Falcarindiol

Name: Falcarindiol
Brand: Selleck Chemicals
SKU: S3292
Rating: 5 (1 reviews)

For research use only.

Catalog No.S3292 Synonyms: FAD, (3R,8S)-Falcarindiol, FaDOH

1 publication

CAS No. 225110-25-8

Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.

Selleck's Falcarindiol has been cited by 1 publication

Front Pharmacol, 2021, 12:656697

PubMed: 34025420 ( click the link to review the publication )

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Biological Activity

Description

Falcarindiol (FAD, (3R,8S)-Falcarindiol, FaDOH) is a natural polyacetylene compound found rich in many plants of the Umbelliferae family. Falcarindiol suppresses LPS-stimulated expression of inducible nitric oxide synthase (iNOS), tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Falcarindiol attenuates the LPS-induced activation of JNK, ERK, STAT1, and STAT3 signaling molecules.

Targets

iNOS ^[1]
()

TNFα ^[1]
()

IL-6 ^[1]
()

IL-1β ^[1]
()

JNK ^[1]
()

Protocol

References

[1] Thamizhiniyan Venkatesan, et al. Mol Cell Biochem. 2018 Aug;445(1-2):169-178.

Solubility (25°C)

In vitro	DMSO	52 mg/mL (199.71 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight	260.37
Formula	C₁₇H₂₄O₂
CAS No.	225110-25-8
Storage	3 years-20°C powder 2 years-80°C in solvent
Synonyms	FAD, (3R,8S)-Falcarindiol, FaDOH
Smiles	CCCCCCCC=CC(C#CC#CC(C=C)O)O

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next addμL PEG300， mix and clarify, next addμL Tween 80，mix and clarify, next add μL ddH₂O，mix and clarify.

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Clinical Trial Information (data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number	Recruitment	interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04555044	Recruiting	Drug: Clinolipid\|Drug: Intralipid	Essential Fatty Acid Deficiency (EFAD)	Baxter Healthcare Corporation	January 22 2021	Phase 4
NCT04273126	Recruiting	Behavioral: Adapted Family Resilience Intervention	Family Relationship\|Coping Skills	University of California Los Angeles\|National Institute on Drug Abuse (NIDA)\|American Academy of Child Adolescent Psychiatry.	June 19 2020	Not Applicable

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Falcarindiol