HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E4752 FOT1（CN128）hydrochloride FOT1 (CN128, CN328) hydrochloride is a potent and orally active hydroxypyridinone iron chelator with potential for treating systemic iron overload and β-thalassemia. It also helps prevent the onset and slows early-stage Parkinson’s disease symptoms by reducing oxidants and toxic intermediates from iron-mediated dopamine oxidation. Mar 24 2025
E8274 Retinyl propionate Retinyl propionate (Vitamin A propionate) is a retinoid ester of retinol that promotes skin renewal, enhances texture, and reduces wrinkles. It penetrates the skin efficiently, converting to active retinoic acid (tRA) with minimal irritation. Mar 24 2025
E5833 KN-93 hydrochloride KN-93 hydrochloride is a methoxybenzenesulfonamide derivative that inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.37 µM. It reduces dopamine (DA) production by influencing the reaction rate of tyrosine hydroxylase (TH), leading to decreased Ca(2+)-mediated phosphorylation of the TH protein. Mar 24 2025
E8273 rac-endo-borneol Rac-endo-borneol is a bicyclic monoterpene with potential antinociceptive and anti-inflammatory properties. It enhances blood-brain barrier (BBB) permeability by inhibiting efflux proteins and modulating tight junctions, thereby improving drug delivery to the brain. Its effects are reversible and transient, associated with increased vasodilatory neurotransmitters. Mar 24 2025
E5912 Asandeutertinib Asandeutertinib (Osimertinib-d3, AZD-9291-d3) is an orally administered, ATP-competitive, irreversible, deuterated third-generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI) and a deuterium-stabilized derivative of osimertinib, with the potential to treat advanced EGFR-mutated NSCLC. Mar 24 2025
E5906 Sunvozertinib Sunvozertinib (DZD9008) is an oral, potent, and selective inhibitor of ErbBs (EGFR or Her2), particularly mutant forms of ErbBs. It also inhibits EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, Her2 exon 20 YVMA, and EGFR WT A431, with IC50 values of 20.4 nM, 20.4 nM, 1.1 nM, 7.5 nM, and 80.4 nM, respectively. Mar 21 2025
P1252 JNJ-77242113(Icotrokinra) Icotrokinra (JNJ-77242113, JNJ-2113, PN-235) is an orally available and selective antagonist of the IL-23 receptor. It also inhibits IL-23–induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 of 5.6 pM and suppresses IL-23–induced IFN-γ production in NK cells with an IC50 of 18.4 pM. It also exhibits anti-inflammatory activity in a TNBS-induced colitis model in rats and holds potential for studying psoriasis, psoriatic arthritis, and inflammatory bowel disease. Mar 20 2025
E5800 G6PD activator AG1 G6PD activator AG1 is a small molecule activator of glucose-6-phosphate dehydrogenase (G6PDH) with an EC50 of 3.4 µM for G6PDH⁴⁵⁹ᴸ that enhances the activity of wild-type and mutant G6PD. It reduces oxidative stress in cells, zebrafish, and human erythrocytes, making it useful for research on G6PD enzymopathies. Mar 19 2025
E5798 GLPG3312 GLPG3312 is a potent and selective inhibitor of pan-SIK, with an IC50 of 2.0 nM for SIK1, 0.7 nM for SIK2, and 0.6 nM for SIK3. It demonstrates anti-inflammatory and immunoregulatory activities in vitro in human primary myeloid cells and in vivo in mouse models. Mar 19 2025
E8271 Sanguinarine citrate Sanguinarine (gluconate) is a benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis. It activates reactive oxygen species (ROS), c-Jun N-terminal kinase (JNK), and nuclear factor-kappaB (NF-κB) signaling pathways to induce apoptosis in head and neck tumor cells and animal models. It also exhibits potent anti-bacterial and anti-inflammatory activities. Mar 19 2025
E5834 DFP00173 DFP00173 is a selective and potent inhibitor of Aquaporin-3 (AQP3), it inhibits mouse and human AQP3 with an IC50 of ∼0.1 μM–0.4 μM. It demonstrates potential for treating human disorders of water retention. Mar 17 2025
E5778 CU-CPT 4a CU-CPT 4a (TLR3-IN-1) is a potent small molecule antagonist of TLR3 with an IC50 of 3.44 µM that also inhibits TLR3/dsRNA-mediated signaling, including TNF-α and IL-1β expression. It is a valuable tool for studying protein-RNA complexes. Mar 17 2025
E8272 Dihydroarteannuin B Dihydroarteannuin B is a cadinane sesquiterpene isolated from the dried leaves of Artemisia annua acts as a microbial metabolite of arteannuin B. It can be used in research for developing malaria treatments. Mar 17 2025
E8270 Eleutherol Eleutherol (Allium A) is a naphthalene extracted from the bulb of E. americana and a potent inhibitor of α-glucosidase with an IC50 of >1.00 μM. It also exhibits significant antifungal activity with MIC values between 7.8µg/mL and 250 µg/mL. It can be used in research on antimicrobial infections and diabetes treatment. Mar 17 2025
E8269 Eleutherin Eleutherin ((+)-Eleutherin) is a pyranonaphthoquinones that is isolated from the bulb of Eleutherine americana and a potent catalytic inhibitor of Topoisomerase II. It exhibits potent anti-cancer activity and protects human umbilical vein endothelial cells (HUVECs) from injury in vitro. Mar 17 2025
A4047 Gen1047 (Anti-B7-H4 & CD3) Gen1047 is a bispecific monoclonal antibody targeting CD3 on T cells and B7-H4. It induces T-cell-mediated cytotoxicity against B7-H4-positive cancer cells, making it a potential immunotherapy for malignant solid tumors with immunostimulating and antineoplastic activities. M.W 144.48 kDa. Mar 16 2025
A4050 Imm0306 (Anti-CD20 & CD47) IMM0306 is a bispecific antibody targeting CD20 on B cells and CD47 to block the CD47-SIRPα immune checkpoint. It enhances macrophage and NK cell-mediated phagocytosis and cytotoxicity, exhibiting potential immunostimulating, phagocytosis-inducing and antineoplastic activities, making it a promising immunotherapy for B-cell malignancies. M.W 174.12 kDa Mar 16 2025
E5875 LY294002 hydrochloride LY294002 hydrochloride is a potent and specific inhibitor of PI3K with an IC50 of 0.5 μM, 0.97 μM, and 0.57 μM for P110α, P110β, P110δ, respectively. It also acts as a direct blocker of L-type Ca2+ channel with IC50 of 20 µM. Mar 14 2025
E4665 NMD670 NMD670 is a first-in-class small molecule inhibitor of skeletal muscle-specific chloride channel (ClC-1) with an EC50 of 1.6 μM. It improves muscle weakness and fatigue in neuromuscular diseases and may serve as a potential therapeutic approach for Myasthenia Gravis (MG). Mar 14 2025
E4744 BI-9787 BI-9787 is a potent zwitterion inhibitor of ketohexokinase(KHK) with IC50 values of 12 nM and 12.8 nM for hKHK-A and hKHK-C. It exhibits good metabolic stability in rat hepatocytes and serves as a potent tool compound for in vitro and in vivo studies in rodents. Mar 14 2025