inhibitor with IC50 of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 can reduce DNA 5-hydroxymethylcytosine abundance by inhibiting TET enzyme function in living cells and provide support for its utility as a viable pharmacological probe. Mar 11 2020
S6683 D-Lin-MC3-DMA (MC3) D-Lin-MC3-DMA is a potent and ionizable cationic lipid. D-Lin-MC3-DMA is used for delivery of siRNA in vivo. Mar 11 2020
S1024 LTI-291 LTI-291 is the first small-molecule activator of Glucocerebrosidase(GCase) for the treatment of parkinson's disease. Mar 11 2020
S6621 CCG215022 CCG215022 serves as a pan-G protein-coupled receptor kinases (GRKs) inhibitor with IC50 of 3.9 μM, 0.15 μM, 0.38 μM for GRK1, GRK2, GRK5, respectively. Mar 11 2020
S6661 VcMMAE VcMMAE,a MMAE derivative with valine-citrulline (Vc) linker,is an antibody-drug conjugate (ADC) with potent antitumor activity. MMAE is a synthetic antineoplastic agent and can be efficiently released from VcMMAE in vitro and exert cytotoxic activity. Mar 11 2020
S6635 Seladelpar sodium (MBX-8025 sodium) MBX-8025 is an orally active, potent and selective agonist of PPAR-δ with an EC50 of 2 nM. MBX-8025 exhibits more than 750-fold, 2500-fold selectivity over PPAR-α and PPAR-γ receptors, respectively. Mar 11 2020
S6664 Gefapixant Gefapixant is an orally active small molecule antagonist of human P2X3 receptor with IC50 of about 30 nM, 100–250 nM for recombinant hP2X3 homotrimers and hP2X2/3 heterotrimeric receptors, respectively. Gefapixant has shown promise for the treatment of refractory and unexplained chronic cough. Mar 11 2020
S8377 ND646 In cell-free systems, ND-646 inhibits the enzymatic activity of recombinant human ACC1 (hACC1) and recombinant hACC2 with IC50 of 3.5 nM and 4.1 nM, respectively. Mar 09 2020
Cat.No. Product Name Information Added
S6759 GPR39-C3 (TC-G-1008) GPR39-C3 is a potent and orally bioavailable agonist of GPR39 with EC50 of 0.4nM and 0.8nM for rat and human receptor, respectively. Mar 09 2020
S6760 LM22B-10 LM22B-10 is a small molecule TrkB/TrkC neurotrophin receptor co-activator, LM22B-10 selectively activates TrkB, TrkC, AKT and ERK in vivo and in vitro. Mar 09 2020
S6761 Dalfopristin Dalfopristin is a semi-synthetic analogue of ostreogyrcin A, Quinupristin/dalfopristin is a new combination streptogramin product with a selective spectrum of antibacterial activity, mainly against gram-positive aerobic bacteria. Mar 09 2020
S6762 Bozitinib (PLB-1001) Bozitinib is a highly selective ATP-competitive small-molecule c-Met inhibitor with blood-brain barrier permeability. Mar 09 2020
S6763 Acrizanib (LHA510) Acrizanib is an inhibitor of VEGFR-2 with IC50 of 17.4 nM in BaF3-Tel-KDR cells. Mar 09 2020
S6764 TAS-115 TAS-115 is a unique VEGFR/MET-targeted inhibitor with IC50 of 30nM and 32nM for rVEGFR2 and rMET, respectively. Mar 09 2020
S8569 KO-947 KO-947 is a potent and selective ERK1/2inhibitor.KO-947 blocks ERK signaling and proliferation of tumor cells exhibiting dysregulation of MAPK pathway signaling at low nanomolar concentrations. Mar 09 2020
S6765 MMAD MMAD is a highly toxic inhibitor of tubulin. Mar 09 2020
S6766 MC-MMAF Mc-MMAF is a protective group-conjugated MMAF. MMAF is a potent inhibitor of tubulin polymerization. Mar 09 2020
S6767 GSK805 GSK805 is a potent and orally bioavailable RORγt inhibitor. Mar 09 2020
S8948 SRX3207 SRX3207 is a novel dual Syk-PI3K inhibitor with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively. SRX3207 can relieve tumor immunosuppression. Mar 09 2020
S8946 CMLD012612 CMLD012612 is a potent inhibitor of eIF4A with IC50 of about 2 nM. CMLD012612 is a promising anti-cancer agent. Mar 09 2020
S6486 ibandronic acid Ibandronic acid is a potent nitrogen-containing bisphosphonate used in both osteoporosis and to prevent the spread of breast cancer to the bones. Mar 09 2020
S6691 AGN 193109 AGN 193109 is a novel class of RAR antagonists which effectively block hormoneinduced activation and is the most potent and effective antagonist of RARα, RARβ, and RARγ, with Kd values of 2 nM, 2 nM, and 3 nM, respectively. Mar 06 2020
S6692 RG7800 RG7800 can modify the alternative splicing of SMN2, increasing the production of fulllength SMN2 mRNA. RG7800 is a first small molecule SMN2 splicing modifier to enter human clinical trials. Mar 06 2020
S6640 GNE-6640 GNE­6640 selectively inhibits recombinant ubiquitin epecific peptidase 7(USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7, USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively. Mar 06 2020
S6693 MRS 1754 MRS 1754 is a selective antagonist ligand of A2B adenosine receptors, with very low affinity for A1 and A3 receptors of both humans and rats. Mar 06 2020
S6641 GW284543 (UNC10225170) GW284543 is a MEK5-selective inhibitor. GW284543 can dose dependently inhibits MEK5 by reduces in pERK5 and decreases endogenous MYC protein. Mar 06 2020
S6694 Grapiprant (CJ-023423) Grapiprant is the first EP4 receptor-specific antagonist approved by FDA for control of pain and inflammation in dogs with osteoarthritis. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor in a concentration-dependent manner with an IC50 value of 35 nM and with a Ki value of 24 nM. Mar 06 2020
S8393 HG-9-91-01 (SIK inhibitor 1) HG-9-91-01 is a potent and highly selective inhibitor of SIK1, SIK2 and SIK3, with IC50 values of 0.92 nM, 6.6 nM and 9.6 nM, respectively. Mar 06 2020
Cat.No. Product Name Information Added
S6695 AB928 (A2aR/A2bR antagonist-1) AB928 is a novel dual A2aR/A2bR antagonist. AB928 inhibits A2aR and A2bR with similar potencies(equilibrium binding constant of 1.4 and 2 nM, respectively). Mar 06 2020
S6696 EZM 2302 (GSK3359088) EZM2302 is an inhibitor of CARM1 enzymatic activity in biochemical assays(IC50 = 6 nM) with broad selectivity against other histone methyltransferases. Mar 06 2020
S6547 Cilofexor (GS‐9674) Cilofexor is a farnesoid X receptor (FXR) agonist. Mar 06 2020
S6697 Tulrampator Tulrampator is an orally bioavailable compound that acts as a positive allosteric modulator of the AMPAR. Mar 06 2020
S6698 TQB3804 (EGFR-IN-7) TQB3804 is a selective and potent EGFR kinase inhibitor, has IC50 values of 7.92 nM,0.218 nM and 0.16 nM for EGFR(WT), EGFR(19del/T790M/C797S) and EGFR(L858R/T790M/C797S) respectively, and shows anti-tumor activity. Mar 06 2020
S6699 Gigantol Gigantol is a novel small-molecule Wnt/β-catenin inhibitor, gigantol has been shown to have promising therapeutic potential in cancer cells. Mar 06 2020
A2103 Anti-mouse CTLA-4 (CD152)-InVivo The UC10-4F10-11 monoclonal antibody reacts with mouse CTLA-4 (cytotoxic T lymphocyte antigen-4) also known as CD152. The UC10-4F10-11 antibody has been shown to promote T cell co-stimulation by blocking CTLA-4 binding to the B7 co-receptors, allowing for CD28 binding. Mar 05 2020
A2104 Anti-mouse CD3ε-InVivo The 145-2C11 monoclonal antibody reacts with mouse CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily. The 145-2C11 antibody has been shown to induce T lymphocyte activation, proliferation, and apoptosis in vitro via binding and stimulating the TCR. When used in vivo the antibody is reported to produce T cell activation, anergy, or death. Mar 05 2020
A2105 Anti-mouse IFNγ-InVivo The R4-6A2 monoclonal antibody reacts with mouse IFNγ (interferon gamma) which is a 20 kDa soluble pleiotropic cytokine and the sole member of the type II class of interferons. The R4-6A2 antibody has been shown to neutralize both natural and recombinant IFNγ. Mar 05 2020
A2114 Anti-mouse NK1.1-InVivo The PK136 monoclonal antibody reacts with mouse NK1.1 also known as CD161b/CD161c, KLRB1, NKR-P1A and Ly-55. Mar 05 2020
A2106 Mouse IgG1 isotype control-InVivo The monoclonal mouse IgG1 K immunoglobulin is ideal for use as a non-reactive isotype-matched control for mouse IgG1 antibodies in most in vivo and in vitro applications. Mar 05 2020
A2107 Anti-mouse CD25 (IL-2Rα)-InVivo The PC-61.5.3 monoclonal antibody reacts with mouse IL-2Rα also known as CD25, Ly-43, p55, or Tac.The PC-61.5.3 antibody has been shown to inhibit the binding of IL-2 to both the low and high affinity IL-2 receptor forms. Additionally, the PC-61.5.3 antibody is commonly used to deplete CD4+FoxP3+ T regulatory cells in vivo. Mar 05 2020
A2108 Anti-mouse CD28-InVivo The PV-1 monoclonal antibody reacts with mouse CD28.The PV-1 antibody has been shown to stimulate the proliferation and cytokine production by activated T and NK cells. Mar 05 2020
A2109 Anti-mouse IL-4-InVivo The 11B11 monoclonal antibody reacts with mouse IL-4 (interleukin-4) which is a multifunctional 14 kDa cytokine.The 11B11 monoclonal antibody has been shown to neutralize the bioactivity of natural or recombinant IL-4. Mar 05 2020
A2110 Anti-mouse CD16/CD32-InVivo The 2.4G2 monoclonal antibody reacts specifically with mouse CD16 (FcγRIII) and CD32 (FcγRII). It has also been reported to react non-specifically via its Fc domain to FcγRI. The 2.4G2 antibody is commonly used in flow cytometry staining experiments to prevent non-specific binding of IgG to the FcγIII and FcγII, and possibly FcγI, receptors prior to staining with antigen specific primary antibodies. Mar 05 2020
A2111 Anti-human CD3-InVivo The OKT-3 monoclonal antibody reacts with human CD3ε which is a 20 kDa transmembrane cell-surface protein that belongs to the immunoglobulin superfamily.The OKT-3 antibody has immunosuppressive properties in vivo and has been shown to effectively treat renal, heart and liver allograft rejection. Mar 05 2020
A2112 Anti-mouse CD40L (CD154)-InVivo The MR-1 monoclonal antibody reacts with mouse CD154 also known as CD40 ligand. The MR-1 monoclonal antibody has been reported to inhibit in vitro activation of B lymphocytes by blocking the binding of CD154 with CD40 on T helper cells as well as inhibit the formation of germinal centers and disrupt antigen-specific T cell responses. Additionally, the MR-1 antibody blocks interactions of T cells and antigen-presenting cells in vitro and blocks the development of experimental autoimmune disease in vivo. Mar 05 2020
A2113 Anti-human/mouse TGF-β-InVivo The 1D11.16.8 monoclonal antibody reacts with mouse, human, rat, monkey, hamster, canine and bovine TGF-β (transforming growth factor beta) isoforms 1, 2 and 3.The 1D11.16.8 monoclonal antibody is a neutralizing antibody. Mar 05 2020
S8884 MRTX849 MRTX849 is a potent, selective, and covalent KRASG12C inhibitor that exhibits favorable drug-like properties, selectively modifies mutant cysteine 12 in GDP-bound KRASG12C and inhibits KRAS-dependent signaling. Mar 04 2020
S1074 Poliumoside Poliumoside exhibits significant inhibition of advanced glycation end product formation with IC50 values of 19.69 µM. In the rat lens aldose reductase assay.Poliumoside exhibits greater inhibitory effects on rat lens aldose reductase(RLAR) with IC50 values of 8.47 µM. Mar 04 2020
Cat.No. Product Name Information Added
S1059 KDM4D-IN-1 KDM4D-IN-1 is a potent inhibitor of KDM4D with an IC50 of 0.41 μM. Mar 04 2020
S6678 Yoda1 Yoda1 acts as an agonist for both human and mouse Piezo1(EC50 of 17.1 and 26.6 μM for mouse and human). Yoda1 activates purified Piezo1 channels in the absence of other cellular components. Mar 04 2020
S2211 AG-13958 AG–013958, a VEGFR tyrosine kinase inhibitor, is in clinical development with ST administration for treatment of choroidal neovascularization associated with age–related macular degeneration (AMD). Mar 04 2020
S2212 AIM-100 AIM-100 is a potent small molecule inhibitor of Ack1 with IC50 of 24nM. Mar 04 2020
S2234 BIBF-0775 BIBF-0775 is a selective inhibitor of transforming growth factor β Receptor I (TGFβRI,Alk5) with an IC50 of 34nM. Mar 04 2020
S2249 PF 4800567 PF 4800567 is a novel and potent inhibitor of casein kinase 1 epsilon (IC50=32 nM) with greater than 20-fold selectivity over casein kinase 1 delta(IC50=711 nM). Mar 04 2020
S7919 AR-C155858 AR-C155858 is a potent inhibitor of MCT1 and MCT2 with Ki of 2.3 nM and 10 nM, respectively. Mar 04 2020
S6672 PF-05175157 PF-05175157 is a broad-spectrum effective ACC inhibitor with IC50 of 27.0 nM, 33.0 nM, 23.5 nM and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively. Feb 28 2020
S6675 (R)-GNE-140 (R)-GNE-140 is a selective inhibitor of the LDHA and LDHB with IC50s of 3 nM and 5 nM, respectively. The R enantiomer of GNE-140 is 18-fold more potent than S enantiomer. Feb 28 2020
S6673 CCG-222740 CCG-222740 is a Rho/MRTF pathway inhibitor. CCG-222740 decreases the activation of stellate cells in vitro and in vivo, by reducing the levels of alpha smooth muscle actin(α-SMA) expression. Feb 28 2020
S6676 Ebselen Ebselen is a small-molecule capsid inhibitor of HIV-1 Replication with IC50 of 46.1 nM in TR-FRET assay. Feb 28 2020
S8531 PF-06650833 PF-06650833 is a potent, selective inhibitor of IRAK4 with an IC50 of 0.2 nM. Feb 24 2020
S6669 MC-Val-Cit-PAB MC-Val-Cit-PAB,also known as MC-Val-Cit-PAB-OH,is a cathepsin cleavable ADC peptide linker and is used for making ADC conjugate (antibody-drug conjugate). Feb 12 2020
S6649 E7046(ER-886406) E7046 is a selective inhibitor of the prostaglandin E2 (PGE2) receptor EP4 with IC50 of 13.5 nM and Ki of 23.14 nM. Feb 12 2020
S8891 JHU-083 Feb 12 2020
S6634 SAR7334 SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels.SAR7334 blocks TRPC6 currents with an IC50 of 7.9 nM in patch-clamp experiment. Feb 12 2020
