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TAC (TERT Activator-1) TERT Activator

Name: TAC (TERT Activator-1)
Brand: Selleck Chemicals
SKU: E4660
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E4660

TAC(TERT activator compound) is an activator of TERT, that upregulates TERT transcription via the MEK/ERK/AP-1 cascade. It enhances telomere synthesis, reduces aging markers, inflammation, and senescence, and preserves brain function, highlighting TERT's potential in combating aging and related diseases.

Chemical Structure

Molecular Weight: 331.77

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Quality Control

Batch: E466001 DMSO]66 mg/mL]false]Ethanol]66 mg/mL]false]Water]Insoluble]false Purity: 98.85%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS/MSDS
Datasheet

98.85

Related Targets	HDAC PARP ATM/ATR DNA-PK WRN DNA/RNA Synthesis Topoisomerase PPAR Sirtuin Casein Kinase
Other Telomerase Inhibitors	BIBR 1532 Costunolide RHPS 4 methosulfate Cycloastragenol Cyclogalegenol Braco-19 trihydrochloride L-778123 hydrochloride Epitalon MST-312

Solubility

In vitro
Batch:

DMSO : 66 mg/mL (198.93 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 66 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	3.300mg/ml (9.95mM)	Taking the 1 mL working solution as an example, add 50 μL of 66 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.100mg/ml (3.32mM)	Taking the 1 mL working solution as an example, add 50 μL of 22 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	331.77	Formula	C₁₄H₁₂ClF₂NO₂S	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	666699-46-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

Targets/IC₅₀/Ki	TERT
References	[1] https://pubmed.ncbi.nlm.nih.gov/38908367/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-06-03)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07352566	NOT_YET_RECRUITING	Psoriasis; Atopic Dermatitis	University of California, San Francisco	2026-08-01	PHASE4
NCT07587034	NOT_YET_RECRUITING	Liver Cancer	Shanghai Zhongshan Hospital	2026-06	PHASE1; PHASE2
NCT07739914	NOT_YET_RECRUITING	Liver Allograft; Liver Diseases; Liver Transplantation	Hannover Medical School	2026-06-30	PHASE3
NCT07290777	RECRUITING	Transplantation, Kidney	Veloxis Pharmaceuticals	2026-08-18	PHASE2
NCT06235892	RECRUITING	Organ Grafts	Nantes University Hospital	2024-12-10	PHASE3
NCT07410234	NOT_YET_RECRUITING	Breast Cancer	Tianjin Medical University Cancer Institute and Hospital	2026-02-21	PHASE2

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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