Home Epigenetics PRMT inhibitor Furamidine dihydrochloride For research use only.

Furamidine dihydrochloride

Synonyms: DB75 dihydrochloride, NSC 305831 dihydrochloride

Furamidine dihydrochloride (DB75 dihydrochloride, NSC 305831 dihydrochloride) is a potent and selective inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 of 9.4 μM. It is also a potent inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1). It exhibits potent anti-Plasmodium vivax and antiparasitic activity in vitro and in vivo, and its ability to disrupt mitochondrial membranes also supports its use as an antimicrobial agent.

Furamidine dihydrochloride Chemical Structure

Furamidine dihydrochloride Chemical Structure

CAS No. 55368-40-6

Purity & Quality Control

Batch: E760301 Water]9 mg/mL]false]DMSO]6 mg/mL]false]Ethanol]Insoluble]false Purity: 98.18%
98.18

Furamidine dihydrochloride Related Products

Biological Activity

Description Furamidine dihydrochloride (DB75 dihydrochloride, NSC 305831 dihydrochloride) is a potent and selective inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 of 9.4 μM. It is also a potent inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1). It exhibits potent anti-Plasmodium vivax and antiparasitic activity in vitro and in vivo, and its ability to disrupt mitochondrial membranes also supports its use as an antimicrobial agent.

Chemical Information & Solubility

Molecular Weight 377.27 Formula

C18H16N4O.2ClH
CAS No. 55368-40-6 SDF Download Furamidine dihydrochloride SDF
Storage (From the date of receipt)

In vitro
Batch:

Water : 9 mg/mL

DMSO : 6 mg/mL ( (15.9 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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