HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E6057 Pamidronate disodium pentahydrate May 15 2025
E1954 DCC-3116 May 15 2025
E5847 olomorasib May 12 2025
E1323 Aldometanib Aldometanib (LXY-05-029) is a selective inhibitor of aldolase (ALDOA) with an IC50 of 50 uM in in vitro enzymatic assays. It also activates lysosomal AMPK by blocking FBP-aldolase binding, mimicking glucose starvation and improving metabolic health without causing hypoglycemia. May 09 2025
E1481 AM-9747 AM-9747 (PRMT5-IN-25) is a potent inhibitor of PRMT5 with a Ki of 0.06 nM. It exhibits antiproliferative activity and a significant oral antitumor effect in mouse models employing patient-derived xenografts (PDX). May 09 2025
E4720 Flonoltinib Flonoltinib (JAK2/FLT3-IN-1) is a potent and selective dual inhibitor of JAK2 and FLT3, with IC50 of of 0.8, 1.4, and 15 nM against JAK2, JAK2V617F, and FLT3, respectively, in in vitro kinase assays. It also inhibits cell proliferation and induces G2/M cell cycle arrest and apoptosis in Hemophagocytic Lymphohistiocytosis (HLH) patients' CD8+T cells, CTLL2 cells, and RAW 264.7 cells. May 09 2025
E6053 tetrabenazine Tetrabenazine (Ro 1-9569) is a non-competitive inhibitor of the vesicular monoamine transporter (VMAT), with a higher selectivity for VMAT2 over VMAT1. It exhibits an IC50 of 0.3 µM for VMAT2 and 3 µM for VMAT1, and a Kd of 60 nM for VMAT2 and 9.38 nM for VMAT1. It treats Huntington’s chorea by reducing excessive dopaminergic activity and impairing monoamine storage in synaptic vesicles. May 08 2025
E6059 prednisolone hemisuccinate Prednisolone hemisuccinate (Prednisolone 21-hemisuccinate) is a synthetic glucocorticoid with anti-inflammatory properties. It is used in the treatment of inner ear diseases and vertigo caused by vestibular hypofunction. May 08 2025
E1943 Tunlametinib Tunlametinib (HL-085) is a highly selective and oral inhibitor of MEK1/2 with an IC50 of 1.9 nM for MEK1, with the potential to treat RAS/RAF mutant cancers. It also induces cell cycle arrest at the G0/G1 phase and promotes apoptosis in a dose-dependent manner. It also exhibits antitumor activity in patients with advanced NRAS-mutant melanoma. May 08 2025
E5816 PF-07265028 PF-07265028 is a potent and selective inhibitor of hematopoietic progenitor kinase 1 (HPK1/MAP4K1) with a Ki of <0.05 nM, and exhibits potent cellular activity, with a pSLP76 IC50 of 17 nM. May 08 2025
E5964 AkaLumine hydrochloride AkaLumine hydrochloride is a luciferin analogue, with a Km of 2.06 μM for recombinant firefly luciferase (Fluc) protein. Its near-infrared emission peak enables deep tissue imaging and enhances target-detection sensitivity, allowing more accurate, non-invasive bioluminescence imaging at very low concentrations in animal models. May 07 2025
E5889 PI3K/Akt/mTOR-IN-2 PI3K/Akt/mTOR-IN-2 is a specific inhibitor of the PI3K/Akt/mTOR signaling pathway. It exhibits an effective anti-cancer activity with IC50 value of 2.29 μM and can induce cancer cell cycle arrest and apoptosis. May 07 2025
E5904 6K465 6K465 is a pyrimidine-based inhibitor of Aurora A, that reduces levels of c-MYC and N-MYC oncoproteins. It demonstrates compelling antitumor efficacy. May 07 2025
E5955 CCR6 antagonist 1 CCR6 antagonist 1 is a potent antagonist of CCR6 that inhibits the CCL20/CCR6 axis. It can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs). May 05 2025
E4736 COH34 COH34 is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG) with an IC50 value of 0.37 nM. It binds to the catalytic domain of PARG with Kd of 0.547 μM thereby prolonging PARylation at DNA lesions and trapping DNA repair factors and can be used in research of cancer therapies. May 05 2025
E5913 LXG6403 LXG6403 is a bi-thiazole potent inhibitor of LOX cellular activity with an IC50 of 1.3 μM. It exhibits anti-cancer activity by remodeling the extracellular matrix, enhancing chemotherapy penetration, inducing ROS generation, and promoting DNA damage-mediated cell death to overcome chemotherapy resistance in triple-negative breast cancer. Apr 22 2025
E4629 AZD0780 AZD0780 (Laroprovstat, Pcsk9-IN-12) is an orally potent inhibitor of PCSK9 with a Kd value of <200 nM. It directly binds to PCSK9, blocks its function, and significantly reduces LDL cholesterol levels, making it useful for dyslipidemia research. Apr 22 2025
E6060 BUSPIRONE BUSPIRONE (Ansial) is a potent agonist of serotonin 5-HT1A receptor as well as an antagonist of dopamine D2 autoreceptor. It exhibits anxiolytic and antidepressant activity, alleviates anxiety, depression, and colitis, suppresses neuroinflammation, modulates gut microbiota, and can be used in research for treating anxiety and depression. Apr 22 2025
E1519 DB2313 DB2313 is a potent inhibitor of the transcription factor PU.1, effectively blocking PU.1-dependent reporter gene transactivation with an IC50 of 5 μM. DB2313 demonstrated significant anti-leukemic activity by inducing apoptosis in acute myeloid leukemia (AML) cells. It also increases survival rates and reduces tumor burden in vivo. Apr 20 2025
E5842 Nudifloramide Nudifloramide (2PY, N-methyl-2-pyridone-5- carboxamide) is a pyridine derivative of nicotinamide that inhibits PARP-1 (poly (ADP-ribose) polymerase-1) activity in vitro, with an IC50 of 8 µM. Apr 20 2025