All New Products Listed Chronologically

Cat.No. Product Name Information Added
S8781 Selpercatinib (LOXO-292, ARRY-192) Selpercatinib (LOXO-292, ARRY-192) is a potent and specific RET inhibitor with IC50 values of 1 nM, 2 nM, 2 nM, 4 nM, 2 nM, 2 nM for WT RET, RET V804M, RET V804L, RET A883F, RET M918T and RET S891A respectively. Nov 13 2019
S6475 Polaprezinc Polaprezinc is an orally bioavailable chelate composed of zinc and L-carnosine, with potential gastroprotective, anti-oxidant, anti-ulcer and anti-inflammatory activities. Nov 13 2019
S8506 SCH-527123 SCH-527123 is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively. Nov 13 2019
S6717 TCS-OX2-29 TCX-OX2-29 is a OX2R antagonist (pKi = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC50s = 40 nM and >10,000 nM, respectively). Nov 13 2019
S8670 Vipivotide tetraxetan (PSMA-617) Vipivotide tetraxetan (PSMA-617) is a chemically modified PSMA(prostate-specific membrane antigen) inhibitor with a Ki of 0.37 nM. Nov 11 2019
S8703 Milademetan (DS-3032b) Milademetan (DS-3032b) is a novel potent MDM2 inhibitor that inhibits MDM2-p53 interaction with an IC50 of 5.57 nM in the HTRF assay. Nov 11 2019
S8730 BAY 1251152 BAY1251152 is a potent PTEFb/CDK9 inhibitor with an IC50 value of 3 nM for CDK9 and an at least 50-fold selectivity against other CDKs in enzymatic assays. BAY1251152 binds to and blocks the phosphorylation and kinase activity of CDK9, thereby preventing PTEFb-mediated activation of RNA Pol II and leading to the inhibition of gene transcription of various anti-apoptotic proteins. Nov 11 2019
S8734 AZD7624 AZD7624 is a potent and selective competitive inhibitor against p38α/β with pIC50s of 10 and 8.8 for p38α and p38β respectively. Nov 11 2019
S8766 AT1 AT1 is highly selective Brd4 degrader which is a designed molecule based on the crystal structures of MZ1 bound to BRD4 as well as models of VHL proteins. Nov 11 2019
S8563 TVB-3664 TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor. Nov 11 2019
S8574 BI 894999 BI894999 is a novel potent and selective BET inhibitor with IC50 values of 5 nM and 41 nM for the binding of BRD4-BD1 and BRD4-BD2 to acetylated histones, respectively. BI894999 is highly selective for BRD2/3/4 and BRDT (Kd of 0.49-1.6 nM), with at least a 200-fold selectivity vs. BRD4-BD1. Nov 11 2019
S8610 Pegcantratinib (SNA-120) Pegcantratinib (SNA-120) is a potent tropomyosin receptor kinase inhibitor allowing retention in the skin to exert its effects at nanomolar concentrations. Nov 11 2019
S8838 LHC165 LHC165 is a TLR7 agonist designed for localized intratumoral therapies. Nov 11 2019
S8844 BRD0539 BRD0539 is a potent inhibitor of spCas9 which disrupts spCas9-DNA binding and exerts dose and temporal control of spCas9 in human cell lines. Nov 11 2019
S8851 Elexacaftor (VX-445) Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Nov 11 2019
S8855 JNJ-4796 JNJ-4796 is an oral active fusion inhibitor of influenza virus Nov 11 2019
S8863 YKL-5-124 YKL-5-124 is a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for inhibiting CDK7/Mat1/CycH, CDK2 and CDK9 respectively. It displays biochemical and cellular selectivity for CDK7 over CDK12/13. Nov 11 2019
S8880 Lobaplatin ( D-19466) Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity. Nov 11 2019
S8881 DS-1001b (DS 1001, DS-1001) DS-1001 is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) mutant forms, including substitution mutations at the arginine in position 132, IDH1(R132) (IDH1-R132), with potential antineoplastic activity. Nov 11 2019
S6715 YHO-13177 YHO-13177, a novel acrylonitrile derivative, is a potent BCRP inhibitor. Nov 06 2019
Cat.No. Product Name Information Added
S6598 IRAK-1-4 Inhibitor I IRAK-1-4 Inhibitor I is an inhibitor of interleukin-1 receptor associated kinase (IRAK) with IC50 values of 0.3 μM and 0.2 μM for IRAK-1 and IRAK-4, respectively. It displays IC50 values >10 µM in a panel of 27 other kinases tested. Nov 06 2019
S6719 E6446 (dihydrochloride)) E6446 is a specific Toll-like receptor 9 inhibitor. Nov 06 2019
S6732 7ACC2 7ACC2 is a potent inhibitor of mitochondrial pyruvate transport 1 (MCT1) with an IC50 value of 10 nM for lactate uptake in SiHa human cervix carcinoma cells. Nov 06 2019
S6731 Eliprodil (SL-820715) Eliprodil (SL-820715) is a non-competitive NR2B-selective NMDA antagonist with IC50 value of 1 μM and is less potent for NR2A- and NR2C-containing receptors with IC50 > 100 μM. Nov 06 2019
S6735 JD-5037 JD-5037 is a peripherally restricted (PR) cannabinoid-1 receptor blocker with an IC50 value of 2 nM for CB1 receptor and > 1000 nM for CB2 receptor. Nov 06 2019
S6727 AX-024 HCl AX-024 blocks the interaction of the CD3ε PRS with SH3.1(Nck). Nov 06 2019
S6596 AG-126 AG126 is a tyrosine kinase inhibitor which selectively inhibits the phosphorylation of ERK1 (p44) and ERK2 (p42) at 25-50 μM. Nov 06 2019
S6713 ITD-1 ITD-1 is a potent TGF-β inhibitor. It does not block the kinase activity of either type I (TGFBR1) or type II (TGFBR2) TGFβ receptors but potently blocks phosphorylation of the effector SMAD2/3 proteins induced by TGFβ2, and only minimally in response to Activin A. Nov 06 2019
S6716 NSC 185058 NSC185058 inhibits ATG4B, the lipidation of LC3B, and autophagy without affecting the MTOR or PtdIns3K pathways. Nov 06 2019
S6711 IQ-1S IQ-1S is a JNK3 inhibitor with Kd values of 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively. Nov 06 2019
S6710 SGC-GAK-1 SGC-GAK-1 is a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK) with Ki value of 3.1 nM and >50-fold selectivity over nearest kinase. Nov 06 2019
S6712 S107 S107 is a Type 1 ryanodine receptor (RyR1) stabilizer that binds RyR1 and enhances the binding affinity of calstabin-1. Nov 06 2019
S6718 MKT-077 MKT-077 is a newly synthesized, highly water-soluble rhodacyanine dye that exhibits significant antitumor activity in a variety of model systems. Nov 06 2019
S6721 JG98 JG-98 is an allosteric inhibitor of Hsp70 that binds tightly to a deep pocket that is conserved in members of the Hsp70 family. Nov 06 2019
S6599 KM11060 KM11060 is a small molecule that corrects the processing of cystic fibrosis transmembrane conductance regulator (CFTR) proteins bearing the F508 deletion (F508del) mutation. Nov 06 2019
S6595 THZ531 THZ531 is a selective covalent inhibitor of CDK12 and CDK13 with IC50 values of 158 and 69 nM, respectively. Nov 06 2019
S6723 LXS-196 LXS-196 is a selective inhibitor of protein kinase C (PKC). Nov 06 2019
S6622 BMS309403 BMS309403 is a small-molecule FABP4 inhibitor with nM affinity (Kd=4 nM for FABP4) and >100-fold selectivity against FABP5 as well as the heart isoform FABP3. Nov 06 2019
S2933 AM580 AM580 is a retinoic acid receptor agonist with Kd values of 8 nM, 131 nM and 450 nM for RARα, RARβ and RARγ. Nov 06 2019
S6714 INH14 INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively. Nov 06 2019
Cat.No. Product Name Information Added
S8874 PLX5622 PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing > 20-fold selectivity over KIT and FLT3. Nov 06 2019
S6726 MK1064 MK1064 is a selective orexin 2 receptor antagonist (2-SORA) with an IC50 of 18 nM. Oct 30 2019
S6725 PCI 29732 PCI 29732 is a selective and irreversible Btk inhibitor with an IC50 of 0.5 nM. Oct 30 2019
S8843 AZD7648 AZD7648 is a potent inhibitor of DNA-PK with an IC50 of 0.6 nM in biochemical assay and more than 100-fold selective against 396 other kinases. Oct 30 2019
S6733 Edonerpic maleate Edonerpic maleate is a novel neurotrophic agent which can inhibit amyloid-β peptides (Aβ). Oct 30 2019
S6729 Besifovir Besifovir is novel and potent acyclic nucleotide phosphonate used to treat hepatitis B virus (HBV) infection. Oct 30 2019
S6730 CC-401 Hydrochloride CC-401 is a potent inhibitor of JNK with at least 40-fold selectivity against other related kinases. Oct 30 2019
S6616 ETC-159 ETC-159 is an orally available, potent porcupine inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells. Oct 30 2019
S6617 MSX-122 MSX-122 is a novel small molecule and partial CXCR4 antagonist (IC50~10 nM). Oct 30 2019
S6619 ABT 702 dihydrochloride ABT-702 is a novel, potent non-nucleoside Adenosine kinase inhibitor with an IC50 of 1.7 nM. It has oral activity in animal models of pain and inflammation. Oct 30 2019
S8774 DT-061(SMAP) DT-061(SMAP) is a bioavailable PP2A activator. It decreases cell viability in HCC827 and HCC3255 cell lines, with IC50 values of 14.3 μM and 12.4 μM respectively. Oct 30 2019
S6552 CYM5541 CYM5541 is a selective, allosteric agonist of S1P3 with an EC50 of between 72 and 132 nM and exhibits exquisite selectivity over other S1P receptor subtypes in vitro: S1P1 EC50 > 10 μM, S1P2 EC50 > 50 μM, S1P4 EC50 > 50 μM, and S1P5 EC50 > 25 μM. Oct 23 2019
S6724 SR1001 SR1001 is a RORα inverse agonist with Ki values of 172 nM and 111 nM for RORα and RORγ respectively. Oct 23 2019
S6734 PF-670462 PF-670462 is a potent and selective inhibitor of CK1ε and CK1δ with IC50 value of 90 nM and 13 nM, respectively. Oct 23 2019
S6618 JNJ-42153605 JNJ-42153605 is a potent and selective mGlu2 receptor positive allosteric modulator with an EC50 of 17 nM. Oct 23 2019
S6620 Danirixin (GSK1325756) Danirixin (GSK1325756) is a small molecule, non-peptide, high affinity (IC50 for CXCL8 binding = 12.5 nM), selective, and reversible CXCR2 antagonist. Oct 23 2019
S8455 Talabostat (Val-boroPro, PT-100) Talabostat (Val-boroPro, PT-100) is a dipeptidyl peptidase inhibitor with IC50 values of <4 nM, 4 nM, 11 nM, 310 nM, 560 nM and 390 nM for DPP-IV, DPP8, DPP9, QPP, FAP and PEP respectively. It has antineoplastic and hematopoiesis- stimulating activities. Oct 23 2019
S7716 TAS-116 TAS-116 is a novel, small-molecule HSP90 inhibitor which inhibits geldanamycin-FITC binding to HSP90 proteins with Ki values of 34.7 nmol/L, 21.3 nmol/L, >50,000 nmol/L, and >50,000 nmol/L for HSP90α, HSP90β, GRP94, and TRAP1, respectively. Furthermore, TAS-116 does not inhibit other ATPases such as HSP70 (IC50 >200 μmol/L). Oct 15 2019
S6551 Adelmidrol Adelmidrol is an analogue of palmitoylethanolamide (PEA) with anti-inflammatory activities. Oct 10 2019
S8860 Cintirorgon (LYC-55716) Cintirorgon (LYC-55716) is a selective, first-in-class, oral, small-molecule investigational agent that selectively activates RORγ. Oct 10 2019
Cat.No. Product Name Information Added
S8862 PDD00017273 PDD00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor with an IC50 of 26 nM. PDD00017273 exhibits >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. Oct 10 2019
S2931 Aurora Kinase Inhibitor III Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase with an IC50 of 42 nM and has high selectivity for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively). Oct 10 2019
S6572 ML335 ML335 is a potent and selective TREK-1/2 activator. ML335 is an agonist for OPRM1-OPRD1 heterdimerization with an EC50 of 403 nM, and selectivities vs. OPRM1, OPRD1, and HTR5A of 37, 2.7, and >99, respectively. Oct 10 2019
S8877 Imidazole ketone erastin Imidazole ketone erastin (IKE) is a potent, selective, and metabolically stable system xc– inhibitor and inducer of ferroptosis. Oct 10 2019
S8868 NG25 NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively. Oct 10 2019
S8716 BLU-667 BLU-667 is a highly potent and selective RET inhibitor with an IC50 of 0.4 nM for WT RET. It also demonstrates potent activity (IC50 0.4 nmol/L) against common oncogenic RET alterations, including RET (M918T). Oct 10 2019
S8828 Gboxin Gboxin is an inhibitor of oxidative phosphorylation in cancer cells. It specifically inhibits the growth of primary mouse and human glioblastoma cells but not that of mouse embryonic fibroblasts or neonatal astrocytes. Oct 10 2019
S6581 Fosamprenavir calcium salt Fosamprenavir is a pro-drug of the protease inhibitor and antiretroviral drug amprenavir. It is used for the treatment of HIV-1 infections. Sep 24 2019
S7455 Resatorvid (TAK-242) Resatorvid (TAK-242) is a small-molecule-specific inhibitor of Toll-like receptor (TLR) 4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC50 values of 1-11 nM. Sep 24 2019
S8865 BAI1 BAI1 is a direct allosteric inhibitor of BAX with a dissociation constant (Kd) of 15.0 ± 4 μM. Sep 17 2019
S6702 Tween 80 Tween 80 is a widely used non-ionic emulsifier that is added to cosmetics, pharmaceuticals, and foods. Sep 17 2019
S6703 CMC-Na Sodium carboxymethyl cellulose (CMC-Na) is one of the important modified cellulose, a water-soluble cellulose, which is widely used in many application of food, pharmaceuticals, detergent, paper coating, dispersing agent, and others. Sep 17 2019
S6704 PEG300 PEG300 is a water-miscible polyether widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries. It serves as a kind of solubilizer, excipient, lubricant, and chemical reagent. Sep 17 2019
S6705 PEG400 Polyethylene glycol 400 (PEG400) is a commonly used co-solvent used in a variety of pharmaceutical formulations. Sep 17 2019
P1085 Angiotensin II human Acetate Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. It works via binding to specific receptors present on cell membranes. Sep 15 2019
S8832 Branebrutinib (BMS-986195) Branebrutinib (BMS-986195) is a potent inhibitor of BTK with IC50 values of 0.1 nM, 0.9 nM, 1.5 nM, 5 nM for BTK, TEC, BMX, TXK, respectively. Sep 11 2019
S6546 PD153035 PD153035 is a specific and potent inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (Ki = 5.2 pM). Sep 11 2019
S6531 Bohemine Bohemine is a CDK inhibitor with IC50s of 4.6, 83, and 2.7 μM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively. Sep 11 2019
S6530 EBE-A22 EBE-A22 is a derivative of PD 153035 which can inhibit ErbB-1-phosphorylation, whereas EBE-A22 is inactive. Sep 11 2019
S6602 TB5 TB5 is a potent and selective MAO-B inhibitor with Ki values of 110 and 1,450 nM for MAO-B and MAO-A, respectively. Sep 11 2019
Cat.No. Product Name Information Added
S6568 ML346 ML346 is a Hsp70 activator and a novel modulator of proteostasis for protein conformational diseases. Sep 11 2019
S6564 ML348 ML348 is a potent and selective APT1 (Acyl protein thioesterase 1) inhibitor with Ki values of 280 nM and >10 μM for APT1 and APT2, respectively. Sep 11 2019
S6540 NG 52 NG-52 is a tri-substituted purine that binds to the ATP-binding site of yeast cyclin-dependent kinases, inhibiting Cdc28p and Pho85p with IC50s of 7 and 2 μM, respectively. Sep 11 2019
S6539 ASP5878 ASP5878 is a novel FGFR-selective inhibitor with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L for recombinant FGFR1, 2, 3, and 4, respectively. Sep 11 2019
S6606 CDD3505 CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity. Sep 11 2019
S6607 YL-109 YL-109 is a novel antitumor agent that has ability to inhibit breast cancer cell growth and invasiveness in vitro and in vivo. Sep 11 2019
S6526 SKLB 610 SKLB-610 is a multi-target inhibitor of the tyrosine kinases. It is most potent against VEGFR2 and exhibits slightly weaker inhibitor of FGFR2 and PDGFR. Sep 11 2019
S6534 CZC-54252 CZC-54252 is a potent and selective LRRK2 inhibitor with IC50s of 1.28 nM and 1.85 nM for human wild type LRRK2 and G2019S LRRK2, respectively. Sep 11 2019
S4421 Josamycin Josamycin is a macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens. Sep 11 2019
S6579 RCGD423 RCGD-423 is a modulator of gp130 signalling that regulates cartilage growth and differentiation. Sep 11 2019
S6560 PDM2 PDM2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist. Sep 11 2019
S6589 Norethisterone Enanthate Norethisterone Enanthate is a form of progestogen-only injectable birth control which is used to prevent pregnancy in women. Sep 11 2019
S6563 DMNQ Sep 11 2019
S6558 Irosustat (STX64, BN83495) Irosustat (STX64, BN83495), a tricyclic coumarin sulfamate, is an orally active, nonsteroid-based, irreversible steroid sulfatase inhibitor with an IC50 of 8 nM. Sep 11 2019
S6583 Apraclonidine HCl Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. Sep 11 2019
S6582 Ozenoxacin Ozenoxacin is a quinolone antibiotic used for the treatment of impetigo. Sep 11 2019
S8809 MC180295 MC180295 is a novel potent and selective CDK9 inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs. Sep 11 2019
S6593 Methylprednisolone sodium succinate Methylprednisolone sodium succinate is a corticosteroid medication that reduces inflammation. Sep 11 2019
S2188 Phenprocoumon Phenprocoumon(Marcumar) is a vitamin K reductase with an IC50 of 1 μM Sep 09 2019
A2102 Anti-mouse CD8α-InVivo Grade Anti-mouse CD8α reacts with mouse CD8α. CD8 is a transmembrane glycoprotein that acts as a co-receptor for the T cell receptor (TCR). It binds to class I MHC molecules displayed by antigen presenting cells (APC). Sep 09 2019
Cat.No. Product Name Information Added
S3153 Levalbuterol tartrate Levalbuterol HCl is a relatively selective beta2-adrenergic receptor agonist used for the treatment of asthma. Sep 09 2019
S8746 H3B-5942 H3B-5942 is a selective and irreversible estrogen receptor covalent antagonist, inactivates both ERα WT and ERα mutation. The Ki values are 1 nM and 0.41 nM, respectively. Sep 05 2019
S6590 Hydrocortisone butyrate Hydrocortisone butyrate is a potent topical corticosteroid that can be used to treat a range of inflammatory skin conditions. Sep 05 2019
S5797 Metyrosine Metyrosine, an antihypertensive drug, is a tyrosine hydroxylase inhibitor. Sep 05 2019
S6588 Methylprednisolone hemisuccinate Methylprednisolone sodium succinate is a glucocorticoid used to treat a variety health issues including severe allergic reactions, asthma, autoimmune diseases, blood disorders, gastrointestinal diseases and endocrine disorders. Sep 05 2019
S8872 GSK8612 GSK8612 is a highly potent and selective inhibitor for TBK1 (Tank-binding Kinase-1) with pKd of 8.0. Within 10-fold affinity with respect to TBK1, no off-targets of GSK8612 could be identified. Sep 05 2019
S6592 Diquafosol Tetrasodium Diquafosol Tetrasodium, a P2Y2 receptor agonist, is a pharmaceutical drug for the treatment of dry eye disease. Sep 05 2019
S8859 BMS-1166 BMS-1166 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 interaction with an IC50 of 1.4 nM. Sep 05 2019
S8871 Omadacycline tosylate Omadacycline is a first-in-class aminomethylcycline antibiotic, demonstrating antimicrobial activity in vitro against a range of Gram-positive and Gram-negative aerobes and some anaerobic bacteria. Sep 05 2019
S6587 Clobetasone butyrate Clobetasone butyrate is a new corticosteroid that is often employed topically as a treatment for a variety of conditions such as eczema, psoriasis, various forms of dermatitis, and also for certain ophthalmologic conditions. Sep 05 2019
S4622 3,4-Diaminopyridine 3,4-Diaminopyridine blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations. It is a drug predominantly used in the treatment of a number of rare muscle diseases. Sep 05 2019
S8864 ZT-12-037-01 ZT-12-037-01 is a specific and ATP-competitive STK19 inhibitor with IC50s of 23.96 nM and 27.94 nM for STK19 (WT) and STK19 (D89N), respectively. It displays extremely high kinase selectivity using KINOMEscan against a panel of 468 diverse kinases using an in vitro ATP-site competition binding assay at 1 μM. Sep 05 2019
S6585 Triethylenetetramine Dihydrochloride Triethylenetetramine, a Cu(II)-selective chelator, is commonly used for the treatment of Wilson's disease. Sep 05 2019
S6577 PKC-theta inhibitor PKC-theta inhibitor inhibits PKC-θ with an IC50 of 12 nM. Aug 28 2019
S6557 ML355 ML355 is a potent and selective inhibitor of human 12-Lipoxygenase with an IC50 of 290 nM and shows excellent selectivity over related lipoxygenases and cyclooxygenases. Aug 28 2019
S6550 URB602 URB602 is an inhibitor of monoacylglycerol lipase (MGL), a serine hydrolase involved in the biological deactivation of the endocannabinoid 2-arachidonoyl-sn-glycerol (2-AG). Aug 28 2019