S9466 Methenamine Hippurate Methenamine Hippurate is the hippurate salt form of methenamine, a prodrug and inactive weak base that is hydrolyzed to formaldehyde in acid urine.Methenamine Hippurate is the component of Hiprex drug which has antibacterial activity. Feb 12 2020
S6666 FT113 FT113 is a potent inhibitor of fatty acid synthase(FASN) with ic50 of 213 nM. Jan 20 2020
S6663 Resmetirom (MGL-3196) Resmetirom is a liver-directed, orally active, selective thyroid hormone receptor β(THR-β) agonist with an EC50 of 0.21 μM,shows 28-fold selective for THR-β over THR-α in a functional assay. Jan 20 2020
S6667 STING inhibitor C-178 C-178 is a covalent inhibitor of STING,covalently bind to Cys91. Jan 20 2020
Cat.No. Product Name Information Added
S8907 Dapansutrile (OLT1177) Dapansutrile (OLT1177) is a novel and selective NLRP3 inflammasome inhibitor. Jan 20 2020
S8909 UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines. Jan 20 2020
S6665 Sparsentan (PS-433540,RE-021,DARA) Sparsentan is a dual endothelin type A receptor(ETA) and angiotensin II type 1 receptor antagonist. Jan 20 2020
S6668 NVS-ZP7-4 NVS-ZP7-4,a Zinc transporter SLC39A7 (ZIP7) inhibitor,is the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel druggable node in the Notch pathway. Jan 20 2020
S6639 BAY-545 BAY-545 is an A2B adenosine receptor antagonist with ic50 of 59 nM. Jan 20 2020
S8904 USP25/28 inhibitor AZ1 AZ1 is a potent and noncompetitive dual Inhibitors of the ubiquitin-specific protease (USP) 25/28 with IC50s of 0.62 μM and 0.7 μM in Ub-RH110 assay,respectively. Jan 15 2020
S6659 Rimegepant (BMS-927711) Rimegepant is a potent, selective, competitive human calcitonin gene-related peptide (CGRP) receptor antagonist with ki of 0.027 nM. Jan 15 2020
S6658 ETC-206 (AUM 001) ETC-206 is an orally available highly selective small-molecule MNK 1/2 inhibitor with IC50s of 64 nM and 86 nM, respectively. Jan 15 2020
S6650 EN6 EN6 is a novel covalent autophagy activator and targets cysteine 277 in the ATP6V1A subunit of the lysosomal v-ATPase with an IC50 of 1.7 μM for recombinant human ATP6V1A protein. Jan 15 2020
S6662 AST-487 (NVP-AST487) AST-487,a N,N'-diphenyl urea,is an ATP competitive inhibitor of Flt3 with ki of 0.12 μM.Besides FLT3, AST487 also inhibits RET,KDR,c-KIT,and c-ABL kinase with IC50 values below 1 μM. Jan 15 2020
S6660 B-Raf inhibitor 1 (Compound 13) dihydrochloride B-Raf inhibitor 1 (Compound 13) is a type IIA Raf inhibitor which bind to the DFG-out conformation with ki of 1 nM,1 nM,and 0.3 nM for B-Raf(WT), B-Raf(V600E) and C-Raf, respectively. Jan 15 2020
S8834 GB1107 GB1107 is a novel galectin-3 inhibitor with high affinity in man galectin-3 at 37 nM,shows >1000 fold selectively over galectins 1, 8 and 9. Jan 15 2020
S8466 ST2825 ST2825,a synthetic peptido-mimetic compound,inhibits myeloid differentiation factor 88(MyD88) homodimerization in a TIR‐dependent manner and interferes with recruitment of IRAK1 and IRAK4 by MyD88. Jan 15 2020
S8923 AQX-435 AQX-435 is a novel SHIP1 activator. Jan 15 2020
S6654 SRI-011381 SRI-011381 is a novel agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease. Jan 08 2020
S6647 Bardoxolone Bardoxolone,acts by releasing Nrf2 from KEAP1,is a highly potent activator of Nrf2 that induce programmed cell death (apoptosis) in cancer cells. Jan 08 2020
S6651 G15 (GRB-G15) G15 is a cell-permeable high affinity and selective G-protein coupled estrogen receptor 1 (GPER) antagonist with an affinity of approximately 20 nM that displays no affinity for ERα and ERβ at concentrations up to 10 μM. Jan 08 2020
S6657 2-Aminoethyl Diphenylborinate (2-APB) 2-Aminoethyl Diphenylborinate (2-APB) is an IP3 receptor inhibitor and regulate IP3-induced calcium release.2-APB also inhibits the SOC channel activity and activates TRP channel at higher concentrations. Jan 08 2020
S6656 VAS2870 VAS2870 is a pan-NADPH oxidase (NOX) inhibitor. Jan 08 2020
S8893 Firsocostat (GS-0976) Firsocostat is a reversible inhibitor of acetyl CoA carboxylase (ACC) with IC50s of 2.1 nM,6.1 nM for hACC1 and hACC2,respectively. Jan 08 2020
Cat.No. Product Name Information Added
S8882 ODM-203 ODM-203 is a selective inhibitor of FGFR and VEGFR with ic50s of 11 nM,16 nM,6 nM, 35 nM,26 nM,9 nM,5 nM for recombinant FGFR1, FGFR2, FGFR3,FGFR4, VEGFR1, VEGFR2 and VEGFR3, respectively. Jan 08 2020
S8902 ERD-308 ERD-308 is a highly potent PROTAC degrader of Estrogen Receptor (ER) with DC50 of 0.17 nM in MCF-7 cell lines. Jan 08 2020
S8890 MK-8719 MK-8719 is a selective and potent small molecule inhibitor of the O-GlcNAcase (OGA) enzyme with ki of 7.9nM for hOGA. Jan 08 2020
S6652 H-151 H-151 is a highly potent and covalent antagonist of STING that has noteworthy inhibitory activity both in human cells and in vivo. Jan 02 2020
S8901 DS-6051b DS-6051b is a new-generation selective ROS1/NTRK inhibitor with ic50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM for ROS1,NTRK1,NTRK2 and NTRK3,respectively. Dec 31 2019
S8847 BAY 2402234 BAY 2402234 is a novel and selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 1.2 nM. Dec 31 2019
S6636 Azaindole 1 (TC-S 7001) Azaindole 1 (TC-S 7001) is a selective Rho-associated protein kinase (ROCK) inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2 in an ATP-competitive manner. Dec 31 2019
S6637 HC-067047 HC-067047 is a selective TRPV4 channel antagonist with IC50 values of 48 nM,133 nM,and 17 nM for human, rat, and mouse TRPV4 orthologs,respectively. Dec 31 2019
S6655 WM-8014 WM-8014 is a highly potent inhibitor of histone acetyltransferase KAT6A with an IC50 of 8 nM. Dec 31 2019
S8785 A1874 A1874 is a much improved nutlin-based, BRD4-degrading PROTAC and is able to degrade its target protein by 98% with nanomolar potency. Dec 31 2019
S8899 FF-10101 FF-10101 is a novel irreversible FLT3 inhibitor with ic50 of 0.20 nM and 0.16 nM for FLT3 (WT) and FLT3(D835Y), respectively. Dec 31 2019
S8878 NDI-091143 NDI-091143 is a potent inhibitor of human ATP-citrate lyase(ACLY) with a Ki of 7.0 nM and an IC50 of 2.1 nM in the ADP-Glo assay. Dec 31 2019
S6747 SW-044248 SW-044248 is a non-canonical Top1 inhibitor with a pattern of selective toxicity for NSCLC cells. Dec 25 2019
S5650 Sodium Hyaluronate Sodium hyaluronate is the sodium salt of hyaluronic acid, a glycosaminoglycan found in various connective tissue of humans. Dec 25 2019
S4303 9-Aminoacridine 9-Aminoacridine is a highly fluorescent dye used clinically as a topical antiseptic and experimentally as a mutagen, an intracellular pH indicator and a negative mode small molecule MALDI matrix. Dec 19 2019
S4345 Pentoxifylline Pentoxifylline is a competitive nonselective phosphodiesterase inhibitor which raises intracellular cAMP, activates PKA, inhibits TNF and leukotriene synthesis, and reduces inflammation and innate immunity. Dec 19 2019
S4353 Terfenadine Terfenadine is an antihistamine, generally completely metabolizes to the active form fexofenadine in the liver by the enzyme cytochrome P450 CYP3A4 isoform. Dec 19 2019
S8848 TAS-120 TAS-120 is an irreversible fibroblast growth factor receptor (FGFR) inhibitor which inhibits all 4 subtypes of FGFR with enzyme IC50 values of 3.9 nM, 1.3 nM, 1.6 nM and 8.3 nM for FGFR1, FGFR2, FGFR3 and FGFR4 respectively. Dec 19 2019
S4357 Tacrine HCl Tacrine is a centrally acting anticholinesterase and indirect cholinergic agonist. Dec 19 2019
S4360 Tolmetin Sodium Tolmetin is a non-steroidal anti-inflammatory drug of the arylalkanoic acids. Dec 19 2019
Cat.No. Product Name Information Added
S4368 Carbenoxolone Sodium Carbenoxolone, a synthetic derivative of glycyrrhetinic acid, is also used as a blocker of the enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD), of pannexon membrane channels (comprising 6 subunits of pannexin) and the related innexon channels. Dec 19 2019
S4377 Imipramine HCl Imipramine is a tricyclic antidepressant (TCA) of the dibenzazepine group, mainly used in the treatment of major depression and enuresis (inability to control urination). Dec 19 2019
S4382 Pyrilamine Maleate Pyrilamine is a histamine H1 receptor inverse agonist, it binds to a G protein-coupled form of the receptor and promotes a G protein-coupled inactive state of the H1 receptor that interferes with the Gq/11-mediated signaling. Dec 19 2019
S4393 Cephapirin Sodium Cephapirin Sodium is the sodium salt form of cephapirin, a semi-synthetic, first-generation cephalosporin antibiotic with bactericidal activity.Cephapirin Sodium is effective against gram-negative and gram-positive organisms. Dec 19 2019
S4404 Pasiniazid Pasiniazid is a composition of isoniazid and 4-aminosalicylic acid, used to treat tuberculosis patients. Dec 19 2019
S4414 Sodium 4-aminohippurate Sodium 4-aminohippurate is a derivative of hippuric acid. Dec 19 2019
S6648 PF-06282999 PF-06282999 is an orally bioavailable, irreversible inactivator of myeloperoxidase enzyme and is currently in clinical trials for the potential treatment of cardiovascular diseases. Dec 18 2019
P1089 Goserelin Acetate Goserelin is a luteinizing hormone releasing hormone (LHRH) agonist, which is used to suppress production of the sex hormones. Dec 18 2019
S8895 Ziritaxestat (GLPG1690) Ziritaxestat (GLPG1690) is a selective autotaxin inhibitor with an IC50 of 131 nM and Ki of 15 nM. Dec 18 2019
S9521 Pentostatin Pentostatin is a potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. Dec 18 2019
S6646 CPI-444 CPI-444 is a potent and selective Adenosine A2A receptor antagonist. It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes. Dec 18 2019
S6645 AZD5069 AZD5069 is a novel antagonist of CXCR2, which is shown to inhibit binding of CXCL8 to CXCR2 with a pIC50 value of 8.8 and inhibit CXCL8 binding to CXCR1 with pIC50 values of 6.5. Dec 18 2019
S9522 Valrubicin Valrubicin is a chemotherapy drug used to treat bladder cancer. Dec 18 2019
S9520 Lasofoxifene Tartrate Lasofoxifene Tartrate is a third-generation, non-steroidal selective estrogen receptor modulator (SERM) which binds with high affinity to the human estrogen receptor-α with IC50 value of 1.5 nM. Dec 18 2019
S6633 AM 095 AM095 is an antagonist of the LPA type 1 receptor with IC50 values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively. Dec 18 2019
S5631 L-Alanine Alanine is a naturally occuring non-essential amino acid that is involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brainR, and the CNS. Dec 15 2019
S5629 L-Proline L-Proline is one of non-essential amino acids and an essential component of collagen that is important for proper functioning of joints and tendons. Dec 15 2019
S5630 L-lysine Lysine is an α-amino acid that is used in the biosynthesis of proteins and is required for growth and tissue repair. Dec 15 2019
S5634 L-arginine Arginine is an important amino acid used in the biosynthesis of proteins. L-arginine plays an important role in immune regulation by affecting the immune response and inflammation. It is also implicated in cell division, wound healing and the release of hormones. Dec 15 2019
S5633 L-methionine L-Methionine is an essential sulfur-containing, free-form amino acid, acts as an antioxidant promoter, and contributes to the synthesis of S-adenosyl-L-methionine (SAMe). Dec 15 2019
Cat.No. Product Name Information Added
S9519 Fadrozole Fadrozole is a potent, selective, nonsteroidal inhibitor of aromatase with an IC50 of 4.5 nM and selectivity over other cytochrome P-450 enzymes. Dec 11 2019
S6643 R-7050 R-7050 is a cell permeable TNF-α receptor antagonist and is 2.3-fold more selective for TNF-α-mediated signaling than for that driven by IL-1β. Dec 11 2019
S6642 Branaplam (LMI070) Branaplam (LMI070) is a highly selective, small-molecule splicing modulators of survival motor neuron‑2 (SMN2) with an EC50 of 0.02 μM. Dec 11 2019
S8839 Borussertib Borussertib is a covalent-allosteric inhibitor of protein kinase Akt with an IC50 of 0.8 nM and a Ki of 2.2 nM for WT Akt. Dec 11 2019
S6740 DB07268 DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM and exhibits at least 70- to 90-fold greater potency against JNK1 than CHK1, CK2, and PLK. Dec 09 2019
S6623 APY29 APY29 is a type I kinase inhibitor of IRE1α that binds to the ATP-binding site on IRE1α and inhibits its autophosphorylation (IC50 = 280 nM) and enhances its RNase function (EC50 = 460 nM). Dec 09 2019
S6625 Temsavir (BMS-626529) Temsavir (BMS-626529) is a novel small-molecule HIV-1 attachment inhibitor active against both CCR5- and CXCR4-tropic viruses. Dec 09 2019
S6751 Brevianamide F Brevianamide F, belonging to a class of naturally occurring 2,5-diketopiperazines, is the simplest member and the biosynthetic precursor of a large family of biologically active prenylated tryptophan-proline 2,5-diketopiperazines that are produced by the fungi A.fumigates and Aspergillus sp.. Dec 09 2019
S6749 ASP-9521 ASP-9521 is a selective, orally bioavailable inhibitor of 17beta-hydroxysteroid dehydrogenase type 5 (17β-HSD5). Dec 09 2019
S6739 MN 64 MN-64 is a potent inhibitor of TNKS1 and TNKS2 with IC50 value of 6 and 72 nM, respectively. Dec 09 2019
S6746 APD668 APD668 is a potent GPR119 agonist with EC50s of 2.7 and 33 nM for human and rat forms, respectively. Dec 09 2019
