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Falcarindiol

Catalog No.S3292 Synonyms: FAD, (3R,8S)-Falcarindiol, FaDOH

For research use only.

Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.

Falcarindiol Chemical Structure

CAS No. 225110-25-8

Selleck's Falcarindiol has been cited by 1 Publication

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Biological Activity

Description Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.
Targets
iNOS [1] TNFα [1] IL-6 [1] IL-1β [1] JNK [1] Click to View More Targets

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 260.37
Formula

C17H24O2
CAS No. 225110-25-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CCCCCCCC=CC(C#CC#CC(C=C)O)O

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04555044 Recruiting Drug: Clinolipid|Drug: Intralipid Essential Fatty Acid Deficiency (EFAD) Baxter Healthcare Corporation January 22 2021 Phase 4

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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