S6549 PBTZ169 PBTZ169, an antibiotic with antimycobacterial activity, is an irreversible inhibitor of DprE1. Aug 28 2019
S6580 D-Luciferin Potassium Salt D-Luciferin is a substrate for the enzyme firefly luciferase. Aug 28 2019
S6571 BQR695 BQR695 is a quinoxaline that displays sub-micromolar potency against human PI4KIIIβ (IC50~90 nM). Aug 28 2019
S6574 KDU691 KDU691 is a Plasmodium PI4K-specific inhibitor with IC50 values of 0.18 μM and 0.061 μM against hypnozoite forms and liver schizontsm, respectively. Aug 28 2019
Cat.No. Product Name Information Added
S6573 MD2-IN-1 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD value of 189 μM. Aug 28 2019
S8867 Bentamapimod (AS602801) Bentamapimod (AS602801) is a novel, orally active JNK inhibitor with IC50 values of 80 nM, 90 nM and 230 nM for JNK1, JNK2 and JNK3 respectively. Aug 28 2019
S6566 NSC23005 Sodium NSC 23005 is a small molecule inhibitor of p18 (ED50=5.21 nM). Aug 28 2019
S6554 ML365 ML365 is a novel selective small molecule inhibitor of the TASK1 or potassium channel, subfamily K, member 9 (KCNK3). Aug 28 2019
S6555 AZD2098 AZD2098 is a potent and bioavailable CCR4 receptor antagonist with pIC50 of 7.8. Aug 28 2019
S6567 Src Inhibitor 1 Src Inhibitor 1 is a potent competitive inhibitor of both Src and Lck (IC50 = 44 and 88 nM, respectively), as well as Csk and Yes. Aug 28 2019
S6562 KKL-35 KKL-35 inhibits the trans-translation tagging reaction with an IC50 of 0.9 µM. It has broad-spectrum antibiotic activity. Aug 28 2019
S6565 JK184 JK184 inhibits Gli in the Hedgehog (Hh) pathway with IC50 of 30 nM in mammalian cells. Aug 28 2019
S6561 4-IBP 4-IBP is a selective σ1 receptor agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM). Aug 28 2019
S6614 Fursultiamine Fursultiamine is a nutritional supplement and vitamin B1 derivative, with potential antineoplastic activity. Aug 28 2019
S7791 Phorbol 12-myristate 13-acetate (PMA) Phorbol 12-myristate 13-acetate (PMA), a potent activator of PKC, is active at nanomolar concentrations. Aug 21 2019
S8869 UNBS5162 UNBS5162 is a pan-antagonist of CXCL chemokine expression with in vitro cytotoxic activity (IC50 range of 0.5-5 µM) against a range of human cancer cell lines including glioblastoma (Hs683 and U373MG), colorectal (HCT-15 and LoVo), non-small-cell lung (A549) and breast (MCF-7). Aug 21 2019
S6612 Betazole Dihydrochloride Betazole Dihydrochloride is a histamine H2 agonist used clinically to test gastric secretory function. Aug 21 2019
S6575 C-176 STING inhibitor STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway. Aug 21 2019
S6576 BW-A78U BW-A78U, an adenine derivative PDE inhibitor, has anticonvulsant activity. Aug 21 2019
S6578 Longdaysin Longdaysin is a Casein Kinase inhibitor with IC50 values of 8.8 μM, 5.6 μM, 52 μM and 29 μM for CKIδ, CKIα, ERK2 and CDK7. Aug 21 2019
S6569 VUF10460 VUF10460 is a histamine H4 receptor agonist. Aug 21 2019
S6611 Cyclothiazide Cyclothiazide is a positive allosteric modulator of ionotropic α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors with critical roles in neurological development and function. Aug 21 2019
S6613 Vanillylmandelic acid Vanillylmandelic acid (VMA) is a chemical intermediate in the synthesis of artificial vanilla flavorings and is an end-stage metabolite of the catecholamines Aug 21 2019
S8162 Upadacitinib (ABT-494) Upadacitinib (ABT-494) is a selective JAK1 inhibitor which demonstrates activity against JAK1 (0.045 μM) and JAK2 (0.109 μM), with > 40 fold selectivity over JAK3 (2.1 μM) and 100 fold selectivity over TYK2 (4.7 μM) as compared to JAK1. Aug 21 2019
Cat.No. Product Name Information Added
S6532 kb-NB77-78 kb-NB77-78 is an analog of CID797718. However, it shows no inhibitory activty towards PKD1. Aug 13 2019
S6605 AR7 AR7 is a retinoic acid receptor α (RARα) antagonist. Aug 13 2019
S8873 Letermovir(AIC246, MK-8228) Letermovir(AIC246, MK-8228) is a novel anti-CMV compound which targets the viral terminase complex and remains active against virus resistant to DNA polymerase inhibitors. Aug 13 2019
S6529 NIH-12848 NIH-12848 is a specific PI5P4Kγ inhibitor with an IC50 of approximately 1 μM but does not inhibit the α and β PI5P4K isoforms at concentrations up to 100 μM. Aug 08 2019
S6537 CVT-313 CVT-313 is a potent CDK2 inhibitor with an IC50 of 0.5 microM in vitro. It has no effect on other, nonrelated ATP-dependent serine/threonine kinases. Aug 08 2019
S6502 SD 0006 SD0006 is an inhibitor of p38 kinase-alpha (p38alpha) with IC50 values of 0.016 μM and 0.677 μM for p38α and p38β. It is selective for p38α kinase over 50 other kinases screened (including p38γ and p38δ with modest selectivity over p38β). Aug 08 2019
S6545 BI-4464 BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. Aug 08 2019
S6541 MTX-211 MTX-211 is a first-in-class dual inhibitor of PI3K and EGFR kinase. Aug 08 2019
S6608 AL082D06 AL082D06 is a nonsteroidal glucocorticoid receptor (GR) antagonist with no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. Aug 08 2019
S6609 JZL195 JZL195 is a potent inhibitor of both FAAH and MAGL with IC50s of 2 and 4 nM respectively. Aug 08 2019
S6610 GSK2981278 GSK2981278 is a highly potent and selective inverse agonist for RORγ. Aug 08 2019
S6538 B-Raf IN 1 B-Raf IN 1 is an inhibitor of Raf wih IC50 values of 24 nM and 25 nM for B-Raf and C-Raf respectively. It is selective over 13 other kinases, including PKCα, IKKβ, and PI3Kα. Aug 08 2019
S6527 Kobe2602 Kobe2602 is a selective Ras inhibitor that blocks H-Ras GTP binding to c-Raf-1 (Ki = 149 µM). Aug 08 2019
S6518 Desmethylanethol trithione Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. Aug 08 2019
S6536 TTP 22 TTP22 is a casein kinase 2 (CK2) inhibitor with an IC50 value of 100 nM. It displays selectivity for CK2 over JNK3, ROCK1, and MET with no inhibitory effects towards these kinases at 10 μM. Aug 08 2019
S8854 JNJ-38877618(OMO-1) JNJ-38877618 (OMO-1) is a potent, highly selective, orally bioavailable MET kinase inhibitor with binding affinity (Kd) of 1.4 nM and enzyme inhibitory activity against wt and M1268T mutant MET (2 and 3 nM IC50). Aug 08 2019
S8297 ARV-825 ARV-825 is a BRD4 Inhibitor that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 and sustained down-regulation of MYC. Aug 08 2019
S8722 ICEC0942 (CT7001) ICEC0942 (CT7001) is a new, orally bioavailable CDK7 inhibitor with an IC50 of 40nM. The IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. Aug 08 2019
A2101 Anti-mouse CD4-InVivo Grade Anti-mouse CD4 antibody reacts with mouse CD4, which is a 55 kDa cell surface type I membrane glycoprotein. CD4 is a co-receptor of the T cell receptor (TCR) and assists the latter in communicating with antigen-presenting cells. Aug 06 2019
S8735 BI-3812 BI-3812 is a highly potent and efficacious BCL6 inhibitor probe compound with an IC50 less than 3 nM. Jul 31 2019
Cat.No. Product Name Information Added
S6496 Genz-123346 free base Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1, the first step in the biosynthesis of gangliosides and other glycosphingolipids. Jul 31 2019
S6510 Iso-H7 dihydrochloride Iso-H7 dihydrochloride is an inhibitor of phosphokinase C. Jul 31 2019
S6495 6-Bromo-2-hydroxy-3-methoxybenzaldehyde 6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative that participates in the synthesis of (±)-norannuradhapurine. Jul 31 2019
S6504 BX517 BX517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM). Jul 31 2019
S6509 AG 494 AG-494, a member of the tyrphostin family of tyrosine kinase inhibitors, is a potent inhibitor of EGF receptor autophosphorylation (IC50=1.2 μM) and EGF-dependent cell growth (IC50=6 μM). Jul 31 2019
S6508 Mitapivat Mitapivat is an activator of a pyruvate kinase PKM2, an enzyme involved in glycolysis. Jul 31 2019
S6503 LX2343 LX2343 is a multi-target agent that exhibits a high capability for ameliorating multi-abnormalities of AD pathogenesis. It is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. Jul 31 2019
S6506 Compound 401 Compound 401 is a synthetic inhibitor of DNA-PK and mTOR (IC50=5.3 μM). It has no inhibition on p110α/p85α PI3K (>100 μM) and blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells. Jul 31 2019
S6512 Defensamide (MHP) Defensamide (MHP) is an activator of sphingosine kinase (SPHK1). It can modulate the innate epidermal immune response by potentiating SPHK1 activity and inducing cAMP production. Jul 31 2019
S6499 PF-6260933 PF-6260933 is a potent inhibitor of MAP4K4 with an IC50 of 3.7 nM, possessing excellent kinome selectivity. Jul 31 2019
S6494 CCCP CCCP, an oxidative phosphorylation inhibitor, is a protonophore mitochondrial uncoupler that increases membrane permeability to protons, leading to a disruption in the mitochondrial membrane potential. Jul 31 2019
S6497 SMI-16a SMI-16a is a selective Pim kinase inhibitor with IC50 values of 150 nM and 20 nM for Pim1 and Pim2 respectively. Jul 31 2019
S6498 T56-LIMKi Jul 31 2019
S8826 BAY-293 BAY-293 selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21 nM. Jul 31 2019
S8568 G1T38 Lerociclib (G1T38) is a novel, potent, selective, and orally bioavailable CDK4/6 inhibitor with IC50 values of 0.001 μM, 0.002 μM and 0.028 μM for CDK4, CDK6 and CDK9 respectively. Jul 31 2019
S6500 KX1-004 KX1-004 is a non-ATP competitive inhibitor of Src protein tyrosine kinase (Src-PTK; IC50 = 40 µM). Jul 31 2019
S6533 Briciclib Briciclib is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E). Jul 31 2019
S6507 KN-92 phosphate KN-92 is an inactive derivative of KN-93, the selective inhibitor of Ca2+/calmodulin-dependent kinase type II (CaMKII). Jul 31 2019
S6523 RG14620 RG14620, an EGFR inhibitor of the tyrphostin family, directly inhibits the transport function of ABCG2. Jul 31 2019
S8842 BAY-218 BAY-218 is a potent and selective small-molecule AhR inhibitor, inhibiting AhR nuclear translocation, dioxin response element (DRE)-luciferase reporter expression and AhR-regulated target gene expression induced by both exogenous and endogenous AhR ligands. Jul 31 2019
Cat.No. Product Name Information Added
S6524 NSC 42834 NSC42834 is an inhibitor of the autophosphorylation of wild type and V617F mutant forms of JAK2 with IC50 values between 10 and 30 μM. Jul 31 2019
S8676 Glumetinib (SCC244) Glumetinib (SCC244) is a potent and highly selective c-Met inhibitor with an IC50 of 0.42 ± 0.02 nmol/L. Glumetinib has greater than 2,400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, and TyrO3. Jul 31 2019
S6522 ST 271 ST271 is a tyrphostin-like protein tyrosine kinase (PTK) inhibitor which inhibits phospholipase D (PLD) activity. Jul 24 2019
S6521 WHI-P258 WHI-P258 is an inhibitor of JAK3 with Ki value of 72 μM. Jul 24 2019
S6525 AG 555 AG-555 is an inhibitor of tyrosine kinase, interacts directly with topoisomerase I, thus preventing DNA relaxation. It inhibits EGFR with an IC50 of 0.7 μM. Jul 24 2019
S6519 R112 R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor with Ki value of 96 nM. Jul 24 2019
S6520 WHI-P180 WHI-P180 is a multi-kinase inhibitor with IC50 values of 4.5 and 66 nM for the human proto-oncogene RET and kinase insert domain receptor (KDR), respectively. Jul 24 2019
S6511 RIPA-56 RIPA-56 is a highly-potent, selective, and metabolically stable RIP1 (RIPK1) inhibitor. Jul 24 2019
S6513 HG-14-10-04 HG-14-10-04 is an inhibitor of ALK. Jul 24 2019
S6501 NVP 231 NVP 231 is a novel CerK inhibitor that inhibits the catalytic activity of recombinant CerK in vitro with an IC50 of 12 nM. Jul 24 2019
S6543 ZD-4190 ZD-4190 is a submicromolar inhibitor of VEGF RTK activity in vitro with IC50 values of 29 ± 4 nM and 708 ± 63 nM for KDR and Flt-1, respectively. Jul 24 2019
S6544 SR-3029 SR-3029 is a potent and selective casein kinase 1δ/1ε (CK1δ/ε) inhibitor with IC50 values of 44 and 260 nM for CK1δ and CK1ε, respectively. Jul 24 2019
S6535 SU1498 SU1498, a powerful inhibitor of KDR (IC50 = 0.7 μM), stimulates accumulation of phosphorylated ERK1/2 in endothelial cells. Jul 24 2019
S8643 AZD5991 AZD5991 is a macrocyclic MCL-1 inhibitor with sub-nanomolar affinity for MCL-1 (Ki = 0.13 nM). The binding affinity of AZD5991 is about 25-fold lower for mouse Mcl-1 vs. human Mcl-1 but only four-fold lower for rat Mcl-1. Jul 24 2019
S6505 X-376 X-376 is an ALK inhibitor and potentially useful in non-small cell lung cancer. Jul 24 2019
S6489 Lasmiditan succinate Lasmiditan succinate is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (Ki=2.21 nM) without vasoconstrictor activity. Jul 24 2019
S6490 Vadadustat Vadadustat is a novel, titratable, oral HIF-PH inhibitor. Jul 24 2019
S8830 AMG510 AMG-510 is a potent KRAS G12C covalent inhibitor with potential antineoplastic activity. Jul 24 2019
S1553 ABT-492(Delafloxacin, RX-3341, WQ-3034) ABT-492 is a new fluoroquinolone against 155 aerobic and 171 anaerobic pathogens. Jul 24 2019
S6412 Altiratinib Altiratinib is a potent single-digit nanomolar inhibitor of TRK, MET, TIE2, and VEGFR2 kinases with IC50 vaules of 0.9 nM, 4.6 nM, and 0.8 nM for TRKA, B, and C, respectively. It inhibits MET and MET mutant with IC50 values in the range of 0.3-6 nM. Jul 24 2019
Cat.No. Product Name Information Added
S6516 GNE-477 GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor with an IC50 of 4 nM for PI3Kα and Kiapp of 21 nM for mTOR. Jul 24 2019
S8818 V-9302 V-9302 is a competitive small molecule antagonist of transmembrane glutamine flux, that selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) with an IC50 value of 9.6 μM for inhibition of glutamine uptake in HEK-293 cells. Jul 17 2019
S8600 Elenbecestat Elenbecestat is a novel BACE1 inhibitor, demonstrating prolonged reductions in plasma beta-amyloid levels after single dosing. Jul 17 2019
S6492 Doravirine (MK-1439) Doravirine is a novel HIV-1 nonnucleoside reverse transcriptase inhibitor with IC50 values of 12, 9.7, and 9.7 nM against the wild type (WT) and K103N and Y181C reverse transcriptase (RT) mutants, respectively, in a biochemical assay. It is highly specific with minimum off-target activities. Jul 17 2019
S8743 SKLB-23bb SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor with IC50 values under 100 nmol/L, against most of the cell lines checked. It also has microtubule-disrupting ability. Jul 09 2019
S6484 uridine triacetate Uridine triacetate is an orally active prodrug of the naturally occurring nucleoside uridine. It is used for the treatment of hereditary orotic aciduria (Xuriden), or for the emergency treatment of fluorouracil or capecitabine overdose or toxicity. Jul 09 2019
S6486 ibandronic acid Ibandronic acid is a potent nitrogen-containing bisphosphonate used in both osteoporosis and to prevent the spread of breast cancer to the bones. Jul 09 2019
S6488 Gadoxetate sodium Gadoxetate is a paramagnetic gadolinium-containing contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Jul 09 2019
S8704 iCRT14 iCRT14 is a β-catenin/Tcf inhibitor with a Ki value of 54 ± 5.2 μM in homogeneous fluorescence polarization (FP) assay. Jul 09 2019
S6487 fluticasone furoate Fluticasone furoate is an inhaled corticosteroid/long-acting beta-agonist combination with a prolonged bronchodilator duration of action. It is used for the treatment of non-allergic and allergic rhinitis administered by a nasal spray. Jul 09 2019
S8438 T-3775440 HCl T-3775440 HCl is an irreversible LSD1 inhibitor that is highly selective for LSD1 relative to other monoamine oxidases (e.g., MAO-A and MAO-B), with an IC50 value of 2.1 nmol/L. Jul 09 2019
S6416 JNJ 31020028 JNJ 31020028 is a novel neuropeptide Y Y2 receptor antagonist which bound with high affinity with human and rat Y2 receptor (pIC50=8.07±0.05 for human Y2 receptor, and pIC50=8.22±0.06 for rat Y2 receptor) and >100-fold selective versus human Y1, Y4, and Y5 receptors. Jul 03 2019
S6432 Cevimeline Cevimeline is a parasympathomimetic agent that act as an agonist at the muscarinic acetylcholine receptors M1 and M3. Jul 03 2019
S5952 Baloxavir marboxil Baloxavir marboxil, a cap-endonuclease inhibitor, is an antiviral drug. Jul 03 2019
S8836 S64315 (MIK665) S64315 (MIK665) is an inhibitor of induced myeloid leukemia cell differentiation protein Mcl-1 with Ki value of 1.2 nM and has potential pro-apoptotic and antineoplastic activities. Jul 03 2019
S5773 NS1643 NS1643 is one of the small molecule HERG (Kv11.1) channel activators and has also been found to increase erg2 (Kv11.2) currents. Jun 26 2019
S8769 Tinostamustine(EDO-S101) Tinostamustine(EDO-S101) is a first-in-class alkylating deacetylase inhibitor with IC50 values of 9 nM, 9 nM, 25 nM and 107 nM for HDAC1, HDAC2, HDAC3 and HDAC8 (Class 1 HDACs) respectively and 6 nM, 72 nM for HDAC6 and HDAC10 (Class II HDACs). Jun 26 2019
S5921 Cyclopentolate Hydrochloride Cyclopentolate is an antagonist of muscarinic acetylcholine receptors with Ki values of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively. Jun 26 2019
S8846 compound 3i (666-15) Compound 3i (666-15) is a potent and selective inhibitor of CREB-mediated gene transcription (IC50 = 0.081 ± 0.04 μM) and also potently inhibits cancer cell growth without harming normal cells. Jun 26 2019
S6482 Fosphenytoin (disodium) Fosphenytoin (disodium) is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin upon parental administration. Jun 26 2019
Cat.No. Product Name Information Added
S8530 BAY 1436032 BAY-1436032 is a highly selective, potent and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). It is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displays potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants. Jun 26 2019
S6420 AGI 1067 AGI-1067 is a novel, phenolic, intra- and extracellular antioxidant that inhibits the expression of a number of proinflammatory genes involved in atherosclerosis. Jun 24 2019
S6465 Tafamidis Tafamidis is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. Jun 24 2019
S8747 BAY-8002 BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport. BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels. Jun 24 2019
S6456 Glycyrrhetinic acid Glycyrrhetinic acid is a triterpenoid aglycone component of the natural product glycyrrhizinic acid and possesses remarkable anti-proliferative and apoptosis-inducing activity in various cancer cell lines. Jun 24 2019
S6479 Isohomovanillic acid Isohomovanillic acid is a deaminated metabolite of catecholamines formed by the enzyme catechol-O-methyltransferase which catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. Jun 24 2019
S6480 Triphosphopyridine nucleotide disodium salt Triphosphopyridine nucleotide serves as an electron carrier in a number of reactions, being alternately oxidized (NADP+) and reduced (NADPH). Jun 24 2019
S6481 3beta-hydroxy-delta5-cholenic acid 3beta-hydroxy-delta5-cholenic acid is a monohydroxy bile acid of endogenous origin. It is found in biologic fluids beginning in fetal life. Jun 24 2019
S8817 HS-10296 HS-10296 is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR. Jun 24 2019
S6483 O-Phosphoethanolamine Phosphoethanolamine (PE) is a phosphomonoester metabolite of the phospholipid metabolism. Jun 24 2019
S8693 Selective PI3Kδ Inhibitor 1 (compound 7n) Selective PI3Kδ Inhibitor 1 (compound 7n) is an inhibitor of PI3Kδ with an IC50 of 0.9 nM and >1000-fold selectivity against other class I PI3K isoforms [PI3K α/γ/β=3670/1460/21300 nM]. Jun 24 2019
S8792 UAMC-3203 UAMC-3203 is an improved ferroptosis inhibitor with an IC50 value of 10 nM in IMR-32 neuroblastoma cells. Jun 11 2019
S6473 Pinaverium bromide Pinaverium bromide acts as a calcium channel blocker and is useful for functional gastrointestinal disorders. Jun 11 2019
S8684 Selective JAK3 inhibitor 1 Selective JAK3 inhibitor 1 is an irreversible JAK3 inhibitor with Ki values of 0.07 nM, 320 nM, 740 nM for JAK3, JAK1 and JAK2 respectively. It is also selective over the other kinases possessing a cysteine in the same region as JAK3, such as BMX, EGFR, ITK, and BTK. Jun 11 2019