S2934 Ensartinib (X-396) dihydrochloride Ensartinib (X-396) is a potent new-generation ALK inhibitor with high activity against a broad range of known crizotinib-resistant ALK mutations and CNS metastases. It potently inhibits both wild-type ALK and ALK variants (F1174, C1156Y, L1196M, S1206R, T1151, and G1202R mutants) with in vitro IC50s of <4 nM. Dec 09 2019
S6632 Mirogabalin (DS-5565) Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand that has been used in trials studying the treatment of Post-herpetic Neuralgia, Pain Associated With Fibromyalgia, and Diabetic peripheral neuropathic pain. Dec 09 2019
S6628 E7820 E7820 is a unique angiogenesis inhibitor with antitumor activities. Dec 09 2019
S6629 GNE-617 GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM. Dec 09 2019
S6644 Radiprodil (RGH-896) Radiprodil (RGH-896) is a NR2B-selective NMDA receptor antagonist, initially developed for the treatment of neuropathic pain. Dec 09 2019
S6638 AMG-333 AMG-333 is a potent and highly selective antagonist of TRPM8 with IC50 values of 13 nM and 30 nM for human TRPM8 and rat TRPM8. Dec 09 2019
S6624 Avatrombopag Avatrombopag is an orally administered, small-molecule thrombopoietin receptor (c-Mpl) agonist which increases platelet number, but not platelet activation. Dec 09 2019
S8820 PTC596 PTC596 is a second-generation BMI-1 inhibitor that accelerates BMI-1 degradation. It inhibits cell proliferation and induces apoptosis in a dose- and time-dependent manner. IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines. Dec 09 2019
S6631 Belotecan (CKD-602) hydrochloride Belotecan (CKD-602) is a potent DNA topoisomerase I inhibitor that exerts a clinical anticancer effect on various types of tumor. Dec 09 2019
Cat.No. Product Name Information Added
S6741 SB-756050 SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor). Dec 09 2019
S6753 CP 640186 CP 640186 is an isozyme-nonselective ACC (Acetyl-CoA carboxylase) inhibitor with IC50 values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively. Dec 09 2019
S6744 Inauhzin Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity. Dec 09 2019
S6737 C7280948 C7280948 is a protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 12.8 μM in vitro. Dec 09 2019
S6755 NS 11394 NS11394 is a subtype-selective positive allosteric modulator at GABAA receptors, with selectivity for the α3 and α5 subtypes. Dec 09 2019
S6728 IDO-IN-1 IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 59 nM. Dec 09 2019
S6758 I-CBP112 I-CBP112 is a potent and selective CBP/p300 inhibitor with dissociation constant (KD) of 151 ± 6 nM and 167 ± 8 nM for CBP and p300, respectively. Dec 09 2019
S6752 Y16 Y16 is an inhibitor of G-protein-coupled Rho GEFs. It blocks the binding of LARG, a DBL-family Rho guanine nucleotide exchange factor, with Rho (Kd = 80 nM). Dec 09 2019
S6736 1-Methoxy PMS 1-methoxy PMS is stable electron-transport mediator between NAD(P)H and tetrazolium dyes. Dec 09 2019
S6754 S1RA S1RA is a selective sigma-1 receptor (σ1R) antagonist with a reported binding affinity of Ki = 17.0 ± 7.0 nM for human σ1 receptor , selective over the sigma-2 receptor and against a panel of other 170 receptors, enzymes, transporters and ion channels. Nov 28 2019
S6742 Etofenamate Etofenamate is a nonsteroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain. Nov 28 2019
S6748 ML364 ML364 is a small molecule inhibitor of the deubiquitinase USP2 with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate. Nov 28 2019
S6745 JW55 JW55 is a potent and selective inhibitor of the canonical Wnt pathway that functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1/2). Nov 28 2019
S6756 Siramesine HCl Siramesine is a sigma receptor agonist, selective for the σ2 subtype with IC50 values of 0.12 nM and 17 nM for σ2 and σ1 receptors respectively. Nov 28 2019
S6626 Brequinar Brequinar is an inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of ∼20 nM in vitro. Nov 28 2019
S6627 E-4031 dihydrochloride E-4031 is an experimental class III antiarrhythmic drug that blocks potassium channels of the hERG-type. Nov 28 2019
S8796 diABZI STING agonist(compound 3) STING agonist 1 (compound 3) is a potent non-nucleotide STING agonist and has tremendous potential to improve treatment of cancer in humans. Nov 28 2019
S8814 TAS6417 TAS6417 is a novel EGFR inhibitor that targets EGFR exon 20 insertion mutations while sparing wild-type (WT) EGFR. IC50 values ranges from 1.1 ± 0.1 to 8.0 ± 1.1 nmol/L. Nov 19 2019
S8853 Belvarafenib Belvarafenib (GDC5573, HM95573, RG6185) is a selective and orally bioavailable pan-RAF kinase inhibitor with IC50 values of 41 nM, 7 nM and 2 nM for BRAF WT, BRAF(V600E) and CRAF kinases, respectively. Nov 19 2019
S8861 Mavacamten (MYK-461) Mavacamten (MYK-461) is a small-molecule modulator of cardiac myosin that targets the underlying sarcomere hypercontractility of hypertrophic cardiomyopathy (HCM), one of the most prevalent heritable cardiovascular disorders. Nov 19 2019
Cat.No. Product Name Information Added
S8781 Selpercatinib (LOXO-292) Selpercatinib (LOXO-292, ARRY-192) is a potent and specific RET inhibitor with IC50 values of 1 nM, 2 nM, 2 nM, 4 nM, 2 nM, 2 nM for WT RET, RET V804M, RET V804L, RET A883F, RET M918T and RET S891A respectively. Nov 13 2019
S6475 Polaprezinc Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities. Nov 13 2019
S8506 SCH-527123 SCH-527123 is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively. Nov 13 2019
S6717 TCS-OX2-29 TCX-OX2-29 is a OX2R antagonist (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively). Nov 13 2019
S8670 Vipivotide tetraxetan (PSMA-617) Vipivotide tetraxetan (PSMA-617) is a chemically modified PSMA(prostate-specific membrane antigen) inhibitor with a Ki of 0.37 nM. Nov 11 2019
S8703 Milademetan (DS-3032b) Milademetan (DS-3032b) is a novel potent MDM2 inhibitor that inhibits MDM2-p53 interaction with an IC50 of 5.57 nM in the HTRF assay. Nov 11 2019
S8730 BAY 1251152 BAY1251152 is a potent PTEFb/CDK9 inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. Nov 11 2019
S8734 AZD7624 AZD7624 is a potent and selective competitive inhibitor against p38α/β with pIC50s of 10 and 8.8 for p38α and p38β respectively. Nov 11 2019
S8766 AT1 AT1 is highly selective Brd4 degrader which is a designed molecule based on the crystal structures of MZ1 bound to BRD4 as well as models of VHL proteins. Nov 11 2019
S8563 TVB-3664 TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor. Nov 11 2019
S8574 BI 894999 BI894999 is a novel potent and selective BET inhibitor with IC50 values of 5 nM and 41 nM for the binding of BRD4-BD1 and BRD4-BD2 to acetylated histones, respectively. BI894999 is highly selective for BRD2/3/4 and BRDT (Kd of 0.49-1.6 nM), with at least a 200-fold selectivity vs. BRD4-BD1. Nov 11 2019
S8838 LHC165 LHC165 is a TLR7 agonist designed for localized intratumoral therapies. Nov 11 2019
S8844 BRD0539 BRD0539 is a potent inhibitor of spCas9 which disrupts spCas9-DNA binding and exerts dose and temporal control of spCas9 in human cell lines. Nov 11 2019
S8851 Elexacaftor (VX-445) Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector.This is a compound which is not chiral purity. Nov 11 2019
S8863 YKL-5-124 YKL-5-124 is a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for inhibiting CDK7/Mat1/CycH, CDK2 and CDK9 respectively. It displays biochemical and cellular selectivity for CDK7 over CDK12/13. Nov 11 2019
S8880 Lobaplatin ( D-19466) Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity. Nov 11 2019
S8881 DS-1001b (DS 1001) DS-1001b is an oral selective inhibitor of mutant IDH1 R132X with potential antineoplastic activity and is designed to penetrate the blood-brain barrier. Nov 11 2019
S6715 YHO-13177 YHO-13177, a novel acrylonitrile derivative, is a potent BCRP inhibitor. Nov 06 2019
S6598 IRAK-1-4 Inhibitor I IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor associated kinase (IRAK) with IC50 values of 0.3 μM and 0.2 μM for IRAK-1 and IRAK-4, respectively. It displays IC50 values >10 µM in a panel of 27 other kinases tested. Nov 06 2019
S6719 E6446 (dihydrochloride) E6446 is a specific Toll-like receptor 9 inhibitor. Nov 06 2019
Cat.No. Product Name Information Added
S6732 7ACC2 7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells. Nov 06 2019
S6731 Eliprodil (SL-820715) Eliprodil (SL-820715) is a non-competitive NR2B-selective NMDA antagonist with IC50 value of 1 μM and is less potent for NR2A- and NR2C-containing receptors with IC50 > 100 μM. Nov 06 2019
S6735 JD-5037 JD-5037 is a peripherally restricted (PR) cannabinoid-1 receptor blocker with an IC50 value of 2 nM for CB1 receptor and > 1000 nM for CB2 receptor. Nov 06 2019
S6727 AX-024 HCl AX-024 blocks the interaction of the CD3ε PRS with SH3.1(Nck). Nov 06 2019
S6596 AG-126 AG126 is a tyrosine kinase inhibitor which selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. Nov 06 2019
S6713 ITD-1 ITD-1 is a potent TGF-β inhibitor. It does not block the kinase activity of either type I (TGFBR1) or type II (TGFBR2) TGFβ receptors but potently blocks phosphorylation of the effector SMAD2/3 proteins induced by TGFβ2, and only minimally in response to Activin A. Nov 06 2019
S6716 NSC 185058 NSC185058 inhibits ATG4B, the lipidation of LC3B, and autophagy without affecting the MTOR or PtdIns3K pathways. Nov 06 2019
S6711 IQ-1S IQ-1S is a JNK3 inhibitor with Kd values of 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively. Nov 06 2019
S6710 SGC-GAK-1 SGC-GAK-1 is a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK) with Ki value of 3.1 nM and >50-fold selectivity over nearest kinase. Nov 06 2019
S6712 S107 S107 is a Type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1. Nov 06 2019
S6718 MKT-077 MKT-077 is a newly synthesized, highly water-soluble rhodacyanine dye that exhibits significant antitumor activity in a variety of model systems. Nov 06 2019
S6721 JG98 JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. Nov 06 2019
S6599 KM11060 KM11060 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation. Nov 06 2019
S6595 THZ531 THZ531 is a selective covalent inhibitor of CDK12 and CDK13 with IC50 values of 158 and 69 nM, respectively. Nov 06 2019
S6723 LXS-196 LXS-196 is a selective inhibitor of protein kinase C (PKC). Nov 06 2019
S6622 BMS309403 BMS309403 is a small-molecule FABP4 inhibitor with nM affinity (Kd=4 nM for FABP4) and >100-fold selectivity against FABP5 as well as the heart isoform FABP3. Nov 06 2019
S2933 AM580 AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ. Nov 06 2019
S6714 INH14 INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively. Nov 06 2019
S8874 PLX5622 PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing > 20-fold selectivity over KIT and FLT3. Nov 06 2019
S6726 MK1064 MK1064 is a selective orexin 2 receptor antagonist (2-SORA) with an IC50 of 18 nM. Oct 30 2019
Cat.No. Product Name Information Added
S6725 PCI 29732 PCI 29732 is a selective and irreversible Btk inhibitor with an IC50 of 0.5 nM. Oct 30 2019
S8843 AZD7648 AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6 nM in biochemical assay and more than 100-fold selective against 396 other kinases. Oct 30 2019
S6733 Edonerpic maleate Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ). Oct 30 2019
S6729 Besifovir Besifovir is novel and potent acyclic nucleotide phosphonate used to treat hepatitis B virus (HBV) infection. Oct 30 2019
S6730 CC-401 Hydrochloride CC-401 is a potent inhibitor of JNK with at least 40-fold selectivity against other related kinases. Oct 30 2019
S6616 ETC-159 ETC-159 is an orally available, potent porcupine inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells. Oct 30 2019
S6617 MSX-122 MSX-122 is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM). Oct 30 2019
S6619 ABT 702 dihydrochloride ABT-702 is a novel, potent non-nucleoside Adenosine kinase inhibitor with an IC50 of 1.7 nM. It has oral activity in animal models of pain and inflammation. Oct 30 2019
S8774 DT-061(SMAP) DT-061(SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively. Oct 30 2019
S6552 CYM5541 CYM5541 is a selective, allosteric agonist of S1P3 with an EC50 of between 72 and 132 nM and exhibits exquisite selectivity over other S1P receptor subtypes in vitro: S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM. Oct 23 2019
S6724 SR1001 SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively. Oct 23 2019
S6734 PF-670462 PF-670462 is a potent and selective inhibitor of CK1ε and CK1δ with IC50 value of 90 nM and 13 nM, respectively. Oct 23 2019
S6618 JNJ-42153605 JNJ-42153605 is a potent and selective mGlu2 receptor positive allosteric modulator with an EC50 of 17 nM. Oct 23 2019
S6620 Danirixin (GSK1325756) Danirixin (GSK1325756) is a small molecule, non-peptide, high affinity (IC50 for CXCL8 binding = 12.5 nM), selective, and reversible CXCR2 antagonist. Oct 23 2019
S8455 Talabostat (PT-100) Talabostat (Val-boroPro, PT-100) is a dipeptidyl peptidase inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has antineoplastic and hematopoiesis- stimulating activities. Oct 23 2019
S7716 TAS-116 TAS-116 is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L). Oct 15 2019
S6551 Adelmidrol Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities. Oct 10 2019
