Home DNA Damage/DNA Repair DNA/RNA Synthesis Chemical L-Asparaginase

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L-Asparaginase DNA/RNA Synthesis Chemical

Cat.No.E8190

L-Asparaginase(L-ASNase) is a deamidating enzyme that hydrolyzes L-asparagine and L-glutamine, depleting L-asparagine in the blood and bone marrow. It exhibits anti-leukemic effects by inhibiting RNA and DNA synthesis, leading to blastic cell apoptosis, and is used in acute lymphoblastic leukemia (ALL) research and treatment.
L-Asparaginase DNA/RNA Synthesis Chemical Chemical Structure

Molecular Weight: 34.5KDa

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Quality Control

Batch: E819001 DMSO]100 mg/mL]true]Water]100 mg/mL]false]Ethanol]Insoluble]false Purity: 98.5%
98.5

Solubility

In vitro
Batch:

DMSO : 100 mg/mL Warmed with 60°C water bath; Ultrasonicated;
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 100 mg/mL

Ethanol : Insoluble

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Mass Concentration Volume Molecular Weight
Dilution Calculator Molecular Weight Calculator

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 34.5KDa Formula Storage (From the date of receipt) 2 years 4°C, in dark and seal
CAS No. 9015-68-3 -- Storage of Stock Solutions Solutions are unstable. Prepare fresh or purchase small, pre-packaged sizes. Repackage upon receipt.

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Mechanism of Action

References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-07-29)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT06099366 RECRUITING
Lymphoblastic Leukemia in Children
Hee Young Ju
 2024-03-05 PHASE2
NCT06336395 RECRUITING
B Lymphoblastic Leukemia
National University Hospital, Singapore
 2020-03-04 PHASE2
NCT03286634 ACTIVE_NOT_RECRUITING
Down Syndrome; Acute Lymphoblastic Leukemia; Childhood Cancer
National Hospital Organization Nagoya Medical Center
 2017-04-18 PHASE2
NCT03150693 RECRUITING
B Acute Lymphoblastic Leukemia
Alliance for Clinical Trials in Oncology
 2017-09-20 PHASE3
NCT04440267 RECRUITING
Acute Leukemia of Ambiguous Lineage
Institute of Hematology & Blood Diseases Hospital, China
 2020-07-08 PHASE2
NCT03156790 TERMINATED
Acute B-Cell Lymphoblastic Leukaemia
medac GmbH
 2019-04-26 PHASE2

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