Pimavanserin

Catalog No.S8183 Synonyms: ACP-103

For research use only.

Pimavanserin (ACP-103) is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease.

Pimavanserin  Chemical Structure

CAS No. 706782-28-7

Selleck's Pimavanserin has been cited by 3 Publications

Purity & Quality Control

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Biological Activity

Description Pimavanserin (ACP-103) is a potent and selective serotonin 5-HT2A inverse agonist with pIC50 of 8.73, used to treat psychosis associated with Parkinson’s disease.
Targets
5-HT2A [1]
(cell-based assay)
8.7(pIC50)
In vivo In rats, Pimavanserin (3 mg/kg, p.o.) attenuates DOI-induced head twitches. In mice, Pimavanserin (3 mg/kg, p.o.) significantly attenuates MK-801-induced hyperactivity. [1] In a rat model of parkinsonian tremor, Pimavanserin (40 mg/kg, i.p.) produces a significant overall reduction of tacrine-induced tremulous jaw movements. [2]

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Male Sprague-Dawley rats
  • Dosages: 3 mg/kg
  • Administration: p.o.

Solubility (25°C)

In vitro

DMSO 100 mg/mL
(99.48 mM)
Water 100 mg/mL
(99.48 mM)
Ethanol 100 mg/mL
(99.48 mM)

Chemical Information

Molecular Weight 1005.2
Formula

C50H68F2N6O4.C4H6O6

CAS No. 706782-28-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)COC1=CC=C(C=C1)CNC(=O)N(CC2=CC=C(C=C2)F)C3CCN(CC3)C.CC(C)COC1=CC=C(C=C1)CNC(=O)N(CC2=CC=C(C=C2)F)C3CCN(CC3)C.C(C(C(=O)O)O)(C(=O)O)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO % % Tween 80 % ddH2O
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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04794413 Completed Drug: Pimavanserin Tourette Syndrome|Tardive Dyskinesia Joseph Jankovic|Andrew Billnitzer MD|Baylor College of Medicine November 12 2018 Early Phase 1
NCT03121586 Recruiting Drug: Pimavanserin Schizophrenia ACADIA Pharmaceuticals Inc. January 2017 Phase 3
NCT00087542 Completed Drug: ACP-103 Hallucinations|Psychoses|Parkinson''s Disease ACADIA Pharmaceuticals Inc. March 2004 Phase 2

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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