S8860 Cintirorgon (LYC-55716) Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ. Oct 10 2019
S8862 PDD00017273 PDD00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor with an IC50 of 26 nM. PDD00017273 exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Oct 10 2019
S2931 Aurora Kinase Inhibitor III Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase with an IC50 of 42 nM and has high selectivity for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively). Oct 10 2019
Cat.No. Product Name Information Added
S6572 ML335 ML335 is a potent and selective TREK-1/2 activator. ML335 is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively. Oct 10 2019
S8877 Imidazole ketone erastin Imidazole ketone erastin (IKE) is a potent, selective, and metabolically stable system xc– inhibitor and inducer of ferroptosis. Oct 10 2019
S8868 NG25 NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively. Oct 10 2019
S8716 BLU-667 BLU-667 is a highly potent and selective RET inhibitor with an IC50 of 0.4 nM for WT RET. It also demonstrates potent activity (IC50 0.4 nmol/L) against common oncogenic RET alterations, including RET (M918T). Oct 10 2019
S8828 Gboxin Gboxin is an inhibitor of oxidative phosphorylation in cancer cells. It specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes. Oct 10 2019
S6581 Fosamprenavir calcium salt Fosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections. Sep 24 2019
S7455 Resatorvid (TAK-242) Resatorvid (TAK-242) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC50 values of 1-11 nM. Sep 24 2019
S8865 BAI1 BAI1 is a direct allosteric inhibitor of BAX with a dissociation constant (Kd) of 15.0 ± 4 μM. Sep 17 2019
S6702 Tween 80 Tween 80 is a widely used non-ionic emulsifier that is added to cosmetics, pharmaceuticals, and foods. Sep 17 2019
S6703 CMC-Na Sodium carboxymethyl cellulose (CMC-Na) is one of the important modified cellulose, a water-soluble cellulose, which is widely used in many application of food, pharmaceuticals, detergent, paper coating, dispersing agent, and others. Sep 17 2019
S6704 PEG300 PEG300 is a water-miscible polyether widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries. It serves as a kind of solubilizer, excipient, lubricant, and chemical reagent. Sep 17 2019
S6705 PEG400 Polyethylene glycol 400 (PEG400) is a commonly used co-solvent used in a variety of pharmaceutical formulations. Sep 17 2019
P1085 Angiotensin II human Acetate Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. It works via binding to specific receptors present on cell membranes. Sep 15 2019
S8832 Branebrutinib (BMS-986195) Branebrutinib (BMS-986195) is a potent inhibitor of BTK with IC50 values of 0.1 nM, 0.9 nM, 1.5 nM, 5 nM for BTK, TEC, BMX, TXK, respectively. Sep 11 2019
S6546 PD153035 PD153035 is a specific and potent inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (Ki = 5.2 pM). Sep 11 2019
S6531 Bohemine Bohemine is a CDK inhibitor with IC50s of 4.6, 83, and 2.7 μM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively. Sep 11 2019
S6530 EBE-A22 EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive. Sep 11 2019
S6602 TB5 TB5 is a potent and selective MAO-B inhibitor with Ki values of 110 and 1,450 nM for MAO-B and MAO-A, respectively. Sep 11 2019
S6568 ML346 ML346 is a Hsp70 activator and a novel modulator of proteostasis for protein conformational diseases. Sep 11 2019
S6564 ML348 ML348 is a potent and selective APT1 (Acyl protein thioesterase 1) inhibitor with Ki values of 280 nM and >10 μM for APT1 and APT2, respectively. Sep 11 2019
Cat.No. Product Name Information Added
S6540 NG 52 NG-52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p with IC50s of 7 and 2 μM, respectively. Sep 11 2019
S6539 ASP5878 ASP5878 is a novel FGFR-selective inhibitor with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L for recombinant FGFR1, 2, 3, and 4, respectively. Sep 11 2019
S6606 CDD3505 CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity. Sep 11 2019
S6607 YL-109 YL-109 is a novel antitumor agent that has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo. Sep 11 2019
S6526 SKLB 610 SKLB-610 is a multi-target inhibitor of the tyrosine kinases. It is most potent against VEGFR2 and exhibits slightly weaker inhibitor of FGFR2 and PDGFR. Sep 11 2019
S6534 CZC-54252 CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for human wild type LRRK2 and G2019S LRRK2, respectively. Sep 11 2019
S4421 Josamycin Josamycin is a macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens. Sep 11 2019
S6579 RCGD423 RCGD-423 is a modulator of gp130 signalling that regulates cartilage growth and differentiation. Sep 11 2019
S6560 PDM2 PDM2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist. Sep 11 2019
S6589 Norethisterone Enanthate Norethisterone Enanthate is a form of progestogen-only injectable birth control which is used to prevent pregnancy in women. Sep 11 2019
S6563 DMNQ DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation. Sep 11 2019
S6558 Irosustat (BN83495) Irosustat (STX64, BN83495), a tricyclic coumarin sulfamate, is an orally active, nonsteroid-based, irreversible steroid sulfatase inhibitor with an IC50 of 8 nM. Sep 11 2019
S6583 Apraclonidine HCl Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. Sep 11 2019
S6582 Ozenoxacin Ozenoxacin is a quinolone antibiotic used for the treatment of impetigo. Sep 11 2019
S8809 MC180295 MC180295 is a novel potent and selective CDK9 inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs. Sep 11 2019
S6593 Methylprednisolone sodium succinate Methylprednisolone sodium succinate is a corticosteroid medication that reduces inflammation. Sep 11 2019
S2188 Phenprocoumon Phenprocoumon(Marcumar) is a vitamin K reductase with an IC50 of 1 μM Sep 09 2019
A2102 Anti-mouse CD8α-InVivo Anti-mouse CD8α reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC). Sep 09 2019
S3153 Levalbuterol tartrate Levalbuterol HCl is a relatively selective beta2-adrenergic receptor agonist used for the treatment of asthma. Sep 09 2019
S8746 H3B-5942 H3B-5942 is a selective and irreversible estrogen receptor covalent antagonist, inactivates both ERα WT and ERα mutation. The Ki values are 1 nM and 0.41 nM, respectively. Sep 05 2019
Cat.No. Product Name Information Added
S6590 Hydrocortisone butyrate Hydrocortisone butyrate is a potent topical corticosteroid that can be used to treat a range of inflammatory skin conditions. Sep 05 2019
S5797 Metyrosine Metyrosine, an antihypertensive drug, is a tyrosine hydroxylase inhibitor. Sep 05 2019
S6588 Methylprednisolone hemisuccinate Methylprednisolone sodium succinate is a glucocorticoid used to treat a variety health issues including severe allergic reactions, asthma, autoimmune diseases, blood disorders, gastrointestinal diseases and endocrine disorders. Sep 05 2019
S8872 GSK8612 GSK8612 is a highly potent and selective inhibitor for TBK1 (Tank-binding Kinase-1) with pKd of 8.0. Within 10-fold affinity with respect to TBK1, no off-targets of GSK8612 could be identified. Sep 05 2019
S6592 Diquafosol Tetrasodium Diquafosol Tetrasodium, a P2Y2 receptor agonist, is a pharmaceutical drug for the treatment of dry eye disease. Sep 05 2019
S8859 BMS-1166 BMS-1166 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 interaction with an IC50 of 1.4 nM. Sep 05 2019
S8871 Omadacycline tosylate Omadacycline is a first-in-class aminomethylcycline antibiotic, demonstrating antimicrobial activity in vitro against a range of Gram-positive and Gram-negative aerobes and some anaerobic bacteria. Sep 05 2019
S6587 Clobetasone butyrate Clobetasone butyrate is a new corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions. Sep 05 2019
S4622 3,4-Diaminopyridine 3,4-Diaminopyridine blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations. It is a drug predominantly used in the treatment of a number of rare muscle diseases. Sep 05 2019
S8864 ZT-12-037-01 ZT-12-037-01 is a specific and ATP-competitive STK19 inhibitor with IC50s of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. It displays extremely high kinase selectivity using KINOMEscan against a panel of 468 diverse kinases using an in vitro ATP-site competition binding assay at 1 μM. Sep 05 2019
S6585 Triethylenetetramine Dihydrochloride Triethylenetetramine, a Cu(II)-selective chelator, is commonly used for the treatment of Wilson's disease. Sep 05 2019
S6577 PKC-theta inhibitor PKC-theta inhibitor inhibits PKC-θ with an IC50 of 12 nM. Aug 28 2019
S6557 ML355 ML355 is a potent and selective inhibitor of human 12-Lipoxygenase with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases. Aug 28 2019
S6550 URB602 URB602 is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). Aug 28 2019
S6549 PBTZ169 PBTZ169, an antibiotic with antimycobacterial activity, is an irreversible inhibitor of DprE1. Aug 28 2019
S6580 D-Luciferin Potassium Salt D-Luciferin is a substrate for the enzyme firefly luciferase. Aug 28 2019
S6571 BQR695 BQR695 is a quinoxaline that displays sub-micromolar potency against human PI4KIIIβ (IC50~90 nM). Aug 28 2019
S6574 KDU691 KDU691 is a Plasmodium PI4K-specific inhibitor with IC50 values of 0.18 μM and 0.061 μM against hypnozoite forms and liver schizontsm, respectively. Aug 28 2019
S6573 MD2-IN-1 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD value of 189 μM. Aug 28 2019
S8867 Bentamapimod (AS602801) Bentamapimod (AS602801) is a novel, orally active JNK inhibitor with IC50 values of 80 nM, 90 nM and 230 nM for JNK1, JNK2 and JNK3 respectively. Aug 28 2019
Cat.No. Product Name Information Added
S6566 NSC23005 Sodium NSC 23005 is a small molecule inhibitor of p18 (ED50=5.21 nM). Aug 28 2019
S6554 ML365 ML365 is a novel selective small molecule inhibitor of the TASK1 or potassium channel, subfamily K, member 9 (KCNK3). Aug 28 2019
S6555 AZD2098 AZD2098 is a potent and bioavailable CCR4 receptor antagonist with pIC50 of 7.8. Aug 28 2019
S6567 Src Inhibitor 1 Src Inhibitor 1 is a potent competitive inhibitor of both Src and Lck (IC50 = 44 and 88 nM, respectively), as well as Csk and Yes. Aug 28 2019
S6562 KKL-35 KKL-35 inhibits the trans-translation tagging reaction with an IC50 of 0.9 µM. It has broad-spectrum antibiotic activity. Aug 28 2019
S6565 JK184 JK184 inhibits Gli in the Hedgehog (Hh) pathway with IC50 of 30 nM in mammalian cells. Aug 28 2019
S6561 4-IBP 4-IBP is a selective σ1 receptor agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM). Aug 28 2019
S6614 Fursultiamine Fursultiamine is a nutritional supplement and vitamin B1 derivative, with potential antineoplastic activity. Aug 28 2019
S7791 Phorbol 12-myristate 13-acetate (PMA) Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC, is active at nanomolar concentrations. Aug 21 2019
S8869 UNBS5162 UNBS5162 is a pan-antagonist of CXCL chemokine expression with in vitro cytotoxic activity (IC50 range of 0.5-5 µM) against a range of human cancer cell lines including glioblastoma (Hs683 and U373MG), colorectal (HCT-15 and LoVo), non-small-cell lung (A549) and breast (MCF-7). Aug 21 2019
S6612 Betazole Dihydrochloride Betazole Dihydrochloride is a histamine H2 agonist used clinically to test gastric secretory function. Aug 21 2019
S6575 C-176 STING inhibitor STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway. Aug 21 2019
S6576 BW-A78U BW-A78U, an adenine derivative PDE inhibitor, has anticonvulsant activity. Aug 21 2019
S6578 Longdaysin Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7. Aug 21 2019
S6569 VUF10460 VUF10460 is a histamine H4 receptor agonist. Aug 21 2019
S6611 Cyclothiazide Cyclothiazide is a positive allosteric modulator of ionotropic α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors with critical roles in neurological development and function. Aug 21 2019
S6613 Vanillylmandelic acid Vanillylmandelic acid (VMA) is a chemical intermediate in the synthesis of artificial vanilla flavorings and is an end-stage metabolite of the catecholamines Aug 21 2019
S8162 Upadacitinib (ABT-494) Upadacitinib (ABT-494) is a selective JAK1 inhibitor which demonstrates activity against JAK1 (0.045 μM) and JAK2 (0.109 μM), with > 40 fold selectivity over JAK3 (2.1 μM) and 100 fold selectivity over TYK2 (4.7 μM) as compared to JAK1. Aug 21 2019
S6532 kb-NB77-78 kb-NB77-78 is an analog of CID797718. However, it shows no inhibitory activty towards PKD1. Aug 13 2019
S6605 AR7 AR7 is a retinoic acid receptor α (RARα) antagonist. Aug 13 2019
Cat.No. Product Name Information Added
S8873 Letermovir(AIC246) Letermovir(AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. Aug 13 2019
S6529 NIH-12848 NIH-12848 is a specific PI5P4Kγ inhibitor with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. Aug 08 2019
S6537 CVT-313 CVT-313 is a potent CDK2 inhibitor with an IC50 of 0.5 microM in vitro. It has no effect on other, nonrelated ATP-dependent serine/threonine kinases. Aug 08 2019
S6502 SD 0006 SD0006 is an inhibitor of p38 kinase-alpha (p38alpha) with IC50 values of 0.016 μM and 0.677 μM for p38α and p38β. It is selective for p38α kinase over 50 other kinases screened (including p38γ and p38δ with modest selectivity over p38β). Aug 08 2019
S6545 BI-4464 BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. Aug 08 2019
S6541 MTX-211 MTX-211 is a first-in-class dual inhibitor of PI3K and EGFR kinase. Aug 08 2019
