HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E7522 Palosuran Palosuran (ACT-058362) is a potent, selective, and orally active antagonist of urotensin II receptor, with an IC50 of 3.6 nM for CHO cell membranes expressing human recombinant receptors. Palosuran can improves pancreatic and renal function in diabetic rats. Dec 20 2024
E7778 GW274150 GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 also displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 exerts a protective role in an acute model of lung injury inflammation. Dec 20 2024
E8033 DO-264 DO-264 is a potent, selective, and in vivo-active inhibitor of ABHD12, a lysophospholipid hydrolase enzyme, with an IC50 of 11 nM. It dose-dependently increases levels of lysophosphatidylserine (lyso-PS) and 20:4 phosphatidylserine (20:4 PS) in brain tissue. It also enhances immunological responses in lymphocytic choriomeningitis virus (LCMV) infection. Dec 20 2024
S9565 Vigabatrin Vigabatrin (γ-Vinyl-GABA), a derivative of GABA vinyl-inhibitory neurotransmitter, is an orally active and irreversible inhibitor of GABA transaminase. Vigabatrin is an antiepileptic agent, which acts by increasing GABA levels in the brain by irreversibly inhibiting GABA degradation. Dec 20 2024
E7523 Naspm Naspm (1-Naphthyl acetyl spermine), a synthetic analogue of Joro spider toxin, is a calcium permeable AMPA (CP-AMPA) receptors antagonist. Dec 20 2024
E8034 1-Stearoyl-2-arachidonoyl-sn-glycerol 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity. Dec 20 2024
E5034 Senkyunolide A Senkyunolide A is a phthalein compound. Senkyunolide A inhibits the proliferation of tumor cells and has anticancer activity. Senkyunolide A inhibits the progression of osteoarthritis through the NLRP3 signaling pathway. Senkyunolide A protects nerve cells from Corticosterone (HY-B1618) -induced apoptosis by regulating protein phosphatase 2A and α-synuclein signaling pathways. Senkyunolide A inhibits the expression of CD137, a diagnostic biomarker for atherosclerosis. Dec 20 2024
E7524 G-418 G-418 (Geneticin, Antibiotic G-418) is an aminoglycoside antibiotic originally isolated from Micromonospora rhodorangea. It functions by binding to the ribosomal subunit, thereby inhibiting translational elongation and disrupting protein synthesis in both prokaryotic and eukaryotic cells, thus impairing cell growth and viability. Dec 20 2024
E7780 Lck Inhibitor Lck Inhibitor is a potent and selective inhibitor of lymphocyte-specific kinase (Lck) with IC50 values of 7 nM, 21 nM, 42 nM, 200 nM for Lck, Lyn, Src and Syk kinases, respectively It suppresses T-cell activation, inhibits T-cell proliferation, and demonstrates therapeutic potential in T-cell-mediated arthritis. Dec 20 2024
E8035 NSC 146109 hydrochloride NSC 146109 hydrochloride is a small-molecule p53 activator that target MDMX and can be used for breast cancer research. NSC 146109 hydrochloride is a pseudourea derivative, promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Dec 20 2024
E7525 MI-538 MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. Dec 20 2024
E7781 ML224 ML224 (NCGC00242364) is a selective TSHR antagonist with an IC50 value of 2.1 µM. ML224 can be used in the study of Graves' disease and other thyroid disorders. Dec 20 2024
E8036 AM404 AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC50 values in the low micromolar range. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 µM). Neuroprotective Effect. Dec 20 2024
E7526 AVN-944 AVN-944 (VX-944) is an orally active, potent, selective, noncompetitive and specific inhibitor of IMPDH (inosine monophosphate dehydrogenase). AVN-944 is an essential rate-limiting enzyme in de novo guanine nucleotide synthesis. AVN-944 is also an inhibitor of arenavirus RNA synthesis, and blocks arenavirus infection. AVN-944 has broad anti-cancer activities, and can be used for multiple myeloma (MM) and acute myeloid leukemia (AML) research. Dec 20 2024
E7782 HIV-1 integrase inhibitor HIV-1 integrase inhibitor is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. Dec 20 2024
E8037 TCH-165 TCH-165 is a small molecule modulator of proteasome assembly, which increases 20S levels and facilitates 20S-mediated protein degradation. Dec 20 2024
E7527 ATN-224 ATN-224 is an oral Cu2+/Zn2+-superoxide dismutase 1 (SOD1) inhibitor. ATN-224 inhibits SOD1 activity in endothelial cells, an effect that is dose dependent with an IC50 of 17.5±3.7 nM. Dec 20 2024
E7783 NBD-557 NBD-557 is a potentially HIV-1 inhibitor.IC50 Value: Target: HIVNBD-557, is small molecule organic compounds with drug-like properties. It showed potent cell fusion and virus-cell fusion inhibitory activity at low micromolar levels. A systematic study showed that NBD-557 target viral entry by inhibiting the binding of HIV-1 envelope glycoprotein gp120 to the cellular receptor CD4 but did not inhibit reverse transcriptase, integrase, or protease, indicating that they do not target the later stages of the HIV-1 life cycle to inhibit HIV-1 infection. NBD-557 potent inhibitors of both X4 and R5 viruses tested in CXCR4 and CCR5 expressing cell lines, respectively, indicating that its anti-HIV-1 activity is not dependent on the coreceptor tropism Dec 20 2024
E8038 Nourseothricin sulfate Nourseothricin sulfate (Streptothricin sulfate) is a broad-spectrum antibiotic that destroys the outer membrane of Gram-negative bacteria and is a dominant selective marker for Fonsecaea pedrosoi. Nourseothricin sulfate inhibits protein biosynthesis in prokaryotic cells and strongly inhibits the growth of eukaryotes like fungi and can also be used as a elective marker for a wide range of organisms including bacteria, yeast, filamentous fungi, and plant cells. Dec 20 2024
E7528 2',5'-Dideoxyadenosine 2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site with an IC50 of 3 µM . 2',5'-Dideoxyadenosine is a nucleoside analog and exerts a potent antiadrenergic action in heart. Dec 20 2024