HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E7585 10,12-Tricosadiynoic acid 10,12-Tricosadiynoic acid is a highly specific, selective, high-affinity, and orally active inhibitor of acyl-CoA oxidase-1 (ACOX1), it enhances hepatic mitochondrial FAO via the SIRT1-AMPK pathway and PPARα activation. It also reduces liver lipids, ROS accumulation, and insulin resistance, indicating its potential for treating metabolic diseases such as fatty liver, hypertriglyceridemia, and possibly diabetes. Dec 20 2024
E8096 NF449 octasodium NF449 octasodium is a highly potent P2X1 receptor antagonist, with IC50s of 0.28, 0.69, and 120 nM for rP2X1, rP2X1+5, P2X2+3, respectively. NF449 octasodium is a Gsα-selective G Protein antagonist. NF449 octasodium suppresses the rate of GTP[γS] binding to Gsα-s, inhibits the stimulation of adenylyl cyclase activity, and blocks the coupling of β-adrenergic receptors to Gs. Dec 20 2024
E7586 R121919 R121919 (NBI30775) is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats. Dec 20 2024
E7842 Rhodiolin Rhodiolin is a flavonoid isolated from Rhodiola rosea. Dec 20 2024
E8097 Syzalterin Syzalterin is an inhibitor of NO production with an IC50 of 1.87 μg/mL. Dec 20 2024
E7587 ITI-214 ITI-214 is a potent, CNS-active, orally bioavailable PDE1 inhibitor (Ki of 58 pM) with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters and ion channels. ITI-214 inhibits recombinant full-length human PDE1A, PDE1B and PDE1C with Kis of 33 pM, 380 pM and 35 pM, respectively. ITI-214 shows efficacy in various animal models of motor and cognitive functions. Dec 20 2024
E7843 Hernandezine Hernandezine (Hernandesine) is isolated from Thalictrum glandulosissimum. Dec 20 2024
E8098 BIIE-0246 BIIE-0246 is a potent and highly selective non-peptide neuropeptide Y (NPY) Y2 receptor antagonist, with an IC50 of 15 nM. Dec 20 2024
E7588 Cytidine-5'-triphosphate Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii. Dec 20 2024
E7844 Tpl2 Kinase Inhibitor 1 Tpl2 Kinase Inhibitor 1 is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 plays an important role in the regulation of the inflammatory response and the progression of some cancers. Dec 20 2024
E8099 Trofosfamide Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity. Dec 20 2024
E7589 α-Bungarotoxin α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC50 of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM. Dec 20 2024
E7845 Actinomycin X2 Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection. Dec 20 2024
E8100 THIP THIP (Gaboxadol) is a selective extrasynaptic GABAA receptors (eGABARs) agonist (with blood-brain barrier permeability), shows an EC50 value of 13 µM for δ-GABAAR. THIP induces strong tense GABAA-mediated currents in layer 2/3 neurons, but shows on effect on miniature IPSCs. THIP can be used in studies of sleep disorders. Dec 20 2024
E1890 A-967079 A-967079 is a selective antagonist of TRPA1 receptor with IC50 values of 67 nM and 289 nM at human and rat TRPA1 receptors, respectively. A-967079 decreases the responses of wide dynamic range (WDR), and nociceptive specific (NS) neurons following noxious pinch stimulation and high-intensity mechanical stimulation in rats. It demonstrates strong penetration into the central nervous system (CNS). Dec 20 2024
E5661 3,5-O-Dicaffeoylquinic acid 3,5-O-Dicaffeoylquinic acid reverses Trimethyltin-induced learning and memory deficits. Dec 20 2024
E7590 OTS514 OTS514 is a highly potent TOPK inhibitor with an IC50 of 2.6 nM. OTS514 strongly suppresses the growth of TOPK-positive cancer cells. OTS514 induces cell cycle arrest and apoptosis. Dec 20 2024
E7846 Soblidotin Soblidotin (Auristatin PE) is a novel synthetic Dolastatin 10 derivative and inhibitor of tubulin polymerization. Dec 20 2024
E8101 AC-262536 AC-262536 is a selective and non-steroidal androgen receptor modulators (SARMs) with beneficial anabolic effects. AC-262536 exhibits potent agonist activity at the androgen receptor, with an affinity in the low nanomolar range (1-10 nM). Dec 20 2024
E7591 tBID tBID is a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2) with an IC50 of  0.33 µM. Dec 20 2024