S6608 AL082D06 AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. Aug 08 2019
S6609 JZL195 JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively. Aug 08 2019
S6610 GSK2981278 GSK2981278 is a highly potent and selective inverse agonist for RORγ. Aug 08 2019
S6538 B-Raf IN 1 B-Raf IN 1 is an inhibitor of Raf wih IC50 values of 24 nM and 25 nM for B-Raf and C-Raf respectively. It is selective over 13 other kinases, including PKCα, IKKβ, and PI3Kα. Aug 08 2019
S6527 Kobe2602 Kobe2602 is a selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki = 149 µM). Aug 08 2019
S6518 Desmethylanethol trithione Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. Aug 08 2019
S6536 TTP 22 TTP22 is a casein kinase 2 (CK2) inhibitor with an IC50 value of 100 nM. It displays selectivity for CK2 over JNK3, ROCK1, and MET with no inhibitory effects towards these kinases at 10 μM. Aug 08 2019
S8854 JNJ-38877618(OMO-1) JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable MET kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant MET (2 and 3 nM IC50). Aug 08 2019
S8297 ARV-825 ARV-825 is a BRD4 Inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 and sustained down-regulation of MYC. Aug 08 2019
S8722 ICEC0942 (CT7001) ICEC0942 (CT7001) is a new, orally bioavailable CDK7 inhibitor with an IC50 of 40nM. The IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. Aug 08 2019
A2101 Anti-mouse CD4-InVivo Anti-mouse CD4 antibody reacts with mouse CD4, which is a 55 kDa cell surface type I membrane glycoprotein. CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. Aug 06 2019
S8735 BI-3812 BI-3812 is a highly potent and efficacious BCL6 inhibitor probe compound with an IC50 less than 3 nM. Jul 31 2019
S6496 Genz-123346 free base Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids. Jul 31 2019
S6510 Iso-H7 dihydrochloride Iso-H7 dihydrochloride is an inhibitor of phosphokinase C. Jul 31 2019
Cat.No. Product Name Information Added
S6495 6-Bromo-2-hydroxy-3-methoxybenzaldehyde 6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative that participates in the synthesis of (±)-norannuradhapurine. Jul 31 2019
S6504 BX517 BX517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM). Jul 31 2019
S6509 AG 494 AG-494, a member of the tyrphostin family of tyrosine kinase inhibitors, is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 μM) and EGF-dependent cell growth (IC50=6 μM). Jul 31 2019
S6508 Mitapivat Mitapivat is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis. Jul 31 2019
S6503 LX2343 LX2343 is a multi-target agent that exhibits a high capability for ameliorating multi-abnormalities of AD pathogenesis. It is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. Jul 31 2019
S6506 Compound 401 Compound 401 is a synthetic inhibitor of DNA-PK and mTOR (IC50=5.3 μM). It has no inhibition on p110α/p85α PI3K (>100 μM) and blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells. Jul 31 2019
S6512 Defensamide (MHP) Defensamide (MHP) is an activator of sphingosine kinase (SPHK1). It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production. Jul 31 2019
S6499 PF-6260933 PF-6260933 is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity. Jul 31 2019
S6494 CCCP CCCP, an oxidative phosphorylation inhibitor, is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. Jul 31 2019
S6497 SMI-16a SMI-16a is a selective Pim kinase inhibitor with IC50 values of 150 nM and 20 nM for Pim1 and Pim2 respectively. Jul 31 2019
S6498 T56-LIMKi Jul 31 2019
S8826 BAY-293 BAY-293 selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21 nM. Jul 31 2019
S8568 G1T38 Lerociclib (G1T38) is a novel, potent, selective, and orally bioavailable CDK4/6 inhibitor with IC50 values of 0.001 μM, 0.002 μM and 0.028 μM for CDK4, CDK6 and CDK9 respectively. Jul 31 2019
S6500 KX1-004 KX1-004 is a non-ATP competitive inhibitor of Src protein tyrosine kinase (Src-PTK; IC50 = 40 µM). Jul 31 2019
S6533 Briciclib Briciclib is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E). Jul 31 2019
S6507 KN-92 phosphate KN-92 is an inactive derivative of KN-93, the selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII). Jul 31 2019
S6523 RG14620 RG14620, an EGFR inhibitor of the tyrphostin family, directly inhibits the transport function of ABCG2. Jul 31 2019
S8842 BAY-218 BAY-218 is a potent and selective small-molecule AhR inhibitor, inhibiting AhR nuclear translocation, dioxin response element (DRE)-luciferase reporter expression and AhR-regulated target gene expression induced by both exogenous and endogenous AhR ligands. Jul 31 2019
S6524 NSC 42834 NSC42834 is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2 with IC50 values between 10 and 30 μM. Jul 31 2019
S8676 Glumetinib (SCC244) Glumetinib (SCC244) is a potent and highly selective c-Met inhibitor with an IC50 of 0.42 ± 0.02 nmol/L. Glumetinib has greater than 2,400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, and TyrO3. Jul 31 2019
Cat.No. Product Name Information Added
S6522 ST 271 ST271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor which inhibits phospholipase D (PLD) activity. Jul 24 2019
S6521 WHI-P258 WHI-P258 is an inhibitor of JAK3 with Ki value of 72 μM. Jul 24 2019
S6525 AG 555 AG-555 is an inhibitor of tyrosine kinase, interacts directly with topoisomerase I, thus preventing DNA relaxation. It inhibits EGFR with an IC50 of 0.7 μM. Jul 24 2019
S6519 R112 R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor with Ki value of 96 nM. Jul 24 2019
S6520 WHI-P180 WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET and kinase insert domain receptor (KDR), respectively. Jul 24 2019
S6511 RIPA-56 RIPA-56 is a highly-potent, selective, and metabolically stable RIP1 (RIPK1) inhibitor. Jul 24 2019
S6513 HG-14-10-04 HG-14-10-04 is an inhibitor of ALK. Jul 24 2019
S6501 NVP 231 NVP 231 is a novel CerK inhibitor that inhibits the catalytic activity of recombinant CerK in vitro with an IC50 of 12 nM. Jul 24 2019
S6543 ZD-4190 ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively. Jul 24 2019
S6544 SR-3029 SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with IC50 values of 44 and 260 nM for CK1δ and CK1ε, respectively. Jul 24 2019
S6535 SU1498 SU1498, a powerful inhibitor of KDR (IC50 = 0.7 μM), stimulates accumulation of phosphorylated ERK1/2 in endothelial cells. Jul 24 2019
S8643 AZD5991 AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM). The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1. Jul 24 2019
S6505 X-376 X-376 is an ALK inhibitor and potentially useful in non-small cell lung cancer. Jul 24 2019
S6489 Lasmiditan succinate Lasmiditan succinate is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (Ki=2.21 nM) without vasoconstrictor activity. Jul 24 2019
S6490 Vadadustat Vadadustat is a novel, titratable, oral HIF-PH inhibitor. Jul 24 2019
S8830 AMG510 AMG-510 is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity.This AMG510 is a chiral compound. Jul 24 2019
S1553 Delafloxacin(ABT-492,RX-3341) ABT-492 is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens. Jul 24 2019
S6412 Altiratinib Altiratinib is a potent single-digit nanomolar inhibitor of TRK, MET, TIE2, and VEGFR2 kinases with IC50 vaules of 0.9 nM, 4.6 nM, and 0.8 nM for TRKA, B, and C, respectively. It inhibits MET and MET mutant with IC50 values in the range of 0.3-6 nM. Jul 24 2019
S6516 GNE-477 GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with an IC50 of 4 nM for PI3Kα and Kiapp of 21 nM for mTOR. Jul 24 2019
S8818 V-9302 V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. Jul 17 2019
Cat.No. Product Name Information Added
S8600 Elenbecestat Elenbecestat is a novel BACE1 inhibitor, demonstrating prolonged reductions in plasma beta-amyloid levels after single dosing. Jul 17 2019
S6492 Doravirine (MK-1439) Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities. Jul 17 2019
S8743 SKLB-23bb SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability. Jul 09 2019
S6484 uridine triacetate Uridine triacetate is an orally active prodrug of the naturally occurring nucleoside uridine. It is used for the treatment of hereditary orotic aciduria (Xuriden), or for the emergency treatment of fluorouracil or capecitabine overdose or toxicity. Jul 09 2019
S6488 Gadoxetate sodium Gadoxetate is a paramagnetic gadolinium-containing contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Jul 09 2019
S8704 iCRT14 iCRT14 is a β-catenin/Tcf inhibitor with a Ki value of 54 ± 5.2 μM in homogeneous fluorescence polarization (FP) assay. Jul 09 2019
S6487 fluticasone furoate Fluticasone furoate is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. It is used for the treatment of non-allergic and allergic rhinitis administered by a nasal spray. Jul 09 2019
S8438 T-3775440 HCl T-3775440 HCl is an irreversible LSD1 inhibitor that is highly selective for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B), with an IC50 value of 2.1 nmol/L. Jul 09 2019
S6416 JNJ 31020028 JNJ 31020028 is a novel neuropeptide Y Y2 receptor antagonist which bound with high affinity with human and rat Y2 receptor (pIC50=8.07±0.05 for human Y2 receptor, and pIC50=8.22±0.06 for rat Y2 receptor) and >100-fold selective versus human Y1, Y4, and Y5 receptors. Jul 03 2019
S6432 Cevimeline Cevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. Jul 03 2019
S5952 Baloxavir marboxil Baloxavir marboxil, a cap-endonuclease inhibitor, is an antiviral drug. Jul 03 2019
S8836 S64315 (MIK665) S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with Ki value of 1.2 nM and has potential pro-apoptotic and antineoplastic activities. Jul 03 2019
S5773 NS1643 NS1643 is one of the small molecule HERG (Kv11.1) channel activators and has also been found to increase erg2 (Kv11.2) currents. Jun 26 2019
S8769 Tinostamustine(EDO-S101) Tinostamustine(EDO-S101) is a first-in-class alkylating deacetylase inhibitor with IC50 values of 9 nM, 9 nM, 25 nM and 107 nM for HDAC1, HDAC2, HDAC3 and HDAC8 (Class 1 HDACs) respectively and 6 nM, 72 nM for HDAC6 and HDAC10 (Class II HDACs). Jun 26 2019
S5921 Cyclopentolate Hydrochloride Cyclopentolate is an antagonist of muscarinic acetylcholine receptors with Ki values of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively. Jun 26 2019
S8846 compound 3i (666-15) Compound 3i (666-15) is a potent and selective inhibitor of CREB-mediated gene transcription (IC50 = 0.081 ± 0.04 μM) and also potently inhibits cancer cell growth without harming normal cells. Jun 26 2019
S6482 Fosphenytoin (disodium) Fosphenytoin (disodium) is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin upon parental administration. Jun 26 2019
S8530 BAY 1436032 BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants. Jun 26 2019
S6420 AGI 1067 AGI-1067 is a novel, phenolic, intra- and extracellular antioxidant that inhibits the expression of a number of proinflammatory genes involved in atherosclerosis. Jun 24 2019
S6465 Tafamidis Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. Jun 24 2019
Cat.No. Product Name Information Added
S8747 BAY-8002 BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels. Jun 24 2019
S6456 Glycyrrhetinic acid Glycyrrhetinic acid is a triterpenoid aglycone component of the natural product glycyrrhizinic acid and possesses remarkable anti-proliferative and apoptosis-inducing activity in various cancer cell lines. Jun 24 2019
S6479 Isohomovanillic acid Isohomovanillic acid is a deaminated metabolite of catecholamines formed by the enzyme catechol-O-methyltransferase which catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. Jun 24 2019
S6480 Triphosphopyridine nucleotide disodium salt Triphosphopyridine nucleotide serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). Jun 24 2019
S6481 3beta-hydroxy-delta5-cholenic acid 3beta-hydroxy-delta5-cholenic acid is a monohydroxy bile acid of endogenous origin. It is found in biologic fluids beginning in fetal life. Jun 24 2019
S8817 HS-10296 HS-10296 is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR. Jun 24 2019
S6483 O-Phosphoethanolamine Phosphoethanolamine (PE) is a phosphomonoester metabolite of the phospholipid metabolism. Jun 24 2019
S8693 Selective PI3Kδ Inhibitor 1 (compound 7n) Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM]. Jun 24 2019
S8792 UAMC-3203 UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 neuroblastoma cells. Jun 11 2019
S6473 Pinaverium bromide Pinaverium bromide acts as a calcium channel blocker and is useful for functional gastrointestinal disorders. Jun 11 2019
S8684 Selective JAK3 inhibitor 1 Selective JAK3 inhibitor 1 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM, 740 nM for JAK3, JAK1 and JAK2 respectively. It is also selective over the other kinases possessing a cysteine in the same region as JAK3, such as BMX, EGFR, ITK, and BTK. Jun 11 2019
S6476 Eicosapentaenoic Acid Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid with antiinflammatory properties, and is present in fish and fish oils, including salmon, cod, and krill oils. Jun 11 2019
S6449 Ferrous Bisglycinate Ferrous bisglycinate is a chelate that is used as a source of dietary iron. It acts as both a chelate and a nutritionally functional. Jun 05 2019
