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Voclosporin phosphatase inhibitor

Name: Voclosporin
Brand: Selleck Chemicals
SKU: E1027
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.E1027

Voclosporin is a potent, inhibitor of Calcineurin. It exhibits both immunomodulatory and non-immune effects by inhibiting T-cell proliferation, reducing proteinuria through podocyte cytoskeleton stabilization and afferent arteriole vasoconstriction, and effectively suppressing lymphocyte proliferation and cytokine production, making it useful for systemic lupus erythematosus (SLE) research.

Chemical Structure

Molecular Weight: 1214.62

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Quality Control

Batch: E102701 DMSO]100 mg/mL]false]Ethanol]100 mg/mL]false]Water]Insoluble]false Purity: 98.43%

Cited in Nature Medicine for its top-tier quality
COA
SDS/MSDS
Datasheet

98.43

Related Targets	Dehydrogenase HSP Transferase P450 (e.g. CYP17) PDE PPAR Vitamin Carbohydrate Metabolism Mitochondrial Metabolism Casein Kinase
Other phosphatase Inhibitors	Osunprotafib (ABBV-CLS-484) SHP099 Hydrochloride RMC-4550 SHP099 Batoprotafib (TNO155) GSK2830371 β-Glycerophosphate sodium salt hydrate NSC87877 TPI-1 Suramin sodium salt

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (82.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 100 mg/mL

Water : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	5mg/ml (4.12mM)	Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.3mg/ml (0.25mM)	Taking the 1 mL working solution as an example, add 50 μL of 6 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	1214.62	Formula	C₆₃H₁₁₁N₁₁O₁₂	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	515814-01-4	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent

Read more about storage stability stock solution CAS number

Mechanism of Action

References	[1] https://pubmed.ncbi.nlm.nih.gov/34244988/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-08-12)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT07760480	RECRUITING	Lupus Nephritis; Systemic Lupus Erythematosus (SLE)	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2026-04-23	PHASE4
NCT06406205	RECRUITING	Lupus Nephritis	Qilu Pharmaceutical Co., Ltd.	2023-12-25	PHASE3
NCT07225387	RECRUITING	Lupus Nephritis	NephroNet, Inc.	2024-10-01	PHASE4
NCT05962788	TERMINATED	Adolescent Lupus Nephritis; Pediatric Lupus Nephritis	Aurinia Pharmaceuticals Inc.	2024-03-28	PHASE3
NCT05288855	TERMINATED	Adolescent Lupus Nephritis; Pediatric Lupus Nephritis	Aurinia Pharmaceuticals Inc.	2023-10-10	PHASE3
NCT05306873	TERMINATED	Systemic Lupus Erythematosus	National Institute of Allergy and Infectious Diseases (NIAID)	2022-11-30	PHASE2

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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