Ro 67-7476

GluR modulator

Home GPCR & G Protein GluR modulator Ro 67-7476

research use only

Ro 67‑7476 is a potent positive allosteric modulator (PAM) of mGluR1, enhancing glutamate‑evoked responses in calcium mobilization assays with an EC50 of 60.1 nM. It also exhibits intrinsic agonist activity, inducing ERK1/2 phosphorylation in the absence of exogenous glutamate with an EC50 of 163.3 nM.

Ro 67-7476 Chemical Structure

Ro 67-7476 Chemical Structure

Molecular Weight: 319.40

Purity & Quality Control

Ro 67-7476 Related Products

Signaling Pathway

GluR Signaling Pathways

GluR Signaling Pathway

Mechanism of Action

Description Ro 67‑7476 is a potent positive allosteric modulator (PAM) of mGluR1, enhancing glutamate‑evoked responses in calcium mobilization assays with an EC50 of 60.1 nM. It also exhibits intrinsic agonist activity, inducing ERK1/2 phosphorylation in the absence of exogenous glutamate with an EC50 of 163.3 nM.

References
  • https://pubmed.ncbi.nlm.nih.gov/16645124/
  • https://pubmed.ncbi.nlm.nih.gov/18625258/

Chemical Information

Molecular Weight 319.40 Formula

C17H18FNO2S
CAS No. 298690-60-5 SDF Download Ro 67-7476 SDF

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