S6476 Eicosapentaenoic Acid Eicosapentaenoic acid (EPA) is an omega-3 polyunsaturated fatty acid with antiinflammatory properties, and is present in fish and fish oils, including salmon, cod, and krill oils. Jun 11 2019
S6449 Ferrous Bisglycinate Ferrous bisglycinate is a chelate that is used as a source of dietary iron. It acts as both a chelate and a nutritionally functional. Jun 05 2019
S6445 Chlorophyllin (sodium copper salt) Chlorophyllin, the sodium and copper salt of chlorophyll, is an antioxidant and antimutagenic agent. Jun 05 2019
S6440 Halazone Halazone is widely used to disinfect drinking water. Jun 05 2019
S6441 Riboflavin Tetrabutyrate Riboflavin tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity. Jun 05 2019
S6436 magnesium 2-aminoacetate magnesium 2-aminoacetate is essential for DNA and RNA synthesis, cellular repair, and maintaining the antioxidant status of the cell. Jun 05 2019
Cat.No. Product Name Information Added
S6435 Mequitazine Mequitazine is a histamine H1 antagonist which competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. Jun 05 2019
S6478 Fipexide hydrochloride Fipexide (hydrochloride) is a psychoactive drug of the piperazine class. Jun 05 2019
S6454 Docosahexaenoic Acid Docosahexaenoic Acid (DHA) is essential for the growth and functional development of the brain in infants. DHA is also required for maintenance of normal brain function in adults. Jun 05 2019
S6460 Sugammadex (sodium) Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery in adults. Jun 05 2019
S6477 Octodrine (2-Amino-6-methylheptan) Octodrine (2-Amino-6-methylheptan) is a stimulant drug that can increase blood pressure and cardiac output in animals. Jun 05 2019
S8840 SEL120(SEL120-34,SEL120-34A) SEL120(SEL120-34,SEL120-34A) is a novel inhibitor of Cyclin-dependent kinase 8 (CDK8) with IC50 values of 4.4 nM and 10.4 nM for CDK8/Cyclin C and CDK19/CyclinC respectively. Jun 05 2019
S6443 Chromium picolinate Chromium picolinate is a coordination complex consisting of chromium(III) and picolinic acid. It is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. May 30 2019
S6444 Triclocarban Triclocarban is an antibacterial agent common used in personal care products. May 30 2019
S6451 Salifungin Salifungin (Bromochlorosalicylanilide) is an antifungal and may cause allergic contact dermatitis in some individuals. May 30 2019
S6450 Apronal Apronal is a hypnotic/sedative drug. May 30 2019
S6442 Chlorphenesin Chlorphenesin is a synthetic preservative used in skin care as a cosmetic biocide. May 30 2019
S6438 Ufiprazole Ufiprazole (Omeprazole sulfide) is an intermediate used in the production of the gastric proton pump inhibitors omeprazole and esomeprazole. May 30 2019
S6447 Carazolol Carazolol is a non-specific β-adrenergic receptor blocking agent and binds to β receptors irreversibly. May 30 2019
S6462 Amezinium (methylsulfate) Amezinium is a sympathomimetic used for its vasopressor effects in the treatment of hypotensive states. It is a MAO inhibitor, antagonizes the response to tyramine and blocks neuronal uptake of noradrenaline. May 30 2019
S6464 Ftaxilide Ftaxilide is a novel antituberculosis agent. May 30 2019
S6459 Nifurtimox Nifurtimox is an antiprotozoal agent. May 30 2019
S6439 Talniflumate Talniflumate is an anti-inflammatory molecule studied and used as a mucin regulator in the treatment of cystic fibrosis, chronic obstructive pulmonary disease (COPD) and asthma. May 30 2019
S6448 Ibuprofen piconol Ibuprofen is a nonsteroidal anti-inflammatory agent (NSAIA) or nonsteroidal anti-inflammatory drug (NSAID), with analgesic and antipyretic properties. May 30 2019
S6471 Lucanthone Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1. May 30 2019
S6467 Fosfluconazole Fosfluconazole is a water-soluble phosphate prodrug of fluconazole, which is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. May 30 2019
Cat.No. Product Name Information Added
S6472 Tinoridine hydrochloride Tinoridine hydrochloride is a non-steroidal anti-inflammatory drug with a potent antiperoxidative activity. May 30 2019
S6468 Trandolapril Trandolapril is a newly developed angiotensin-converting enzyme (ACE) inhibitor that is rapidly hydrolyzed mainly in the liver to its biologically active metabolite trandolaprilat. May 30 2019
S8823 ABX-1431 ABX-1431 is a highly potent, selective, and CNS-penetrant Monoacylglycerol lipase (MGLL) inhibitor with IC50 values of 14 nM and 27 nM for hMGLL and mMGLL respectively. May 30 2019
S6433 Udenafil Udenafil is a potent antagonist of human PDE5 with an IC50 of 8.25 nM and a comparable selectivity profile as sildenafil for the other PDEs. May 30 2019
S6455 Clebopride (malate) Clebopride is a dopamine antagonist drug and is used to treat functional gastrointestinal disorder such as nausea or vomiting. May 30 2019
S6452 Delavirdine (mesylate) Delavirdine Mesylate is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor. May 30 2019
S6453 Bicyclol Bicyclol is a drug that can improve liver function and inhibit HBV replication. May 30 2019
S6469 Thonzylamine Thonzylamine is an antihistamine and anticholinergic drug. May 30 2019
S6457 Flurbiprofen Axetil Flurbiprofen Axetil is one of the commonly used nonsteroidal anti-inflammatory drugs (NSAIDs) that nonselectively inhibits cyclooxygenase. May 30 2019
S6470 Fluralaner Fluralaner is a systemic insecticide and acaricide that is administered orally. May 30 2019
S6461 Permethrin Permethrin is a synthetic Type I pyrethroidal neurotoxic pesticide that has been responsible for accidental animal deaths. May 30 2019
S6358 Indole Indole is an aromatic heterocyclic organic compound widely distributed in the natural environment and can be produced by a variety of bacteria. May 16 2019
S6359 Purine Purine is a heterocyclic aromatic organic compound which plays crucial roles in DNA and RNA. It is also significant components in a number of other important biomolecules, such as ATP, GTP, cyclic AMP, NADH, and coenzyme A. May 16 2019
S6360 2-Hydroxypyridine 2-Hydroxypyridine is used in peptide synthesis. May 16 2019
S6361 3-Amino-4-hydroxybenzoic acid 3-Amino-4-hydroxybenzoic acid is a monohydroxybenzoic acid. May 16 2019
S6362 N-Acetyl-L-phenylalanine N-Acetyl-L-phenylalanine is a hazardous amphipathic metabolite of phenylalanine. May 16 2019
S6363 3-Hydroxybenzyl alcohol 3-Hydroxybenzyl alcohol is used as an intermediate to produce other chemicals. May 16 2019
S6364 1-Hydroxy-2-naphthoic acid 1-Hydroxy-2-naphthoic acid is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms. May 16 2019
S6366 Quinaldic acid Quinaldic acid is a product of l-tryptophan catabolism, via kynurenic acid, found in human urine. May 16 2019
S6367 3-Hydroxybenzoic acid 3-Hydroxybenzoic acid is used as an intermediate in the synthesis of plasticisers, resins, pharmaceuticals, etc. May 16 2019
Cat.No. Product Name Information Added
S6368 Benzylamine Benzylamine is a versatile intermediate and building block in a variety of applications. May 16 2019
S6369 Quinoline Quinoline is a heterocyclic aromatic organic compound used in the manufacture of dyes, the preparation of hydroxyquinoline sulfate and niacin. May 16 2019
S8795 FDL169 FDL169 is a CFTR corrector that is designed to fix and restore the function of the defective CFTR protein. May 16 2019
S8341 TAK-243 (MLN7243) TAK-243 (MLN7243) is a potent, mechanism-based small-molecule inhibitor of the ubiquitin activating enzyme (UAE) with an IC50 of 1 ± 0.2 nM in the UBCH10 E2 thioester assay. It has minimal inhibitory activity in a panel of kinase and receptor assays, as well as on human carbonic anhydrase type I and type II. May 16 2019
S8821 GSK3179106 GSK3179106 is a potent, selective, and gut-restricted pyridone hinge binder small molecule RET kinase inhibitor with a RET IC50 of 0.3 nM and is efficacious in vivo. May 16 2019
S8793 ULK-101 ULK-101 is a potent and selective ULK1 inhibitor with IC50 values of 8.3 nM and 30 nM for ULK1 and ULK2, respectively. May 16 2019
S8804 PF-06700841 PF-06700841 is a potent inhibitor of Tyk2 and Jak1 with IC50s of 23 nM, 17 nM, 77 nM for Tyk2, Jak1 and Jak2 respectively. It has appropriate in-family selectivity against JAK2 and JAK3. May 08 2019
S6422 Lazabemide Lazabemide is a reversible and selective inhibitor of monoamine oxidase B (MAO-B) with Ki value of 7.9 nM. May 08 2019
S6419 BT-11 BT-11 is an orally active lanthionine synthetase C-like 2 (LANCL2) binding compound for treating inflammatory bowel disease (IBD) (Kd value of 7.7 µM). May 08 2019
S6415 Azeliragon Azeliragon (TTP488) is an orally bioavailable small molecule that inhibits the receptor for advanced glycation endproducts (RAGE), which is an immunoglobulin-like cell surface receptor overexpressed in brain tissues of patients with AD. May 08 2019
S6429 Coniferyl alcohol May 08 2019
S6421 Diroximel Fumarete Diroximel Fumarete, also known as ALKS-8700, is a prodrug of monomethyl fumarate in a controlled-release formulation that rapidly and efficiently converts to MMF in the body. Apr 30 2019
S6423 Tildipirosin Tildipirosin is a 16-membered ring, tribasic and semi-synthetic macrolide antibiotic. Apr 30 2019
S6424 TAS-301 TAS-301 is an inhibitor of smooth muscle cell migration and proliferation and inhibits intimal thickening after balloon injury to rat carotid arteries. Apr 30 2019
S6425 JNJ 63533054 JNJ 63533054 is a potent and selective GPR139 agonist. It specifically activated human GPR139 in the calcium mobilization (EC50 = 16 ± 6 nM) and GTPγS binding (EC50 = 17 ± 4 nM) assays. Apr 30 2019
S6430 Nervonic acid Nervonic acid is a long chain unsaturated fatty acid that is enriched in sphingomyelin and may enhance the brain functions and prevent demyelination. Apr 30 2019
S6427 AZ876 AZ876 is a novel high-affinity Liver X Receptor (LXR) agonist with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively. Apr 30 2019
S6410 Clemizole Clemizole, a first-generation histamine receptor (H1) antagonist, is a potent inhibitor of behavioural and electrographic seizure activity. It has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels. Apr 30 2019
S6411 Nimorazole Nimorazole is a water soluble, 5-nitroimidazole compound with antibacterial and potential radiosensitizing activity. Apr 30 2019
S6413 fexaramine Fexaramine is a potent, selective farnesoid X receptor (FXR) agonist with an EC50 of 25 nM and it displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors. Apr 30 2019
Cat.No. Product Name Information Added
S6414 Apilimod Apilimod is a cell permeable small molecule that specifically inhibits PIKfyve with an IC50 of 14 nM in an in vitro kinase assay. It is also an inhibitor of IL-12/23 and shows no activity toward other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K isoforms. Apr 30 2019
S6417 GK921 GK921 is a transglutaminase 2 (TGase 2) inhibitor with an IC50 of 8.93 μM under a modified assay condition. Apr 30 2019
S6418 PF 429242 PF 429242 is known as a S1P inhibitor with an IC50 of 170 nM, showing no significant inhibition of trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, or furin at concentrations up to 100 μM and only modest inhibition of urokinase (IC50 = 50 μM) and factor Xa (IC50 = 100 μM). Apr 30 2019
S6431 Damascenone Damascenone is a potent flavor compound, possessing an extremely low odor threshold of 0.002 ppb in water. Apr 30 2019
S5944 Butenafine Butenafine is a synthetic benzylamine antifungal agent. Apr 24 2019
S8788 CH7057288 CH7057288 is a potent and selective TRK inhibitor with IC50 values of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB, and TRKC respectively. Apr 24 2019
S5939 Bendamustine Bendamustine is a nitrogen mustard drug used in the treatment of chronic lymphocytic leukemia (CLL), multiple myeloma, and non-Hodgkin's lymphoma. Apr 24 2019
S5938 Benazepril Benazepril is used to treat high blood pressure (hypertension), congestive heart failure, and chronic renal failure. Apr 24 2019
S8636 Selitrectinib(LOXO-195) Selitrectinib(LOXO-195) is an orally available, highly potent, and selective TRK kinase inhibitor with low nanomolar inhibitory activity against TRKA G595R, TRKC G623R, and TRKA G667C, IC50s ranging from 2.0 to 9.8 nmol/L. It is more than 1,000-fold selective for 98% of non-TRK kinases tested. Apr 24 2019
S8739 PLX51107 PLX51107 is as a novel BET inhibitor with modest preference for bromodomain-1 (BD1) versus bromodomain-2 (BD2) within each BET protein (Kd = 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1 and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively. Among non-BET proteins, PLX51107 shows significant interactions only with the bromodomains of CBP and EP300 (p300) (Kd in the 100 nM range). Apr 24 2019
S8791 Zanubrutinib (BGB-3111) Zanubrutinib (BGB-3111) is a potent, specific and irreversible BTK inhibitor that has been shown to have a lower off-target inhibitory activity on other kinases, including ITK, JAK3 and EGFR. Apr 24 2019
S6407 Tulobuterol hydrochloride Tulobuterol is a long-acting β2-adrenergic receptor agonist that has bronchodilatory, anti-inflammatory, and antiviral activities. Apr 24 2019
S6409 Zucapsaicin Zucapsaicin, the cis-isomer of capsaicin, is a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is also a TRPV-1 modulator. Apr 24 2019
S8822 Ligandrol (LGD-4033, VK-5211) Ligandrol (LGD-4033, VK-5211) is a novel nonsteroidal, oral selective androgen receptor modulator with high affinity (Ki of ∼1 nM) and selectivity. Apr 24 2019
S6288 Chlorhexidine diacetate Chlorhexidine diacetate is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. Apr 18 2019
S6293 2,4-Dihydroxybenzoic acid 2,4-Dihydroxybenzoic acid is a degradation product of cyanidin glycosides from tart cherries in cell cultures and a metabolite found in human plasma after cranberry juice consumption. Apr 18 2019
S6294 1,3,5-Trimethoxybenzene 1,3,5-Trimethoxybenzene is a potential biomarker of flavonoid intake in human. It is a human xenobiotic metabolite. Apr 18 2019
S6295 2-Methoxybenzoic acid 2-Methoxybenzoic acid is a flavouring agent. Apr 18 2019
S6297 4-Hydroxy-3-methylbenzoic acid 4-Hydroxy-3-methylbenzoic acid is a normal organic acid identified in urine specimens from a healthy population. Apr 18 2019
S6300 1,4-Dichlorobenzene 1,4-Dichlorobenzene is used as a disinfectant, pesticide, and deodorant. Apr 18 2019
Cat.No. Product Name Information Added
S6305 Catechol Catechol is an organic compound essentially used as building block. Apr 18 2019
S6307 2-Methyllactic acid 2-Methyllactic acid is a metabolite of methyl tertiary-butyl ether. Apr 18 2019
S6308 4-Ethylphenol 4-Ethylphenol is a phenolic compound produced in wine and beer by the spoilage yeast Brettanomyces. Apr 18 2019
S6309 Methylguanidine HCl Methylguanidine is a guanidine compound deriving from protein catabolism. Apr 18 2019
S6316 N-Acetyl-L-tyrosine N-Acetyl-L-tyrosine is an acetylated form of the amino acid, L-Tyrosine. It is involved in catecholamine production. Apr 18 2019
S6317 2-Picolinic acid methyl ester 2-Picolinic acid methyl ester (methyl picolinate) is used as pharmaceutical intermediate. Apr 18 2019
S6319 5-Methoxysalicylic acid 5-Methoxysalicylic acid is a chemical compound belongs to the class of organic compounds known as m-methoxybenzoic acids and derivatives. Apr 18 2019
S6320 2,5-Furandicarboxylic acid 2,5-Furandicarboxylic acid is a normal urinary metabolite in humans and an important renewable building block because of its potential as a substitute for a variety of petrochemicals, such as terephthalic acid and adipic acid. Apr 18 2019
S6323 2,6-Dimethoxybenzoic acid 2,6-Dimethoxybenzoic acid is a polyphenol compound found in foods of plant origin. Apr 18 2019
S6324 5-Methoxytryptamine 5-Methoxytryptamine is a tryptamine derivative that acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors. Apr 18 2019
S6326 D-3-Phenyllactic acid D-3-Phenyllactic acid is a chiral building block that is used in preparation of statine. Apr 18 2019
S6332 Nonadecanoic acid Nonadecanoic acid is a long saturated fatty acid found in ox fats and vegetable oils, and in Staphylococcus. It can be used as a phermone by certain insects. Apr 18 2019
S6333 Undecanedioic acid Undecanedioic acid is a long-chain dicarboxylic acid that has applications in corrosion inhibitors, hot melt adhesives, high performance polyamides/Nylon, and more. Apr 18 2019
S6335 Ethyl maltol Ethyl maltol is a common flavourant in some confectioneries. Apr 18 2019
S6338 3,4-Dihydroxyhydrocinnamic acid 3,4-Dihydroxyhydrocinnamic acid is a metabolite product of the hydrogenation of caffeoylquinic acids, occurring in normal human biofluids, with potent antioxidant properties. Apr 18 2019
S6339 Black PN Black PN is a black dye that provides a blackish violet shade in applications. Apr 18 2019
S6343 D-Glucuronic acid D-Glucuronic acid is a key intermediate metabolite of the uronic acid pathway and may plays a role in the detoxification of certain drugs. Apr 18 2019
S6344 Tetradecanedioic acid Tetradecanedioic acid is a C14 dicarboxylic acid. Apr 18 2019
S6348 (+)-Delta-Tocopherol Delta-Tocopherol is the orally bioavailable delta form of the naturally-occurring fat-soluble vitamin E, mostly found in soybean and corn oils, with potential antioxidant activity. Apr 18 2019
S6349 NADH, disodium salt hydrate NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle. Apr 18 2019
Cat.No. Product Name Information Added
S6352 Androsterone Androsterone is a steroid metabolite derived from sex hormones, which displays weak androgenic properties. Apr 18 2019
S6354 Ac-Arg-OH Ac-Arg-OH (N-Acetyl-L-arginine) is one of the guanidino compounds found elevated in the serum of an hemodialyzed renal insufficient (uremic) pediatric population. Apr 18 2019
S6355 Glycochenodeoxycholic acid sodium salt Glycochenodeoxycholic acid is a bile salt formed in the liver from chenodeoxycholic acid and glycine, usually found as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. Apr 18 2019
S6356 2-Methylsuccinic acid 2-Methylsuccinic acid is a normal metabolite found in human fluids. Apr 18 2019
S6357 1,5-Diaminopentane dihydrochloride 1,5-Diaminopentane (Cadaverine) is a foul-smelling diamine formed by bacterial decarboxylation of lysine that occurs during protein hydrolysis during putrefaction of animal tissue. Apr 18 2019
S6016 D-Proline D-proline is an isomer of the naturally occurring amino acid, L-Proline. Apr 18 2019
S6021 5-Methylcytosine 5-Methylcytosine, a methylated form of the DNA base cytosine, is a major epigenetic mark in the nuclear DNA in mammals and may be involved in the regulation of gene transcription. Apr 18 2019
S6054 Glycyl-L-leucine Glycyl-l-leucine is a dipeptide that appears to be a common substrate for glycyl-leucine dipeptidase. Apr 18 2019
S6056 N-Methylsarcosine N-Methylsarcosine is a natural N-methylated glycine that is used in the development of glycine-based ionic liquids and emulsifiers. Apr 18 2019
S6064 Acid Yellow 23 Acid Yellow 23 is a popular colorant for multiple applications, commonly used in ink, pond dyes, and textiles. Apr 18 2019
S6075 Nepsilon-Acetyl-L-lysine Nepsilon-Acetyl-L-lysine is an R-chain N-acetylated α amino acid used together with other lysine analogues to differentiate and characterized various aminoacylases and regulator 2 (Sir2) enzymes/sirtuins. Apr 18 2019
S6082 8-Aminooctanoic acid 8-Aminooctanoic acid is a chemical. Apr 18 2019
S6102 Thiamine pyrophosphate hydrochloride Thiamine pyrophosphate hydrochloride is a thiamine (vitamin B1) derivative which is produced by the enzyme thiamine diphosphokinase. It is a coenzyme of many enzymes, most of which occur in prokaryotes and is involved in the regulation of basic metabolism. Apr 18 2019
S6103 Inosine 5′-triphosphate trisodium salt Inosine 5′-triphosphate (ITP) is used in studies on the impact of deamination of ATP and GTP by various enzymes and chemical processes. Apr 18 2019
