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Pyr6

Cat.No.E8027

Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).IC50 value: 0.49 uM Target: TRPC3 inhibitorThis compound is a selective SOCE inhibitor (Yonetoku et al., 2008; Sweeney et al., 2009), it displayed 37-fold (1.58 OM) higher potency for RBL SOCE than for TRPC3 ROCE, with an IC50 comparable to that of Pyr2 and Pyr3. This chemical at 3 uM diminished TRPC3 currents to only 52%. Consistent with inhibition of Orai channel activity Pyr2, Pyr3 or this compound substantially inhibited typical Orai downstream signalling events in RBL mast cells (NFAT activation and degranulation) activated by passive store depletion.
Pyr6 Chemical Structure

Chemical Structure

Molecular Weight: 418.27

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Quality Control

Chemical Information, Storage & Stability

Molecular Weight 418.27 Formula Storage (From the date of receipt)
CAS No. 245747-08-4 -- Storage of Stock Solutions Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

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