Falcarindiol
For research use only.
Catalog No.S3292 Synonyms: FAD, (3R,8S)-Falcarindiol, FaDOH

CAS No. 225110-25-8
Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.
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Biological Activity
Description | Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules. | ||||||
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Targets |
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Protocol
Solubility (25°C)
In vitro | DMSO | 52 mg/mL (199.71 mM) |
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* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
Molecular Weight | 260.37 |
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Formula | C17H24O2 |
CAS No. | 225110-25-8 |
Storage |
powder in solvent |
Synonyms | FAD, (3R,8S)-Falcarindiol, FaDOH |
Smiles | CCCCCCCC=CC(C#CC#CC(C=C)O)O |
In vivo Formulation Calculator (Clear solution)
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment) | ||||||||||
Dosage | mg/kg | Average weight of animals | g | Dosing volume per animal | ul | Number of animals | ||||
Step 2: Enter the in vivo formulation () | ||||||||||
% DMSO % % Tween 80 % ddH2O | ||||||||||
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: : mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL,)
Method for preparing in vivo formulation:Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80,mix and clarify, next add μL ddH2O,mix and clarify.
1.Please make sure the liquid is clear before adding the next solvent.
2.Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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Molarity Calculator
Clinical Trial Information
NCT Number | Recruitment | interventions | Conditions | Sponsor/Collaborators | Start Date | Phases |
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NCT04555044 | Recruiting | Drug: Clinolipid|Drug: Intralipid | Essential Fatty Acid Deficiency (EFAD) | Baxter Healthcare Corporation | November 19 2020 | Phase 4 |
NCT04273126 | Recruiting | Behavioral: Adapted Family Resilience Intervention | Family Relationship|Coping Skills | University of California Los Angeles|National Institute on Drug Abuse (NIDA)|American Academy of Child Adolescent Psychiatry. | February 2020 | Not Applicable |
NCT03563222 | Recruiting | Drug: Smoflipid|Drug: Intralipid 20% | Malnutrition Child | Fresenius Kabi | December 18 2019 | Phase 4 |
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