S6109 H-HoArg-OH H-HoArg-OH (L-Homoarginine) is an organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases. Apr 18 2019
S6116 N-Acetylornithine N-Acetylornithine is an intermediate in the enzymatic biosynthesis of the amino acid L-arginine from L-glutamate. It is a minor component of deproteinized blood plasma of human blood. Apr 18 2019
S6120 Glycyl-L-valine Glycyl-L-valine is a dipeptide composed of glycine and valine. It is an incomplete breakdown product of protein digestion or protein catabolism. Apr 18 2019
S6128 L-Homocitrulline L-Homocitrulline is an amino acid and a metabolite of ornithine in mammalian metabolism. Apr 18 2019
S6129 Aminomalonic acid Aminomalonic acid is an amino dicarboxylic acid. It has a role as a human metabolite and a Daphnia magna metabolite. Apr 18 2019
S6133 H-Gly-Pro-OH H-Gly-Pro-OH is a dipeptide composed of glycine and proline, and is an end product of collagen metabolism that is further cleaved by prolidase. The resulting proline molecules are recycled into collagen or other proteins. Apr 18 2019
Cat.No. Product Name Information Added
S6134 3-Aminoisobutyric acid 3-Aminoisobutyric acid (β-aminoisobutyric acid) is a product formed by the catabolism of thymine. Apr 18 2019
S6137 4-Guanidinobutanoic acid 4-Guanidinobutanoate is a normal metabolite present in low concentrations. Apr 18 2019
S6141 Anserine Anserine is a dipeptide containing β-alanine and 1-methylhistidine. It is normally absent from human tissues and body fluids, and its appearance there is an artifact of diet and serum carnosinase deficiency. Apr 18 2019
S6142 3-Amino-4-methylpentanoic acid 3-Amino-4-methylpentanoic acid is a human metabolite. Apr 18 2019
S6153 L-Leucyl-L-alanine Hydrate L-Leucyl-L-alanine is a dipeptide composed of L-leucine and L-alanine joined by a peptide linkage. It is a metabolite. Apr 18 2019
S6201 Malachite green Malachite green is a synthetic dyestuff and antimicrobial with potential carcinogenicity. Apr 18 2019
S6203 H-Abu-OH H-Abu-OH (2-Aminobutyric acid) is a non-proteinogenic alpha amino acid that is used by nonribosomal peptide synthases. Apr 18 2019
S6222 Ethyl potassium malonate Ethyl potassium malonate is used as a competitive inhibitor of the enzyme succinate dehydrogenase. It acts as a precursor to produce (trimethylsilyl)ethyl malonate, which is utilized to prepare beta-ketoesters by acylation and serves as an intermediate for the preparation of ethyl tert-butyl malonate. Apr 18 2019
S6224 (R)-Serine (R)-Serine is the R-enantiomer of serine, which is used in the biosynthesis of proteins. Apr 18 2019
S6270 2-Aminoisobutyric acid 2-Aminoisobutyric acid is a rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin. Apr 18 2019
S6276 Bicine Bicine is an organic compound used as a buffering agent. Apr 18 2019
S6290 D-Fructose-1,6-diphosphate trisodium salt octahydrate D-Fructose-1,6-diphosphate, a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. Apr 18 2019
S6302 L(-)-Pipecolinic acid L(-)-Pipecolinic acid is a normal human metabolite present in human blood. Apr 18 2019
S6306 Guanosine 5'-monophosphate disodium salt Guanosine 5′-monophosphate (GMP) is a ribonucleoside monophospate which upon phosphorylation to GTP becomes incorporated into ribonucleic acids (RNAs) by various RNA polymerase(s). Apr 18 2019
S6315 Sodium phytate hydrate Phytate (Phytic acid) functions as a storage depot and precursor for other inositol phosphates and pyrophosphates. It can be used clinically as a hypocalcemic agent and a complexing agent for removal of traces of heavy metal ions. Apr 18 2019
S6322 Pipecolic acid Pipecolic acid, a metabolite of lysine found in human physiological fluids such as urine, plasma and CSF, is an important regulator of immunity in plants and humans alike. Apr 18 2019
S6325 Adenosine 5′-diphosphate sodium salt Adenosine 5′-diphosphate (ADP) is an important organic compound in metabolism and is essential to the flow of energy in living cells. ADP can be interconverted to adenosine triphosphate (ATP) and adenosine monophosphate (AMP). Apr 18 2019
S6330 D(-)-2-Aminobutyric acid D(-)-2-Aminobutyric acid is an unnatural amino acid serving as an important intermediate in pharmaceutical production. Apr 18 2019
S6334 DL-Norvaline DL-Norvaline is an important pharmaceutical intermediate. Apr 18 2019
S6023 Creatine monohydrate Creatine is a key player in the phosphagen energy system, the primary source of ATP during short-term, high intensity activities. Apr 18 2019
Cat.No. Product Name Information Added
S6044 H-Tyr(3-I)-OH H-Tyr(3-I)-OH is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway. Apr 18 2019
S6083 DL-Dopa DL-Dopa is an immediate precursor of dopamine. Apr 18 2019
S6106 3-Chloro-L-tyrosine 3-Chloro-L-tyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. Apr 18 2019
S6115 Pyridoxal 5′-phosphate hydrate Pyridoxal 5′-phosphate, a vitamin B6 phosphate, is a coenzyme in a variety of enzymatic reactions. Apr 18 2019
S6230 Methyl 3-aminopyrazine-2-carboxylate Methyl 3-aminopyrazine-2-carboxylate is used in chemical synthesis. Apr 18 2019
S6253 H-D-Trp-OH H-D-Trp-OH is the D-enantiomer of tryptophan, which is an essential amino acid in the human diet. Apr 18 2019
S6266 (S)-Glutamic acid (S)-Glutamic acid (L-Glutamic acid) is an endogenous, non-selective glutamate receptor agonist. Apr 18 2019
S6310 N-(2-Acetamido)-2-Iminodiacetic acid N-(2-Acetamido)-2-Iminodiacetic acid is a biological buffer component and can be used as a pharmaceutical intermediate. Apr 18 2019
S6312 L-Threonic acid Calcium Salt L-Threonic acid Calcium Salt (Calcium threonate) is a calcium salt of threnoic acid. L-Threonic acid is a metabolite of ascorbic acid (vitamin C). Apr 18 2019
S8421 Fenebrutinib (GDC-0853) Fenebrutinib (GDC-0853) is a potent, selective, and non-covalent bruton's tyrosine kinase (BTK) inhibitor with an Ki value of 0.91 nM for Btk with >100-fold selectivity over 3 off-targets (Bmx :153-fold, Fgr: 168-fold, Src:131-fold). Apr 18 2019
S8810 SPHINX31 SPHINX31 is a SRPK1 inhibiror with an IC50 of 5.9 nM with highly selectivity for SRPK1 over SRPK2 (50-fold) and CLK1 (100-fold). Apr 18 2019
S8584 Theliatinib (HMPL-309) Theliatinib (HMPL-309) is a highly potent EGFR inhibitor with Ki value of 0.05 nM against the wild type EGFR and IC50 values of 3 nM and 22 nM against EGFR and EGFR T790M/L858R mutant. It demonstrats 50 fold greater selectivity for EGFR compared to 72 other kinases. Apr 18 2019
S6406 Ferrous fumarate Ferrous fumarate is the fumarate salt form of the mineral iron and is used in treatment of iron deficiency anemia. Apr 18 2019
S6408 Hexetidine Hexetidine is an anti-bacterial and anti-fungal agent with local anesthetic, astringent, deodorant and antiplaque activity. Apr 18 2019
S6233 Tartaric acid Tartaric acid is a white crystalline organic acid that occurs naturally in many plants, most notably in grapes. It has several applications for industrial and pharmaceutical use. Apr 11 2019
S6234 Pentadecanoic acid Pentadecanoic acid is a saturated fatty acid of exogenous (primarily ruminant) origin. It also has a role as a plant metabolite, a food component, a Daphnia magna metabolite, a human blood serum metabolite and an algal metabolite. Apr 11 2019
S6235 Sodium dehydroacetate Sodium dehydroacetate is the sodium salt of dehydroacetic acid, a fungicide and bactericide that is commonly used as a food preservative. Sodium dehydroacetate is a preservative that is used in the formulation of cosmetics and personal care products in order to extend the shelf-life by preventing microbial contamination. Apr 11 2019
S6237 2-Ketoglutaric acid 2-Ketoglutaric acid, also known as alpha-ketoglutarate and AKG, is a key molecule in the TCA cycle, playing a fundamental role in determining the overall rate of this important metabolic process. In the TCA cycle, AKG is decarboxylated to succinyl-CoA and carbon dioxide by AKG dehydrogenase, which functions as a key control point of the TCA cycle. Apr 11 2019
S6241 β-D-Glucose pentaacetate β-D-Glucose pentaacetate is an enantiomer of D-glucose pentaacetate. Apr 11 2019
S6242 2,4-Dichlorophenol 2,4-Dichlorophenol is the precursor to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). Apr 11 2019
Cat.No. Product Name Information Added
S6245 N-Acetylglutamic acid N-Acetylglutamic acid is the first intermediate involved in the biosynthesis of arginine in prokaryotes and simple eukaryotes and a regulator in the process known as the urea cycle that converts toxic ammonia to urea for excretion from the body in vertebrates. Apr 11 2019
S6247 Senecioic acid Senecioic acid is an unsaturated fatty acid found in the pheromones of mealybug species and appears in the urine of patients with 3-Methylcrotonic aciduria. Apr 11 2019
S6249 Picolinic acid (PCL 016) PCL016 is a pyridine carboxylate metabolite of tryptophan and acts as an anti-infective and immunomodulator. It acts by binding with the zinc associated with zinc finger proteins to alter their structure and inhibit function. Apr 11 2019
S6251 Terephthalic acid Terephthalic acid, a raw material for polyethylene terephthalate (PET) production, is one of the most important chemicals in petrochemical industry. Apr 11 2019
S6252 3-Hydroxypicolinic acid 3-Hydroxy picolinic acid is a picolinic acid derivative and is a member of the pyridine family. It is used as a matrix for nucleotides in MALDI mass spectrometry analyses Apr 11 2019
S6254 Hydrocinnamic acid Hydrocinnamic acid is a substrate of the enzyme oxidoreductases in the pathway phenylalanine metabolism (KEGG). It is an antifungal agent and a metabolite. Apr 11 2019
S6256 Isocytosine Isocytosine (2-aminouracil) is an isomer of cytosine used in physical chemical studies involving metal complex binding, hydrogen-bonding, and tautomerism and proton transfer effects in nucleobases. Apr 11 2019
S6257 N-Acetylglucosamine N-Acetylglucosamine is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. It may be helpful for the treatment of autoimmune diseases. Apr 11 2019
S6259 Ureidosuccinic acid Ureidosuccinic acid is an intermediary product in pyrimidine biosynthesis. Apr 11 2019
S6261 2-Acetylpyrazine 2-Acetylpyrazine is one of the volatile flavor constituents in popcorn, wheat and rye bread crust. Apr 11 2019
S6262 Ammonium formate Ammonium Formate is the ammonium salt of formic acid. It is widely used in various organic reactions. Apr 11 2019
S6267 Dodecanedioic acid Dodecanedioic acid is a dicarboxylic acid mainly used in antiseptics, top-grade coatings, painting materials, corrosion inhibitors, surfactants, and engineering plastics. Apr 11 2019
S6269 Leucomalachite green Leucomalachite green is a chief metabolite of malachite green, a triphenylmethane dye. It is one of the most commonly used reagents for presumptive blood test and gives a characteristic green color in the presence of blood. Apr 11 2019
S6271 (S)-2-Hydroxy-3-phenylpropanoic acid (S)-2-Hydroxy-3-phenylpropanoic acid is a valuable building block in the pharmaceutical and chemical industry—has recently emerged as an important monomer in the composition of the novel degradable biocompatible material of polyphenyllactic acid. Apr 11 2019
S6272 Glycolic acid Glycolic acid (or hydroxyacetic acid) is the smallest alpha-hydroxy acid. Due to its excellent capability to penetrate skin, glycolic acid is often used in skin care products, most often as a chemical peel. Apr 11 2019
S6273 2-(4-Methoxyphenyl)acetic acid 2-(4-Methoxyphenyl)acetic acid is a 4-O-Methylated catecholamine metabolite found in normal human urine, cerebrospinal fluid and brain tissue. Apr 11 2019
S6280 Methyl 3-indolyacetate Methyl 3-indolyacetate is a phytohormone. Apr 11 2019
S6281 Sodium Thiocyanate Sodium Thiocyanate, one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals. Apr 11 2019
S6283 3,3-Dimethylglutaric acid 3,3-Dimethylglutaric acid is a compound that has occasionally found in human urine. Apr 11 2019
S6284 Tetraethylammonium bromide Tetraethylammonium bromide is used as the source of tetraethylammonium ions in pharmacological and physiological studies, but is also used in organic chemical synthesis. It blocks selective potassium channels. Apr 11 2019
Cat.No. Product Name Information Added
S6285 6-Hydroxynicotinic acid 6-Hydroxynicotinic acid is widely used in the manufacture of industrial products. Apr 11 2019
S6286 Tricarballylic acid Tricarballylic acid is an inhibitor of aconitase and therefore interferes with the Krebs cycle. Apr 11 2019
S4755 lanosterol Lanosterol is a tetracyclic triterpenoid and is the compound from which all animal and fungal steroids are derived. By contrast plant steroids are produced via cycloartenol. Apr 11 2019
S6404 Salicylamide Salicylamide is a non-prescription drug with analgesic and antipyretic properties. Apr 11 2019
S6403 Chloramine-T Chloramine-T is a N-chlorinated and N-deprotonated sulfonamide used as a biocide and a mild disinfectant. Apr 11 2019
S6405 Octisalate Apr 11 2019
S8296 dBET1 dBET1 is a CRBN-based BET degrader with an IC50 of 20 nM, showing highly selectivity. Out of 7,429 proteins, only the expression of the oncoproteins MYC and PIM1, as well as BRD2, BRD3 and BRD4 are significantly downregulated by dBET1 treatment. Apr 11 2019
S6096 5-Phenylvaleric Acid 5-Phenylvaleric acid is a Pentanoic acid of bacterial origin, occasionally found in human biofluids. Apr 11 2019
S6097 3-Furoic acid 3-Furoic acid is an organic acid regularly occurring in urine of healthy individuals. Apr 11 2019
S6098 2-Hydroxy-3-methylbutanoic acid 2-Hydroxy-3-methylbutanoic acid is a metabolite found in the urine of patients with phenylketonuria, methylmalonic acidemia, propionic acidemia, 3-ketothiolase deficiency, isovaleric acidemia, 3-methylcrotonylglycemia, 3-hydroxy-3-methylglutaric acidemia, multiple carboxylase deficiency, glutaric aciduria, ornithine transcarbamylase deficiency, glyceroluria, tyrosinemia type I, galactosemia, and maple syrup urine disease. Apr 11 2019
S6101 Solvent Blue 35 Solvent Blue 35 is a member of the Sudan family of hydrophobic fat-staining dyes, predominantly used for staining triglycerides in animal tissues (frozen sections). Apr 11 2019
S6105 trans-3-Indoleacrylic acid trans-3-Indoleacrylic acid is a metabolite of tryptophan. Apr 11 2019
S6110 2-Methylpentanedioic acid 2-Methylglutaric acid is a metabolite of succinic acid, a citric acid cycle intermediate. Apr 11 2019
S6111 L-Hydroorotic acid L-Dihydroorotic acid is an intermediate in the metabolism of Pyrimidine. It is a substrate for Dihydroorotate dehydrogenase (mitochondrial). Apr 11 2019
S6113 Tridecanoic acid Tridecanoic acid is a 13-carbon saturated fatty acid found in many foods, some of which are nutmeg, muskmelon, black elderberry, and coconut. Apr 11 2019
S6114 D-Arabitol D-Arabitol is a water soluble sugar alcohol. Apr 11 2019
S6121 Maltotriose Maltotriose is a trisaccharide consisting of three glucose molecules linked with α-1,4 glycosidic bonds. It is a common oligosaccharide metabolite found in human urine after maltose ingestion or infusion. Apr 11 2019
S6123 DL-Benzylsuccinic acid DL-Benzylsuccinic acid is a bacterial xenobiotic metabolite. Apr 11 2019
S6126 Beclometasone dipropionate Apr 11 2019
S6127 5-Hydroxymethyluracil 5-Hydroxymethyluracil (5hmU) is a thymine base modification found in the genomic DNA of diverse organisms ranging from bacteriophages to mammals Apr 11 2019
Cat.No. Product Name Information Added
S6131 2-Oxo-3-phenylpropanoic acid 2-Oxo-3-phenylpropanoic acid (Phenylpyruvic acid) is used in the synthesis of 3-phenyllactic acid (PLA) by lactate dehydrogenase. Apr 11 2019
S6132 All trans-Retinal All trans-Retinal, a component of the retinoid cycle, is converted to retinoic acid in vivo by the action of retinal dehydrogenase. Retinoic acid is a ligand for both RAR and RXR. All trans-retinal ias a potent photosensitizer. Apr 11 2019
S6138 5-Methylcytidine 5-Methylcytidine is a modified nucleoside derived from 5-methylcytosine. It is found in ribonucleic acids of animal, plant, and bacterial origin. Apr 11 2019
S6139 Piperonyl acetone Piperonyl acetone is a food additive used in food flavouring. Apr 11 2019
S6140 16-Dehydroprogesterone 16-Dehydroprogesterone is a chemical derived from a progesterone. Apr 11 2019
S6143 Ureidopropionic acid Ureidopropionic acid is an intermediate in the metabolism of uracil. Apr 11 2019
S6144 O-Acetylserine O-Acetylserine is an intermediate in the biosynthesis of the common amino acid cysteine in bacteria and plants. Apr 11 2019
S6146 Glycoursodeoxycholic acid Glycoursodeoxycholic acid is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environment. Apr 11 2019
S6147 Hexadecanedioic acid Hexadecanedioic acid is a common saturated fatty acid found in animals, plants and microorganisms. It has antitumor activity. Apr 11 2019
S6152 Acid Red 27 Acid Red 27 is a modified red azo dye used as a food dye and to color cosmetics. Apr 11 2019
S6154 2-Hydroxyphenylacetic acid 2-Hydroxyphenylacetic acid is a substrate of the enzyme oxidoreductases in the pathway styrene degradation. Apr 11 2019
S6155 L-Tryptophanamide Hydrochloride L-tryptophanamide is an amino acid amide that is the carboxamide of L-tryptophan. Apr 11 2019
S6156 5-Methyluridine 5-Methyluridine is a pyrimidine nucleoside that acts as an human endogenous metabolite. Apr 11 2019
S6157 Benzyldimethylstearylammonium Chloride Hydrate Benzyldimethylstearylammonium Chloride Hydrate is a chemical with mild odor. Apr 11 2019
S6158 Acid orange 7 Acid orange 7 is an azo dye used for dyeing wool. Apr 11 2019
S6159 Food Yellow 3 Food Yellow 3 is an azo dye that is useful in fermented foods which must be heat treated. Apr 11 2019
S6160 3,5-Dihydroxybenzoic acid 3,5-Dihydroxybenzoic acid is a primary metabolite of alkylresinols which has been hydrolyzed by liver enzymes during phase I metabolism after several cycles of beta oxidation. Apr 11 2019
S6165 Erythrosine B Erythrosine B is cherry or melon-pink synthetic, primarily used for food coloring. Apr 11 2019
S6168 trans-trans-Muconic acid trans-trans-Muconic acid is a metabolite of benzene in humans. Apr 11 2019
S6169 3-Methyladipic acid 3-Methyladipic acid is a metabolite of the catabolism of phytanic acid. Apr 11 2019
Cat.No. Product Name Information Added
S6170 Benzyldodecyldimethylammonium Chloride Dihydrate Benzyldodecyldimethylammonium Chloride Dihydrate is a chemical. Apr 11 2019
S6171 trans-β-Hydromuconic acid trans-β-Hydromuconic acid is a normal human unsaturated dicarboxylic acid metabolite with increased excretion in patients with Dicarboxylic aciduria caused by fatty acid metabolism disorders. Apr 11 2019
S6172 Brucine sulfate heptahydrate Brucine is an alkaloid that acts as an antagonist at glycine receptors and paralyzes inhibitory neurons. Apr 11 2019
S6175 1,5,5-Trimethylhydantoin 1,5,5-Trimethylhydantoin is a chemical. Apr 11 2019
S6178 DL-6,8-Thioctamide DL-6,8-Thioctamide is used for protecting liver and health care products. Apr 11 2019
S6180 L-Gulose L-Gulose is an unnatural monosaccharide that exists as a syrup with a sweet taste. It is an L-hexose sugar and an intermediate in the biosynthesis of L-Ascorbate (vitamin C). Apr 11 2019
S6181 N-Isovaleroylglycine N-Isovaleroylglycine is an acyl glycine that is normally minor metabolites of fatty acids. Apr 11 2019
S6182 L-Gulono-1,4-lactone L-Gulono-1,4-lactone is the substrate of the enzyme L-gulono-1,4-lactone oxidoreductase, which catalyzes the last step of the biosynthesis of L-ascorbic acid (vitamin C) in plants and animals. Apr 11 2019
S6183 2-Hydroxy-2-methylbutanoic acid 2-Hydroxy-2-methylbutyric acid is an unusual metabolite found in the urine of patients with 2-hydroxyglutaric aciduria and maple syrup urine disease. 2-Hydroxy-2-methylbutyric acid is also a secondary metabolite found in human urine after exposure to the gasoline additive tert-amyl-Me-ether (TAME). Apr 11 2019
