HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E7394 Methotrexate metabolite Methotrexate metabolite (DAMPA) is an active metabolite of Methotrexate. Methotrexate is a Folic acid (HY-16637) antagonist, widely used as an immunosuppressant. Methotrexate metabolite is an antimalarial agent that inhibits parasite growth under physiological folic acid conditions, with IC50 values of 446 nM and 812 nM against folic acid-sensitive strains and highly resistant strains, respectively. Methotrexate metabolite exhibits pharmacokinetic characteristics of rapid clearance and extensive metabolism, with a mean clearance rate of 1.9 l/kg/h and a mean terminal half-life of 51 minutes. Methotrexate metabolite is promising for research in the field of inflammation. Dec 19 2024
E5056 4-Allylcatechol 4-Allylcatechol (4-Allylpyrocatechol) is a xylan isolated from the root of Piper taiwanense. 4-Allylcatechol has a strong inhibitory activity against collagen-induced platelet aggregation (IC50=5.3 μM). In addition, 4-Allylcatechol has anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv (MIC=27.6 μg/mL). Dec 19 2024
E7170 KAT8-IN-1 KAT8-IN-1 is an inhibitor of lysine acetyltransferase 8 (KAT8)> with IC50 values of 141 μM, 221 μM and 106 μM for KAT8, KAT2B, KAT3B respectively. By inhibiting histone acetyltransferases (HATs), it helps investigate their role in disease and holds potential as a therapeutic agent for cancer and inflammatory conditions. Dec 19 2024
E7395 Salcaprozate sodium Salcaprozate sodium (SNAC) is an oral absorption promoter, with potential as a delivery agent for oral forms of heparin and insulin. It is intestinal permeation enhancer (PE) that increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation. It can be used in manufacturing uncoated oral tablet, by blending the active pharmaceutical ingredient (API) using conventional processes. Dec 19 2024
E7171 PIK-75 PIK-75 is a reversible DNA-PK and p110α-selective inhibitor, which inhibits DNA-PK, p110α and p110γ with IC50s of 2, 5.8 and 76 nM, respectively. PIK-75 inhibits p110α >200-fold more potently than p110β (IC50=1.3 μM). PIK-75 induces apoptosis. Dec 19 2024
E7396 5-Hydroxypyrazine-2-Carboxylic Acid 5-Hydroxypyrazine-2-Carboxylic Acid, a metabolite of anti-tuberculosis drug pyrazinamide (PZA). Dec 19 2024
E7172 6-FAM 6-FAM (6-Carboxyfluorescein) is an isomer of carboxyfluorescein and is mainly used for sequencing and labeling of nucleic acids. Dec 19 2024
E7397 Falcarindiol Falcarindiol, an orally active polyacetylenic oxylipin, activates PPARγ and increases the expression of the cholesterol transporter ABCA1 in cells. Falcarindiol induces apoptosis and autophagy. Falcarindiol has anti-inflammatory, antifungal, anticancer and antidiabetic properties. Falcarindiol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Dec 19 2024
E7173 5-ROX 5-ROX (5-Carboxy-X-rhodamine) is a rhodamine dye that exhibits strong fluorescence in aqueous buffer with an excitation maximum (λₑₓᵢₜ) at 580 nm (ε = 3.6 × 10⁴ M⁻¹ cm⁻¹) and an emission maximum (λₑₘᵢₜ) at 604 nm (ϕ = 0.94). It is highly photostable and widely used for biomolecular labeling and fluorescence-based detection. Dec 19 2024
E7398 Ezetimibe phenoxy glucuronide Ezetimibe phenoxy glucuronide (Ezetimibe glucuronide) is the active metabolite of Ezetimibe. Antihyperlipoproteinemic activity. Ezetimibe is a potent cholesterol absorption inhibitor. Dec 19 2024
E7174 D-α-Tocopherol Succinate D-α-tocopherol succinate (Vitamin E succinate) is an antioxidant tocopherol and a salt form of vitamin E that significantly reduces the cisplatin-induced increase of ROS and decreases cellular necrosis and late apoptosis, thereby inhibiting cisplatin-induced cytotoxicity in HEIOC1 cells. It also exhibits an anti-apoptotic effect. Dec 19 2024
E7399 Ajmalicine Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity. Dec 19 2024
E7175 Gramicidin A Gramicidin A is a peptide component of gramicidin, an antibiotic mixture originally isolated from B. brevis. Gramicidin A is a highly hydrophobic channel-forming ionophore that forms channels in model membranes that are permeable to monovalent cations. Gramicidin A induces degradation of hypoxia inducible factor 1 α (HIF-1α). Dec 19 2024
E7400 Furafylline Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with an IC50 of 0.07 μM. Dec 19 2024
E7176 Glucose oxidase Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O2) to produce hydrogen peroxide (H2O2) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation. Dec 19 2024
E7401 (S)-b-aminoisobutyric acid (S)-b-aminoisobutyric acid is a non-protein amino acid originating from the catabolism of thymine and valine. Dec 19 2024
E7000 Ponatinib hydrochloride Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively. Dec 19 2024
E7402 Ac-IETD-AFC Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B. Dec 19 2024
E7177 5(6)-TAMRA 5(6)-TAMRA is a fluorescent dye molecule widely used as a label for peptides and proteins. Dec 19 2024
E7403 Ac-LEHD-AFC Ac-LEHD-AFC is a fluorescent substrate for caspase-9, can be used to assess the activity of caspase. Dec 19 2024