Home Microbiology Bacterial inhibitor Omadacycline hydrochloride

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Omadacycline hydrochloride Bacterial inhibitor

Cat.No.E4983

Omadacycline hydrochloride (PTK0796 hydrochloride) is a first-in-class orally active member of the tetracycline class of antibiotics. This compound inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It exhibits broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria.
Omadacycline hydrochloride Bacterial inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 593.12

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Quality Control

Batch: E498301 DMSO]100 mg/mL]false]Water]100 mg/mL]false]Ethanol]100 mg/mL]false Purity: 98.80%
98.80

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (168.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : 100 mg/mL

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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 593.12 Formula

C29H40N4O7.xClH

 Storage (From the date of receipt)
CAS No. 1196800-39-1 Download SDF Storage of Stock Solutions

Read more about storage stability stock solution CAS number

Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-06-03)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07228702 ENROLLING_BY_INVITATION
Non-Tuberculous Mycobacterial (NTM) Pneumonia; Mycobacterium Abscessus Infection
Vancouver Coastal Health
 2026-01-11 PHASE1
NCT05753215 ACTIVE_NOT_RECRUITING
Bone Infection; Joint Infection; Bone and Joint Infection
Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
 2023-05-09 PHASE2
NCT05217537 COMPLETED
Bacterial Infections
Paratek Pharmaceuticals Inc
 2022-04-06 PHASE1
NCT06162286 UNKNOWN
Community-acquired Bacterial Pneumonia
Zai Lab (Hong Kong), Ltd.
 2023-11-17 PHASE3
NCT06462326 COMPLETED
Healthy Volunteer
Zai Lab (Hong Kong), Ltd.
 2024-04-16 PHASE1
NCT04922554 COMPLETED
Mycobacterium Infections, Nontuberculous; Mycobacterium Abscessus Infection; Nontuberculous Mycobacterial Lung Disease; Nontuberculous Mycobacterial Pulmonary Infection
Paratek Pharmaceuticals Inc
 2021-10-15 PHASE2

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