S6184 N-Methylhydantoin N-Methylhydantoin is a small molecular weight polar substance, the product of degradation of creatinine by bacteria. It is an unexpected metabolite of the intelligence-affecting substance dupracetam. Apr 11 2019
S6188 p-Toluenesulfonic acid monohydrate p-Toluenesulfonic acid is an extremely strong acidic compound. Apr 11 2019
S6189 Acid Yellow 36 Acid Yellow 36 is a dye of the azo class and used as a pH indicator and it has a color change from red to yellow between pH 1.2 and 2.3. Apr 11 2019
S6190 Isethionic acid sodium salt Isethionic acid sodium salt is an amphoteric detergent used in detergent bar soaps. Apr 11 2019
S6191 Sudan I Sudan I is an azo dye. It causes tumors in the liver or urinary bladder in rats, mice, and rabbits and may be a potential carcinogen for humans. Apr 11 2019
S6194 Chitin Chitin is a large, structural polysaccharide found in the exoskeletons of insects, the cell walls of fungi, and certain hard structures in invertebrates and fish. Apr 11 2019
S6196 4-Nitrophenol 4-Nitrophenol is a phenolic compound that can be used as a pH indicator and an intermediate in the synthesis of paracetamol. Apr 11 2019
S6197 Dimethylamine hydrochloride Dimethylamine is a precursor to several industrially significant compounds. Apr 11 2019
S6202 Butylated hydroxytoluene Butylated hydroxytoluene is a lipophilic organic compound that is useful for its antioxidant properties. Apr 11 2019
S6205 N-Acetyl-L-methionine N-Acetyl-L-methionine is an L-methionine derivative that is nutritionally and metabolically equivalent to L-methionine. It is a superior ROS scavenger. Apr 11 2019
S6210 Ethanolamine hydrochloride Ethanolamine is a viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. Apr 11 2019
Cat.No. Product Name Information Added
S6215 Phthalic acid Phthalic acid is an aromatic dicarboxylic acid. It is a human xenobiotic metabolite. Apr 11 2019
S6217 o-Toluic acid o-Toluic acid is an aromatic dicarboxylic acid. It is a human xenobiotic metabolite. Apr 11 2019
S6218 Sodium lauryl sulfate Sodium lauryl sulfate is an anionic detergent and surfactant found in many personal care products. Apr 11 2019
S6219 β-Alanine methyl ester hydrochloride β-Alanine ethyl ester is the ethyl ester of the non-essential amino acid β-alanine. Apr 11 2019
S6220 Octanedioic acid Octanedioic acid is a dicarboxylic acid used in drug syntheses and plastics manufacture. Apr 11 2019
S6227 Acrylamide monomer Acrylamide is a neurotoxic monomer with extensive industrial applications. It could be used as a precursor to polyacrylamides. Apr 11 2019
S6228 Indole-2-carboxylic acid Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Apr 11 2019
S6229 Lauryl gallate Lauryl gallate is the ester of dodecanol and gallic acid that exhibits both potent chain-breaking and preventive antioxidant activity. Apr 11 2019
S6231 Methyl nicotinate Methyl nicotinate is an ester of methyl alcohol and nicotinic acid. It is a rubefacient. Apr 11 2019
S6232 Methylamine hydrochloride Methylamine is used as a building block for the synthesis of many other commercially available compounds. Apr 11 2019
S5945 Alverine Alverine is a smooth muscle relaxant. Apr 03 2019
S5940 Bepotastine Bepotastine is a non-sedating, selective antagonist of the histamine 1 (H1) receptor that is indicated in allergic rhinitis, urticaria, and pruritus associated with skin disease. Apr 03 2019
S5947 Amitriptyline Amitriptyline is a tricyclic antidepressant (TCA) with analgesic properties, widely used to treat depression and neuropathic pain. Apr 03 2019
S5936 Cefazolin Cefazolin is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine. Apr 03 2019
S6401 (1,5-dimethylhexyl)ammonium chloride (1,5-dimethylhexyl)ammonium chloride is used as a systemic acidifying agent in treatment of severe metabolic alkalosis, in oral acid loading test to diagnose distal renal tubular acidosis, to maintain the urine at an acid pH in the treatment of some urinary-tract disorders. Apr 03 2019
S6402 2-Aminoethanethiol 2-Aminoethanethiol (cysteamine) is a radiation-protective agent that oxidizes in air to form cystamine. Apr 03 2019
S8760 Iberdomide(CC220) Iberdomide (CC-220) is a novel oral immunomodulatory compound that targets cereblon, part of the CRL4CRBN E3 ubiquitin ligase complex, with an IC50 of 60 nM in a competitive TR-FRET assay. Apr 03 2019
S8807 PFK158 PFK158 is a potent and selective inhibitor of PFKFB3. It has improved PK properties and causes ~80% growth inhibition in several mouse models of human-derived tumors. Apr 03 2019
S6006 Imidazole Imidazole is a heterocyclic aromatic organic compound. It can be incorporated into many important biological molecules and acts as a corrosion inhibitor for industrial applications. Apr 03 2019
S6007 Bisphenol A Bisphenol A is a starting material for the synthesis of plastics, primarily certain polycarbonates and epoxy resins, as well as some polysulfones and certain niche materials. It exhibits estrogen-mimicking, hormone-like properties. Apr 03 2019
Cat.No. Product Name Information Added
S8780 AZD3229 AZD3229 is a potent, pan-KIT mutant inhibitor with potent single digit nM growth inhibition against a diverse panel of mutant KIT driven Ba/F3 cell lines (GI50=1-50 nM), with good margin to KDR-driven effects. It also inhibits PDGFR mutants (Tel-PDGFRα, Tel-PDGFRβ, V561D/D842V). Apr 03 2019
S7564 SAR125844 SAR125844 is a potent intravenously active and highly selective MET kinase inhibitor, displaying nanomolar activity against the wild-type kinase (IC50 value of 4.2 nmol/L) and H1094Y, Y1235D, M1250T, L1195V, and D1228H kinase domain mutants (IC50 values of 0.22, 1.7, 6.5, 65, and 81 nmol/L, respectively). Apr 03 2019
S6010 Sodium L-lactate Sodium L-lactate is used as a food additive, preservative, acidity regulator and bulking agent. Apr 03 2019
S6013 3-Methoxyphenylacetic acid 3-Methoxyphenylacetic acid is a monocarboxylic acid. Apr 03 2019
S6014 Isonicotinic acid Isonicotinic acid is a metabolite of isoniazid. It is an isomer of nicotinic acid. Apr 03 2019
S6015 Benzylcetyldimethylammonium chloride hydrate Benzylcetyldimethylammonium chloride hydrate is a chemical. Apr 03 2019
S6020 Potassium thioacetate Potassium thioacetate is widely used as a sulfur source in the synthesis of sulfur-containing organic compounds. It has been employed for the synthesis of heterocycles, polymers, transition-metal ligands, nanoparticles, bioactive compounds and macromolecular inclusion complexes. Apr 03 2019
S6022 Cyclohexaneacetic acid Cyclohexaneacetic acid is a flavouring ingredient. Apr 03 2019
S6025 3-Methoxybenzoic acid 3-Methoxybenzoic acid is a food additive that acts as a flavouring ingredient. Apr 03 2019
S6027 D-(−)-Pantolactone D-(−)-Pantolactone is the degradation product of pantothenic acid, which is a water-soluble essential vitamin. Apr 03 2019
S6048 3-Oxopentanedioic acid 3-Oxopentanedioic acid is an intermediate for organic compound synthesis. Apr 03 2019
S6028 α-D-Glucose anhydrous Alpha-D-Glucose is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is an intermediate in glycolysis/gluconeogenesis pathway. Apr 03 2019
S6030 3-(3-Methoxyphenyl)propionic acid 3-(3-Methoxyphenyl)propionic acid is a naturally occurring human metabolite, It is an organic acid and excreted in human urine. Apr 03 2019
S6031 2,6-Dihydroxybenzoic acid 2,6-Dihydroxybenzoic acid is a phenolic compound which is known to have poor biological performance such as DPPH scavenging activity and microbial growth inhibition. Apr 03 2019
S6032 2-Aminobenzenesulfonic acid 2-Aminobenzenesulfonic acid is a biological acid with roles in benzoate degradation and microbial metabolism in diverse environments. Apr 03 2019
S6033 Azo Rubine Azo Rubine is an synthetic red food dye and is used for the purposes where food is heat-treated after fermentation. Apr 03 2019
S6034 p-Benzoquinone p-Benzoquinone has multiple functions, exhibiting properties of a ketone, an oxidant and an alkene. Apr 03 2019
S6035 2-Naphthol 2-Naphthol, a potential antinematodal drug, is a widely used intermediate for the production of dyes and other compounds. Apr 03 2019
S6042 Trimethylamine N-oxide dihydrate Trimethylamine N-oxide dihydrate, a product of the oxidation of trimethylamine, is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays. Apr 03 2019
S6046 (S)-Leucic acid Leucic acid is a metabolite of the branched chain amino acid known as leucine, which plays a significant role in the synthesis of muscle protein. Apr 03 2019
Cat.No. Product Name Information Added
S6050 1,3-Dimethyluracil 1,3-Dimethyluracil is a methyl derivative of uric acid, found occasionally in human urine. Apr 03 2019
S6051 Phenyl-ac-Gly-OH Phenyl-ac-Gly-OH (Phenylacetylglycine) is one of acyl glycines that are normally minor metabolites of fatty acids. Apr 03 2019
S6052 Saccharin sodium salt hydrate Saccharin is an artificial sweetener with effectively no food energy. Apr 03 2019
S6053 Phenylglyoxylic acid Phenylglyoxylic acid is a key building block in the field of chemical synthesis and is widely used to synthesize pharmaceutical intermediates or food additives. Apr 03 2019
S6063 1,11-Undecanedicarboxylic acid 1,11-Undecanedicarboxylic acid is an unusual odd-numbered dicarboxylic acid that appears in the urines of children with neonatal adrenoleukodystrophy and Zellweger syndrome, as an additional marker of these peroxisomal disorders. Apr 03 2019
S6065 Congo Red Congo Red is an indicator dye that is blue-violet at pH 3.0 and red at pH 5.0. It is an acid dye used in testing for hydrochloric acid in gastric contents but has carcinogenic properties. Apr 03 2019
S6066 Methyl 4-aminobutyrate HCl Methyl 4-aminobutanoate is a methyl ester resulting from the formal condensation of gamma-aminobutyric acid with methanol. Apr 03 2019
S6067 2,4-dichlorobenzyl alcohol 2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections. Apr 03 2019
S6068 Doxycycline monohydrate Doxycycline is a synthetic, broad-spectrum tetracycline antibiotic exhibiting antimicrobial activity. Apr 03 2019
S6069 trans-4-Hydroxycyclohexanecarboxylic Acid trans-4-Hydroxycyclohexanecarboxylic acid is used as an organic intermediate. Apr 03 2019
S6073 Diclofenac acid Diclofenac acid is a nonsteroidal anti-inflammatory drug that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. It inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) with relative equipotency. Apr 03 2019
S6074 3-(3-Hydroxyphenyl)propionic Acid 3-(3-Hydroxyphenyl)propionic acid is one of the major metabolites of ingested caffeic acid and of the phenolic degradation products of proanthocyanidins by the microflora in the colon. Apr 03 2019
S5847 Ethacrynate Sodium Ethacrynate Sodium is the sodium salt form of ethacrynic acid, which inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. Apr 03 2019
S6077 Cytidine 5′-triphosphate (disodium salt) Cytidine 5'-triphosphate is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases. Apr 03 2019
S6081 5-Hydroxymethyl-2-furancarboxylic acid 5-Hydroxymethyl-2-furancarboxylic acid is the main metabolite of 5-hydroxymethyl-2-furfural, a product of acid-catalyzed degradation of sugars during the heating and storage of foods that influences taste and physiological functions in the body. Apr 03 2019
S6088 6-(Dimethylamino)purine 6-Dimethylaminopurine is a serine threonine protein kinase inhibitor. It inhibits the germinal vesicle breakdown and the meiotic maturation of oocytes. Apr 03 2019
S6091 Glycodeoxycholic acid sodium salt Glycochenodeoxycholic acid (GCDC) is a bile salt that is used as an anionic detergent to solubilize lipids. Apr 03 2019
S6092 cis,cis-Muconic acid cis,cis-Muconic acid is a polyunsaturated dicarboxylic acid that can be produced renewably via the biological conversion of sugars and lignin-derived aromatic compounds. Apr 03 2019
S6094 Imidazole-4(5)-acetic Acid Hydrochloride Imidazole-4(5)-acetic Acid Hydrochloride is a competitive antagonist at GABAC receptors. Apr 03 2019
S6095 Quinoline-4-carboxylic acid Quinoline-4-carboxylic acid is a very important structure in a synthetic medicinal chemistry. Apr 03 2019
Cat.No. Product Name Information Added
S8753 INCB054329(INCB-054329,INCB-54329) INCB054329(INCB-054329; INCB-54329) is a structurally distinct bromodomain and extraterminal domain (BET) inhibitor with IC50 values of 44 nM, 5 nM, 9 nM, 1 nM, 28 nM, 3 nM, 119 nM and 63 nM for BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, BRDT-BD1 and BRDT-BD2, respectively. Apr 03 2019
S8762 dBET6 dBET6 is a highly cell-permeable degrader of BET bromodomains with an IC50 of 14 nM for BRD4 binding. Mar 27 2019
S5849 Cariprazine HCl Cariprazine, a novel second-generation antipsychotic, is a D3-preferring dopamine D2/D3 receptor partial agonist. Mar 27 2019
S5943 Bromhexine Bromhexine is an expectorant/mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus Mar 27 2019
S5946 Argireline Argireline is an innovative neuropeptide widely applied topically on the skin. Mar 27 2019
S5941 Besifloxacin Besifloxacin is a fourth generation fluoroquinolone-type opthalmic antibiotic for the treatment of bacterial conjunctivitis. Mar 27 2019
S6400 Glucosamine Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. It is commonly used as a treatment for osteoarthritis. Mar 27 2019
S8787 GSK'547 GSK'547 is a highly selective and potent inhibitor of RIP1 (RIPK1) exhibiting a 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK'963 Mar 27 2019
S5942 Bisoprolol Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. Mar 27 2019
S6282 1-Methyl-2-pyrrolidone 1-Methyl-2-pyrrolidone is a highly refined solvent and intended for use in biological, proteomics, and other sensitive assays. Mar 27 2019
S6287 3-Methylbutanoic acid 3-Methylbutanoic acid is a natural fatty acid found in a wide variety of plants and essential oils. It has a strong pungent cheesy or sweaty smell, but its volatile esters have pleasing scents and are used widely in perfumery. Mar 27 2019
S6296 Octanoic acid Octanoic acid is found naturally in the milk of various mammals, and as a minor constituent of coconut oil and palm kernel oil. It is used in the production of esters used in perfumery and also in the manufacture of dyes. Mar 27 2019
S6298 2,5-Dimethyl-2,3-dihydrofuran-3-one 2,5-Dimethyl-2,3-dihydrofuran-3-one is a chemical. Mar 27 2019
S6299 Methyl cyclohexanecarboxylate Methyl cyclohexanecarboxylate is a flavouring ingredient and is used as a material for chemical synthesis. Mar 27 2019
S6303 trans-2-Hexenal Trans-2-hexenal is an α,β-unsaturated carbonyl compound protecting plants against harmful substances. Mar 27 2019
S6311 Dimethyl Trisulfide Dimethyl trisulfide (DMTS) is an organic chemical compound and the simplest organic trisulfide. Mar 27 2019
S6313 Thiolactic Acid Thiolactic acid is a carboxylic acid like lactic acid and is predominantly used in cosmetic applications and hair permanent waving formulations. Mar 27 2019
S6314 Bis(2-methyl-3-furyl)disulphide Bis(2-Methyl-3-furyl) disulfide is a volatile sulfur compound that is a key contributor to the meat-like aroma in cooked meat. Mar 27 2019
S6321 2-Phenylpropionic acid 2-Phenylpropionic acid is an intermediate in alpha-Methylstyrene (2-phenylpropylene) metabolism. Mar 27 2019
S6327 trans-2-Methyl-2-pentenoic Acid 2-methyl-2-pentenoic acid, also known as strawberry acid, has a sweet berry-like aroma and flavor and is widely used in food flavor. Mar 27 2019
Cat.No. Product Name Information Added
S6328 2-Methylvaleraldehyde 2-Methylvaleraldehyde is a flavouring ingredient. Mar 27 2019
S6329 2-Oxobutanoic acid 2-Oxobutanoic acid is a substance that is involved in the metabolism of many amino acids as well as propanoate metabolism and C-5 branched dibasic acid metabolism. Mar 27 2019
S6331 m-Cresol m-Cresol is an isomer of p-cresol and o-cresol. m-Cresol, p-cresol and m/p-cresol mixtures are absorbed across the respiratory and gastrointestinal tracts and through the skin, and are distributed throughout the body. They are corrosive to the skin and may cause serious damage to the eyes. m-Cresol is used as an intermediate in the production of other chemicals. Mar 27 2019
S6341 3-(Methylthio)propionic acid 3-(Methylthio)propionic acid is a thia fatty acid acid consisting of propionic acid with a methylthio substituent at the 3-position and an intermediate in mammalian methionine metabolism in vitro. Mar 27 2019
S6342 Glycerol Tri-n-octanoate Glycerol Tri-n-octanoate is a well-known raw material largely used in cosmetic products. Mar 27 2019
S5887 Khellin Khellin, a compound isolated from the seeds of Ammi Visnaga Lam (Umbelliferae), is used to treat a variety of maladies. Mar 27 2019
S5948 Amodiaquine Amodiaquine is a synthetic aminoquinoline that acts by binding to the protozoal or parasitic DNA and preventing DNA and RNA production and subsequent protein synthesis. It is used for the therapy of malaria. Mar 27 2019
S9564 p-Hydroxy-cinnamic Acid Mar 26 2019
S6225 10-Undecen-1-ol 10-Undecen-1-ol is used as a flavoring agent. Mar 26 2019
S6226 4-Methyl-2-pentanone 4-Methyl-2-pentanone is an organic solvent used in industry. Mar 26 2019
S6236 Cyclohexanone Cyclohexanone is an industrially important intermediate in the synthesis of materials such as nylon. Mar 26 2019
S6238 2-Methyl-1-propanol 2-Methyl-1-propanol is widely used as an solvent for chemical reaction and an useful material for organic synthesis. Mar 26 2019
S6243 Ethyl pyruvate Ethyl pyruvate is a simple aliphatic ester of pyruvic acid and has been shown to have robust neuroprotective effects via its anti-inflammatory, anti-oxidative, and anti-apoptotic functions. Mar 26 2019
S6244 Iso-Valeraldehyde Iso-Valeraldehyde, a normal component of the chemical profile of cheddar cheese, spirits (beer, rum, sake, wine), is used as a reagent for the production of pharmaceuticals and pesticides. Mar 26 2019
S6246 Pyrrolidine Pyrrolidine is a saturated heterocycle and a flavouring agent which could be found in the leaves of tobacco and carrot naturally. Mar 26 2019
S6250 L-Lactic acid L-Lactic acid is a natural product that is used as a food additive. Mar 26 2019
S6255 3-Methyl-1-butanol 3-Methyl-2-butanol is a flavouring ingredient. It is found in apple, cider, grape, honey, wine, orange juice and strawberry. Mar 26 2019
S6258 1,2-Propanediol 1,2-Propanediol (Propylene glycol) is a synthetic liquid substance that is commonly used as an excipient in a variety of drugs and it is also authorised in food products and cosmetics. Mar 26 2019
S6260 (S)-(−)-α-Methylbenzylamine Mar 26 2019
S6263 Glycerol Tributyrate Mar 26 2019
Cat.No. Product Name Information Added
S6265 γ-caprolactone Mar 26 2019
S6268 4-Pentenoic acid Mar 26 2019
S6274 2-Methyltetrahydrofuran-3-one Mar 26 2019
S6275 (−)-β-Pinene Mar 26 2019
S6277 1-Methylnaphthalene Mar 26 2019
S6278 4-Methylvaleric acid Mar 26 2019
S6279 Cyclohexanecarboxylic Acid Mar 26 2019
S6161 2-Methyl-3-Pentanone 2-Methyl-3-Pentanone is an aliphatic ketone with used as a reagent in organic chemistry and as a solvent. Mar 22 2019
S6167 2-Methyl-4-pentenoic Acid 2-Methyl-4-pentenoic acid is a branched-chain fatty acid. Mar 22 2019
S6173 Amylmetacresol Amylmetacresol is an antiseptic used to treat infections of the mouth and throat. Mar 22 2019
S6187 N-(5-Aminopentyl)acetamide N-(5-Aminopentyl)acetamide is the acetylated form of the polyamine cadaverine, which is a foul-smelling diamine compound. Mar 22 2019
S6192 N,N-Dimethylformamide(DMF) N,N-Dimethylformamide (DMF) is a polar organic solvent with a wide range of industrial applications. Mar 22 2019
S6198 2-Hexanone 2-Hexanone, a volatile organic compound, is used as a general solvent. Mar 22 2019
S6199 o-Cresol o-Cresol is a widely used intermediate in the production of other chemicals. Mar 22 2019