S6445 Chlorophyllin (sodium copper salt) Chlorophyllin, the sodium and copper salt of chlorophyll, is an antioxidant and antimutagenic agent. Jun 05 2019
S6440 Halazone Halazone is widely used to disinfect drinking water. Jun 05 2019
S6441 Riboflavin Tetrabutyrate Riboflavin tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity. Jun 05 2019
S6436 magnesium 2-aminoacetate magnesium 2-aminoacetate is essential for DNA and RNA synthesis, cellular repair, and maintaining the antioxidant status of the cell. Jun 05 2019
S6435 Mequitazine Mequitazine is a histamine H1 antagonist which competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. Jun 05 2019
S6478 Fipexide hydrochloride Fipexide (hydrochloride) is a psychoactive drug of the piperazine class. Jun 05 2019
S6454 Docosahexaenoic Acid Docosahexaenoic Acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. Jun 05 2019
Cat.No. Product Name Information Added
S6460 Sugammadex (sodium) Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults. Jun 05 2019
S6477 Octodrine (2-Amino-6-methylheptan) Octodrine (2-Amino-6-methylheptan) is a stimulant drug that can increase blood pressure and cardiac output in animals. Jun 05 2019
S8840 SEL120(SEL120-34A) hydrochloride SEL120(SEL120-34,SEL120-34A) is a novel inhibitor of Cyclin-dependent kinase 8 (CDK8) with IC50 values of 4.4 nM and 10.4 nM for CDK8/Cyclin C and CDK19/CyclinC respectively. Jun 05 2019
S6443 Chromium picolinate Chromium picolinate is a coordination complex consisting of chromium(III) and picolinic acid. It is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. May 30 2019
S6444 Triclocarban Triclocarban is an antibacterial agent common used in personal care products. May 30 2019
S6451 Salifungin Salifungin (Bromochlorosalicylanilide) is an antifungal and may cause allergic contact dermatitis in some individuals. May 30 2019
S6450 Apronal Apronal is a hypnotic/sedative drug. May 30 2019
S6442 Chlorphenesin Chlorphenesin is a synthetic preservative used in skin care as a cosmetic biocide. May 30 2019
S6438 Ufiprazole Ufiprazole (Omeprazole sulfide) is an intermediate used in the production of the gastric proton pump inhibitors omeprazole and esomeprazole. May 30 2019
S6447 Carazolol Carazolol is a non-specific β-adrenergic receptor blocking agent and binds to β receptors irreversibly. May 30 2019
S6462 Amezinium (methylsulfate) Amezinium is a sympathomimetic used for its vasopressor effects in the treatment of hypotensive states. It is a MAO inhibitor, antagonizes the response to tyramine and blocks neuronal uptake of noradrenaline. May 30 2019
S6464 Ftaxilide Ftaxilide is a novel antituberculosis agent. May 30 2019
S6459 Nifurtimox Nifurtimox is an antiprotozoal agent. May 30 2019
S6439 Talniflumate Talniflumate is an anti-inflammatory molecule studied and used as a mucin regulator in the treatment of cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma. May 30 2019
S6448 Ibuprofen piconol Ibuprofen is a nonsteroidal anti-inflammatory agent (NSAIA) or nonsteroidal anti-inflammatory drug (NSAID), with analgesic and antipyretic properties. May 30 2019
S6471 Lucanthone Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1. May 30 2019
S6467 Fosfluconazole Fosfluconazole is a water-soluble phosphate prodrug of fluconazole, which is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. May 30 2019
S6472 Tinoridine hydrochloride Tinoridine hydrochloride is a non-steroidal anti-inflammatory drug with a potent antiperoxidative activity. May 30 2019
S6468 Trandolapril Trandolapril is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat. May 30 2019
S8823 ABX-1431 ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively. May 30 2019
Cat.No. Product Name Information Added
S6433 Udenafil Udenafil is a potent antagonist of human PDE5 with an IC50 of 8.25 nM and a comparable selectivity profile as sildenafil for the other PDEs. May 30 2019
S6455 Clebopride (malate) Clebopride is a dopamine antagonist drug and is used to treat functional gastrointestinal disorder such as nausea or vomiting. May 30 2019
S6452 Delavirdine (mesylate) Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor. May 30 2019
S6453 Bicyclol Bicyclol is a drug that can improve liver function and inhibit HBV replication. May 30 2019
S6469 Thonzylamine Thonzylamine is an antihistamine and anticholinergic drug. May 30 2019
S6457 Flurbiprofen Axetil Flurbiprofen Axetil is one of the commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) that nonselectively inhibits cyclooxygenase. May 30 2019
S6470 Fluralaner Fluralaner is a systemic insecticide and acaricide that is administered orally. May 30 2019
S6461 Permethrin Permethrin is a synthetic Type I pyrethroidal neurotoxic pesticide that has been responsible for accidental animal deaths. May 30 2019
S6358 Indole Indole is an aromatic heterocyclic organic compound widely distributed in the natural environment and can be produced by a variety of bacteria. May 16 2019
S6359 Purine Purine is a heterocyclic aromatic organic compound which plays crucial roles in DNA and RNA. It is also significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A. May 16 2019
S6360 2-Hydroxypyridine 2-Hydroxypyridine is used in peptide synthesis. May 16 2019
S6361 3-Amino-4-hydroxybenzoic acid 3-Amino-4-hydroxybenzoic acid is a monohydroxybenzoic acid. May 16 2019
S6362 N-Acetyl-L-phenylalanine N-Acetyl-L-phenylalanine is a hazardous amphipathic metabolite of phenylalanine. May 16 2019
S6363 3-Hydroxybenzyl alcohol 3-Hydroxybenzyl alcohol is used as an intermediate to produce other chemicals. May 16 2019
S6364 1-Hydroxy-2-naphthoic acid 1-Hydroxy-2-naphthoic acid is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms. May 16 2019
S6366 Quinaldic acid Quinaldic acid is a product of l-tryptophan catabolism, via kynurenic acid, found in human urine. May 16 2019
S6367 3-Hydroxybenzoic acid 3-Hydroxybenzoic acid is used as an intermediate in the synthesis of plasticisers, resins, pharmaceuticals, etc. May 16 2019
S6369 Quinoline Quinoline is a heterocyclic aromatic organic compound used in the manufacture of dyes, the preparation of hydroxyquinoline sulfate and niacin. May 16 2019
S8795 FDL169 FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein. May 16 2019
S8341 TAK-243 (MLN7243) TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and receptor assays, as well as on human carbonic anhydrase type I and type II. May 16 2019
Cat.No. Product Name Information Added
S8821 GSK3179106 GSK3179106 is a potent, selective, and gut-restricted pyridone hinge binder small molecule RET kinase inhibitor with a RET IC50 of 0.3 nM and is efficacious in vivo. May 16 2019
S8793 ULK-101 ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively. May 16 2019
S8804 PF-06700841 PF-06700841 is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively. It has appropriate in-family selectivity against JAK2 and JAK3. May 08 2019
S6422 Lazabemide Lazabemide is a reversible and selective inhibitor of monoamine oxidase B (MAO-B) with Ki value of 7.9 nM. May 08 2019
S6419 BT-11 BT-11 is an orally active lanthionine synthetase C-like 2 (LANCL2) binding compound for treating inflammatory bowel disease (IBD) (Kd value of 7.7 µM). May 08 2019
S6415 Azeliragon Azeliragon (TTP488) is an orally bioavailable small molecule that inhibits the receptor for advanced glycation endproducts (RAGE), which is an immunoglobulin-like cell surface receptor overexpressed in brain tissues of patients with AD. May 08 2019
S6429 Coniferyl alcohol May 08 2019
S6421 Diroximel Fumarete Diroximel Fumarete, also known as ALKS-8700, is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body. Apr 30 2019
S6423 Tildipirosin Tildipirosin is a 16-membered ring, tribasic and semi-synthetic macrolide antibiotic. Apr 30 2019
S6424 TAS-301 TAS-301 is an inhibitor of smooth muscle cell migration and proliferation and inhibits intimal thickening after balloon injury to rat carotid arteries. Apr 30 2019
S6425 JNJ 63533054 JNJ 63533054 is a potent and selective GPR139 agonist. It specifically activated human GPR139 in the calcium mobilization (EC50 = 16 ± 6 nM) and GTPγS binding (EC50 = 17 ± 4 nM) assays. Apr 30 2019
S6430 Nervonic acid Nervonic acid is a long chain unsaturated fatty acid that is enriched in sphingomyelin and may enhance the brain functions and prevent demyelination. Apr 30 2019
S6427 AZ876 AZ876 is a novel high-affinity Liver X Receptor (LXR) agonist with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively. Apr 30 2019
S6410 Clemizole Clemizole, a first-generation histamine receptor (H1) antagonist, is a potent inhibitor of behavioural and electrographic seizure activity. It has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels. Apr 30 2019
S6411 Nimorazole Nimorazole is a water soluble, 5-nitroimidazole compound with antibacterial and potential radiosensitizing activity. Apr 30 2019
S6413 fexaramine Fexaramine is a potent, selective farnesoid X receptor (FXR) agonist with an EC50 of 25 nM and it displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors. Apr 30 2019
S6414 Apilimod Apilimod is a cell permeable small molecule that specifically inhibits PIKfyve with an IC50 of 14 nM in an in vitro kinase assay. It is also an inhibitor of IL-12/23 and shows no activity toward other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K isoforms. Apr 30 2019
S6417 GK921 GK921 is a transglutaminase 2 (TGase 2) inhibitor with an IC50 of 8.93 μM under a modified assay condition. Apr 30 2019
S6418 PF 429242 PF 429242 is known as a S1P inhibitor with an IC50 of 170 nM, showing no significant inhibition of trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, or furin at concentrations up to 100 μM and only modest inhibition of urokinase (IC50 = 50 μM) and factor Xa (IC50 = 100 μM). Apr 30 2019
S6431 Damascenone Damascenone is a potent flavor compound, possessing an extremely low odor threshold of 0.002 ppb in water. Apr 30 2019
Cat.No. Product Name Information Added
S5944 Butenafine Butenafine is a synthetic benzylamine antifungal agent. Apr 24 2019
S8788 CH7057288 CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB, and TRKC respectively. Apr 24 2019
S5939 Bendamustine Bendamustine is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma. Apr 24 2019
S5938 Benazepril Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Apr 24 2019
S8636 Selitrectinib(LOXO-195) Selitrectinib(LOXO-195) is an orally available, highly potent, and selective TRK kinase inhibitor with low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, IC50s ranging from 2.0 to 9.8 nmol/L. It is more than 1,000-fold selective for 98% of non-TRK kinases tested. Apr 24 2019
S8739 PLX51107 PLX51107 is as a novel BET inhibitor with modest preference for bromodomain-1 (BD1) versus bromodomain-2 (BD2) within each BET protein (Kd = 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1 and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively. Among non-BET proteins, PLX51107 shows significant interactions only with the bromodomains of CBP and EP300 (p300) (Kd in the 100 nM range). Apr 24 2019
S8791 Zanubrutinib (BGB-3111) Zanubrutinib (BGB-3111) is a potent, specific and irreversible BTK inhibitor that has been shown to have a lower off-target inhibitory activity on other kinases, including ITK, JAK3 and EGFR. Apr 24 2019
S6407 Tulobuterol hydrochloride Tulobuterol is a long-acting β2-adrenergic receptor agonist that has bronchodilatory, anti-inflammatory, and antiviral activities. Apr 24 2019
S6409 Zucapsaicin Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator. Apr 24 2019
S8822 Ligandrol (LGD-4033) Ligandrol (LGD-4033, VK-5211) is a novel nonsteroidal, oral selective androgen receptor modulator with high affinity (Ki of ∼1 nM) and selectivity. Apr 24 2019
S6288 Chlorhexidine diacetate Chlorhexidine diacetate is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. Apr 18 2019
S6293 2,4-Dihydroxybenzoic acid 2,4-Dihydroxybenzoic acid is a degradation product of cyanidin glycosides from tart cherries in cell cultures and a metabolite found in human plasma after cranberry juice consumption. Apr 18 2019
S6294 1,3,5-Trimethoxybenzene 1,3,5-Trimethoxybenzene is a potential biomarker of flavonoid intake in human. It is a human xenobiotic metabolite. Apr 18 2019
S6295 2-Methoxybenzoic acid 2-Methoxybenzoic acid is a flavouring agent. Apr 18 2019
S6297 4-Hydroxy-3-methylbenzoic acid 4-Hydroxy-3-methylbenzoic acid is a normal organic acid identified in urine specimens from a healthy population. Apr 18 2019
S6300 1,4-Dichlorobenzene 1,4-Dichlorobenzene is used as a disinfectant, pesticide, and deodorant. Apr 18 2019
S6305 Catechol Catechol is an organic compound essentially used as building block. Apr 18 2019
S6307 2-Methyllactic acid 2-Methyllactic acid is a metabolite of methyl tertiary-butyl ether. Apr 18 2019
S6308 4-Ethylphenol 4-Ethylphenol is a phenolic compound produced in wine and beer by the spoilage yeast Brettanomyces. Apr 18 2019
S6309 Methylguanidine HCl Methylguanidine is a guanidine compound deriving from protein catabolism. Apr 18 2019
Cat.No. Product Name Information Added
S6316 N-Acetyl-L-tyrosine N-Acetyl-L-tyrosine is an acetylated form of the amino acid, L-Tyrosine. It is involved in catecholamine production. Apr 18 2019
