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Ulipristal Acetate (CDB 2914)

Name: Ulipristal Acetate (CDB 2914)
Brand: Selleck Chemicals
SKU: S3081
Rating: 5 (2 reviews)

Synonyms: HRP 2000, RU 44675

Catalog No.S3081 Purity: 99.95%

Ulipristal acetate (CDB-2914, HRP 2000, RU 44675) is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.

Ulipristal Acetate (CDB 2914) Chemical Structure

CAS: 126784-99-4

Selleck's Ulipristal Acetate (CDB 2914) has been cited by 2 publications

Purity & Quality Control

Batch: Purity: 99.95%

99.95

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Signaling Pathway

Estrogen/progestogen Receptor Signaling Pathway

Choose Selective Estrogen/progestogen Receptor Inhibitors

Biological Activity

Description

Ulipristal acetate (CDB-2914, HRP 2000, RU 44675) is a selective SPRM for emergency contraception after an unprotected intercourse or contraceptive failure.

Targets

Progesterone receptor ^[1]

In vitro
In vitro	Ulipristal acetate has partial agonistic as well as antagonistic effects on the progesterone receptor. It also binds to theglucocorticoid receptor, but has no relevant affinity to the estrogen, androgen and mineralocorticoid receptors.^[1]

In Vivo
In vivo	Based on clinical trials, ulipristal acetate seems to be a reasonably tolerable and effective method of emergency contraception when used within 120 hours of intercourse. Ulipristal acetate is at least as effective as LNG when used within the first 72 hours after unprotected intercourse. However, ulipristal acetate may be more effective than LNG when used between 72 to 120 hours after unprotected intercourse, extending the window of opportunity for emergency contraception. ^[2][3]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2024-01-11)
NCT03349190	Completed	Infertility Female\|Fibroid Uterus	ASSOCIATION POUR LE DEVELOPPEMENT EN FECONDATION IN VITRO\|Gedeon Richter Plc.	December 29 2017	--
NCT03118297	Completed	Contraception\|Bleeding	Washington University School of Medicine	May 1 2017	Phase 3
NCT03156127	Withdrawn	Uterine Myoma	Boryung Pharmaceutical Co. Ltd	May 19 2017	Phase 1
NCT02408770	Completed	Breast Cancer	Manchester University NHS Foundation Trust\|University of Manchester	January 22 2016	Phase 2
NCT02634437	Completed	Renal Function	Allergan	December 1 2015	Phase 1

References

Chemical Information & Solubility

Molecular Weight	475.62	Formula	C₃₀H₃₇NO₄
CAS No.	126784-99-4	SDF	Download Ulipristal Acetate (CDB 2914) SDF
Smiles	CC(=O)C1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)OC(=O)C
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vitro
Batch:

DMSO : 83 mg/mL ( (174.5 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Ethanol : 14 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo
Batch:

Add solvents to the product individually and in order.

In vivo Formulation Calculator

Preparing Stock Solutions

Molarity Calculator

Dilution Calculator Molecular Weight Calculator

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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