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Escitalopram Serotonin Transporter inhibitor

Name: Escitalopram
Brand: Selleck Chemicals
SKU: E4898
Availability: InStock
Rating: 5 (2 reviews)

Cat.No.E4898

Escitalopram ((S)-Citalopram), (S)-+ Citalopram)) is a selective serotonin reuptake inhibitor (SSRI) with a Ki value of 0.89 nM. This compound has approximately 30-fold higher binding affinity than its R(-)-enantiomer and exhibits selectivity over both norepinephrine transporter (NET) and dopamine transporter (DAT).

Chemical Structure

Molecular Weight: 324.39

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Quality Control

Batch: E489801 DMSO]65 mg/mL]false]Water]65 mg/mL]false]Ethanol]65 mg/mL]false Purity: 99.69%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS/MSDS
Datasheet

99.69

Related Targets	Adrenergic Receptor AChR 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE)
Other Serotonin Transporter Inhibitors	Dapoxetine

Solubility

In vitro
Batch:

DMSO : 65 mg/mL (200.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 65 mg/mL

Ethanol : 65 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	324.39	Formula	C₂₀H₂₁FN₂O	Storage (From the date of receipt)	2 years -20°C liquid
CAS No.	128196-01-0	Download SDF		Storage (From the date of receipt)	2 years -20°C liquid

Read more about storage stability stock solution CAS number

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/20672825/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-12-16)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06433635	ACTIVE_NOT_RECRUITING	Bipolar I Disorder; Depression	Massachusetts General Hospital	2024-10-01	PHASE4
NCT05901571	NOT_YET_RECRUITING	Depressive Disorder, Major	Shanghai 7th People's Hospital	2026-11
NCT05017311	RECRUITING	Major Depressive Disorder	Nova Scotia Health Authority	2023-01-20	PHASE4
NCT06216535	RECRUITING	Asthma	University of Texas Southwestern Medical Center	2025-05-19	PHASE2
NCT05973786	RECRUITING	Bipolar Depression	Dr. Inge Winter	2025-02-11	PHASE3
NCT05603104	RECRUITING	Schizophrenia and Related Disorders; Major Depressive Disorder; Bipolar Depression	Dr. Inge Winter	2025-04-27	PHASE3

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