Home Epigenetics HDAC inhibitor PB94 For research use only.

PB94

PB94 is a potent and selective inhibitor of HDAC11 with an IC50 of 108 nM and exhibits >40-fold selectivity over other HDAC isoforms. It ameliorates neuropathic pain in mouse models and can be radiolabeled with carbon-11 as [¹¹C]PB94 for PET imaging, demonstrating significant brain uptake and potential for in vivo imaging applications.

PB94 Chemical Structure

PB94 Chemical Structure

CAS No. 3032970-74-1

Purity & Quality Control

PB94 Related Products

Signaling Pathway

HDAC Signaling Pathways

HDAC Signaling Pathway

Biological Activity

Description PB94 is a potent and selective inhibitor of HDAC11 with an IC50 of 108 nM and exhibits >40-fold selectivity over other HDAC isoforms. It ameliorates neuropathic pain in mouse models and can be radiolabeled with carbon-11 as [¹¹C]PB94 for PET imaging, demonstrating significant brain uptake and potential for in vivo imaging applications.
  • https://pubmed.ncbi.nlm.nih.gov/37972387/

Chemical Information & Solubility

Molecular Weight 487.59 Formula

C29H33N3O4
CAS No. 3032970-74-1 SDF Download PB94 SDF
Storage (From the date of receipt)

In vivo
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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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