HomeAll New Products Listed Chronologically

All New Products Listed Chronologically

Catalog No. Product Name Information Isotype
E8081 BMS-582949 hydrochloride BMS-582949 hydrochloride is an orally active and highly selective p38α MAPK inhibitor, with an IC50 of 13 nM. BMS-582949 hydrochloride displays a significantly improved pharmacokinetic profile and is effective in inflammatory disease. Dec 20 2024
E7571 FPR Agonist 43 FPR Agonist 43 (compound 43) is a dual formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2)/ALX agonist. Dec 20 2024
E7827 KDM5-IN-1 KDM5-IN-1 is a potent, selective and orally bioavailable KDM5 inhibitor with an IC50 of 15.1 nM. Dec 20 2024
E8082 Terutroban Terutroban is a thromboxane-prostaglandin receptor antagonist. Dec 20 2024
E7572 IT1t dihydrochloride IT1t dihydrochloride is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. Dec 20 2024
E7828 Edelinontrine Edelinontrine (PF-04447943) is a potent inhibitor of human recombinant PDE9A (IC50=12 nM) with >78-fold selectivity, respectively, over other PDE family members (IC50>1000 nM). Dec 20 2024
E8083 I2906 I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis.IC50 Value: Target: AntibacterialUnder in vitro conditions, I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv, the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further, the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover, survival rate was increased by I2906 treatment. For multidrug-resistant strain infection, bacterial counts were reduced significantl Dec 20 2024
E7573 Flagelin 22 Flagelin 22 (Flagellin 22), a fragment of bacterial flagellin, is an effective elicitor in both plants and algae. Dec 20 2024
E7829 Sangivamycin Sangivamycin (NSC 65346), a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers. Dec 20 2024
E8084 Trimethylamine N-oxide-d9 Trimethylamine N-oxide-d9 is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating the ROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating the TGF-β/smad2 signaling pathway. Dec 20 2024
E7574 EGTA-AM EGTA-AM (ethylene glycol tetraacetic acid, acetoxymethyl ester, EGTA Acetoxymethyl ester) is a cell-permeable derivative of EGTA, a calcium chelator. The acetoxymethyl (AM) ester group allows EGTA to cross the cell membrane, where intracellular esterases hydrolyze it, releasing the active EGTA form. This active form binds calcium ions (Ca²⁺) in the cytosol. Dec 20 2024
E7830 R(+)-Methylindazone R(+)-Methylindazone (R(+)-IAA-94) is a potentand specific indanyloxyacetic inhibitor of the renal epithelial chloride channel and exacerbates myocardial infarction by impairing mitochondrial calcium retention capacity (CRC), leading to mitochondrial permeability transition pore (mPTP) opening and increased cell death during ischemia-reperfusion injury. Dec 20 2024
E7575 MAFP MAFP (Methyl Arachidonyl Fluorophosphonate) is an selective, active-site directed and irreversible inhibitor of cPLA2 and iPLA2. MAFP is also a potent irreversible inhibitor of anandamide amidase. Dec 20 2024
E7831 Doxorubicinone Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Dec 20 2024
E8086 Lupeol acetate Lupeol acetate is a derivative of Lupeol. Lupeol acetate is an anti-inflammatory, antibacterial, anti-trypanosomic and anticancer agent with oral activity. Lupeol acetate significantly improves the symptoms of rheumatoid arthritis by down-regulating the expression of inflammatory cytokines and osteoclast production. Lupeol acetate inhibits spermatogenesis in male rats and eventually led to infertility. Dec 20 2024
E7576 Ubiquitin Isopeptidase Inhibitor I, G5 Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively. Dec 20 2024
E7832 trans-AUCB trans-AUCB (t-AUCB) is a potent, orally active and selective soluble epoxide hydrolase (sEH) inhibitor with IC50s of 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively. trans-AUCB has anti-glioma activity. Dec 20 2024
E8087 NEP(1-40) NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide, reversing the injury-induced shift in distribution of microglia morphologies by limiting myelin-based inhibition. Dec 20 2024
E7577 Benfluorex hydrochloride Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator. Dec 20 2024
E7833 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death. Dec 20 2024