S6204 Allyl Methyl Sulfide Allyl Methyl Sulfide, a bioactive organosulfur compound found in garlic, is reported to modulate disease states such as cancer and infection. Mar 22 2019
S6207 Levulinic acid Levulinic acid is used as a precursor for pharmaceuticals, plasticizers, and various other additives. Mar 22 2019
S6209 Diethyl succinate Diethyl succinate is the diethyl ester of succinate and acts as an irritant. Mar 22 2019
S6211 Furfural Furfural is one of the key chemicals produced in the so-called lignocellulosic biorefineries and produced from renewable agricultural sources such as food crop residues and wood wastes. Mar 22 2019
S6213 m-Dichlorobenzene m-Dichlorobenzene is an intermediate for agrochemicals and pharmaceuticals. Mar 22 2019
S6216 1-Methylpyrrolidine 1-Methylpyrrolidine is extensively used in the synthesis of pyrrolidine based ionic liquids. Mar 22 2019
Cat.No. Product Name Information Added
S6223 Triethyl citrate Triethyl citrate is used in pharmaceutical coatings and plastics. Mar 22 2019
S5951 Cefoxitin Cefoxitin is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Mar 20 2019
S5848 Frovatriptan Succinate Frovatriptan Succinate is the succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity especially for the 5-HT1B/1D receptors. Mar 20 2019
S5885 Rabeprazole Related Compound E Rabeprazole Related Compound E is an active metabolite of rabeprazole, which is a proton pump inhibitor. Mar 20 2019
S5886 Hodostin Hodostin is a reversible inhibitor of acetylcholinesterase (AChE), but can not cross the blood-brain barrier. It is used in the treatment of myasthenia gravis. Mar 20 2019
S5856 Trifluoperazine Trifluoperazine is an FDA-approved antipsychotic drug for schizophrenia. It is an inhibitor of calmodulin (CaM) and Dopamine D2 receptor with an IC50 value of 1.2 nM for D2 receptor. Mar 20 2019
S5854 Xylometazoline Xylometazoline is a nasal vasoconstricting decongestant drug which is used to improve symptoms of nasal congestion, allergic rhinitis, and sinusitis. Mar 20 2019
S5857 Trazodone Trazodone is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders. Mar 20 2019
S6009 1-Phenyl-1,2-propanedione 1-Phenyl-1,2-propanedione is an eukaryotic metabolite produced during a metabolic reaction in plants. Mar 20 2019
S6012 Methyloxalacetic acid diethyl ester Methyloxalacetic acid diethyl ester is a member of the class of compounds known as beta-keto acids and derivatives. Mar 20 2019
S6017 p-Cresol p-Cresol is a metabolite of aromatic amino acid metabolism produced by intestinal microflora in humans and animals. Mar 20 2019
S6024 Ethyl acetoacetate Ethyl acetoacetate, found in coffee and coffee products as well as in strawberry and yellow passion fruit juice, is a flavouring agent used as a chemical intermediate in the production of a wide variety of compounds. Mar 20 2019
S6029 4-Methyl-n-octanoic Acid 4-Methyl-n-octanoic Acid is a flavouring ingredient. Mar 20 2019
S6037 Methyl p-tert-butylphenylacetate Methyl 4-tert-butylphenylacetate is a flavouring ingredient with a roasted, chocolate-like flavour. Mar 20 2019
S6039 4-Ethyloctanoic acid 4-ethyloctanoic acid is identified from flue-cured Virginia tobacco and is mainly used as daily flavor, food flavor, industrial flavor, nutrient, stabilizers, surfactants and emulsifiers. Mar 20 2019
S6040 2,3-Butanediol (mixture of isomers) 2,3-Butanediol is an important microbial metabolite and has been widely used in many fields such as food, medicine, chemical, and so on. Mar 20 2019
S6041 Dibutyl sebacate Dibutyl sebacate is an organic chemical which is mainly used as a plasticizer in the production of plastics. Mar 20 2019
S6057 2-Ethylbutyric Acid 2-Ethylbutyric Acid is a chemical used to make paint dryers and plasticizers. Mar 20 2019
S6072 Monomethyl glutarate Monomethyl glutaric acid is a dicarboxylic acid monoester and has a role as a human urinary metabolite. Mar 20 2019
S6079 2-Methylhexanoic acid 2-Methylhexanoic acid is a flavouring ingredient. Mar 20 2019
Cat.No. Product Name Information Added
S6086 2-Phenylbutyric acid 2-Phenylbutyric acid, belongs to the class of organic compounds known as phenylpropanes, is used as an anticholesteremic. Mar 20 2019
S6089 3-Methylvaleric acid 3-Methylvaleric acid is a flavouring ingredient. Mar 20 2019
S6099 2-Methylheptanoic Acid 2-Methylheptanoic Acid is a flavouring ingredient. Mar 20 2019
S6104 (±)-α-Tocopherol (±)-α-Tocopherol is a biologically active form of vitamin E, which is a lipid-soluble antioxidant that protects cellular membranes from oxidative damage. Mar 20 2019
S6107 1-Furfurylpyrrole 1-Furfurylpyrrole is a potential contributor of flavor and aroma to popcorn. Mar 20 2019
S6108 Propiolic acid Propiolic acid is an acetylenic fatty acid, a monounsaturated fatty acid and used for synthesis. Mar 20 2019
S6117 Acetoin dimer Acetoin is an important physiological metabolite excreted by many microorganisms. It is widely used in food and cosmetic industry as taste and fragrance enhancer. Mar 20 2019
S6124 3-Hydroxyisovaleric acid 3-Hydroxyisovaleric acid is a normal human metabolite excreted in the urine. Mar 20 2019
S6125 Glycerol trilinoleate Glycerol trilinoleate is a triacylglycerol and has been reported to provide a number of beneficial effects including reducing thrombogenicity and arrhythmias and increasing erythrocyte deformability. It is also an antioxidant. Mar 20 2019
S6136 (±)-α-Bisabolol α-bisabolol is a small, plant-derived, oily sesquiterpene alcohol with some anti-inflammatory and even anti-microbial properties. Mar 20 2019
S6148 3-Methyl-2-oxobutanoic acid 3-Methyl-2-oxobutanoic acid, a neurotoxin, an acidogen and a metabotoxin, is an abnormal metabolite that arises from the incomplete breakdown of branched-chain amino acids. Mar 20 2019
S6149 2-Pyrrolidinone 2-Pyrrolidinone is a lactam cyclization product of gamma-aminobutyric acid (GABA). It is an intermediate in the production of vinylpyrrolidone and the drug piracetam. Mar 20 2019
S5932 BIA 10-2474 BIA 10-2474 is a novel fatty acid amide hydrolase (FAAH) inhibitor, with a potent inhibitory effect upon FAAH and prolonged action in vivo. Mar 20 2019
S5859 Sancycline Sancycline is a semi-synthetic tetracycline antibiotic. Mar 20 2019
S5868 DL-Menthol DL-Menthol is a racemic mixture of D- and L-menthol. Menthol is a covalent organic compound made synthetically or obtained from peppermint or other mint oils. Mar 20 2019
S8808 DC661 DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ). Mar 14 2019
S5873 Scopolamine HBr trihydrate Scopolamine HBr is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM. Mar 14 2019
S6122 Cyclohexanecarboxamide Cyclohexanecarboxamide is a cooling agent and an agonist at TRPM8 receptors (EC50 = 3.7 μM). Mar 14 2019
S5871 Trans-Tranilast Trans-Tranilast is an antiallergic drug, used to treat bronchial asthma, allergic rhinitis and atopic dermatitis. Mar 14 2019
S5872 Estradiol dipropionate Estradiol dipropionate (17-Beta-Estradiol-3,17-Dipropionate) is a semisynthetic, steroidal estrogen which has been used in hormone therapy for menopausal symptoms and low estrogen levels in women and in the treatment of gynecological disorders. Mar 14 2019
Cat.No. Product Name Information Added
S5874 L-Carnitine hydrochloride Carnitine is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids. Mar 14 2019
S5950 Fingolimod Fingolimod is a sphingosine 1-phosphate receptor modulator used for the treatment of relapsing-remitting multiple sclerosis. Mar 14 2019
S8778 UPGL00004 UPGL00004 is a potent glutaminase C (GAC) inhibitor with an IC50 of 29 nM, showing high selectivity for GAC over GLS2. Mar 14 2019
S5858 Vilazodone Vilazodone is a novel antidepressant having a selective serotonin (5-HT) reuptake inhibitory and 5-HT1A receptor partial agonist activity. The affinity of vilazodone is much higher in the 5-HT reuptake site (Ki=0.1 nM) than in norepinephrine (Ki=56 nM) and dopamine (Ki=37 nM) sites. Mar 14 2019
S5867 Bendazac L-lysine Bendazac L-lysine has a protective effect against lens protein denaturation both in vitro and in vivo. It is also a nonsteroidal anti-inflammatory drug (NSAID) used for joint and muscular pain. Mar 14 2019
S5866 Gastrodenol Gastrodenol is used to treat certain conditions caused by too much acid being produced in the stomach, such as stomach ulcers and ulcers of the upper part of the intestine (duodenal ulcers). Mar 14 2019
S5869 Cortisone Cortisone is a pregnane steroid hormone and one of main substance released by the body as a reaction to stress. It suppresses the immune system, thus reducing inflammation and attendant pain and swelling at the site of the injury. Mar 14 2019
S4415 Misoprostol Mar 08 2019
S6119 2-Hydroxybutyric acid 2-Hydroxybutyric acid is a chiral compound having two enantiomers, D-2-hydroxybutyric acid and L-2-hydroxybutyric acid. It is produced in mammalian tissues (principally hepatic) that catabolize L-threonine or synthesize glutathione. Mar 06 2019
S5853 2'-Hydroxy-2-methoxychalcone 2'-Hydroxy-2-methoxychalcone is a chemical. Mar 06 2019
S5844 Lobelin sulphate Lobelin sulphate is an alkaloid that has actions similar to nicotine on nicotinic cholinergic receptors but is less potent. It has a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation. Mar 06 2019
S8755 AZ304 AZ304 is a synthetic inhibitor designed to interact with the ATP-binding site of wild type and V600E mutant BRAF with IC50 values of 79 nM and 38 nM, respectively. It also inhibits CRAF, p38 and CSF1R at sub 100 nM potencies. Mar 06 2019
S9482 2-methoxycinnamaldehyde 2-methoxycinnamaldehyde, found in ceylan cinnamon, is a flavouring ingredient. Mar 06 2019
S9485 Waltonitone Waltonitone, an ursane-type pentacyclic triterpene extracted from Gentiana waltonii Burkill, exerts anti-tumor effect. Mar 06 2019
S9494 Darutigenol Darutigenol has antithrombotic effect and may be related to inhibition of platelet aggregation and adhesion. Mar 06 2019
S8765 PF-04965842 PF-04965842 is a potent JAK1 inhibitor with IC50s of 29 nM, 803 nM, > 10 000 nM and 1250 nM for JAK1, JAK2, JAK3 and tyrosine kinase (TYK) 2, respectively. Mar 06 2019
S5919 KHS101 hydrochloride KHS101 is a small-molecule inhibitor of TACC3, which is a key component of centrosome-microtubule dynamic networks. Mar 06 2019
S5935 Alvimopan Alvimopan (LY-246736) is a potent, relatively nonselective opioid antagonist with Ki values of 0.77, 4.4, and 40 nM for the μ, δ, and κ opioid receptors, respectively, displaying >100-fold selectivity over other aminergic G-protein-coupled receptors. Mar 06 2019
S5861 Lercanidipine Lercanidipine is a vasoselective dihydropyridine calcium antagonist used for the treatment of essential hypertension. Mar 06 2019
S5863 Metronidazole Benzoate Metronidazole Benzoate is the benzoate ester of metronidazole, a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Mar 06 2019
Cat.No. Product Name Information Added
S5604 Diphenylamine Hydrochloride Diphenylamine, a derivative of aniline, is widely used as an industrial antioxidant, dye mordant and reagent and is also employed in agriculture as a fungicide and antihelmintic. Mar 06 2019
S5611 2-cyano-Pyrimidine 2-cyano-Pyrimidine is a cathepsin K inhibitor with an IC50 of 170 nM. Mar 06 2019
S5612 Isonipecotic acid Isonipecotic acid is a heterocyclic compound that mainly acts as a GABAA receptor partial agonist. Mar 06 2019
S5613 2-Thiohydantoin 2-Thiohydantoin is a reactant for chemical synthesis. Mar 06 2019
S5862 Metoclopramide Metoclopramide is a dopamine antagonist used for the treatment of nausea and vomiting. Mar 06 2019
S8744 PHY34 PHY34 is a late-stage autophagy inhibitor with nanomolar potency and significant antitumor efficacy as a single agent against HGSOC in vivo. Feb 27 2019
S5920 CA-5f CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. Feb 27 2019
S5842 Cabergoline Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. Feb 27 2019
S8719 AZD4573 AZD4573 is a potent inhibitor of CDK9 (IC50 of <0.004 μM) with fast-off binding kinetics (t1/2 = 16 min) and high selectivity versus other kinases, including other CDK family kinases. Feb 27 2019
S5841 DKM 2-93 DKM 2-93 is a relatively selective lead inhibitor of ubiquitin-like modifier activating enzyme 5 (UBA5). Feb 27 2019
S5845 Chalcone Chalcone is an aromatic ketone that forms the central core for a variety of important biological compounds, which are known collectively as chalcones with antibacterial, antifungal, antitumor and anti-inflammatory properties. Feb 27 2019
S2072 Seratrodast(AA-2414, ABT-001) Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist with IC50 of 40 nM used primarily in the treatment of asthma and used as anti-inflammatory agent. Feb 25 2019
S5815 WAY-316606 WAY-316606, a specific antagonist of SFRP1, functions as an activator of canonical Wnt/β-catenin signalling in the human hair bulb. Feb 20 2019
S5818 acalisib (GS-9820) acalisib (GS-9820) is a highly selective and potent p110δ inhibitor (IC50 = 14 nM) with 114- to 400-fold selectivity over the other class I PI3K enzymes and no activity against Class II and III PI3K family members or other PI3K-related proteins including mTOR and DNA-PK. Feb 20 2019
S5839 L-Kynurenine L-Kynurenine is a metabolite of the amino acid L-tryptophan used in the production of niacin. It is also a central compound of the tryptophan metabolism pathway. Feb 20 2019
S5840 Palifosfamide Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity. Feb 20 2019
S5837 BRL-50481 BRL-50481 is a novel and selective inhibitor of phosphodiesterase (PDE) 7 with a Ki value, derived from secondary (Dixon) plots, of 180±10 nM, being at least 200-fold selective for hrPDE7A1 over all other PDEs. Feb 20 2019
S5817 GSK0660 GSK0660 is a potent PPARβ/δ antagonist with a pIC50 of 6.8 (binding assay IC50 = 155 nM; antagonist assay IC50 = 300 nM) and is nearly inactive on PPARα and PPARγ with IC50s above approximately 10 μM. Feb 20 2019
S5838 SDMA SMDA (symmetric dimethylarginine) is a methylated form of arginine found within all nucleated cells that is released into circulation after proteolysis, then excreted through the kidneys, and correlates well with GFR (glomerular filtration rate) in people, dogs, and cats. Feb 20 2019
S5843 Cinitapride Hydrogen Tartrate Cinitapride Hydrogen Tartrate is a gastroprokinetic agent that acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors Feb 20 2019
Cat.No. Product Name Information Added
S1858 Dienestrol Dienestrol(Restrol) is a synthetic, non-steroidal estrogen. It is an estrogen receptor agonist. Feb 15 2019
S2083 Procaterol HCl Procaterol HCl is a short-acting β2-adrenergic receptor agonist with Kp of 8 nM, used for the treatment of asthma Feb 15 2019
S8775 HS-1371 HS-1371 is a potent RIP3 kinase inhibitor with an IC50 of 20.8 nM. It binds to the ATP binding pocket of RIP3 and inhibits ATP binding to prevent RIP3 enzymatic activity in vitro. Feb 14 2019
S8813 LIT-927 LIT-927 is a novel neutraligand of CXCL12 with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma. Feb 14 2019
S8773 TH34 TH34 is a HDAC inhibitor that shows pronounced selectivity for HDACs 6, 8 and 10 over HDACs 1, 2 and 3. In a NanoBRET assay, TH34 strongly binds HDAC6, 8 and 10 with low-micromolar IC50 concentrations (HDAC6: 4.6 µM, HDAC8: 1.9 µM, HDAC10: 7.7 µM). Feb 14 2019
S5928 Zerumbone Zerumbone, derived from several plant species of the Zingiberaceae family, is a naturally occurring dietary compound and may have multiple biomedical properties, such as antiproliferative, antioxidant, anti-inflammatory, and anticancer activities. Feb 14 2019
S8803 MK-3903 MK-3903 is a potent and selective AMPK activator with an EC50 of 8 nM for α1 β1 γ1 subunit. It activates 10 of the 12 pAMPK complexes with EC50 values in the range of 8-40 nM and maximal activation >50%. Feb 14 2019
S5812 Choline Fenofibrate Choline fenofibrate is a newly developed choline salt of fenofibric acid, a synthetic phenoxy-isobutyric acid derivate with antihyperlipidemic activity that acts as an PPARα agonist. Feb 14 2019
S5776 Proflavine Proflavine is a disinfectant bacteriostatic against many gram-positive bacteria. It is a topical antiseptic used mainly in wound dressings. Feb 14 2019
S5779 Trimetazidine Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of long-chain 3-ketoacyl CoA thiolase activity and results in a reduction in fatty acid oxidation and a stimulation of glucose oxidation. Feb 14 2019
S5781 Raloxifene Raloxifene is a second generation selective estrogen receptor modulator (SERM) used to prevent osteoporosis in postmenopausal women. Feb 14 2019
S5782 Doxazosin Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. Feb 14 2019
S5783 Montelukast Montelukast is a leukotriene receptor antagonist used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Feb 14 2019
S9567 Indinavir Sulfate Indinavir sulfate is a specific and potent inhibitor of HIV-1 protease and is widely used in the treatment of AIDS. Feb 14 2019
S9568 Sapropterin Dihydrochloride Sapropterin Dihydrochloride, a synthetic preparation of the dihydrochloride salt of naturally occurring tetrahydrobiopterin (BH4), is a phenylalanine hydroxylase activator. Feb 14 2019
S5923 Celiprolol hydrochloride Celiprolol is a β1-adrenoceptor antagonist with partial β2 agonist activity. Feb 14 2019
S5929 4-Octyl Itaconate 4-Octyl Itaconate activates Nrf2 signaling to inhibit the production of pro-inflammatory cytokines in human macrophages and systemic lupus erythematosus (SLE) patient-derived PBMCs. Feb 14 2019
S5930 PNU 282987 PNU 282987 is a potent agonist of α7-containing neuronal nicotinic acetylcholine receptors with Ki value of 26 nM for the rat receptor. Feb 14 2019
S5933 K 858 K858 is a novel and potent inhibitor of Eg5 with an IC50 of 1.3 μM for inhibiting the ATPase activity of Eg5, showing at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. Feb 14 2019
S5931 BQCA BQCA is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor (mAChR). Feb 14 2019
Cat.No. Product Name Information Added
S5836 IBMX Isobutylmethylxanthine (IBMX) is a nonspecific inhibitor of phosphodiesterase (PDE) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively. It may enhance the intracellular cAMP levels and also acts as an adenosine (A1) receptor antagonist. Feb 14 2019
S5924 Olanexidine Hydrochloride semihydrate Olanexidine is a monobiguanide compound with bactericidal activity. Feb 14 2019
S9566 Bepridil hydrochloride Bepridil hydrochloride is an anti-anginal drug classified as a calcium channel blocker. It also blocks multiple other ion channels, including sodium and potassium channels. Feb 14 2019
S8714 INCB057643 INCB057643 is a BET inhibitor that binds to the acetylated lysine recognition motifs found in the BRD of BET proteins, thereby preventing the interaction between the BET proteins and acetylated lysines on histones. Jan 29 2019
S5816 pyrvinium Pyrvinium is an anthelmintic effective for pinworms. Jan 29 2019
S5814 cariporide Cariporide is a selective and potent inhibitor of NHE1 with an IC50 of 30 nM for hNHE1 in CHO-K1 cells. Jan 29 2019
S5819 MRE-269(ACT-333679) MRE-269(ACT-333679) is a prostaglandin I2 (IP) receptor agonist with a binding affinity for the human IP receptor that is 130-fold greater than that for other human prostanoid receptor. Jan 29 2019
S5780 Prazosin Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension. Jan 29 2019
S5787 Dronedarone Dronedarone is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV). Jan 29 2019
S5795 Rasagiline Rasagiline is a novel selective and irreversible MAO-B propargylamine inhibitor with in vitro IC50s of 4.43 nM and 412 nM for MAO-B and MAO-A, respectively. Jan 29 2019
S5925 Olodaterol hydrochloride Olodaterol hydrochloride is the hydrochloride salt form of Olodaterol, which is a long-acting beta2-adrenergic agonist. Jan 29 2019