S6317 2-Picolinic acid methyl ester 2-Picolinic acid methyl ester (methyl picolinate) is used as pharmaceutical intermediate. Apr 18 2019
S6319 5-Methoxysalicylic acid 5-Methoxysalicylic acid is a chemical compound belongs to the class of organic compounds known as m-methoxybenzoic acids and derivatives. Apr 18 2019
S6320 2,5-Furandicarboxylic acid 2,5-Furandicarboxylic acid is a normal urinary metabolite in humans and an important renewable building block because of its potential as a substitute for a variety of petrochemicals, such as terephthalic acid and adipic acid. Apr 18 2019
S6323 2,6-Dimethoxybenzoic acid 2,6-Dimethoxybenzoic acid is a polyphenol compound found in foods of plant origin. Apr 18 2019
S6324 5-Methoxytryptamine 5-Methoxytryptamine is a tryptamine derivative that acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors. Apr 18 2019
S6326 D-3-Phenyllactic acid D-3-Phenyllactic acid is a chiral building block that is used in preparation of statine. Apr 18 2019
S6332 Nonadecanoic acid Nonadecanoic acid is a long saturated fatty acid found in ox fats and vegetable oils, and in Staphylococcus. It can be used as a phermone by certain insects. Apr 18 2019
S6333 Undecanedioic acid Undecanedioic acid is a long-chain dicarboxylic acid that has applications in corrosion inhibitors, hot melt adhesives, high performance polyamides/Nylon, and more. Apr 18 2019
S6335 Ethyl maltol Ethyl maltol is a common flavourant in some confectioneries. Apr 18 2019
S6338 3,4-Dihydroxyhydrocinnamic acid 3,4-Dihydroxyhydrocinnamic acid is a metabolite product of the hydrogenation of caffeoylquinic acids, occurring in normal human biofluids, with potent antioxidant properties. Apr 18 2019
S6339 Black PN Black PN is a black dye that provides a blackish violet shade in applications. Apr 18 2019
S6343 D-Glucuronic acid D-Glucuronic acid is a key intermediate metabolite of the uronic acid pathway and may plays a role in the detoxification of certain drugs. Apr 18 2019
S6344 Tetradecanedioic acid Tetradecanedioic acid is a C14 dicarboxylic acid. Apr 18 2019
S6348 (+)-Delta-Tocopherol Delta-Tocopherol is the orally bioavailable delta form of the naturally-occurring fat-soluble vitamin E, mostly found in soybean and corn oils, with potential antioxidant activity. Apr 18 2019
S6349 NADH Disodium Salt Hydrate NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle. Apr 18 2019
S6352 Androsterone Androsterone is a steroid metabolite derived from sex hormones, which displays weak androgenic properties. Apr 18 2019
S6354 Ac-Arg-OH Ac-Arg-OH (N-Acetyl-L-arginine) is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population. Apr 18 2019
S6355 Glycochenodeoxycholic acid sodium salt Glycochenodeoxycholic acid is a bile salt formed in the liver from chenodeoxycholic acid and glycine, usually found as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Apr 18 2019
S6356 2-Methylsuccinic acid 2-Methylsuccinic acid is a normal metabolite found in human fluids. Apr 18 2019
Cat.No. Product Name Information Added
S6357 1,5-Diaminopentane dihydrochloride 1,5-Diaminopentane (Cadaverine) is a foul-smelling diamine formed by bacterial decarboxylation of lysine that occurs during protein hydrolysis during putrefaction of animal tissue. Apr 18 2019
S6016 D-Proline D-proline is an isomer of the naturally occurring amino acid, L-Proline. Apr 18 2019
S6021 5-Methylcytosine 5-Methylcytosine, a methylated form of the DNA base cytosine, is a major epigenetic mark in the nuclear DNA in mammals and may be involved in the regulation of gene transcription. Apr 18 2019
S6054 Glycyl-L-leucine Glycyl-l-leucine is a dipeptide that appears to be a common substrate for glycyl-leucine dipeptidase. Apr 18 2019
S6056 N-Methylsarcosine N-Methylsarcosine is a natural N-methylated glycine that is used in the development of glycine-based ionic liquids and emulsifiers. Apr 18 2019
S6064 Acid Yellow 23 Acid Yellow 23 is a popular colorant for multiple applications, commonly used in ink, pond dyes, and textiles. Apr 18 2019
S6075 Nepsilon-Acetyl-L-lysine Nepsilon-Acetyl-L-lysine is an R-chain N-acetylated α amino acid used together with other lysine analogues to differentiate and characterized various aminoacylases and regulator 2 (Sir2) enzymes/sirtuins. Apr 18 2019
S6082 8-Aminooctanoic acid 8-Aminooctanoic acid is a chemical. Apr 18 2019
S6102 Thiamine pyrophosphate hydrochloride Thiamine pyrophosphate hydrochloride is a thiamine (vitamin B1) derivative which is produced by the enzyme thiamine diphosphokinase. It is a coenzyme of many enzymes, most of which occur in prokaryotes and is involved in the regulation of basic metabolism. Apr 18 2019
S6103 Inosine 5′-triphosphate trisodium salt Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. Apr 18 2019
S6109 H-HoArg-OH H-HoArg-OH (L-Homoarginine) is an organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases. Apr 18 2019
S6116 N-Acetylornithine N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate. It is a minor component of deproteinized blood plasma of human blood. Apr 18 2019
S6120 Glycyl-L-valine Glycyl-L-valine is a dipeptide composed of glycine and valine. It is an incomplete breakdown product of protein digestion or protein catabolism. Apr 18 2019
S6128 L-Homocitrulline L-Homocitrulline is an amino acid and a metabolite of ornithine in mammalian metabolism. Apr 18 2019
S6129 Aminomalonic acid Aminomalonic acid is an amino dicarboxylic acid. It has a role as a human metabolite and a Daphnia magna metabolite. Apr 18 2019
S6133 H-Gly-Pro-OH H-Gly-Pro-OH is a dipeptide composed of glycine and proline, and is an end product of collagen metabolism that is further cleaved by prolidase. The resulting proline molecules are recycled into collagen or other proteins. Apr 18 2019
S6134 3-Aminoisobutyric acid 3-Aminoisobutyric acid (β-aminoisobutyric acid) is a product formed by the catabolism of thymine. Apr 18 2019
S6137 4-Guanidinobutanoic acid 4-Guanidinobutanoate is a normal metabolite present in low concentrations. Apr 18 2019
S6141 Anserine Anserine is a dipeptide containing β-alanine and 1-methylhistidine. It is normally absent from human tissues and body fluids, and its appearance there is an artifact of diet and serum carnosinase deficiency. Apr 18 2019
S6142 3-Amino-4-methylpentanoic acid 3-Amino-4-methylpentanoic acid is a human metabolite. Apr 18 2019
Cat.No. Product Name Information Added
S6153 L-Leucyl-L-alanine Hydrate L-Leucyl-L-alanine is a dipeptide composed of L-leucine and L-alanine joined by a peptide linkage. It is a metabolite. Apr 18 2019
S6201 Malachite green Malachite green is a synthetic dyestuff and antimicrobial with potential carcinogenicity. Apr 18 2019
S6203 H-Abu-OH H-Abu-OH (2-Aminobutyric acid) is a non-proteinogenic alpha amino acid that is used by nonribosomal peptide synthases. Apr 18 2019
S6222 Ethyl potassium malonate Ethyl potassium malonate is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate. Apr 18 2019
S6224 (R)-Serine (R)-Serine is the R-enantiomer of serine, which is used in the biosynthesis of proteins. Apr 18 2019
S6270 2-Aminoisobutyric acid 2-Aminoisobutyric acid is a rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin. Apr 18 2019
S6276 Bicine Bicine is an organic compound used as a buffering agent. Apr 18 2019
S6290 D-Fructose-1,6-diphosphate trisodium salt octahydrate D-Fructose-1,6-diphosphate, a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. Apr 18 2019
S6302 L(-)-Pipecolinic acid L(-)-Pipecolinic acid is a normal human metabolite present in human blood. Apr 18 2019
S6306 Guanosine 5'-monophosphate disodium salt Guanosine 5′-monophosphate (GMP) is a ribonucleoside monophospate which upon phosphorylation to GTP becomes incorporated into ribonucleic acids (RNAs) by various RNA polymerase(s). Apr 18 2019
S6315 Sodium phytate hydrate Phytate (Phytic acid) functions as a storage depot and precursor for other inositol phosphates and pyrophosphates. It can be used clinically as a hypocalcemic agent and a complexing agent for removal of traces of heavy metal ions. Apr 18 2019
S6322 Pipecolic acid Pipecolic acid, a metabolite of lysine found in human physiological fluids such as urine, plasma and CSF, is an important regulator of immunity in plants and humans alike. Apr 18 2019
S6325 Adenosine 5′-diphosphate sodium salt Adenosine 5′-diphosphate (ADP) is an important organic compound in metabolism and is essential to the flow of energy in living cells. ADP can be interconverted to adenosine triphosphate (ATP) and adenosine monophosphate (AMP). Apr 18 2019
S6330 D(-)-2-Aminobutyric acid D(-)-2-Aminobutyric acid is an unnatural amino acid serving as an important intermediate in pharmaceutical production. Apr 18 2019
S6334 DL-Norvaline DL-Norvaline is an important pharmaceutical intermediate. Apr 18 2019
S6023 Creatine monohydrate Creatine is a key player in the phosphagen energy system, the primary source of ATP during short-term, high intensity activities. Apr 18 2019
S6044 H-Tyr(3-I)-OH H-Tyr(3-I)-OH is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. Apr 18 2019
S6083 DL-Dopa DL-Dopa is an immediate precursor of dopamine. Apr 18 2019
S6106 3-Chloro-L-tyrosine 3-Chloro-L-tyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. Apr 18 2019
S6115 Pyridoxal 5′-phosphate hydrate Pyridoxal 5′-phosphate, a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. Apr 18 2019
Cat.No. Product Name Information Added
S6230 Methyl 3-aminopyrazine-2-carboxylate Methyl 3-aminopyrazine-2-carboxylate is used in chemical synthesis. Apr 18 2019
S6253 H-D-Trp-OH H-D-Trp-OH is the D-enantiomer of tryptophan, which is an essential amino acid in the human diet. Apr 18 2019
S6266 (S)-Glutamic acid (S)-Glutamic acid (L-Glutamic acid) is an endogenous, non-selective glutamate receptor agonist. Apr 18 2019
S6310 N-(2-Acetamido)-2-Iminodiacetic acid N-(2-Acetamido)-2-Iminodiacetic acid is a biological buffer component and can be used as a pharmaceutical intermediate. Apr 18 2019
S6312 L-Threonic acid Calcium Salt L-Threonic acid Calcium Salt (Calcium threonate) is a calcium salt of threnoic acid. L-Threonic acid is a metabolite of ascorbic acid (vitamin C). Apr 18 2019
S8421 Fenebrutinib (GDC-0853) Fenebrutinib (GDC-0853) is a potent, selective, and non-covalent bruton's tyrosine kinase (BTK) inhibitor with an Ki value of 0.91 nM for Btk with >100-fold selectivity over 3 off-targets (Bmx :153-fold, Fgr: 168-fold, Src:131-fold). Apr 18 2019
S8810 SPHINX31 SPHINX31 is a SRPK1 inhibiror with an IC50 of 5.9 nM with highly selectivity for SRPK1 over SRPK2 (50-fold) and CLK1 (100-fold). Apr 18 2019
S8584 Theliatinib (HMPL-309) Theliatinib (HMPL-309) is a highly potent EGFR inhibitor with Ki value of 0.05 nM against the wild type EGFR and IC50 values of 3 nM and 22 nM against EGFR and EGFR T790M/L858R mutant. It demonstrats 50 fold greater selectivity for EGFR compared to 72 other kinases. Apr 18 2019
S6406 Ferrous fumarate Ferrous fumarate is the fumarate salt form of the mineral iron and is used in treatment of iron deficiency anemia. Apr 18 2019
S6408 Hexetidine Hexetidine is an anti-bacterial and anti-fungal agent with local anesthetic, astringent, deodorant and antiplaque activity. Apr 18 2019
S6233 Tartaric acid Tartaric acid is a white crystalline organic acid that occurs naturally in many plants, most notably in grapes. It has several applications for industrial and pharmaceutical use. Apr 11 2019
S6234 Pentadecanoic acid Pentadecanoic acid is a saturated fatty acid of exogenous (primarily ruminant) origin. It also has a role as a plant metabolite, a food component, a Daphnia magna metabolite, a human blood serum metabolite and an algal metabolite. Apr 11 2019
S6235 Sodium dehydroacetate Sodium dehydroacetate is the sodium salt of dehydroacetic acid, a fungicide and bactericide that is commonly used as a food preservative. Sodium dehydroacetate is a preservative that is used in the formulation of cosmetics and personal care products in order to extend the shelf-life by preventing microbial contamination. Apr 11 2019
S6237 2-Ketoglutaric acid 2-Ketoglutaric acid, also known as alpha-ketoglutarate and AKG, is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. Apr 11 2019
S6241 β-D-Glucose pentaacetate β-D-Glucose pentaacetate is an enantiomer of D-glucose pentaacetate. Apr 11 2019
S6245 N-Acetylglutamic acid N-Acetylglutamic acid is the first intermediate involved in the biosynthesis of arginine in prokaryotes and simple eukaryotes and a regulator in the process known as the urea cycle that converts toxic ammonia to urea for excretion from the body in vertebrates. Apr 11 2019
S6247 Senecioic acid Senecioic acid is an unsaturated fatty acid found in the pheromones of mealybug species and appears in the urine of patients with 3-Methylcrotonic aciduria. Apr 11 2019
S6249 Picolinic acid (PCL 016) PCL016 is a pyridine carboxylate metabolite of tryptophan and acts as an anti-infective and immunomodulator. It acts by binding with the zinc associated with zinc finger proteins to alter their structure and inhibit function. Apr 11 2019
S6251 Terephthalic acid Terephthalic acid, a raw material for polyethylene terephthalate (PET) production, is one of the most important chemicals in petrochemical industry. Apr 11 2019
