For research use only. Not for use in humans.

Ozoralizumab (Anti-TNF-α)

Synonyms: ATN-103 Cat.No.A4046

Ozoralizumab is a humanized trivalent, bispecific NANOBODY targeting TNFα with two anti-TNFα domains and an anti-HSA domain. It demonstrates strong anti-arthritis efficacy in human TNF transgenic mice, effective both at arthritis onset and during secondary failure of anti-TNFα IgG therapy. M.W 38.44 kDa.

Quality Control

Specificity

Name	Citation	TNF-α	TNF-alpha	Others
QNZ (EVP4593)	155	++++		NF-κB
JTE-607 Dihydrochloride	0	++++	++++	IL-1beta,IL-8,IL-6
PF-3644022	1	+		MK2
UCB-9260	0	+++	+++	NF-κB
MD2-TLR4-IN-1	0	+		TLR4,IL-6
R-7050	8	+		IL-1β
Resatorvid (TAK-242)	62	++++		TLR4,IL-6,NO
Apigenin-7-O-glucuronide	0	✔
UTL-5g	0	✔
Benpyrine racemate	1	✔
Amarogentin	0	✔		TAS2R1,AMPK
Stylopine	0	✔		IL-1β,NO,COX-2
Myrislignan	1	✔		iNOS,IL-6,NF-κB
NE 52-QQ57	1	✔		iNOS,IL-6,IL-1β
(3R,8S)-Falcarindiol	3	✔		IL-1β,IL-6,iNOS
Gardenoside	0	✔		NF-κB,P2X7 Receptor,IL-6
Cucurbitacin IIb	0	✔		JNK,STAT3,NF-κB
IQ 3	1	✔		IL-6,JNK3,JNK1
Isuzinaxib (APX-115 free base)	0	✔		IL-6,MCP-1/CCL2,NOX2
AUDA	0	✔		Smad3,TGF-β,IL-1β
CPI-1189	1	✔
Madecassic acid	1	✔		IL-1β,COX-2,iNOS
Homoplantaginin	1	✔		IL-6,IKKβ,NF-κB
2',5'-Dihydroxyacetophenone	1	✔		IL-6,NF-κB,ERK1/2
Forsythoside B	0	✔		IκB,NF-κB,IL-6
Mulberroside A	0	✔		ERK,NF-κB,Caspase-1
Ginsenoside Rb1	4	✔		TLR3,NF-κB,IRAK-1
Muscone	4	✔		IL-6,IL-1β,NLRP3 inflammasome
(±)-Shikonin	38	✔		NF-κB,Proteasome,chemokine receptor
Methylthiouracil	0	✔		IL-6,ERK1/2,NF-κB

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Ozoralizumab is a humanized trivalent, bispecific NANOBODY targeting TNFα with two anti-TNFα domains and an anti-HSA domain. It demonstrates strong anti-arthritis efficacy in human TNF transgenic mice, effective both at arthritis onset and during secondary failure of anti-TNFα IgG therapy. M.W 38.44 kDa.

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	1167985-17-2
Source	CHO
Storage (From the date of receipt)	-80℃(avoid freeze-thaw cycles)

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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