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DiI

Name: DiI
Brand: Selleck Chemicals
SKU: E4783
Rating: 5 (1 reviews)

Synonyms: DiIC18(3)

Catalog No.E4783

DiI (DiIC18(3)) is a lipid-soluble fluorescent dye that traces neuronal pathways through retrograde and anterograde transport in neurons. It labels cell bodies, axons, dendrites, and dendritic spines, offering high brightness, slow fading, and long-lasting persistence without leakage. It is employed to investigate brain connectivity, including in postmortem human brain tissue.

DiI Chemical Structure

CAS No. 41085-99-8

Purity & Quality Control

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Biological Activity

Description	DiI (DiIC18(3)) is a lipid-soluble fluorescent dye that traces neuronal pathways through retrograde and anterograde transport in neurons. It labels cell bodies, axons, dendrites, and dendritic spines, offering high brightness, slow fading, and long-lasting persistence without leakage. It is employed to investigate brain connectivity, including in postmortem human brain tissue.

References

[1] Mufson EJ, et al. Neurobiol Aging. 1990 Nov-Dec;11(6):649-53.

Chemical Information & Solubility

Molecular Weight	933.87	Formula	C₅₉H₉₇N₂.ClO₄
CAS No.	41085-99-8	SDF	Download DiI SDF
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

In vivo
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In vivo Formulation Calculator

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In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

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% DMSO + % + % Tween 80 + % ddH₂O

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
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