HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E8163 GW3965 GW3965 is a potent, selective liver X receptor (LXR) agonist with EC50s of 190 nM and 30 nM for hLXRα and hLXRβ, respectively. Dec 26 2024
E8164 Daunorubicin Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor. Dec 26 2024
E8165 MMAF hydrochloride MMAF (Monomethylauristatin F) hydrochloride is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF hydrochloride is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A. Dec 26 2024
E8166 PF429242 dihydrochloride PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM. Dec 26 2024
E8167 MRT68921 dihydrochloride MRT68921 dihydrochloride is a potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively. Dec 26 2024
E8168 Substance P Substance P (Neurokinin P) is an 11-amino-acid neuropeptide and an agonist for the neurokinin-1 receptor (NK1R), binding with high affinity to regulate pain, anxiety, and stress responses. It is present in the CNS and PNS, playing a key role in neurotransmission, neuromodulation, and wound healing research. Dec 26 2024
E8169 C12-200 C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B. Dec 26 2024
E8170 SCH 546738 SCH 546738 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. Dec 26 2024
E8171 NSC 23766 NSC 23766 is a cell-permeable, reversible and specific inhibitor of Rac GTPase, used for cancer treatment. Dec 26 2024
E8172 Pyridostatin Pyridostatin (RR82) is a highly selective small molecule that stabilizes telomeric DNA G-quadruplex with a Kd of 490 nM, promoting their folding and inducing dysfunctional telomeres by uncapping POT1 and activating DNA damage signaling. It also modulates gene expression, reducing SRC protein levels and SRC-dependent motility in breast cancer cells, contributing to its anti-proliferative effects. Dec 26 2024
E8173 AZD-5991 AZD-5991 is a potent and selective Mcl-1 inhibitor with an IC50 of 0.7 nM in FRET assay and a Kd of 0.17 nM in surface plasmon resonance (SPR) assay. Dec 26 2024
E8174 Streptomycin Streptomycin (Agrept) is an effective antibiotic against M. tuberculosis, is used for the research of tuberculosis (TB). Streptomycin also is a bacteriocidal agent that can be used for the research of a number of bacterial infections. Streptomycin can bind strongly to nucleic acids, interferes and blocks protein synthesis while permitting continued RNA and DNA synthesis. Streptomycin, as a common antibiotic used in culture media, also is a blocker of stretch-activated and mechanosensitive ion channels in neurons and cardiac myocytes . Dec 26 2024
E8175 Hoechst 33342 trihydrochloride Hoechst 33342 trihydrochloride (Bisbenzimide ethoxide trihydrochloride, HOE 33342 trihydrochloride) is a bis-benzimide fluorescent dye that specifically binds to AT-rich sequences in the minor groove of double-stranded DNA. When exposed to UV light, it emits bright fluorescence at Hoechst Red (630–650 nm) and Hoechst Blue (405–450 nm) wavelengths. This dye is used to determine cell cycle status, conduct apoptosis assays, and act as a nuclear marker in microscopy. Dec 26 2024
E8176 TMA-DPH TMA-DPH is a hydrophobic fluorescent membrane probe (Ex=355 nm; Em=430 nm). TMA-DPH is able to anchor on the cell surface and localize to different regions of the phospholipid bilayer. By analyzing the fluorescence polarization values of TMA-DPH in the plasma membrane and membrane substructures, the fluidity of the cell membrane can be determined. Dec 26 2024
E8177 5-Ph-IAA The 5-Ph-IAA is a bumped-IAA analogue, that establishes the auxin-inducible degron 2 (AID2) system with the OsTIR1(F74G) mutant, enabling precise, rapid degradation with 670-fold lower ligand concentration. It induces rapid and efficient depletion of mAID-fused proteins to study protein function in living cells, exhibiting significant tumor suppression properties. Dec 26 2024
E8178 Quisinostat Quisinostat(JNJ-26481585) is a potent and orally active second-generation inhibitor of pan-Histone Deacetylase (HDAC). It inhibits HDAC1, HDAC2, HDAC4, HDAC10, HDAC11 with IC50s of 0.11 nM , 0.33 nM , 0.64 nM , 0.46 nM, 0.37 nM respectively. It exhibits potent in vivo antitumor activity and potential clinical use in various solid and hematologic malignancies. Dec 26 2024
E8179 2’3’-c-di-AM(PS)2 (Rp,Rp) (disodium salt) 2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt (ADU-S100 disodium salt) is an activator of stimulator of interferon genes (STING). Dec 26 2024
E8180 Zosuquidar Zosuquidar (LY335979) is a P-glycoprotein (P-gp) inhibitor (Ki=59 nM). Zosuquidar shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research. Dec 26 2024
E8183 Firategrast Firategrast (SB 683699) is an orally active and specific α4β1/α4β7 integrin antagonist. Firategrast reduces trafficking of lymphocytes into the central nervous system (CNS) and decreases multiple sclerosis (MS) activity. Dec 26 2024
E8184 FAPI-4 FAPI-4 is a potent fibroblast activation protein (FAP) inhibitor for the targeting FAP. FAPI-4 can be used in cancer research. 68Ga-FAPI-4 PET/CT is a promising new diagnostic method for imaging various kinds of cancer, with good tumor-to-background contrast ratios. Dec 26 2024