S5926 Pitolisant hydrochloride Pitolisant acts as a high-affinity competitive antagonist (Ki=0.16 nM) and as an inverse agonist (EC50=1.5 nM) at the human histamine H3 receptor subtype. Jan 29 2019
S5784 Vancomycin Vancomycin is an antibiotic used to treat serious bacterial infections. It works by stopping the growth of bacteria. Jan 29 2019
S8702 EBI-2511 EBI-2511 is a highly potent and orally active EZH2 inhibitor with an IC50 of 4 nM for EZH2(A667G). Jan 29 2019
S5927 Proguanil Proguanil is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication. Jan 29 2019
S5182 GSK4112 GSK4112 is a functional Rev-erbα agonist with an EC50 of 0.4 μM. It represses the expression of gluconeogenic genes in liver cells and reduces glucose output in primary hepatocytes. Jan 29 2019
S5778 Esmolol Esmolol is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilising activity at therapeutic dosages. Jan 29 2019
S5835 3-(4-Hydroxyphenyl)-1-propanol 3-(4-Hydroxyphenyl)-1-propanol is a reagent in the synthesis of (−)-Centrolobine, which is an anti-Leishmania agent. Jan 29 2019
S5833 Methyl Nonadecanoate Methyl nonadecanoate is a fatty acid methyl ester, which is less water soluble but more amenable for the formulation of nonadecanoate-containing diets and dietary supplements. Jan 29 2019
S5826 Monobutyl phthalate Monobutyl phtalate is a metabolite of di(n-butyl)phthalate. It affects the expressions of EMT-related proteins and enhances the migration and invasion of MLTC-1 cells. Jan 29 2019
Cat.No. Product Name Information Added
S5825 1,4-Diaminobutane Putrescine is a foul-smelling organic chemical produced by the breakdown of amino acids in living and dead organisms. Jan 29 2019
S5831 Furfuryl acetate Furfuryl acetate is widely used as a flavoring agent in food and bakery. Jan 29 2019
S5822 Butyl benzyl phthalate Butyl benzyl phthalate is a member of the group of chemicals known as phthalates. It is a toxicant and may be used as a plasticiser. Jan 29 2019
S5832 Pyrrole-2-carboxylic acid Pyrrole-2-carboxylic acid is a degradation product of sialic acids and a derivative of the oxidation of the D-hydroxyproline isomers by mammalian D-amino acid oxidase. Jan 29 2019
S5827 Citronellyl acetate Citronellyl acetate is a natural flavouring ingredient. Jan 29 2019
S5834 p-Coumaric acid ethyl ester p-Coumaric acid ethyl ester is the ethyl ester of p-Coumaric acid, which is a plant metabolite which exhibits antioxidant and anti-inflammatory properties. Jan 29 2019
S5830 L-Xylose L-Xylose is a synthesized levorotary form of Xylose, a sugar first isolated from wood. Jan 29 2019
S5829 Monomyristin Monomyristin, a monoacylglyceride, shows high antibacterial and antifungal activities. Jan 29 2019
S8761 Adavivint (SM04690) SM04690 is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ∼150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays. Jan 23 2019
S5913 Cambinol Cambinol is a novel uncompetitive nSMase2 inhibitor with a K i value of 7 μM (IC50 = 5 ± 1 μM). Jan 23 2019
S5917 Solcitinib Solcitinib is an inhibitor of JAK1 with an IC50 of 8-9 nM, and shows 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively. Jan 23 2019
S4993 Timonacic Timonacic is a cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activities. Jan 23 2019
S5915 OAC2 OAC-2 is an Octamer-binding transcription factor 4 (OCT4) activator, enhancing iPSC reprogramming efficiency. Jan 23 2019
S5916 GSK 5959 GSK5959 is a potent and selective BRPF1 bromodomain inhibitor with an IC50 of 80 nM and exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Jan 23 2019
S5918 CAY10602 CAY10602 is a potent SIRT1 activator. Jan 23 2019
S5914 AK 7 AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM. Jan 23 2019
S5808 Relugolix Relugolix is a selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with an IC50 of 0.12 nM. Jan 16 2019
S5807 HMN-176 HMN-176 is an active metabolite of HMN-214, which has a potent antitumor activity in mouse xenograft models. Jan 16 2019
S5810 UF010 UF010 is a class I HDAC-selective inhibitor with IC50 values of 0.5 nM, 0.1 nM, 0.06 nM, 1.5 nM, 9.1 nM and 15.3 nM for HDAC1, HDAC2, HDAC3, HDAC8, HDAC6 and HDAC10, respectively. Jan 16 2019
S5811 Kevetrin hydrochloride Kevetrin hydrochloride is a water-soluble, small molecule and activator of the tumor suppressor protein p53, with potential antineoplastic activity. Jan 16 2019
Cat.No. Product Name Information Added
S5766 Alfuzosin Alfuzosin, a quinazoline derivative, is a selective and competitive α1-adrenoceptor antagonist. Jan 16 2019
S5903 JANEX-1 JANEX-1 is a small molecule inhibitor of JAK3 that selectively inhibits JAK3 at an IC50 of 78 µM without altering the activity of JAK1 or JAK2, or any other protein tyrosine kinases (IC50 ≥ 350 µM). Jan 16 2019
S9464 Tranylcypromine Sulfate Tranylcypromine is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity. Jan 16 2019
S5905 Suberohydroxamic acid Suberohydroxamic acid is a competitive HDAC inhibitor with IC50 values of 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively. Jan 16 2019
S5902 1,2,3,4,5,6-Hexabromocyclohexane 1,2,3,4,5,6-Hexabromocyclohexane is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation with IC50 value to be estimated in low micromolar range. Jan 16 2019
S5699 Scopolamine N-Oxide HydrobroMide Monohydrate Scopolamine N-Oxide is a muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors. Jan 16 2019
S4672 Dimenhydrinate Dimenhydrinate is an over-the-counter drug used to prevent nausea, vomiting, and dizziness caused by motion sickness. Jan 16 2019
S5911 Bictegravir Bictegravir is a novel, potent, once-daily, unboosted inhibitor of HIV-1 integrase. Jan 16 2019
S5909 Anagliptin Anagliptin is an orally active and highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor and exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-κB activation. Jan 16 2019
S8800 INCB053914 INCB053914 is a novel, ATP-competitive, small molecule, pan-inhibitor of PIM kinases with IC50 values of 0.24 nM, 30 nM and 0.12 nM for PIM1, PIM2 and PIM3 respectively in biochemical assays. Jan 16 2019
S8718 RMC-4550 RMC-4550 is a potent SHP-2inhibitor with an IC50 of 1.55 nM and it has no significant activity vs. 468 kinases, the catalytic domain of 15 phosphatases and other cellular targets including GPCRs, transporters and ion channels. Jan 16 2019
S8381 BMS-986142 BMS-986142 is a potent and highly selective reversible small molecule inhibitor of BTK with an IC50 of 0.5 nM. In a panel of 384 kinases, only five kinases were inhibited by BMS-986142 with less than 100-fold selectivity for BTK (TEC, ITK, BLK, TXK and BMX). Jan 16 2019
S4720 Cefotaxime Cefotaxime is a third-generation cephalosporin antibiotic and has broad spectrum activity against Gram positive and Gram negative bacteria. Jan 16 2019
S8352 PT2385 PT2385 is a HIF-2α antagonist with luciferase EC50 of 27 nM and no significant off-target activity. Jan 16 2019
S5796 Vanoxerine dihydrochloride Vanoxerine is a potent and selective inhibitor of the presynaptic dopamine uptake complex. Jan 16 2019
S5669 Isoxsuprine hydrochloride Isoxsuprine hydrochloride is a beta-adrenergic agonist with vasodilator activity. Jan 16 2019
S4956 Benzamidine HCl Benzamidine is an inhibitor of serine proteases with Ki values of 35, 350, and 220 µM for trypsin, plasmin, and thrombin, respectively. Jan 16 2019
S7302 TEPP-46 (ML265, CID-44246499, NCGC00186528) ML265 is a potent activator of PKM2 in both biochemical (AC50 = 92 nM) and cell-based assays with high selectivity over PKM1, PKR and PKL. Jan 09 2019
S8654 ex229 (compound 991) EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK. Jan 09 2019
S8776 WM-1119 WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively. Jan 09 2019
Cat.No. Product Name Information Added
S8752 leniolisib(CDZ 173) Leniolisib(CDZ 173) is a potent PI3Kδ selective inhibitor with biochemical IC50 values of 0.244, 0.424, 2.23 and 0.011 μM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. Jan 09 2019
S5904 WHI-P97 WHI-P97 is a potent inhibitor of JAK-3 with an estimated Ki value of 0.09 μM in modeling studies and a measured IC50 value of 2.5 μM in EGFR kinase inhibition assays. Jan 09 2019
S5774 CY-09 CY-09 is a specific NLRP3 inflammasome inhibitor that directly targeted NLRP3 itself。 It is tested against the five major cytochrome P450 enzymes 1A2, 2C9, 2C19, 2D6, and 3A4 with half maximal inhibitory concentration (IC50) values of 18.9, 8.18, >50, >50, and 26.0 µM, respectively. Jan 09 2019
S5775 SR1078 SR1078, a synthetic ligand for RORα and RORγ, functions as a RORα/γ agonist. Jan 09 2019
S5793 Motesanib (AMG-706) Motesanib (AMG-706) is an orally bioavailable receptor tyrosine kinase inhibitor with IC50 values of 2 nM, 3 nM, 6 nM, 8 nM, 84 nM, 59 nM for VEGFR1, VEGFR2, VEGFR3, Kit, PDGFR and Ret, respectively. Jan 09 2019
S5907 5-Methyl-2'-deoxycytidine 5-Methyl-2'-deoxycytidine (5-Me-dC) is a minor component found in most eukaryotic DNA. Jan 09 2019
S8772 LY 3200882 LY 3200882 is a potent, highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). It potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors in a dose dependent fashion. Jan 09 2019
S5791 Cyclic Pifithrin-α hydrobromide Cyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53. Jan 09 2019
S5908 Garenoxacin Garenoxacin (T-3811ME, BMS-284756) is a novel des-F(6) quinolone that has been shown to be effective in vitro against a wide range of clinically important pathogens, including gram-positive and gram-negative aerobes and anaerobes. Jan 09 2019
S5906 2,4-Pyridinedicarboxylic acid 2,4-Pyridinedicarboxylic acid is a compound that structurally mimics 2-oxoglutarate (2-OG) and chelates zinc, thus affecting a range of enzymes. It blocks the activity of 2-OG oxygenases. Jan 09 2019
S8801 CC-90003 CC-90003 is an irreversible inhibitor of ERK1/2 with IC50s in the 10-20 nM range and shows good kinase selectivity in a 258-kinase biochemical assay. Jan 09 2019
S5792 CID 2011756 CID 2011756 is an inhibitor of protein kinase D (PKD) with IC50 values of 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively. Jan 09 2019
S8771 IDF-11774 IDF-11774 is a hypoxia-inducible factor-1 (HIF-1) inhibitor. It reduces the HRE-luciferase activity of HIF-1α (IC50 = 3.65 μM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells. Dec 26 2018
S8754 Alofanib(RPT835) Alofanib(RPT835) is a novel selective allosteric inhibitor of FGFR2 and has a dramatic inhibitory effect with IC50 <10 nM on FGF2-induced phoshphorylation of FRS2a in KATO III cells. It has no direct effect on FGF2-dependent FGFR1 and FGFR3 phosphorylation levels in either cell lines and no effects on FGF2-FGFR2 binding. Dec 26 2018
S5901 Canagliflozin hemihydrate Canagliflozin hemihydrate is the hemihydrate form of canagliflozin, which is a SGLT2 inhibitor with IC50 of 2.2 nM for hSGLT2 in a cell-free assay, exhibits 413-fold selectivity over hSGLT1. Dec 26 2018
S8763 ZL0420 ZL0420 is a potent and selective BRD4 inhibitor with IC50 values of 27 nM against BRD4 BD1 and 32 nM against BRD4 BD2 respectively and good selectivity over that of the related BRD2 homolog. Dec 26 2018
S5801 Ala-Gln Ala-Gln, a dipeptide composed of alanine and Gln, is an alternative supplement to L-glutamine in the production of biopharmaceuticals with better solubility and stability than glutamine (Gln). Dec 26 2018
S5772 AS-8351 AS-8351 is a histone demethylase inhibitor that could induces reprogramming of human fetal lung fibroblasts into functional cardiomyocytes. Dec 26 2018
S5696 JNJ0966 JNJ0966 is a highly selective compound that inhibits activation of MMP-9 zymogen and subsequent generation of catalytically active enzyme. It has no effect on MMP-1, MMP-2, MMP-3, MMP-9, or MMP-14 catalytic activity and did not inhibit activation of the highly related MMP-2 zymogen. Dec 20 2018
S5695 Icatibant Acetate Icatibant Acetate acts as an antagonist of the bradykinin B2 receptor and is used in the treatment of hereditary angioedema. Dec 20 2018
Cat.No. Product Name Information Added
S5768 Fenoterol hydrobromide Fenoterol hydrobromide is the the hydrobromide salt of fenoterol, a β2 adrenoreceptor agonist with bronchodilator activity. Dec 20 2018
S5802 Alprenolol hydrochloride Alprenolol hydrochloride is the hydrochloride salt form of alprenolol, which is an beta adrenergic receptorantagonist and is used as an antihypertensive, anti-anginal, and anti-arrhythmic agent. Dec 20 2018
S5800 Alda 1 Alda 1 is an ALDH2 agonist that activates catalysis for both wild-type ALDH2 (ALDH2*1) and ALDH2*2. Dec 20 2018
S5803 Alrestatin Alrestatin is an inhibitor of aldose reductase which is involved in the pathogenesis of complications of diabetes mellitus, including diabetic neuropathy. Dec 20 2018
S5900 Edrophonium chloride Edrophonium chloride is the chloride salt of edrophonium, which is a rapid-onset, short-acting, readily reversible inhibitor of acetylcholinesterase. Dec 20 2018
S8701 MK-8353 (SCH900353) MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK inhibitor that inhibits activated ERK1 and ERK2 in vitro, with IC50 values of 23.0 nM and 8.8 nM, respectively (IMAP kinase assay), and nonactivated ERK2, with an IC50 of 0.5 nM (MEK1-ERK2-coupled assay). Dec 20 2018
S5698 Ketorolac tromethamine salt Ketorolac tromethamine is a synthetic pyrrolizine carboxylic acid derivative with anti-inflammatory, analgesic and antipyretic properties. It is a non-selective COX inhibitor with IC50s of 20 nM for both COX-1 and COX-2. Dec 20 2018
S5804 N-Acetylcysteine amide N-acetylcysteine amide is a membrane penetrating antioxidant with anti-inflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. Dec 20 2018
S5769 Fenoterol Fenoterol is a β2 adrenoreceptor agonist with bronchodilator activity. Dec 20 2018
S8759 S55746 (S 055746,BCL201) S55746 (S 055746,BCL201) is a novel, orally active BCL-2 specific inhibitor (Ki = 1.3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1, BFL-1 (BCL2A1/A1). The selectivity of S55746 for BCL-2 versus BCL-XL ranges from ~70 to 400 folds. Dec 20 2018
S8708 AZD0364 AZD0364 is a pre-clinical ERK1/2 inhibitor with an IC50 of 0.6 nM for ERK2. Dec 20 2018
S5767 Aliskiren Aliskiren is a renin inhibitor with antihypertensive activity. Dec 20 2018
S5806 Cilostamide Cilostamide is an inhibitor of type III phosphodiesterases with IC50 values of 27 nM and 50 nM for PDE3A and PDE3B, respectively. Dec 20 2018
S9452 10-Undecenoic acid 10-Undecenoic acid, a natural or synthetic fungistatic fatty acid, is used for the preparation of active pharmaceutical ingredients, cosmetics, perfumes, antidandruff shampoos and antimicrobial powders. Dec 12 2018
S5697 Isopropamide Iodide Isopropamide iodide is a long-acting quaternary anticholinergic drug used in the treatment of peptic ulcer and other gastrointestinal disorders. Dec 12 2018
S5371 Ajmaline Ajmaline, found in the root of Rauwolfia serpentina, is a class Ia antiarrhythmic agent. Dec 12 2018
S5372 Methyl Aminolevulinate Hydrochloride Methyl Aminolevulinate is a prodrug that is metabolised to protoporphyrin IX used in photodynamic therapy. Dec 12 2018
S9225 Santalol Santalol is a naturally occuring sesquiterpene that has antibacterial, anti-hyperglycaemic, anti inflammatory and antioxidant effects. Dec 12 2018
S5581 Olmesartan Olmesartan is an an angiotensin 2 receptor antagonist with antihypertensive activity. Dec 12 2018
S9320 Efetaal Efetaal has a fresh floral hyacinth note with a suggestion of muguet and green leaves. Dec 12 2018
Cat.No. Product Name Information Added
S8777 Evobrutinib Evobrutinib is a highly selective BTK inhibitor with an IC50 of 37.9 nM. It has potential anti-neoplastic activity. Dec 12 2018
S5565 Triflupromazine hydrochloride Triflupromazine hydrochloride is an antipsychotic medication of the phenothiazine class. Dec 12 2018
S8790 ML385 ML385 is a novel and specific NRF2 inhibitor with an IC50 of 1.9 μM. It inhibits the downstream target gene expression of NRF2. Dec 12 2018
S8789 SSE15206 SSE15206 is a tubulin polymerization inhibitor that has potent antiproliferative activities in cancer cell lines of different origins and overcomes resistance to microtubule-targeting agents. Dec 12 2018
S5491 Lomefloxacin Lomefloxacin is a fluoroquinolone antibiotic used to treat bacterial infections. Dec 12 2018
S9451 Uridine 5'-monophosphate Uridine 5'-monophosphate is a nucleotide that is used as a monomer in RNA. Dec 12 2018
S5539 Olprinone Olprinone is a phosphodiesterase III (PDE3) inhibitor with IC50 values of 0.35 mM, 150 mM and 100 mM for human cardiac PDE III, PDE I and PDE II, respectively. Dec 12 2018
S9449 Urocanic acid Urocanic acid is an intermediate in the catabolism of L-histidine. Dec 12 2018
S5758 2-Methoxycinnamic acid 2-Methoxycinnamic acid is a cinnamic acid with magnetic properties. Dec 12 2018
S5700 Phthalylsulfathiazole Phthalylsulfathiazole is a broad-spectrum antimicrobial that can treat different types of infections including intestinal. Dec 12 2018
S5703 Carvedilol Phosphate Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intrinsic sympathomimetic activity. Dec 12 2018
S5752 Abametapir Abametapir, the active ingredient of Xeglyze Lotion, is an inhibitor of metalloproteinases critical for louse survival and egg development. Dec 12 2018
S5395 Phenolphthalein Phenolphthalein is an acid-base pH indicator. Dec 12 2018
S5762 Methyl Oleate Methyl Oleate is a methyl ester of oleic acid, which is a monounsaturated fatty acid and is one of the major components of membrane phospholipids. Dec 12 2018
S4744 Anethole trithione Anethole trithione is a drug used in the treatment of dry mouth. Dec 12 2018
S5396 4'-Hydroxypropiophenone 4'-Hydroxypropiophenone is a member of acetophenones. Dec 12 2018
S5721 edetate calcium disodium Edetate calcium disodium is a chelating agent that is primarily used for the management of severe lead poisoning. Dec 12 2018
S5397 Chlorhexidine Chlorhexidine is a disinfectant and topical anti-infective agent that is active against Gram-positive and Gram-negative organisms, facultative anaerobes, aerobes, and yeasts. Dec 12 2018
S5398 Nefazodone hydrochloride Nefazodone hydrochloride is the hydrochloride salt form of nefazodone, which is an atypical antidepressant showing antagonistic activity on serotonin reuptake. Dec 12 2018
S5693 Levomilnacipran Hydrochloride Levomilnacipran Hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor with antidepressant activity. Dec 12 2018
Cat.No. Product Name Information Added
S5713 Pravastatin Pravastatin is a lipoprotein-lowering drug via reversibly inhibiting hydroxymethylglutaryl-CoA (HMG-CoA) reductase and the synthesis of very-low-density lipoproteins. Dec 12 2018
S5715 atorvastatin Atorvastatin is a lipid lowering agent. It is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway. Dec 12 2018
S5754 Baricitinib phosphate Baricitinib phosphate is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2. Dec 12 2018
S5702 Fenipentol Fenipentol is a member of benzenes and stimulates plasma secretion & exocrine pancreatic secretion. Dec 12 2018
S5706 Edetate Trisodium Edetate Trisodium (EDTA trisodium salt) is the organic sodium salt of ethylenediaminetetraacetic acid (EDTA). EDTA is a chelating agent capable of removing a heavy metal, such as lead or mercury, from the blood. Dec 12 2018
S5387 D-Tagatose D-Tagatose is an isomer of fructose and is used as a sweetener in beverages, yogurt, creams, and dietetic candy. Dec 12 2018
S5603 5-Bromocytosine 5-Bromocytosine can be used in the synthesis of cross-link products under anaerobic and aerobic conditions. Dec 12 2018
S5606 Sulfamide Sulfamide is used in organic chemistry for synthesis. Dec 12 2018
S5637 Cefotiam Hexetil Hydrochloride Cefotiam Hexetil Hydrochloride is the hydrochloride salt of cefotiam hexetil. Cefotiam is a semi-synthetic, beta-lactam cephalosporin antibiotic with antibacterial activity. Dec 12 2018
