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RMC5127 Ras inhibitor

Cat.No.E6403

RMC-5127 is an orally bioavailable, mutant-selective tri-complex inhibitor of the GTP-bound (ON) form of RASG12V. It non-covalently binds cyclophilin A (CypA) to form a binary complex that creates a high-affinity tri-complex with RASG12V(ON), sterically blocking effector binding and potently suppressing RAS signaling. It exhibits CNS penetration and induces robust anti-tumor activity in KRASG12V-mutant NSCLC, PDAC, and CRC xenograft models.
RMC5127 Ras inhibitor Chemical Structure

Chemical Structure

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Quality Control

Batch: E640301 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]Insoluble]false Purity: 99.14%
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  • NMR
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99.14

Solubility

In vitro
Batch:

DMSO : 100 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

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In vivo
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight Formula Storage (From the date of receipt)
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Mechanism of Action

References

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