HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E7943 6-FITC 6-FITC (6-Fluorescein Isothiocyanate) is a derivative of fluorescein used in wide-ranging applications including flow cytometry. Dec 20 2024
E1534 GSK840 GSK840 (GSK'840) is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 0.9 nM, and inhibits kinase activity with an IC50 of 0.3 nM. Dec 20 2024
E7688 L67 L67 (DNA Ligase Inhibitor) is a competitive inhibitor of DNA ligase that effectively targets both DNA ligases I and III, with an IC50 of 10 μM for both enzymes. It specifically disrupts mitochondrial DNA metabolism in cancer cells. Inhibition of DNA ligase IIIα (LigIIIα) by L67 leads to significant alterations in mitochondrial morphology, reduces mitochondrial DNA levels, and increases reactive oxygen species (ROS). Dec 20 2024
E7944 Vipadenant Vipadenant (BIIB-014; CEB-4520) is an adenosine receptor antagonist, with Kis of 1.3 nM and 68 nM for A2A and A1, respectively. Dec 20 2024
E7689 (R)-(-)-Rolipram (R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively. Dec 20 2024
E7945 MF498 MF498 is a selective and orally active E prostanoid Receptor 4 (EP4) antagonist with a Ki value of 0.7 nM. MF498 can be used in the research of inflammation, such as rheumatoid and osteoarthritis. Dec 20 2024
E7690 7α,25-Dihydroxycholesterol 7α,25-Dihydroxycholesterol (7α,25-OHC) is a potent and selective endogenous agonist of the orphan G protein-coupled receptor EBI2 (GPR183). It exhibits high potency in activating EBI2, with an EC50 of 140 pM and a Kd of 450 pM. Dec 20 2024
E7946 Esculentoside H Esculentoside H (EsH) is a saponin isolated from the root extract of perennial plant Phytolacca esculenta. Esculentoside H (EH) has anti-tumor activity, the mechanism is related to the capacity for TNFrelease.Esculentoside H (EsH) suppresses colon cancer cell migration through blockage of the JNK1/2 and NF-κB signaling-mediated matrix metalloproteinases-9 (MMP-9) expression. Dec 20 2024
S4487 Gilteritinib hemifumarate Gilteritinib (ASP2215) hemifumarate is a potent and ATP-competitive FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively. Dec 20 2024
E7691 Mps1-IN-3 Mps1-IN-3 is a potent and selective MPS1 kinase inhibitor, with an IC50 of 50 nM. Dec 20 2024
E1250 (R)-CPP (R)-CPP is a highly potent NMDA receptor antagonist. Dec 20 2024
E7692 N-Acetyltyramine N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceum ATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells. Dec 20 2024
E4633 Pyocyanin Pyocyanin (Pyocyanine) is a toxic, quorum sensing (QS) controlled metabolite produced by Pseudomonas aeruginosa. Pyocyanin is a REDOX active compound that promotes the production of reactive oxygen species (ROS). Pyocyanin has antibacterial and anti-inflammatory activity. Dec 20 2024
E7693 Tofacitinib metabolite-1 Tofacitinib metabolite-1 is a metabolite of Tofacitinib, a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib. Dec 20 2024
E7948 Sisomicin Sisomicin is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin is highly active against Gram-positive bacteria. Dec 20 2024
E4863 Phentolamine Phentolamine is a potent, selective and orally active α1 adrenergic and α2 adrenergic receptor antagonist. Phentolamine can be used for the research of erectile dysfunction. Dec 20 2024
E7694 VU 0240551 VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) and is selective versus NKCC1. VU 0240551 also inhibits hERG and L-type Ca2+ channels. VU 0240551 attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential and enhances P cell synaptic transmission. Dec 20 2024
E4027 SB 202474 SB 202474, a negative analog of SB203580. SB 202474, which has no ability to inhibit p38 MAPK activity and is widely used as a negative control compound in p38 MAPK studies, also suppressed melanin synthesis induction. Dec 20 2024
E7695 SB-277011 SB-277011 is a potent and delective dopamine D3 receptor antagonist (pKi values are 8.0, 6.0, 5.0 and <5.2 for D3, D2, 5-HT1D and 5-HT1B respectively); brain penetrant.IC50 value: 8.0 (pKi)Target: D3 receptor Dec 20 2024
E1420 Talampanel Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain. Dec 20 2024