S6252 3-Hydroxypicolinic acid 3-Hydroxy picolinic acid is a picolinic acid derivative and is a member of the pyridine family. It is used as a matrix for nucleotides in MALDI mass spectrometry analyses Apr 11 2019
Cat.No. Product Name Information Added
S6254 Hydrocinnamic acid Hydrocinnamic acid is a substrate of the enzyme oxidoreductases in the pathway phenylalanine metabolism (KEGG). It is an antifungal agent and a metabolite. Apr 11 2019
S6256 Isocytosine Isocytosine (2-aminouracil) is an isomer of cytosine used in physical chemical studies involving metal complex binding, hydrogen-bonding, and tautomerism and proton transfer effects in nucleobases. Apr 11 2019
S6257 N-Acetylglucosamine N-Acetylglucosamine is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. It may be helpful for the treatment of autoimmune diseases. Apr 11 2019
S6259 Ureidosuccinic acid Ureidosuccinic acid is an intermediary product in pyrimidine biosynthesis. Apr 11 2019
S6261 2-Acetylpyrazine 2-Acetylpyrazine is one of the volatile flavor constituents in popcorn, wheat and rye bread crust. Apr 11 2019
S6262 Ammonium formate Ammonium Formate is the ammonium salt of formic acid. It is widely used in various organic reactions. Apr 11 2019
S6267 Dodecanedioic acid Dodecanedioic acid is a dicarboxylic acid mainly used in antiseptics, top-grade coatings, painting materials, corrosion inhibitors, surfactants, and engineering plastics. Apr 11 2019
S6269 Leucomalachite green Leucomalachite green is a chief metabolite of malachite green, a triphenylmethane dye. It is one of the most commonly used reagents for presumptive blood test and gives a characteristic green color in the presence of blood. Apr 11 2019
S6271 (S)-2-Hydroxy-3-phenylpropanoic acid (S)-2-Hydroxy-3-phenylpropanoic acid is a valuable building block in the pharmaceutical and chemical industry—has recently emerged as an important monomer in the composition of the novel degradable biocompatible material of polyphenyllactic acid. Apr 11 2019
S6272 Glycolic acid Glycolic acid (or hydroxyacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel. Apr 11 2019
S6273 2-(4-Methoxyphenyl)acetic acid 2-(4-Methoxyphenyl)acetic acid is a 4-O-Methylated catecholamine metabolite found in normal human urine, cerebrospinal fluid and brain tissue. Apr 11 2019
S6280 Methyl 3-indolyacetate Methyl 3-indolyacetate is a phytohormone. Apr 11 2019
S6281 Sodium Thiocyanate Sodium Thiocyanate, one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals. Apr 11 2019
S6283 3,3-Dimethylglutaric acid 3,3-Dimethylglutaric acid is a compound that has occasionally found in human urine. Apr 11 2019
S6284 Tetraethylammonium bromide Tetraethylammonium bromide is used as the source of tetraethylammonium ions in pharmacological and physiological studies, but is also used in organic chemical synthesis. It blocks selective potassium channels. Apr 11 2019
S6285 6-Hydroxynicotinic acid 6-Hydroxynicotinic acid is widely used in the manufacture of industrial products. Apr 11 2019
S6286 Tricarballylic acid Tricarballylic acid is an inhibitor of aconitase and therefore interferes with the Krebs cycle. Apr 11 2019
S4755 lanosterol Lanosterol is a tetracyclic triterpenoid and is the compound from which all animal and fungal steroids are derived. By contrast plant steroids are produced via cycloartenol. Apr 11 2019
S6404 Salicylamide Salicylamide is a non-prescription drug with analgesic and antipyretic properties. Apr 11 2019
S6403 Chloramine-T Chloramine-T is a N-chlorinated and N-deprotonated sulfonamide used as a biocide and a mild disinfectant. Apr 11 2019
Cat.No. Product Name Information Added
S6405 Octisalate Apr 11 2019
S8296 dBET1 dBET1 is a CRBN-based BET degrader with an IC50 of 20 nM, showing highly selectivity. Out of 7,429 proteins, only the expression of the oncoproteins MYC and PIM1, as well as BRD2, BRD3 and BRD4 are significantly downregulated by dBET1 treatment. Apr 11 2019
S6096 5-Phenylvaleric Acid 5-Phenylvaleric acid is a Pentanoic acid of bacterial origin, occasionally found in human biofluids. Apr 11 2019
S6097 3-Furoic acid 3-Furoic acid is an organic acid regularly occurring in urine of healthy individuals. Apr 11 2019
S6098 2-Hydroxy-3-methylbutanoic acid 2-Hydroxy-3-methylbutanoic acid is a metabolite found in the urine of patients with phenylketonuria, methylmalonic acidemia, propionic acidemia, 3-ketothiolase deficiency, isovaleric acidemia, 3-methylcrotonylglycemia, 3-hydroxy-3-methylglutaric acidemia, multiple carboxylase deficiency, glutaric aciduria, ornithine transcarbamylase deficiency, glyceroluria, tyrosinemia type I, galactosemia, and maple syrup urine disease. Apr 11 2019
S6101 Solvent Blue 35 Solvent Blue 35 is a member of the Sudan family of hydrophobic fat-staining dyes, predominantly used for staining triglycerides in animal tissues (frozen sections). Apr 11 2019
S6105 trans-3-Indoleacrylic acid trans-3-Indoleacrylic acid is a metabolite of tryptophan. Apr 11 2019
S6110 2-Methylpentanedioic acid 2-Methylglutaric acid is a metabolite of succinic acid, a citric acid cycle intermediate. Apr 11 2019
S6111 L-Hydroorotic acid L-Dihydroorotic acid is an intermediate in the metabolism of Pyrimidine. It is a substrate for Dihydroorotate dehydrogenase (mitochondrial). Apr 11 2019
S6113 Tridecanoic acid Tridecanoic acid is a 13-carbon saturated fatty acid found in many foods, some of which are nutmeg, muskmelon, black elderberry, and coconut. Apr 11 2019
S6114 D-Arabitol D-Arabitol is a water soluble sugar alcohol. Apr 11 2019
S6121 Maltotriose Maltotriose is a trisaccharide consisting of three glucose molecules linked with α-1,4 glycosidic bonds. It is a common oligosaccharide metabolite found in human urine after maltose ingestion or infusion. Apr 11 2019
S6123 DL-Benzylsuccinic acid DL-Benzylsuccinic acid is a bacterial xenobiotic metabolite. Apr 11 2019
S6127 5-Hydroxymethyluracil 5-Hydroxymethyluracil (5hmU) is a thymine base modification found in the genomic DNA of diverse organisms ranging from bacteriophages to mammals Apr 11 2019
S6131 2-Oxo-3-phenylpropanoic acid 2-Oxo-3-phenylpropanoic acid (Phenylpyruvic acid) is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase. Apr 11 2019
S6132 All trans-Retinal All trans-Retinal, a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer. Apr 11 2019
S6138 5-Methylcytidine 5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine. It is found in ribonucleic acids of animal, plant, and bacterial origin. Apr 11 2019
S6139 Piperonyl acetone Piperonyl acetone is a food additive used in food flavouring. Apr 11 2019
S6140 16-Dehydroprogesterone 16-Dehydroprogesterone is a chemical derived from a progesterone. Apr 11 2019
S6143 Ureidopropionic acid Ureidopropionic acid is an intermediate in the metabolism of uracil. Apr 11 2019
Cat.No. Product Name Information Added
S6144 O-Acetylserine O-Acetylserine is an intermediate in the biosynthesis of the common amino acid cysteine in bacteria and plants. Apr 11 2019
S6146 Glycoursodeoxycholic acid Glycoursodeoxycholic acid is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environment. Apr 11 2019
S6147 Hexadecanedioic acid Hexadecanedioic acid is a common saturated fatty acid found in animals, plants and microorganisms. It has antitumor activity. Apr 11 2019
S6152 Acid Red 27 Acid Red 27 is a modified red azo dye used as a food dye and to color cosmetics. Apr 11 2019
S6154 2-Hydroxyphenylacetic acid 2-Hydroxyphenylacetic acid is a substrate of the enzyme oxidoreductases in the pathway styrene degradation. Apr 11 2019
S6155 L-Tryptophanamide Hydrochloride L-tryptophanamide is an amino acid amide that is the carboxamide of L-tryptophan. Apr 11 2019
S6156 5-Methyluridine 5-Methyluridine is a pyrimidine nucleoside that acts as an human endogenous metabolite. Apr 11 2019
S6157 Benzyldimethylstearylammonium Chloride Hydrate Benzyldimethylstearylammonium Chloride Hydrate is a chemical with mild odor. Apr 11 2019
S6158 Acid orange 7 Acid orange 7 is an azo dye used for dyeing wool. Apr 11 2019
S6159 Food Yellow 3 Food Yellow 3 is an azo dye that is useful in fermented foods which must be heat treated. Apr 11 2019
S6160 3,5-Dihydroxybenzoic acid 3,5-Dihydroxybenzoic acid is a primary metabolite of alkylresinols which has been hydrolyzed by liver enzymes during phase I metabolism after several cycles of beta oxidation. Apr 11 2019
S6165 Erythrosine B Erythrosine B is cherry or melon-pink synthetic, primarily used for food coloring. Apr 11 2019
S6168 trans-trans-Muconic acid trans-trans-Muconic acid is a metabolite of benzene in humans. Apr 11 2019
S6169 3-Methyladipic acid 3-Methyladipic acid is a metabolite of the catabolism of phytanic acid. Apr 11 2019
S6170 Benzyldodecyldimethylammonium Chloride Dihydrate Benzyldodecyldimethylammonium Chloride Dihydrate is a chemical. Apr 11 2019
S6171 trans-β-Hydromuconic acid trans-β-Hydromuconic acid is a normal human unsaturated dicarboxylic acid metabolite with increased excretion in patients with Dicarboxylic aciduria caused by fatty acid metabolism disorders. Apr 11 2019
S6172 Brucine sulfate heptahydrate Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons. Apr 11 2019
S6175 1,5,5-Trimethylhydantoin 1,5,5-Trimethylhydantoin is a chemical. Apr 11 2019
S6178 DL-6,8-Thioctamide DL-6,8-Thioctamide is used for protecting liver and health care products. Apr 11 2019
S6180 L-Gulose L-Gulose is an unnatural monosaccharide that exists as a syrup with a sweet taste. It is an L-hexose sugar and an intermediate in the biosynthesis of L-Ascorbate (vitamin C). Apr 11 2019
Cat.No. Product Name Information Added
S6181 N-Isovaleroylglycine N-Isovaleroylglycine is an acyl glycine that is normally minor metabolites of fatty acids. Apr 11 2019
S6182 L-Gulono-1,4-lactone L-Gulono-1,4-lactone is the substrate of the enzyme L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic acid (vitamin C) in plants and animals. Apr 11 2019
S6183 2-Hydroxy-2-methylbutanoic acid 2-Hydroxy-2-methylbutyric acid is an unusual metabolite found in the urine of patients with 2-hydroxyglutaric aciduria and maple syrup urine disease. 2-Hydroxy-2-methylbutyric acid is also a secondary metabolite found in human urine after exposure to the gasoline additive tert-amyl-Me-ether (TAME). Apr 11 2019
S6184 N-Methylhydantoin N-Methylhydantoin is a small molecular weight polar substance, the product of degradation of creatinine by bacteria. It is an unexpected metabolite of the intelligence-affecting substance dupracetam. Apr 11 2019
S6188 p-Toluenesulfonic acid monohydrate p-Toluenesulfonic acid is an extremely strong acidic compound. Apr 11 2019
S6189 Acid Yellow 36 Acid Yellow 36 is a dye of the azo class and used as a pH indicator and it has a color change from red to yellow between pH 1.2 and 2.3. Apr 11 2019
S6190 Isethionic acid sodium salt Isethionic acid sodium salt is an amphoteric detergent used in detergent bar soaps. Apr 11 2019
S6191 Sudan I Sudan I is an azo dye. It causes tumors in the liver or urinary bladder in rats, mice, and rabbits and may be a potential carcinogen for humans. Apr 11 2019
S6194 Chitin Chitin is a large, structural polysaccharide found in the exoskeletons of insects, the cell walls of fungi, and certain hard structures in invertebrates and fish. Apr 11 2019
S6196 4-Nitrophenol 4-Nitrophenol is a phenolic compound that can be used as a pH indicator and an intermediate in the synthesis of paracetamol. Apr 11 2019
S6197 Dimethylamine hydrochloride Dimethylamine is a precursor to several industrially significant compounds. Apr 11 2019
S6202 Butylated hydroxytoluene Butylated hydroxytoluene is a lipophilic organic compound that is useful for its antioxidant properties. Apr 11 2019
S6205 N-Acetyl-L-methionine N-Acetyl-L-methionine is an L-methionine derivative that is nutritionally and metabolically equivalent to L-methionine. It is a superior ROS scavenger. Apr 11 2019
S6210 Ethanolamine hydrochloride Ethanolamine is a viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. Apr 11 2019
S6215 Phthalic acid Phthalic acid is an aromatic dicarboxylic acid. It is a human xenobiotic metabolite. Apr 11 2019
S6217 o-Toluic acid o-Toluic acid is an aromatic dicarboxylic acid. It is a human xenobiotic metabolite. Apr 11 2019
S6218 Sodium lauryl sulfate Sodium lauryl sulfate is an anionic detergent and surfactant found in many personal care products. Apr 11 2019
S6219 β-Alanine methyl ester hydrochloride β-Alanine ethyl ester is the ethyl ester of the non-essential amino acid β-alanine. Apr 11 2019
S6220 Octanedioic acid Octanedioic acid is a dicarboxylic acid used in drug syntheses and plastics manufacture. Apr 11 2019
S6228 Indole-2-carboxylic acid Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Apr 11 2019
Cat.No. Product Name Information Added
S6229 Lauryl gallate Lauryl gallate is the ester of dodecanol and gallic acid that exhibits both potent chain-breaking and preventive antioxidant activity. Apr 11 2019
S6231 Methyl nicotinate Methyl nicotinate is an ester of methyl alcohol and nicotinic acid. It is a rubefacient. Apr 11 2019
S6232 Methylamine hydrochloride Methylamine is used as a building block for the synthesis of many other commercially available compounds. Apr 11 2019
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