Home Neuronal Signaling Histamine Receptor antagonist GSK189254A

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GSK189254A Histamine Receptor antagonist

Cat.No.E7924

GSK189254A (GSK189254 free base) is a histamine H3 receptor antagonist with pKi values of 9.59-9.90 for human H3 and 8.51-9.17 for rat H3.
GSK189254A Histamine Receptor antagonist Chemical Structure

Chemical Structure

Molecular Weight: 351.44

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Chemical Information, Storage & Stability

Molecular Weight 351.44 Formula C21H25N3O2 Storage (From the date of receipt)
CAS No. 720690-73-3 Download SDF Storage of Stock Solutions

Synonyms GSK189254 free base Smiles O=C(NC)C(C=N1)=CC=C1OC2=CC(CC3)=C(C=C2)CCN3C4CCC4

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Mechanism of Action

In vivo
GSK189254 (0.3-3 mg/kg p.o.) increases the release of acetylcholine, noradrenaline, and dopamine in the anterior cingulate cortex and acetylcholine in the dorsal hippocampus. GSK189254 significantly improves performance of rats in diverse cognition paradigms, including passive avoidance, water maze, object recognition, and attentional set shift. In Ox+/+ and Ox / mice, acute administration of GSK189254 increases W and decreases slow wave and paradoxical sleep to a similar degree to modafinil, while it reduces narcoleptic episodes in Ox / mice.
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