HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E4760 YJ1206 YJ1206 is an orally bioavailable, highly specific and potent degrader of CDK12/13 with an IC50 of 12.55 nM in VCaP cells. It increases DNA damage, induces apoptosis, and demonstrates robust anti-tumor activity in vivo. Jan 09 2025
E5804 Gliocidin Gliocidin (SW106065), is a nicotinamide-mimetic prodrug that targets glioblastoma cells with an IC50 of 150 nM, by exploiting a de novo purine synthesis vulnerability via indirect inhibition of IMPDH2. It readily crosses the BBB and can be used in the treatment of all malignant brain tumors. Jan 09 2025
E4683 PI3K/AKT-IN-1 PI3K/AKT-IN-1 is a dual-acting inhibitor of PI3K/AKT pathway with an IC50 of 6.99 µM, 4.01 µM, and 3.36 µM, for PI3Kδ, PI3Kγ and AKT-1 respectively. It also induces S-phase cell cycle arrest, caspase-3-dependent apoptosis, exhibiting strong potential against breast cancer and leukemia. Jan 09 2025
E1360 BAY-069 BAY-069 is a potent dual inhibitor of BCAT1/2 (branched-chain amino acid transaminases), with IC50 values of 31 nM for BCAT1 and 153 nM for BCAT2. It demonstrates high cellular activity, excellent selectivity, and is used as an in vitro probe. Jan 02 2025
E1816 Lorundrostat Lorundrostat (MT-4129) is a highly selective inhibitor of CYP11B2 (aldosterone synthase), with inhibition constant (Ki) values of 1.27 nM for hCYP11B2 and 475 nM for hCYP11B1. It demonstrates potential as a safe and effective treatment for aldosterone-dependent uncontrolled hypertension, including cases of treatment-resistant hypertension. Jan 02 2025
E1915 DDO-2728 DDO-2728 is a selective pyrazolopyrimidine-based inhibitor of ALKBH5 with an IC50 of 2.97 μM. It increases the levels of N6-methyladenosine (m6A) modifications in acute myeloid leukemia (AML) cells and exhibits antiproliferative activity in these cells. It also demonstrates anti-tumor efficacy in the MV4−11 xenograft model. Jan 02 2025
E6003 Gabapentin enacarbil Gabapentin enacarbil (XP13512) is a prodrug of gabapentin, designed to enhance gabapentin absorption and bioavailability and treats restless legs syndrome. It also acts as an anticonvulsant and analgesic within the gabapentinoid class. Jan 02 2025
E4986 Mirodenafil Mirodenafil (SK3530) is a second-generation, highly selective inhibitor of phosphodiesterase type 5 (PDE5) with an IC50 of 0.34 nM, primarily used in the treatment of erectile dysfunction (ED). Jan 02 2025
E4666 O-Propargyl-Puromycin O-Propargyl-Puromycin (OP-puro) is an alkyne puroanalog, a potent inhibitor of protein synthesis . It is used to label nascent proteins in whole animals, allowing the visualization of protein synthesis patterns in large explants from tissues and organs. Dec 30 2024
E6004 Metipranolol hydrochloride Metipranolol hydrochloride is a non-selective antagonist of β-adrenoceptor. It also inhibits iron/ascorbate and sodium nitroprusside-induced lipid peroxidation with an IC50 of 6.9 µM and 25.1 µM respectively. It exhibits antioxidant properties and can be used in research to lower elevated intraocular pressure associated with glaucoma. Dec 30 2024
E4713 BBC0403 BBC0403 is a small-molecule selective inhibitor of Bromodomain-containing protein 2(BRD2) with Kds of 7.64 μM and 41.37 μM for BRD2 (BD2) and BRD2 (BD1), respectively. It is a potential intra-articular injectable therapeutic agent for treating osteoarthritis (OA). Dec 30 2024
E6044 3-O-Methylquercetin 3-O-Methylquercetin is a flavone isolated from Rhamnus nakaharai Hayata (Rhamnaceae), an inhibitor of cAMPand cGMP-phosphodiesterases(PDE) with an IC50 of 13.8 μM and 14.3 μM respectively. It also inhibits β-secretase with an IC50 of 6.5 μM. It exhibits antiviral activity and has been used in folk medicine for constipation, inflammation, tumors, and asthma. Dec 30 2024
E4694 EVT801 EVT801 is a potent and selective inhibitor of VEGFR-3 with an IC50 of 11 nM. It exhibits potent antitumor effects and represents a promising anti-lymphangiogenic drug in patients with VEGFR-3 positive tumors. Dec 30 2024
E6042 Riluzole hydrochloride Riluzole hydrochloride (PK 26124 hydrochloride) is an antiepileptic drug, a state-dependent inhibitor of Na+ channels and a selective inhibitor of glutamate release. It also inhibits GABA uptake with an IC50 of 43 µM. Dec 30 2024
E4942 Talazoparib tosylate Talazoparib tosylate (BMN 673ts) is a novel, potent and orally available PARP1/2 inhibitor with an IC50 of 0.57 nM for PARP1. Dec 26 2024
E1882 THZ1 THZ1 is a potent and covalent inhibitor of CDK7 with an IC50 of 3.2 nM. It also inhibits the CDK12 and CDK13 and downregulates MYC expression. It exhibits strong anti proliferative effect across a broad range of cancer cell lines including human T-cell acute lymphoblastic leukaemia (T-ALL) cancer. Dec 26 2024
E4790 H-89 H-89 is a potent and selective inhibitor of cyclic AMP-dependent protein kinase (protein kinase A) with IC50 of 48 nM and has weak inhibition on PKG, PKC, Casein Kinase, and others kinases. Dec 26 2024
E4787 Etomoxir Etomoxir ((R)-(+)-Etomoxir) is an irreversible, small-molecule inhibitor of carnitine palmitoyl-transferase 1a (CPT1a). It inhibits fatty acid oxidation (FAO) and may have potential in treating diabetes, inflammation, cancer and cardiac metabolic diseases. Dec 26 2024
E4788 Nigericin Nigericin is an antibiotic derived from Streptomyces hygroscopicus that acts as a K+/H+ ionophore, which causes the efflux of potassium from the cell and, thus, influences the mitochondria membrane potential. It also induces pyroptosis in macrophages by activating NLRP3 inflammasome. Dec 26 2024
E1251 Oligomycin Oligomycin is a macrolide antibiotic produced by Streptomyces. It is a mixture of three oligomycin isomers, namely Oligomycin A, B and C. Oligomycin is an inhibitor of mitochondrial F0 subunit H+-ATP synthase, which can disrupt oxidative phosphorylation and the electron transport chain. It can inhibit TNF-induced apoptosis and can be used as an antifungal antibiotic. Dec 26 2024