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Deferoxamine HIF inhibitor

Cat.No.S7925

Deferoxamine (Deferoxamine B, Deferrioxamine) is an iron chelator and a reversible inhibitor of S-phase in DNA synthesis. It enhnaces HIF-1α activation by inhibiting prolyl hydroxylase activity, activating insulin receptor (InsR) and Glut1. It also increases phosphorylation of Akt/PKB, FoxO1, GSK3β, influencing gluconeogenesis and glycogen synthesis, while reducing oxidative stress in diabetic hyperglycemia. It can be used to reduce iron accumulation and deposition in tissues and in studies of neurodegenerative diseases, anti-cancer and anti-COVID-19.
Deferoxamine HIF inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 560.69

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Quality Control

Batch: S792501 Water]8 mg/mL]false]DMSO]Insoluble]false]Ethanol]Insoluble]false Purity: 99.66%
99.66

Solubility

In vitro
Batch:

Water : 8 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

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Chemical Information, Storage & Stability

Molecular Weight 560.69 Formula

C25H48N6O8

 Storage (From the date of receipt)
CAS No. 70-51-9 Download SDF Storage of Stock Solutions

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Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-07-08)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06352632 RECRUITING
Stroke
The George Institute
 2024-09-26 PHASE3
NCT07162363 NOT_YET_RECRUITING
Intracerebral Hemorrhage; ICH - Intracerebral Hemorrhage
University of Illinois at Chicago
 2026-03-01 PHASE2; PHASE3
NCT06763055 RECRUITING
Intracerebral Hemorrhage; Spontaneous Intracerebral Hemorrhage; Supratentorial Intracerebral Haemorrhage; Acute Intracerebral Haemorrhage; Acute Stroke
The George Institute
 2025-02-27 PHASE3
NCT05184816 RECRUITING
Leptomeningeal Metastases
Memorial Sloan Kettering Cancer Center
 2021-12-22 PHASE1
NCT04566991 RECRUITING
Aneurysmal Subarachnoid Hemorrhage
Aditya S. Pandey, MD
 2022-03-20 PHASE2
NCT06244979 COMPLETED
Pulmonary Aspergillosis; Chronic Pulmonary Aspergillosis; Allergic Bronchopulmonary Aspergillosis
Radboud University Medical Center
 2025-05-01 PHASE2

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