S5710 Ambroxol Ambroxol, a substituted benzylamine, is an active metabolite of bromhexine. It is a potent inhibitor of the neuronal Na+ channels. Dec 12 2018
S5704 Myclobutanil Myclobutanil is a widely used triazole fungicide and also a steroid demethylation inhibitor. Dec 12 2018
S5724 Dichlorophene Dichlorophen is an anticestodal agent, fungicide, germicide, and antimicrobial agent. Dec 12 2018
S5731 Glyceryl tridecanoate Glyceryl tridecanoate (Tricaprin) is an orally available precursor of decanoic acid with potential antiandrogen and antihyperglycemic properties. Dec 12 2018
S9376 Benzylacetone Benzylacetone is an attractant compound in flowers. Dec 12 2018
S9377 Eugenyl acetate Eugenyl acetate, an aromatic component of clove essential oil, exhibits various pharmacological activities, including antibacterial and anti-virulence activities against drug-resistant A. baumannii clinical isolates. Dec 12 2018
S9381 5-Methyl furfural 5-Methyl furfural is an important chemical intermediate. Dec 12 2018
S5723 Carvedilol EP IMpurity E Carvedilol is a nonselective beta blocker/alpha-1 blocker and used in management of congestive heart failure (CHF). Dec 12 2018
S5725 Pempidine Pempidine is a long-acting ganglion-blocking compound. Dec 12 2018
S5729 Fosfosal Fosfosal (2-phosphonoxy benzoic acid) is a non-acetylated salicylic acid derivative, with analgesic and anti-inflammatory activity, but without effects on PG biosynthesis in vitro. Dec 12 2018
S9380 5,7-Dihydroxy-4-methylcoumarin 5,7-Dihydroxy-4-methylcoumarin may be used for pharmaceutical synthesis. Dec 12 2018
Cat.No. Product Name Information Added
S5632 L-aspartic Acid L-aspartic Acid is one of non-essential amino acids and may be a neurotransmitter. Dec 09 2018
S9331 7-Hydroxy-4-methyl-8-nitrocoumarin 7-Hydroxy-4-methyl-8-nitrocoumarin is a chemical. Dec 07 2018
S9363 Coumarin 151 Coumarin 151 is a fluorescent tracer used for the detection of proteinases. Dec 07 2018
S9355 2,4'-Dihydroxybenzophenone 2,4'-Dihydroxybenzophenone (DHBP) is an organic compound used for the synthesis of pharmaceutical agents. Dec 07 2018
S9371 1-Iodoadamantane 1-Iodoadamantane is a chemical. Dec 07 2018
S9357 Phenylacetaldehyde Phenylacetaldehyde is an organic compound used in the synthesis of fragrances and polymers. Dec 07 2018
S9327 Carboprost Carboprost is a synthetic prostaglandin analogue of PGF2α with oxytocic properties. Dec 07 2018
S9038 Calycosin Calycosin, an isoflavonoid, is the major active component in Radix Astragali. It shows antitumor, anti-inflammatory, neuroprotective and pro-angiogenesis effects. Dec 07 2018
S9328 5,6,7-Trimethoxyflavone 5,6,7-Trimethoxyflavone, methylations of the hydroxyl groups of oroxylin A or baicalein, has various pharmacological activities including antiviral, anticancer and antibacterial. Dec 07 2018
S9342 1,4-Naphthoquinone 1,4-Naphthoquinone, found in diesel exhaust particles and it is an active metabolite of naphthalene, is a fumigant insecticide. Dec 07 2018
S9351 2'-Deoxyadenosine monohydrate 2'-Deoxyadenosine may be used as an energy source under energy stress conditions and to affect cAMP levels. Dec 07 2018
S9346 1-Indanone 1-Indanone is an oxidation product of Indan, a component of fuels, solvents, and varnishes. It is part of the steroid hormone biosynthesis, and arachidonic acid metabolism pathways. Dec 07 2018
S9359 Anthraquinone-2-carboxylic Acid Anthraquinone-2-carboxylic Acid is a novel electron shuttling mediator, showing potent anti-inflammatory and antinociceptive activities in vivo. Dec 07 2018
S9338 Octyl gallate Octyl gallate, a widely used food additive, shows antimicrobial and antioxidant activity. Dec 07 2018
S5673 Mivacurium chloride Mivacurium chloride is a rapid, non-depolarising, neuromuscular blocking agent of short duration, used therefore as anesthetic, to provide skeletal muscle relaxation in minor surgical operations, in emergency surgical procedures of short to intermediate duration and during intubation of the trachea. Dec 06 2018
S5765 Sodium Dehydrocholate Sodium Dehydrocholate is a semisynthetic bile acid made from cholic acid. It has been used for stimulation of biliary lipid secretion. Dec 06 2018
S8556 AZ31 AZ31 is a selective and novel ATM inhibitor with an IC50 of <0.0012 μM. It shows excellent selectivity over closely related enzymes (>500 fold selective over DNA-PK and PI3Kα and >1000 fold selective over mTOR, PI3Kβ and PI3Kγ). Dec 06 2018
S5627 Amsacrine hydrochloride Amsacrine hydrochloride is the hydrochloride salt form of amsacrine, which is an inhibitor of topoisomerase II with antineoplastic activity. Dec 06 2018
S8764 IITZ-01 IITZ-01 is a potent autophagy inhibitor, enhancing autophagosome accumulation but inhibiting autophagosomal degradation by impairing lysosomal function. Dec 06 2018
S5668 Chlorindione Chlorindione is an antagonist of vitamin K. Dec 06 2018
Cat.No. Product Name Information Added
S9005 Stearyl Glycyrrhetinate Stearyl glycyrrhetinate, the stearyl ester of 18-β-glycyrrhetinic acid, has been demonstrated to improve antiviral effects, reduce inflammation and suppress allergies in the pharmaceutical and cosmetic industry. Dec 06 2018
S5663 Minaprine dihydrochloride Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates. Dec 06 2018
S5683 Isoproterenol sulfate dihydrate Isoproterenol Sulfate is the sulfate salt form of isoproterenol, a beta-adrenergic receptor agonist with bronchodilator activity. Dec 06 2018
S5625 Ammonium lactate Ammonium lactate is the ammonium salt of lactic acid with mild anti-bacterial properties. Dec 06 2018
S5692 Mexenone Mexenone is a benzophenone-derived sunscreening agent. Dec 06 2018
S5670 Chloropyramine hydrochloride Chloropyramine hydrochloride is a histamine receptor H1 antagonist and has anti-cholinergic, antispasmodic, and antiallergic effects. Dec 06 2018
S5665 Drofenine Hydrochloride Drofenine hydrochloride is a potent competitive inhibitor of BChE. It is an anticholinergic that acts both at the level of the nerves and the muscle fibers. Dec 06 2018
S5666 Moxisylyte hydrochloride Moxisylyte hydrochloride is an alpha-adrenergic blocking agent used for the treatment of Raynaud's disease. Dec 06 2018
S5658 Omeprazole Sodium Omeprazole Sodium is the sodium salt form of omeprazole, which is a proton pump inhibitor and suppresses gastric acid secretion. Dec 06 2018
S5679 Dolasetron Mesylate Dolasetron Mesylate is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Dec 06 2018
S5682 Methyl linolenate Methyl linolenate is a fatty acid methyl ester derived from alpha-linolenic acid and acts as a plant metabolite and an insect attractant. Dec 06 2018
S5609 Chicago Sky Blue 6B Chicago Sky Blue 6B is a counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry. It is an inhibitor of macrophage migration inhibitory factor (MIF) with an IC50 of 0.81 μM. Dec 06 2018
S5607 4,4'-Bis(4-aminophenoxy)biphenyl 4,4'-Bis(4-aminophenoxy)biphenyl is a monomer for polyimide production. Dec 06 2018
S5602 Gallocyanine Gallocyanine is a histological dye used in solution with an iron alum mordant as a hematoxylin substitute in the H&E stain. It has a role as a fluorochrome and a histological dye. Dec 06 2018
S5605 Tos-Arg-OMe HCl Tos-Arg-OMe HCl, a kind of amino acid derivatives, is a substrate for trypsin, plasmin, thrombin and orther proteases. Dec 06 2018
S5610 Indole-3-acetamide Indole-3-acetamide is an auxin precursor that is also used in the synthesis of indole-3-acetic acid. Dec 06 2018
S5641 Rhodamine B Rhodamine B is used as a tracer dye in water to determine the rate and direction of flow and transport. It is a staining fluorescent dye used in fluorescence microscopy, flow cytometry, fluorescence correlation spectroscopy and ELISA in biotechnology fields. Dec 06 2018
S5638 Cefozopran hydrochloride Cefozopran Hydrochloride is the hydrochloride salt form of cefozopran, a semi-synthetic, broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Dec 06 2018
S5644 Ceftriaxone Sodium Ceftriaxone Sodium is the sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Dec 06 2018
S5619 Betahistine Betahistine is an antivertigo drug that primarily acts as a histamine H1 agonist. Dec 06 2018
Cat.No. Product Name Information Added
S5653 Indigo carmine Indigo carmine is an indicator at pH 11.5-14, changing from blue to yellow. It has a role as a food colouring and a histological dye. Dec 06 2018
S5649 Hydroxyzine pamoate Hydroxyzine Pamoate is the pamoate salt form of hydroxyzine, a synthetic piperazine histamine H1-receptor antagonist with anti-allergic, antispasmodic, sedative, anti-emetic and anti-anxiety properties. Dec 06 2018
S5660 Clodronate disodium tetrahydrate Clodronate disodium tetrahydrate is a diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification. Dec 06 2018
S5664 Orphenadrine Hydrochloride Orphenadrine Hydrochloride is an uncompetitive NMDAR antagonist, H1 receptor antagonist and nonselective mAChR antagonist with muscle relaxant activity. Dec 06 2018
S5662 Ranitidine Ranitidine is an H2 histamine receptor antagonist that works by blocking histamine and thus decreasing the amount of acid released by cells of the stomach. Dec 06 2018
S4316 Clopamide Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. Dec 04 2018
S7313 Z-LEHD-FMK Z-LEHD-FMK is a cell-permeable, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival. Nov 30 2018
S5568 Tocofersolan Tocofersolan is a synthetic water-soluble version of vitamin E that is used in treatment of vitamin E deficiency. Nov 30 2018
S5601 Balofloxacin Dihydrate Balofloxacin Dihydrate is an orally active fluoroquinolone antibiotic. Nov 30 2018
S9395 N-Benzoyl-(2R,3S)-3-phenylisoserine N-Benzoyl-(2R,3S)-3-phenylisoserine, also known as taxol side chain, is important for strong antitumor activity of taxol. Nov 30 2018
S9399 1,2,3,4,6-O-Pentagalloylglucose 1,2,3,4,6-O-Pentagalloylglucose is the pentagallic acid ester of glucose. It could be used for precipitating proteins. Nov 30 2018
S5744 Spiramycin I Spiramycin I is a main component of spiramycin, which is a macrolide antimicrobial agent with broad spectrum antibiotic activity. Nov 30 2018
S5746 pentetate calcium trisodium hydrate pentetate calcium trisodium hydrate is an iron chelating agent. Nov 30 2018
S5747 Morantel tartrate Morantel is a positive allosteric modulator of neuronal nicotinic acetylcholine receptors (nAChRs). Nov 30 2018
S5748 4′-Deoxyphlorizin 4'-Deoxyphlorizin is an inhibitor of the glucose transport system. Nov 30 2018
S5749 Chlorpromazine Chlorpromazine is a low-potency typical antipsychotic agent that is used to treat psychotic disorders such as schizophrenia. Nov 30 2018
S5750 DL-Norepinephrine hydrochloride Norepinephrine is the neurotransmitter at most sympathetic neuroeffector junctions and has pharmacologic effects on both α1 and β1 adrenoceptors. Nov 30 2018
S9510 Protriptyline hydrochloride Protriptyline Hydrochloride is the hydrochloride salt form of protriptyline. Protriptyline is a tricyclic secondary amine with antidepressant property which acts by inhibition of serotonin and norepinephrine reuptake. Nov 30 2018
S9506 Danazol Danazol is a synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. Nov 30 2018
S9508 Brimonidine Brimonidine is an alpha adrenergic receptor agonist (primarily alpha-2) and is used for the treatment of open-angle glaucoma or ocular hypertension to lower intraocular pressure. Nov 30 2018
Cat.No. Product Name Information Added
S9509 Tiapride Hydrochloride Tiapride is a drug that selectively blocks D2 and D3 dopamine receptors in the brain and is used to treat a variety of neurological and psychiatric disorders. Nov 30 2018
S5751 Dihydroergotamine Mesylate Dihydroergotamine Mesylate is an ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. Nov 30 2018
S5687 Tropinone Tropinone is an alkaloid used for an intermediate in synthesis of atropine sulfate. Nov 30 2018
S5688 Tropolone Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion. It is able to inhibit ferric iron reduction by catecholates, lowering the redox potential of the iron couple. Nov 30 2018
S5689 Tropic acid Tropic acid is a laboratory reagent used in the chemical synthesis of atropine and hyoscyamine. Nov 30 2018
S5740 Palonosetron Palonosetron is a 5-HT3 antagonist with Ki value of 0.17 nM. It is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Nov 30 2018
S5177 Naproxen Naproxen is an anti-inflammatory agent with analgesic and antipyretic properties. It is a nonselective inhibitor of COX-1 and COX-2. Nov 28 2018
S8689 RGX-104 RGX-104 is a orally bioavailable liver X receptor agonist that modulates innate immunity via transcriptional activation of the ApoE gene. Nov 28 2018
S3623 Ceftibuten dihydrate Ceftibuten Dihydrate is the dihydrate form of ceftibuten, a semisynthetic, beta-lactamase-stable, third-generation cephalosporin with antibacterial activity. Nov 28 2018
S5255 Nicardipine Nicardipine is a potent calcium channel blockader with marked vasodilator action. Nov 28 2018
S8740 A-485 A-485 is a potent, selective and drug-like p300/CBP catalytic inhibitor with an IC50 of 0.06 μM for p300 HAT. It is selective over BET bromodomain proteins and >150 non-epigenetic targets. Nov 28 2018
S5533 Tobramycin sulfate Tobramycin sulfate is the sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity. Nov 28 2018
S5531 Doripenem Doripenem is a new parenteral carbapenem antibiotic with broad-spectrum activity against gram-negative and gram-positive pathogens. Nov 28 2018
S5548 7-Hydroxy-4-chromone 7-Hydroxy-4-chromone is a biochemical. Nov 28 2018
S5564 Xylazine Xylazine is a partial alpha-2 adrenergic agonist that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. Nov 28 2018
S5532 Erythromycin estolate Erythromycin, a naturally occurring macrolide, is derived from Streptomyces erythrus. It inhibits bacterial protein synthesis by binding to bacterial 50S ribosomal subunits. Nov 28 2018
S5535 Moxifloxacin Moxifloxacin is an antibiotic used to treat a number of bacterial infections, active against Mycobacterium tuberculosis in vitro. Nov 28 2018
S5386 7-Dehydrocholesterol 7-Dehydrocholesterol is the direct precursor of free cholesterol in the cholesterol biosynthetic pathway in mammalian tissues and also a biosynthetic precursor to vitamin D3. Nov 28 2018
S5221 Diludine Diludine is a synthetic antioxidant agent. Nov 28 2018
S5054 Rifamycin sodium salt Rifamycin sodium is an antibacterial drug used for treatment of mycobacterium infections. Nov 28 2018
Cat.No. Product Name Information Added
S5207 Cephalexin Monohydrate Cephalexin is a semisynthetic cephalosporin antibiotic with antimicrobial activity. Nov 28 2018
S5507 Trimebutine maleate Trimebutine maleate is the maleate salt form of trimebutine, which is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu opioid agonist effects. Nov 28 2018
S5561 Ethacrynic Acid Ethacrynic Acid is a loop or high ceiling diuretic used for the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure. Nov 28 2018
S5502 Ilaprazole sodium Ilaprazole sodium is the sodium salt form of ilaprazole, which is a proton pump inhibitor. Nov 28 2018
S5303 Afalanine (N-Acetyl-DL-phenylalanine) Afalanine (N-Acetyl-DL-phenylalanine) acts as an antidepressant and a metabolite. Nov 28 2018
S5477 Gefarnate Gefarnate is a synthetic compound used for the treatment of gastric ulcers. Nov 28 2018
S4997 4-Butylresorcinol 4-Butylresorcinol is a potent inhibitor of tyrosinase and is used in cosmetics as a depigmenting agent. Nov 28 2018
S5487 Cefoperazone sodium Cefoperazone Sodium is the sodium salt form of cefoperazone, which is a semi-synthetic, broad-spectrum, beta-lactamase resistant antibiotic with bactericidal activity. Nov 28 2018
S5488 Fluorescein Fluorescein is a manufactured organic compound and dye. Nov 28 2018
S5546 Sulfacetamide Sulfacetamide is a synthetic sulfanylacetamide derivative with bacteriostatic activity. It is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections. Nov 28 2018
S5536 Alendronic Acid Alendronic acid (alendronate) is a nitrogen-containing, second generation bisphosphonate used for osteoporosis, osteogenesis imperfecta, and several other bone diseases. Nov 28 2018
S5078 Osimertinib mesylate Osimertinib mesylate is the mesylate form of osimertinib, which is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug. Nov 28 2018
S5478 Dantrolene sodium Dantrolene sodium acts as a postsynaptic muscle relaxant by inhibiting Ca2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors. Nov 28 2018
S5504 Ropivacaine Ropivacaine is a member of the amino amide class of local anesthetics. Nov 28 2018
S9504 Hydroflumethiazide Hydroflumethiazide is a thiazide diuretic. Nov 23 2018
S9000 7,8-Dihydroxy-4-methylcoumarin 7,8-Dihydroxy-4-methylcoumarin is a precursor in the synthesis of derivatives of 4-methyl coumarin, which has excellent radical scavenging properties. Nov 23 2018
S9003 (R)-(-)-Mandelic acid (R)-(-)-Mandelic acid is a synthetic intermediate useful for pharmaceutical synthesis. Nov 23 2018
S9007 2'-Deoxyguanosine monohydrate 2'-Deoxyguanosine monohydrate is a kind of purine nucleoside. Nov 23 2018
S8641 Nec-1s (7-Cl-O-Nec1) Nec-1s is a stable variant of Necrostatin-1. It is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases. Nov 22 2018
S8770 Lanifibranor(IVA-337) Lanifibranor (IVA-337) is a moderately potent and well balanced pan PPAR agonist with EC50 values of 1537 nM, 866 nM and 206 nM for hPPARα, hPPARδ and hPPARγ, respectively. Nov 22 2018
Cat.No. Product Name Information Added
S7965 PLX8394 PLX8394 is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF(V600E), WT BRAF and CRAF respectively. It has potential antineoplastic activity. Nov 22 2018
S9362 1-Naphthaleneacetic acid 1-Naphthaleneacetic acid is a synthetic plant hormone in the auxin family. Nov 22 2018
S9374 2',5'-Dihydroxyacetophenone 2', 5'-Dihydroxyacetophenone is a mixture of dihydroxyacetophenone isomers is used in food flavouring. Nov 22 2018
S9378 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase. Nov 22 2018
S9393 (4S)-4-Hydroxy-L-isoleucine (4S)-4-hydroxy-L-isoleucine is an L-isoleucine derivative that is L-isoleucine bearing a (4S)-hydroxy substituent. It has a role as a plant metabolite. Nov 22 2018
S9418 Parishin B Parishin B is a dominant active ingredient originating from Gastrodia elata Blume, and has good neuroprotective effects against brain disorders. Nov 22 2018
S9424 Liensinine diperchlorate Liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. It is a novel autophagy/mitophagy inhibitor. Nov 22 2018
S9321 Topotecan Topotecan is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases. Nov 16 2018
S9330 6-Hydroxy-4-methylcoumarin 6-Hydroxy-4-methylcoumarin is a chemical. Nov 16 2018
S9336 Ethyl Coumarin-3-carboxylate Ethyl coumarin-3-carboxylate occupies an important position in the organic synthesis and is used in production of biologically active compounds. Nov 16 2018
S9337 Ethyl vanillin acetate Ethyl vanillin acetate is acectate form of ethyl vanillin, which is a flavorant and is used in the production of chocolate. Nov 16 2018
S9340 Bz-RS-ISer(3-Ph)-Ome Bz-RS-ISer(3-Ph)-Ome is a chemical. Nov 16 2018
S9358 Scarlet 808 Scarlet 808 is a chemical dye. Nov 16 2018
S9360 4-Hydroxyquinazoline 4-Hydroxyquinazoline is a PARP inhibitor with a high potency for PARP-1 and no effects on enzymes other than PARP. Nov 16 2018
S9361 Coumarin-3-carboxylic acid Coumarin-3-carboxylic acid is used as a detector for hydroxyl radicals (.OH) in aqueous solution. Nov 16 2018
S7323 CHF 5074 CHF5074 is a gamma-secretase modulator that reduces Aβ42 and Aβ40 secretion. The IC50s of CHF5074 for inhibition of COX-1 and COX-2 is above 100 μmol/L. Nov 15 2018
S9299 Ginsenoside F1 Ginsenoside F1, a pharmaceutical component of ginseng, is known to have antiaging, antioxidant, anticancer, and keratinocyte protective effects. Nov 15 2018
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