GSK4418959

Name: GSK4418959
Brand: Selleck Chemicals
SKU: E6402
Rating: 5 (1 reviews)

Synonyms: IDE275

Catalog No.E6402 Purity:≥99%

GSK4418959 is a non-covalent, reversible, selective and orally active inhibitor of WRN helicase. It inhibits ATPase and DNA unwinding functions in an ATP-competitive manner and can be a potential therapeutic agent that can be used for the study of microsatellite instability-high (MSI-H) cancer research.

GSK4418959 Chemical Structure

CAS No. 3064599-36-3

Purity & Quality Control

≥99

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Biological Activity

Description	GSK4418959 is a non-covalent, reversible, selective and orally active inhibitor of WRN helicase. It inhibits ATPase and DNA unwinding functions in an ATP-competitive manner and can be a potential therapeutic agent that can be used for the study of microsatellite instability-high (MSI-H) cancer research.

References

[1] Joshua P, et al. Cancer Res (2025) 85 (8_Supplement_1): 5750.

Chemical Information & Solubility

Molecular Weight	646.65	Formula	C₃₁H₃₀F₄N₄O₅S
CAS No.	3064599-36-3	SDF	Download GSK4418959 SDF
Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
Storage (From the date of receipt)	3 years-20°Cpowder		1 month-20°Cin solvent

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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