HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
S7925 Deferoxamine Deferoxamine (Deferoxamine B, Deferrioxamine) is an iron chelator and a reversible inhibitor of S-phase in DNA synthesis. It enhnaces HIF-1α activation by inhibiting prolyl hydroxylase activity, activating insulin receptor (InsR) and Glut1. It also increases phosphorylation of Akt/PKB, FoxO1, GSK3β, influencing gluconeogenesis and glycogen synthesis, while reducing oxidative stress in diabetic hyperglycemia. It can be used to reduce iron accumulation and deposition in tissues and in studies of neurodegenerative diseases, anti-cancer and anti-COVID-19. Dec 26 2024
P1247 Exendin-4 Exendin-4 (Exenatide) is a 39-amino acid peptide and a long-acting potent agonist of glucagon-like peptide-1(GLP-1) receptor with an IC50 of 3.22 nM. It is used in research and as a potential long-term treatment for type 2 diabetes mellitus. Dec 26 2024
E1230 Vaborbactam Vaborbactam (RPX7009) is a cyclic boronic acid pharmacophore β-lactamase inhibitor. Dec 26 2024
E1473 BODIPY 581/591 C11 BODIPY 581/591 C11 is a fluorescent probe for detecting lipid peroxidation and oxidative stress in living cells. It shifts emission from 591 nm (red, reduced form) to 510 nm (green, oxidized form) upon oxidation. With high sensitivity, low cytotoxicity, and good light stability, it is widely used to study lipid peroxidation and antioxidant properties in living cells or to detect ferroptosis by reacting with hydroxyl radicals. Dec 26 2024
E4789 Bleomycin hydrochloride Bleomycin hydrochloride is a natural antibiotic, an inhibitor of DNA synthesis. It binds to nuclear DNA, targeting and killing dividing cells in G2 and M phases. It exhibits anticancer activity, showing efficacy against squamous cell carcinoma (SCC) with an IC50 of 4.0 nM in the UT-SCC-19A cell line. Dec 26 2024
E1835 diABZI STING agonist-1 trihydrochloride diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively. Dec 26 2024
E4794 GSK-J4 GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A that ameliorates experimental autoimmune encephalomyelitis (EAE). It is also an inhibitor of TNF-α production, with an IC50 of 9 μM. It shows potential as a treatment for inflammatory and autoimmune disorders. Dec 26 2024
P1235 Raleukin Anakinra (Raleukin, AMG-719) is an exogenous antagonist of recombinant human interleukin-1 receptor that also inhibits caspase-1 and caspase-9 activity with Ki of 0.201 μM and 0.31 μM respectively. It is used in research to study IL-1 blockade in inflammation, tumor growth, islet transplantation, and cardiac injury models. Dec 26 2024
E4795 Bobcat339 Bobcat339 is a cytosine-based small molecule inhibitor of TET enzyme with IC50 of 33 μM and 73 μM for TET1 and TET2, respectively, reducing DNA 5hmC levels in hippocampal neurons. It is useful in epigenetics research and a potential starting point for therapeutics targeting DNA methylation and gene transcription. Dec 26 2024
E4796 SRT 1720 SRT 1720 is a selective activator of human SIRT1 with an EC1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC1.5s of 37 μM and > 300 μM, respectively. Dec 26 2024
E1850 Aldoxorubicin Aldoxorubicin (INNO-206) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models. Dec 26 2024
E4996 Puromycin Puromycin (CL13900, Puromycine) is an antibiotic, analog of the 3' end of aminoacyl-tRNA and an inhibitor of protein synthesis that mimics tyrosyl-tRNA, causing premature termination of translation. It blocks translation by labeling and releasing elongating polypeptide chains from ribosomes and has been widely used in molecular biology research. Dec 26 2024
P1244 PLGA (50:50) PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of poly lactic acid (PLA) and poly glycolic acid (PGA) which can be used to fabricate devices for drug delivery and tissue engineering applications. Dec 26 2024
E1838 Acridine Orange hydrochloride Acridine Orange hydrochloride is a cell-penetrable nucleic acid-selective fluorescent dye. Acridine Orange hydrochloride produces orange fluorescence when it binds to ssDNA or RNA, and green fluorescence when it binds to dsDNA (Ex: 488 nM; Em: green fluorescence at 530 nm, orange fluorescence at 640 nm). Dec 26 2024
E4799 BIX-01294 BIX-01294 is a reversible and highly selective G9a and GLP Histone Methyltransferase inhibitor, with IC50s of of 1.7 μM and 0.9 μM, respectively. BIX-01294 inhibits G9a/GLP by competing for binding with the amino acids N-terminal of the substrate lysine residue. BIX-01294, a (1H-1,4-diazepin-1-yl)-quinazolin-4-yl amine derivative, induces necroptosis and autophagy. BIX-01294 has antitumor activity in recurrent tumor cells. Dec 26 2024
S7879 Tin protoporphyrin IX dichloride Tin Protoporphyrin IX dichloride (NSC 267099, SnPPIX, Sn-Protoporphyrin) is a potent inhibitor of heme oxygenase-1 (HO-1), reduces ozone-induced pulmonary inflammation and BAL cell necrosis, highlighting its protective role. It also sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in a mouse model, suggesting its potential for PDAC treatment. Dec 26 2024
E4992 Afuresertib hydrochloride Afuresertib hydrochloride (GSK 2110183 hydrochloride) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively. Dec 26 2024
S9834 CA-074 CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM. Dec 26 2024
S7407 NFAT Inhibitor NFAT Inhibitor (VIVIT peptide) is a selective inhibitor of nuclear factor of activated Tcells (NFAT) activation that effectively blocks calcineurin-mediated dephosphorylation of NFAT in cell extracts. It also serves as a valuable tool for the direct identification of NFAT target genes across various cell types. Dec 26 2024
E5820 AKT Kinase Inhibitor AKT Kinase Inhibitor is an inhibitor of Akt that reverses the protective effects of Tadalafil (TAD) in LPS-induced RWPE-1 cells by decreasing cell viability, promoting apoptosis, and increasing pro-inflammatory cytokine levels. Dec 26 2024