HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E4900 Enalapril Enalapril(Eletriptan, Amprace, Vaseretic) is an inhibitor of angiotensin-converting enzyme (ACE), primarily used to treat hypertension, heart failure, and asymptomatic left ventricular dysfunction. It also attenuates frailty in aging mice. Sep 26 2024
E4954 Demeclocycline Demeclocycline(Demethylchlortetracycline (DMCT), Ledermycin) is a bacteriostatic antibiotic from the tetracycline class, that induces diuresis and can cause nephrogenic diabetes insipidus. It also manages the syndrome of inappropriate antidiuretic hormone secretion (SIADH) by restoring normal plasma sodium levels and permitting unrestricted water intake. Sep 26 2024
E4834 12-Crown-4 12-crown-4(EOCT, Ethylene oxide cyclic tetramer) is an effective phase-transfer catalyst and complexing agent for lithium, facilitating the dissolution of lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) without requiring acetonitrile. It selectively binds to lithium ions and forms stable complexes, significantly improving electrolyte conductivity in lithium batteries, and positively influencing ion mobility and overall battery performance. Sep 25 2024
E4701 CMP-5 CMP5 is a potent and selective small molecule inhibitor of PRMT5. It is found to selectively block S2Me-H4R3 by inhibiting PRMT5 methyltransferase activity on histone preparations. It also exhibit potential for research into treatment for EBV+ lymphomas and other B-cell NHL subtypes. Sep 25 2024
E4687 NIBR-LTSi NIBR-LTSi is a selective small-molecule inhibitor of LATS kinase . It agonizes YAP signaling and promotes tissue regeneration in vitro and in vivo, supporting future research on the regenerative potential of the YAP/Hippo pathway. Sep 25 2024
E4680 MTX-531 MTX-531(NSC827271) is a first-in-class, potent and selective inhibitor of EGFR and PI3Kα with an IC50 of 14.7 nM and 6.4 nM, respectively. It may play a role in treating Head and Neck Squamous Cell Carcinoma (HSNCC), squamous lung cancers, and certain EGFR/PI3K-driven triple-negative breast cancers. Sep 25 2024
E4844 Valbenazine Valbenazine(Ingrezza, Mt-5199, NBI-98854, VBZ) is a potent inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki of 110–190 nM. It is used to treat tardive dyskinesia and chorea associated with Huntington's disease. Sep 25 2024
E4675 Rezivertinib Rezivertinib(BPI-7711) is a potent third-generation inhibitor of EGFR tyrosine kinase, targeting both EGFR-sensitizing mutations and the EGFR T790M mutation. Additionally, it has excellent CNS penetration and has antitumor activity. Sep 25 2024
E4946 Tafenoquine Succinate Tafenoquine Succinate(WR 238605 Succinate, Etaquine, Krintafel) is an 8-aminoquinoline (8AQ) anti-malarial drug that kills both the liver and blood stages of the parasite, broadening its applicability for chemoprophylaxis to all species of malaria. It is specifically used for the prevention of Plasmodium vivax relapse. Sep 25 2024
E1993 BGB-16673 BGB-16673(BTK-IN-29) is an inhibitor of Bruton’s tyrosine kinase (Btk) and can be used in research for the treatment of autoimmune and inflammatory diseases. Sep 25 2024
E4941 Diflorasone diacetate Diflorasone diacetate(Florone), is a steroid anti-inflammatory drug, an inhibitor of TARC (thymus and activation regulated chemokine; CCL17) in the dinitrochlorobenzene (DNCB) model. It can be used in the treatment of allergic and inflammatory skin diseases such as atopic dermatitis and allergic contact dermatitis. Sep 25 2024
E4932 Amikacin Amikacin(BAY 41-6551, Lukadin) is a semisynthetic aminoglycoside, derived from kanamycin-A, that acts as an inhibitor of the Z ring formation, leading to the inhibition of cell division. It is used to treat serious infections caused by aerobic Gram-negative bacteria, mycobacteria, Nocardia, and life-threatening infections in neonates. Sep 25 2024
E4956 Ozanimod hydrochloride Ozanimod hydrochloride(Zeposia, RPC-1063 HCL) is a potent sphingosine 1-phosphate (S1P)receptor modulator and a selective agonist of S1P receptor subtypes 1 (S1P1) and 5 (S1P5) with EC50's of 1.03 nM and 8.6 nM, respectively. It can be used in the trearment of relapsing multiple sclerosis (MS). Sep 25 2024
E4923 AnaMorelin hydrochloride Anamorelin hydrochloride(RC-1291 HCL, ONO-7643) is a potent and selective agonist of ghrelin receptor with EC50 of 0.74 nM FLIPR assay. It has a significant appetite-enhancing activity and has the potential to treat cancer anorexia-cachexia syndrome. Sep 25 2024
E4907 Clomipramine Clomipramine(Hydiphen, Anafranil base) blocks the production of norepinephrine in the central nervous system and 5-HT reuptake, thereby exerting sedative and anticholinergic effects, with IC50 of 1.5 nM. Clomipramine is also a non-selective monoamine reuptake inhibitor that can affect the transmission of multiple neurotransmitters. Sep 25 2024
E1271 Zunsemetinib Zunsemetinib(ATI-450, CDD-450) is a selective inhibitor of p38α mitogen-activated protein kinase-activated protein kinase 2 (MK2) that mediates inflammatory responses. It reduces inflammation in cryopyrinopathy, alleviates arthritis, and potentially prevents tachyphylaxis. Sep 25 2024
E4921 Azelastine Azelastine(Azelastina; Astelin) is a potent antihistaminic and antiallergic drug, an antagonist of the histamine H1 receptor. It is also effective in treating allergic rhinitis, bronchial asthma, and SARS-CoV-2 and has shown potential in ameliorating aortic calcification, increasing apoA expression, and reducing apoB levels. Sep 25 2024
P1240 Etanercept Etanercept, a dimeric fusion protein, functions as an inhibitor of TNF by binding to TNF. It competitively blocks the attachment of both TNF-α and TNF-β to their cell surface receptors, thereby neutralizing TNF's biological activity. Etanercept has proven effectiveness in treating rheumatoid arthritis, juvenile idiopathic arthritis, and plaque psoriasis. Sep 24 2024
E1491 Brigimadlin Brigimadlin(BI 907828) is a potent, orally active inhibitor of E3 ubiquitin-protein ligase MDM-2. Brigimadlin inhibits MDM-2's suppression of the tumor suppressor p53. It promotes apoptosis and enhances the transcription of p53 targets such as p21 and PUMA in BT48, BT67, and BT73 cells. Sep 23 2024
E4599 BGB-3245(Brimarafenib) BGB-3245(Brimarafenib, Brimarafenibum) is an inhibitor of Raf kinase. BGB-3245 displays potent effects against different RAF isoforms, including BRAF Class I/II/III mutations, BRAF fusions, and heterodimerization with CRAF in preclinical models. It also exhibits antineoplastic effects. Sep 23 2024