Home Protein Tyrosine Kinase Syk inhibitor PRT062607 For research use only.

PRT062607

Synonyms: P505-15, PRT-2607, BIIB-057

PRT062607 is a highly specific, potent and orally bioavailable inhibitor of purified Spleen tyrosine kinase (SYK) with an IC50 of 1-2 nM. It exhibits significant anti-inflammatory activity and can be used in non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia (CLL) and rheumatoid arthritis research.

PRT062607 Chemical Structure

PRT062607 Chemical Structure

CAS No. 1370261-96-3

Purity & Quality Control

Batch: E779301 DMSO]79 mg/mL]false]]]false]]]false Purity: 99.33%
99.33

PRT062607 Related Products

Signaling Pathway

Syk Signaling Pathways

Syk Signaling Pathway

Biological Activity

Description PRT062607 is a highly specific, potent and orally bioavailable inhibitor of purified Spleen tyrosine kinase (SYK) with an IC50 of 1-2 nM. It exhibits significant anti-inflammatory activity and can be used in non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia (CLL) and rheumatoid arthritis research.
  • https://pubmed.ncbi.nlm.nih.gov/22040680/
  • https://pubmed.ncbi.nlm.nih.gov/23220742/

Chemical Information & Solubility

Molecular Weight 393.45 Formula

C19H23N9O
CAS No. 1370261-96-3 SDF Download PRT062607 SDF
Storage (From the date of receipt)

In vitro
Batch:

DMSO : 79 mg/mL ( (200.78 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)


Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.


In vivo Formulation Calculator

Preparing Stock Solutions

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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