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Rezafungin acetate Fungal inhibitor

Name: Rezafungin acetate
Brand: Selleck Chemicals
SKU: E8001
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E8001

Rezafungin acetate (Biafungin acetate, CD101 acetate, SP-3025 acetate) is a next-generation, semi-synthetic echinocandin antifungal approved for Candida, Aspergillus, and Pneumocystis species. It works by selectively inhibiting β-glucan synthase.

Chemical Structure

Molecular Weight: 1285.44

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Quality Control

Batch: E800101 DMSO]100 mg/mL]false]Water]50 mg/mL]false]Ethanol]Insoluble]false Purity: 99.38%

Cited in Nature Medicine for its top-tier quality
COA
HPLC
SDS/MSDS
Datasheet

99.38

Related Targets	Integrase Bacterial Antibiotics Anti-infection Antiviral COVID-19 Parasite Reverse Transcriptase HIV HCV Protease
Other Fungal Inhibitors	Cycloheximide Tolnaftate Manogepix (E1210) Amorolfine HCl Isavuconazole Juglone Bifonazole Thimerosal Pseudolaric Acid B Butylparaben

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (77.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 50 mg/mL

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	1285.44	Formula	C₆₃H₈₅N₈O₁₇.C₂H₃O₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	1631754-41-0	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/39865335/ [2] https://pubmed.ncbi.nlm.nih.gov/29486356/ [3] https://pubmed.ncbi.nlm.nih.gov/39552377/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-10-20)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06774144	ENROLLING_BY_INVITATION	Liver Transplant Infection; Fungal Infection	Fernanda P Silveira, MD, MS	2025-10-15	PHASE3
NCT06794554	ACTIVE_NOT_RECRUITING	Chronic Pulmonary Aspergillosis	Mundipharma Research Limited	2025-06-30	PHASE2
NCT04368559	COMPLETED	Candidemia; Mycoses; Fungal Infection; Fungemia; Invasive Candidiasis; Pneumocystis; Mold Infection; Invasive Fungal Disease; Prophylaxis of Invasive Fungal Infections; Aspergillus	Mundipharma Research Limited	2020-05-11	PHASE3
NCT06985758	NOT_YET_RECRUITING	Candidal Peritonitis	Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal	2025-09	PHASE4
NCT05835479	RECRUITING	Pneumocystis Pneumonia	Mundipharma Research Limited	2023-11-14	PHASE2
NCT06329518	WITHDRAWN	Sepsis	Hartford Hospital	2024-07-01	PHASE1

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Handling Instructions

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