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Pitavastatin HMG-CoA Reductase inhibitor

Name: Pitavastatin
Brand: Selleck Chemicals
SKU: E6038
Availability: InStock
Rating: 5 (8 reviews)

Cat.No.E6038

Pitavastatin (NK-104) is a highly potent inhibitor of HMG-CoA reductase with an IC50 of 6.8 nmol/L, which significantly enhances LDL receptor activity and lowers LDL cholesterol (LDL-C) levels. It also inhibits cholesterol synthesis in vitro and has the potential to manage hypercholesterolemia and reducing cardiovascular risk.

Chemical Structure

Molecular Weight: 421.46

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Quality Control

Batch: E603801 DMSO]84 mg/mL]false]Ethanol]42 mg/mL]false]Water]Insoluble]false Purity: 98.20%

Cited in Nature Medicine for its top-tier quality
COA
NMR
HPLC
SDS/MSDS
Datasheet

98.20

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE phosphatase PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism
Other HMG-CoA Reductase Inhibitors	Mevastatin SR-12813 Clinofibrate Cerivastatin sodium Dihydrolanosterol 7-ketocholesterol

Solubility

In vitro
Batch:

DMSO : 84 mg/mL (199.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 42 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	4.200mg/ml (9.97mM)	Taking the 1 mL working solution as an example, add 50 μL of 84 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.350mg/ml (0.83mM)	Taking the 1 mL working solution as an example, add 50 μL of 7 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	421.46	Formula	C₂₅H₂₄FNO₄	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	147511-69-1	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/21468365/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2025-08-07)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06722521	RECRUITING	Primary Prevention; Vascular Calcification	Asan Medical Center	2025-07-09	PHASE4
NCT06767774	RECRUITING	ASCVD; Diabetes; Statin	Korea University Anam Hospital	2025-04-25	PHASE4
NCT07626840	NOT_YET_RECRUITING	Acute Coronary Syndrome (ACS) Undergoing Percutaneous Coronary Intervention (PCI)	Samsung Medical Center	2026-06-01
NCT07774975	NOT_YET_RECRUITING	Retinitis Pigmentosa (RP)	Kyushu University	2026-09-15	PHASE1
NCT07460960	RECRUITING	Erectile Dysfunction Due to Arterial Disease; Atheroscleroses; Erectile Disfunction; Endothelial Dysfunction; Androgen Profile; Testosterone	Lomonosov Moscow State University Medical Research and Educational Center	2026-03-05	PHASE2
NCT05705804	RECRUITING	Dyslipidemias; Atherosclerotic Cardiovascular Disease	Yonsei University	2023-06-13

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