HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E5869 ML-SA5 ML-SA5 is a potent agonist of TRPML1 cation channel that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and exhibit anticancer activity. Apr 20 2025
E5945 Wu-5 Wu-5 is an inhibitor of USP10 that blocks its activity in vitro with an IC50 of 8.3 µM. It also promotes FLT3-ITD degradation and synergistically enhances crenolanib-induced apoptosis. Apr 20 2025
E6047 Pranlukast hemihydrate Pranlukast hemihydrate (ONO-1078 hemihydrate) is an antagonist of cysteinyl leukotriene receptor-1 (CysLT1) that blocks leukotrienes such as LTC4, LTD4, and LTE4, reducing bronchoconstriction and airway inflammation. It also inhibits NF-κB activation, thereby suppressing proinflammatory cytokine production (e.g., IL-6, IL-1, TNF-α) in monocytes/macrophages and T cells, contributing to its immunomodulatory effects. Apr 17 2025
E5923 ZYS-1 Fludarabine-Cl(ZYS-1) is an inhibitor of ADAR1 that suppresses prostate cancer growth and metastasis, potentiates antitumor immune responses, and can enhance the effect of immunotherapy. Apr 15 2025
E6056 (R)-tamsulosin (R)-Tamsulosin ((R)-(-)-YM12617 free base, LY253351 free base) is the enantiomerically pure, pharmacologically active form of tamsulosin, a selective α₁A-adrenergic receptor antagonist used in the treatment of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS). This form is synthesized using chiral N-(1-phenylethyl)aziridine-2-carboxylate derivatives, which allow for highly stereoselective processes in its production. Apr 15 2025
S7395 PD 150606 PD150606 is a potent and selective inhibitor of calpainwith Ki values of 0.21 µM for µ-calpain and 0.37 µM for m-calpain. It exhibits neuroprotective effects by reducing hypoxic/hypoglycemic injury in cerebrocortical neurons and excitotoxic damage in cerebellar Purkinje cells. Apr 14 2025
E6049 Domperidone monomaleate Domperidone monomaleate (R33812 monomaleate) is a potent antagonist of dopamine D2 receptor that acts as an antiemetic and prokinetic agent by targeting the chemoreceptor trigger zone and motor function of the stomach and small intestine. It also inhibits cardiac Na⁺ channels such as Nav1.5, suggesting a potential molecular mechanism for cardiovascular side effects like malignant arrhythmias. Apr 14 2025
E5815 YB-3-17 YB-3−17 is a dual-target compound that effectively and selectively inhibits mTOR with an IC50 of 0.22 nM, while promoting GSPT1 degradation with an IC50 of 5 nM, leading to substantial tumor growth inhibition both in vitro and in vivo. It also exhibits significant antiproliferative activity in glioblastoma models. Apr 14 2025
E1919 Befotertinib mesylate Befotertinib mesylate (D-0316 mesylate) is third-generation tyrosine kinase inhibitor (TKI) of EGFR . It can be used for the research of EGFR T790M-positive non-small cell lung cancer (NSCLC). Apr 13 2025
E6063 sulphaquinoxaline Sulfaquinoxaline (Sulfaquinoxaline) is a sulfonamide antimicrobial used in veterinary medicine to prevent and treat coccidiosis and bacterial infections. It is effective against a broad range of Gram-positive and Gram-negative bacteria. Apr 13 2025
E6055 Epinastine Epinastine (WAL801) is potent nonsedative antiallergic agent and an antagonist of histamine H1 receptor. It inhibits the actions of leukotrienes, platelet-activating factor (PAF), and bradykinin. It also stabilizes mast cells and reduces IL-8 release from eosinophils, helping to control allergic inflammation. Apr 11 2025
E5792 BAY 2413555 BAY 2413555 is a first selective positive allosteric modulator of the muscarinic acetylcholine receptor (M2R) to restore cardiac autonomic balance. It also inhibits CYP2C8 and CYP2C9 with IC50 values of 17 µM and 13 µM, respectively. Apr 11 2025
E6052 Enrofloxacin hydrochloride Enrofloxacin hydrochloride is a fluoroquinolone antibiotic with potent activity against Mycoplasma bovis, showing an MIC₉₀ of 0.312 μg/mL. It can be used in research to study treatments for pneumonia, mastitis, arthritis, and other conditions in cattle. Apr 11 2025
A2171 Anti-mouse PD-L1 (B7-H1) (10F.2H11)-InVivo Anti-mouse PD-L1 (B7-H1) (10F.2H11)-InVivo reacts with mouse PD-L1 (programmed death ligand 1) also known as B7-H1 or CD274. The 10F.2H11 antibody has been shown to sterically and functionally block PD-L1/CD80 (B7-1) interactions and does not block PD-L1/PD-1 interactions. Apr 10 2025
E5916 RS47 RS47 is a potent and specific inhibitor of the non-canonical NF-κB signaling pathway through disrupting RelB binding to its target DNA with a Kd values of 1.1 μM. It is shown to inhibit colorectal cancer (CRC) cells and B lymphoma growth, holds potential as a research tool for targeting cancers driven by hyperactive non-canonical NF-κB signaling. Apr 09 2025
E4724 MGD-28 MGD-28 is a potent and orally active degrader of Cereblon (CRBN)-dependent IKAROS proteins. It effectively degrades IKZF1 (DC50 = 3.8 nM), IKZF2 (DC50 = 56.3 nM), and IKZF3 (DC50 = 7.1 nM). It demonstrates significant antiproliferative potency across various hematologic cancer cell lines. Apr 08 2025
E5811 ALG-055009 ALG-055009 is a potent and selective agonist of thyroid hormone receptor beta (THR-β), used for treating MASH (Metabolic Dysfunction-Associated Steatohepatitis). Apr 08 2025
E6058 Acetazolamide sodium Acetazolamide sodium is an inhibitor of carbonic anhydrase (CA) IX with an IC50 of 30 nM for hCA IX and also inhibits hCA II with an IC50 of 13 nM. It possesses diuretic, antihypertensive, and anti-gonococcal properties. Apr 08 2025
E6051 niclosamide ethanolamine Niclosamide ethanolamine (Niclosamide-olamine, BAY2353 olamine) is a mild mitochondrial uncoupler, anthelmintic agent, and highly potent inhibitor of STAT3 signaling pathway with an IC50 of 0.25 μM. It improves insulin levels, body weight, and muscle wasting, inhibits artery constriction, suppresses PI3K-mTORC1 signaling to block fibroblast proliferation, inhibits TGF-β1-induced EMT and ECM accumulation via the mTORC1-4EBP1 axis, activates noncanonical autophagy to sensitize fibroblasts to apoptosis, and confers renoprotection in diabetic and adriamycin-induced nondiabetic kidney disease models. Apr 08 2025
E6062 Fludrocortisone Fludrocortisone (Alflorone, 9α-Fludrocortisone) is a synthetic mineralocorticoid which increases pressor sensitivity to circulating catecholamines and angiotensin, alters intravascular volume, and has central adrenergic effects. It is beneficial in the treatment of hypotensive disorders: orthostatic hypotension, vasodepressor carotid sinus syndrome, and vasodepressor neurocardiogenic syndrome. Apr 08 2025