HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E7041 Desmosterol Desmosterol is the immediate unsaturated precursor of cholesterol and the final biosynthetic intermediate in the Bloch pathway and a key activator of liver X receptors(LXR) while inhibiting SREBP to regulate lipid homeostasis. Its reduction promotes mitochondrial ROS production in macrophages and activates the NLRP3 inflammasome exhibiting potential for research in inflammation, metabolism, and cardiovascular diseases. Dec 19 2024
E7257 Menaquinone-7 Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs (orally active), is originally discovered as the anti-hemorrhagic factors. Menaquinone-7 inhibits osteoclast bone resorption in vitro and stimulates bone formation in femoral tissue of aged female rats. Menaquinone-7 has a well-researched potential in the prevention of aging-induced bone degeneration. Menaquinone-7 is also a pharmacological option for activating Gla matrix protein and intervening in the progression of calcific aortic stenosis (CAVS). Dec 19 2024
E7042 SMIP004 SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells. Dec 19 2024
E7258 Polymyxin B Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research. Dec 19 2024
E7044 DSPC DSPC (1,2-Distearoyl-sn-glycero-3-phosphorylcholine) is a cylindrical-shaped lipid. DSPC is used to synthesize liposomes, and is the lipid component in the lipid nanoparticle (LNP) system. Dec 19 2024
E6037 Perindopril Perindopril (S-9490) is a brain-penetrating inhibitor of angiotensin-converting enzyme (ACE) with an IC50 of 0.048 μM for ACE-1. It exhibits anti-hypertensive, anti-inflammatory, and anti-fibrotic properties. Dec 19 2024
E7045 iRGD peptide iRGD peptide is a 9-amino acid cyclic peptide, triggers tissue penetration of agents by first binding to αv-integrins, then proteolytically cleaved in the tumor to produce CRGDK/R to interact with neuropilin-1, and has tumor-targeting and tumor-penetrating properties. Dec 19 2024
E7259 Nelociguat Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator. Dec 19 2024
E7046 TRAP-6 TRAP-6 (PAR-1 agonist peptide) is a synthetic hexapeptide (SFLLRN) that acts as a agonist of PAR-1 (protease-activated receptor-1). It also activates GPR15 on T-cells, regulating immune responses by suppressing acute GvHD while maintaining GvT activity. Dec 19 2024
E7260 Tolrestat Tolrestat is a potent, orally active aldose reductase inhibitor with IC50 of 35 nM. Dec 19 2024
E7047 β-Amyloid (1-40) β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease. Dec 19 2024
E7261 Chlorotoxin Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker. Dec 19 2024
E1799 Streptonigrin Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively. Dec 19 2024
E7048 Pronase E (Activity ≥ 4000 U/mg) Pronase E (Activity ≥ 4000 U/mg) is a mixture of proteolytic enzymes that is obtained from Streptomyces griseus and could digest protein into individual amino acids. Dec 19 2024
E7262 Darifenacin Darifenacin (UK-88525) is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9. Darifenacin binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin inhibits tumor growth in colorectal cancer cells and has anti-tumor effects. Dec 19 2024
E7049 Fexofenadine Fexofenadine (MDL-16455, Terfenadine carboxylate) is a non anticholinergic and non sedative second-generation antagonist of histamine (H1) receptor. It can be used in research to treat allergic disorders by suppressing eosinophilia and systemic anaphylaxis, especially in allergic rhinitis and chronic urticaria. Dec 19 2024
E7263 Elastase, Porcine pancreas Elastase, Porcine pancreas (EC 3.4.21.36) is a single polypeptide chain of 240 amino acid residues, derived from pig pancreas. Elastase, Porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters. Dec 19 2024
E7050 CC-401 CC-401 is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM. Dec 19 2024
E7264 Cyclic GMP sodium Cyclic GMP sodium (cGMP) is an important regulator of short-term changes in smooth muscle tone and longer-term responses to chronic drug research or proliferative signals, it is in response to atrial natriuretic peptide (ANP) or nitric oxide (NO). Cyclic GMP sodium interacts with cation channels to regulate ion transport or activate the cyclic GMP-dependent protein kinase to result in protein phosphorylation. Dec 19 2024
E7051 Tempo Tempo is a nitric oxide radical and a selective scavenger of ROS in mitochondria. Tempo is also an organocatalyst that disproportionates superoxide and oxidizes primary alcohols to aldehydes in a catalytic cycle. Tempo has mutagenic and antioxidant effects and can induceDNA strand breaks. Tempo also exerts cytotoxic and mutagenic properties in mouse lymphoma cells. Dec 19 2024